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| Number | Title | Issue Date |
| 7354928 | Small molecule inhibitors targeted at Bcl-2 The present invention relates to small molecule antagonists of Bcl-2 family proteins such as Bcl-2 and/or Bcl-XL. In particular, the present invention provides non-peptide cell permeable small molecules (e.g., tricyclo-dibenzo-diazocine-dioxides) that bin... | 04/08/2008 |
| 7345046 | Heteroaryl-fused pyrimidinyl compounds as anticancer agents Heteroaryl-fused pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the heteroaryl-fused pyrimidinyl compounds, either alone or in combination with at lea... | 03/18/2008 |
| 7304046 | Phosphoramide compounds The invention provides a compound of formula I: wherein R1, Ra, Rb, Rc, and Rd have any of the values defined in the specification, as well as pharmaceutical... | 12/04/2007 |
| 7268124 | Geranylgeranyl pyrophosphate synthase inhibitors The invention provides novel pyrophosphate synthase inhibitors of formula I as well as compositions comprising such inhibitors and methods for their use. ... | 09/11/2007 |
| 7205001 | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt, complex, organic compound or ionic solution to treat tumors of epithel... | 04/17/2007 |
| 7199111 | Aqueous ifosfamide compositions for parenteral administration and a process for their preparations The present invention provides aqueous Ifosfamide compositions and a process for their preparation, in which the compositions have a reduced toxicity over and above the concomitant use of the uroprotective agent, Mesna. Aqueous Ifosfamide compositions can be prepare... | 04/03/2007 |
| 7166611 | Pharmaceutical compositions having appetite suppressant activity A pharmaceutical composition contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for obtaining the extract and a process for synthesizing compound (1... | 01/23/2007 |
| 7163703 | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt, complex, organic compound or ionic solution to treat tumors of epithel... | 01/16/2007 |
| 7115565 | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability Pharmaceutical compositions suitable for oral administration comprising paclitaxel, a solvent, a surfactant, a substituted cellulosic polymer, and optionally but preferably a P-glycoprotein inhibitor. The composition may further comprise a diglyceride or mixture of ... | 10/03/2006 |
| 7045495 | Combination of bryostatin and paclitaxel for treating cancer This invention provides methods for screening a modulating agent which when combined with antitumor therapeutic agent increases apoptosis in tumor cells. This invention also provides methods for screening antitumor therapeutic agents suitable for combination therapy... | 05/16/2006 |
| 7038039 | Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside A desired isomer is selectively prepared by phosphorolyzing and isomerizing an anomer mixture of a 1-phosphorylated saccharide derivative while crystallizing one of the isomers to displace the equilibrium. Furthermore, using the action of a nucleoside phosphorylase,... | 05/02/2006 |
| 6992106 | Anti-tumor composition The present invention provides composition having as active ingredients a stilbene derivative and a platinum coordination compound which is highly efficacious and highly safe for treating tumors, particularly for the treatment of solid or malignant tumors and thus m... | 01/31/2006 |
| 6951861 | Chemical compounds The invention relates to piperazine derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to their medical use. The novel compounds are antagonists of tachykinins, including substance P and other neurokinins. ... | 10/04/2005 |
| 6916806 | Medicinal composition containing 1,3-thiazine derivative A compound of the formula (I) having a binding activity to the cannabinoid type 2 receptor: wherein R1 is optionally substituted heterocyclic group or the like; R2 and R2 each is indepe... | 07/12/2005 |
| 6875451 | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt, complex, organic compound or ionic solution to treat tumors of epithel... | 04/05/2005 |
| 6770673 | Therapeutic uses of arglabin in combination with other chemotherapy agents Compositions and kits containing a first chemotherapeutic agent that includes arglabin or a derivative thereof and a second chemotherapeutic agent are described. The compositions and kits are effective for treating cancer in a human patient. Methods for suppressing ... | 08/03/2004 |
| 6762174 | Low molecular weight compounds administered together with anti-cancer agents to prevent or treat cancer and pharmaceutical compositions thereof The present invention relates to peptide-like compounds, e.g. aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increa... | 07/13/2004 |
| 6737416 | Phosphonic acid derivative having inhibitory activity against carboxypeptidase B A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: wherein R1 represents hydrogen atom, an alkyl group, a substituted alkyl group and the like; R2... | 05/18/2004 |
| 6703400 | Methods for treating multidrug resistance Methods are provided for treating multidrug resistance in refractory tumor cells comprising administering (1) a P-glycoprotein inhibitor in conjunction with (2) an antineoplastic agent.... | 03/09/2004 |
| 6649614 | Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent for treatment of depression or anxiety The present invention relates to the treatment of depression and/or anxiety by the administration of a combination of a specific class of NK-1 receptor antagonists and an antidepressant or anti-anxiety agent.... | 11/18/2003 |
| 6500811 | Sulfonylaminophosphinic and sulfonylaminophosphonic acid derivatives, methods for their preparation and use Compounds of the formula I ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading enzymes is involved.... | 12/31/2002 |
| 6444638 | Combinations of PKC inhibitors and therapeutic agents for treating cancers This invention provides methods for screening a modulating agent which when combined with antitumor therapeutic agent increases apoptosis in tumor cells. This invention also provides methods for screening antitumor therapeutic agents suitable for combinat... | 09/03/2002 |
| 6319953 | Treatment of depression and anxiety with fluoxetine and an NK-1 receptor antagonist The present invention relates to the treatment or prevention of depression and/or anxiety by the administration of a combination of a specific class of NK-1 receptor antagonists and fluoxetine.... | 11/20/2001 |
| 6204245 | Treatment of narcolepsy with immunosuppressants The invention provides compositions and methods for treatment of narcolepsy or isolated cataplexy. Such methods entail administering a therapeutically effective regime of at least one immunosuppressive agent. The methods are particularly useful for prophy... | 03/20/2001 |
| 6200961 | Concentrates of organophosphorous insecticides A low volatile organic compound co-solvent system is disclosed for preparing emulsion concentrates of low melting organophosphorous insecticides wherein the bioefficacy of the insecticide active is significantly enhanced. The co-solvent system comprises a... | 03/13/2001 |
| 6156749 | Use of NK-1 receptor antagonists for treating movement disorders The present invention provides the use of an orally active, long acting, CNS-penetrant NK-1 antagonist for the manufacture of a medicament for oral administration for the treatment or prevention of movement disorders, methods of treatment using such a NK-... | 12/05/2000 |
| 6133272 | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NOn N-PDE inhibitor where n is 1 or 2. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The... | 10/17/2000 |
| 6117855 | Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent The present invention relates to the treatment or prevention of depression and/or anxiety by the administration of a combination of CNS-penetrant NK-1 receptor antagonists and an antidepressant or anti-anxiety agent.... | 09/12/2000 |
| 6114315 | Use of NK-1 receptor antagonists for treating major depressive disorders with anxiety The present invention provides methods for the treatment or prevention of major depressive disorder with anxiety without concomitant therapy with other anti-depressant or anti-anxiety agents which comprises oral administration of an orally active, long ac... | 09/05/2000 |
| 6096729 | Use of NK-1 receptor antagonists for treating amnestic disorders The present invention provides methods for the treatment or prevention of amnestic disorders which comprises oral administration of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist.... | 08/01/2000 |
| 6087348 | Use of NK-1 receptor antagonists for treating stress disorders The present invention provides the use of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist for the manufacture of a medicament adapted for oral administration for the treatment or prevention of stress disorders without concomitant the... | 07/11/2000 |
| 6054445 | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritis therewith Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compound of formulae IIA, having the structure: ##STR1## wherein R1, R2 | 04/25/2000 |
| 6028063 | Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compounds of formula III having the structure: ##STR1## wherein Ar and X7 ; R | 02/22/2000 |
| 5958969 | Benzob!thiophene compounds, intermediates, formulations, and methods This invention relates to the field of pharmaceutical and organic chemistry and provides benzothiophene compounds, intermediates, formulations, and methods.... | 09/28/1999 |
| 5952315 | Use of NK-1 receptor antagonists for treating bipolar disorders The present invention provides methods for the treatment or prevention of bipolar disorder without concomitant therapy with other antidepressant or anti-anxiety agents which comprises oral administration of an orally active, long acting, CNS-penetrant NK-... | 09/14/1999 |
| 5929054 | Use of NK-1 receptor antagonists for treating sexual dysfunctions The present invention provides a method for the treatment or prevention of sexual dysfunctions which comprises oral administration of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist and pharmaceutical compositions comprising such an ... | 07/27/1999 |
| 5925627 | Use of NK-1 receptor antagonists for treating movement disorders The present invention provides a method for the treatment or prevention of movement disorders using an orally active, long acting, CNS-penetrant NK-1 antagonist and pharmaceutical compositions comprising such an antagonist.... | 07/20/1999 |
| 5914351 | Anti-viral aromatic hydrazones Compounds of the formula ##STR1## wherein Q is a hydrazone derivative; R1 is hydrogen, halogen, alkyl or alkoxy; R2 is hydrogen, halogen, alkyl, alkoxy, alkenoxy, alkynyloxy, halomethyl, trifluoromethoxy, alkylthio, nitro or cyano; a... | 06/22/1999 |
| 5902804 | Pharmaceutical composition for inhibiting the growth of viruses and cancers This invention is a pharmaceutical composition that inhibits the growth of cancers and tumors in mammals, particularly in human and warm blooded animals. The composition is also effective against viruses. The composition contains N-phosphonoglycine deriva... | 05/11/1999 |
| 5880111 | Therapeutic derivations of diphosphonates Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, and infectious urinary tract stones, are obtained by combining chemically a diphosphonate compound with a therapeut... | 03/09/1999 |
