Did You Know...
...that it was melting ice cream that inspired the invention of the outboard motor? It was a lovely August day and Ole Evinrude was rowing his boat to his favorite island picnic spot. As he rowed, he watched his ice cream melt and wished he had a faster way to get to the island. At that moment the idea for the outboard motor was born!
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| Number | Title | Issue Date |
| 8143211 | Bioactive peptides The present invention provides a cytotoxic 7 to 25-mer peptide with three or more cationic residues which has one or more non-generic bulky and lipophilic amino acids, as well as esters, amides, salts and cyclic derivatives thereof as well as methods of preparing th... | 03/27/2012 |
| 8129342 | High purity lipopeptides The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromat... | 03/06/2012 |
| 8058238 | High purity lipopeptides The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromat... | 11/15/2011 |
| 7994128 | Conotoxin peptides useful as inhibitors of neuronal amine transporters The invention relates to an isolated, synthetic or recombinant χ-conotoxin peptide having the ability to inhibit a neuronal amine transporter, nucleic acid molecules encoding all or part of such peptides, antibodies to such peptides and uses and methods of treatmen... | 08/09/2011 |
| 7960340 | Cystine knot molecules The present invention relates generally to a molecular framework having a cyclic structure. More particularly, the present invention provides cyclic proteins and derivatives thereof in which particular turns and other elements of the molecular structure are held in ... | 06/14/2011 |
| 7919458 | Method of inhibiting prostate cancer cell proliferation The present invention relates to a method of inhibiting or reducing the proliferation of prostate cancer cells, such as androgen independent prostate cancer (AIPC) cells, the method comprising administering to the cells a PLA2 inhibitor. In one embodiment... | 04/05/2011 |
| RE42014 | Pharmaceutical compositions A process for preparing an emulsion composition comprising a cyclosporin, a rapamycin or an ascomycin or a derivative thereof as active agent, which process comprises the step of admixing to a placebo fat emulsion a concentrate comprising a) the active ... | 12/28/2010 |
| 7833976 | Methods for treatment of tumors and metastases using a combination of anti-angiogenic and immuno therapies The invention provides methods for treating tumors and tumor metastases in a mammal comprising administering, to a mammal in need of treatment, a therapeutic amount of an antagonist sufficient to inhibit angiogenesis in combination with a therapeutic amount of anti-... | 11/16/2010 |
| 7829533 | Cyclosporin analog formulations The present invention relates to formulations containing cyclosporin analogs that are structurally similar to cyclosporin A, in particular isomeric mixtures of cyclosporin analogs that are structurally similar to cyclosporin A. The formulations form stable microemul... | 11/09/2010 |
| 7825087 | Nanoparticulate and controlled release compositions comprising cyclosporine The present invention is directed to a composition comprising a nanoparticulate cyclosporine having improved bioavailability. The nanoparticulate cyclosporine particles of the composition have an effective average particle size of less than about 2000 nm in diameter... | 11/02/2010 |
| 7807637 | Polymyxin derivatives and uses thereof The present invention relates to a polymyxin derivative wherein R1, R2 and R3 are optional and R1, R2, R3, R5, R8 and R9 are cationic or neutral amino acid residues selected so that the total number of positive charges at physiological pH is at least two but no more... | 10/05/2010 |
| 7799756 | Processes for stereoselective synthesis of trans ISA247 The present invention relates to a process for preparation of a trans ISATX247 compound of the formula: where R1═H or D; R2═H or D; and R3═H or D, by application of organozirconium chemistry. The process involves rea... | 09/21/2010 |
| 7786079 | Substituted nonadepsipeptides The invention relates to nonadepsipeptides and methods for their preparation and their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases. ... | 08/31/2010 |
| 7786078 | Template-fixed δ-hairpin peptidomimetics with CXCR4 antagonizing activity Template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12, 14 or 18 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-t... | 08/31/2010 |
| 7772183 | Hepatitis C virus inhibitors Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed. ... | 08/10/2010 |
| 7763583 | Endoparasiticidal compositions for topical application The present invention relates to transdermally applicable compositions comprising cyclic depsipeptides and/or praziquantel, and to their preparation and their use for controlling endoparasites. ... | 07/27/2010 |
| 7754685 | Methods and pharmaceutical compositions for the treatment and prevention of hepatitis C infection This invention relates to cyclosporin derivatives of general formula (I): wherein A, B, R1, R2 and X are as defined in the specification, and pharmaceutical compositions prepared from the same, for use... | 07/13/2010 |
| 7741281 | Hepatitis C virus inhibitors Macrocyclic peptides are disclosed having the general formula: wherein R′, R3, R3′, R4, R6, X, Q, and W are described. Compositions comprising the com... | 06/22/2010 |
| 7741280 | Multimeric molecules, the preparation method thereof and use of same for the preparation of medicaments The invention relates to a multimeric molecule which can imitate a natural multimeric proteinaceous ligand. The invention also relates to a multimeric molecule as defined above which is characterised in that it has the following general formula: A-Xn, whe... | 06/22/2010 |
| 7737114 | Didemnin analogs and fragments and methods of making and using them The present invention relates to macrocyclic depsipeptides, including didemnin analogs and fragments thereof, which are useful as anti-cancer agents and for other purposes. The invention includes numerous didemnin analogs and fragments and methods of making them. Me... | 06/15/2010 |
| 7737113 | Antiarrhythmic peptides Disclosed are novel peptides including antiarrhythmic peptides that have improved stability. Further disclosed are compositions that include such peptides and methods of using the compositions particularly as medicaments. ... | 06/15/2010 |
| 7727955 | Pharmaceutical compositions based on NK2 antagonists for pediatric use Pharmaceutical compositions containing NK2 antagonists are described, useful for the treatment of infantile colics. ... | 06/01/2010 |
| 7727956 | Deoxonadepsipeptides Nonadepsipeptides and methods for their preparation and their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases are described. ... | 06/01/2010 |
| 7718610 | Retrocyclins: antiviral and antimicrobial peptides Retrocyclin peptides are small antimicrobial agents with potent activity against bacteria and viruses. The peptides are nonhemolytic, and exhibit minimal in vitro cytotoxicity. A pharmaceutical composition comprising retrocyclin as an active agent is administered th... | 05/18/2010 |
| 7709443 | Cyclic peptide antitumor agents Cyclic peptide compounds and derivatives thereof having antitumor activity as shown by treatment of human melanoma, pancreatic, breast, prostate cancer cells. ... | 05/04/2010 |
| RE41287 | Cyclic agonists and antagonists of C5A receptors and G Protein-coupled receptors The present invention relates to novel cyclic or constrained acyclic compounds which modulate the activity of G protein-coupled receptors and are useful in the treatment of conditions mediated by G protein-coupled receptors, for example, inflammatory conditions.... | 04/27/2010 |
| 7691811 | Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye Methods and compositions for enhancing the activity and/or duration of action of loteprednol etabonate and other soft anti-inflammatory steroids of the haloalkyl 17α-alkoxycarbonyloxy-11β-hydroxyandrost-4-cn-3-one-17β-carboxylate type and the corresponding Δ | 04/06/2010 |
| 7687457 | Cyclic molecular framework and derivatives thereof The present invention relates generally to a molecular framework having a cyclic structure. More particularly, the present invention provides cyclic proteins and derivatives thereof in which particular turns and other elements of the molecular structure are held in ... | 03/30/2010 |
| 7674768 | Processes for preparing eptifibatide The present invention provides, inter alia, convergent processes for preparing eptifibatide that involve coupling a 2-6 eptifibatide fragment to an activated cysteinamide residue to form a 2-7 eptifibatide fragment, attaching a mercaptopropionic acid residue to the ... | 03/09/2010 |
| 7666834 | Macrocyclic inhibitors of hepatitis C virus Inhibitors of HCV replication of formula (I) and the N-oxides, salts, or stereoisomers thereof, wherein each dashed line (represented by - - - - -) represents an optional double bond; X is N, CH an... | 02/23/2010 |
| 7659245 | Macrocylic inhibitors of hepatitis C virus Compounds of the formula I: and N-oxides, salts, and stereoisomers thereof wherein A is OR1, NHS(═O)pR2; wherein; R1 is hydrogen, C | 02/09/2010 |
| 7659244 | Rapamycin peptides conjugates: synthesis and uses thereof The present invention relates to new rapamycin derivatives for the inhibition of cell proliferation. The compounds can advantageously target two proteins in dividing cells and interfere with cell cycle. There is thus provided derivatives of rapamycin in which the 42... | 02/09/2010 |
| 7655622 | Composition and method for regulation of body weight and associated conditions Methods for regulating body weight and/or regulating weight gain are provided herein. The methods are useful, for instance, for treating or preventing obesity. Specifically, methods of administering varying levels of various alpha melanocyte stimulating hormone (α-... | 02/02/2010 |
| 7655623 | Dabderivatives of lipopeptide antibiotics and methods of making and using the same The present invention provides Dab9 derivatives of amphomycin-type lipopepetide antibiotics that display antimicrobial activity against Gram-positive bacteria, methods and intermediates for synthesizing the compounds and methods of using the compounds in ... | 02/02/2010 |
| 7645738 | 18-membered nitrobenzyl- and aminobenzyl-substituted cyclohexadepsipeptides for controlling endoparasites and a process for their preparation The invention relates to cyclic depsipeptides, especially 18-membered cyclohexadepsipeptides of general formula (I) and the salts thereof, wherein R1 represents nitrobenzyl or R′R″N-benzyl—wherein R′ and R″ independently represent hydrogen, opti... | 01/12/2010 |
| RE40987 | Cyclosporin with improved activity profile The invention relates to a novel cyclosporin, the pharmaceutical use thereof and a pharmaceutical composition containing it. ... | 11/17/2009 |
| 7598221 | Synthetic HLA binding WT-1 peptide analogues and uses thereof The present invention is directed to a synthetic peptide comprising a sequence of amino acids containing at least a segment that is an analogue of a native peptide that specifically binds to HLA A0201 or HLA A0301 molecules on a cell characteristic of a pathophysiol... | 10/06/2009 |
| 7592308 | F3W variants of the lantibiotic mersacidin and its use The present invention relates to methods and products for improved production of the lantibiotic mersacidin. There is provided a method of producing a mersacidin variant which comprises introducing into a cell which is a ΔMrsA host cell an expression vector encodin... | 09/22/2009 |
| 7585839 | Medical uses of intercellular communication facilitating compounds Disclosed are novel peptides including antiarrhythmic peptides that have improved stability. Further disclosed are compositions that include such peptides and methods of using the compositions particularly as medicaments. ... | 09/08/2009 |
| 7582604 | Template-fixed peptidomimetics with antibacterial activity Template-fixed β-hairpin peptidomimetics of the general formula (I), wherein Z is a template-fixed chain of 12 α-amino acid residues which, depend on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain type... | 09/01/2009 |
