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| Number | Title | Issue Date |
| 7371372 | Compositions comprising IMPDH inhibitors and uses thereof for treating HCV infection The present invention relates to optimal compositions useful in treating HCV infections in humans. These compositions comprise alpha-interferon or pegylated alpha-interferon and an IMPDH inhibitor selected from VX-148 or VX-944, wherein the IMPDH inhibitor is presen... | 05/13/2008 |
| 7364758 | Pharmaceutical use of Graptopetalum and related plants The present invention relates to compositions comprising Graptopetalum and uses thereof Graptopetalum can protect animals from liver diseases and medical conditions, such as inflammation, steatosis, and fibrosis. In particular, Graptopetalum inh... | 04/29/2008 |
| 7335642 | Method for treating a viral infection related or a chemical toxin related hepatic injury with deltorphin D A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A th... | 02/26/2008 |
| 7217730 | Method for the use of pyranoindole derivatives to treat infection with Hepatitis C virus The invention is directed to methods of treating, preventing, or inhibiting a Hepatitis C viral infection in a mammal comprising contacting the mammal with an effective amount of a compound of the formula: Wherei... | 05/15/2007 |
| 7208523 | Alanine- and glycine-containing therapeutic agent for hepatitis The therapeutic agent for hepatitis, containing alanine and glycine, has only a slight toxicity and it can be administered either orally or intravenously to improve the liver function. ... | 04/24/2007 |
| 7138376 | Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides A compound, method and composition for treating a host infected with a hepatitis C viral comprising administering an effective hepatitis C treatment amount of a described 4′-disubstituted nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is prov... | 11/21/2006 |
| 7135195 | Treatment of humans with colloidal silver composition We disclose a colorless composition comprising silver particles and water, wherein said particles comprise an interior of elemental silver and an exterior of ionic silver oxide, wherein the silver particles are present in the water at a level of about 5–40 ppm, an... | 11/14/2006 |
| 7132450 | Hepatic disorder suppressant A hepatic disorder suppressant comprising extracts having hepatic disorder suppressing effect as effective ingredients, wherein the extracts is obtained by extracting an avocado plant and/or a processed product thereof with an organic solvent is disclosed. ... | 11/07/2006 |
| 7115578 | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection Ribavirin derivatives represented by the formula V, pharmaceutical compositions containing them as well as the use of the ribavirin derivatives represented by the formula V for the preparation of a medicament for the treatment of susceptible viral infections, for ex... | 10/03/2006 |
| 7101913 | Hepatic disorder suppressant A hepatic disorder suppressant comprising extracts having hepatic disorder suppressing effect as effective ingredients, wherein the extracts is obtained by extracting an avocado plant and/or a processed product thereof with an organic solvent is disclosed. ... | 09/05/2006 |
| 7097860 | Method and composition for treatment of inflammatory and inflammation-related disorders A method of reducing inflammation in a variety of disorders by using an intraperitoneal solution of magnesium. The solution can be used for treating inflammatory and inflammation-related disorders in animals and/or humans. Application of the solution reduces inflamm... | 08/29/2006 |
| 7081480 | Hepatic disorder suppressant A hepatic disorder suppressant comprising extracts having hepatic disorder suppressing effect as effective ingredients, wherein the extracts is obtained by extracting an avocado plant and/or a processed product thereof with an organic solvent is disclosed. ... | 07/25/2006 |
| 7078064 | Compositions and methods useful for treating and preventing chronic liver disease, chronic HCV infection and non-alcoholic steatohepatitis The invention relates generally to compositions comprising antioxidants useful for reducing oxidative stress and lipid peroxidation, and treating chronic liver disease, chronic hepatitis C virus infection and non-alcoholic steatohepatitis. In particular, the inventi... | 07/18/2006 |
| 7011854 | Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke... | 03/14/2006 |
| 6995133 | Utilization of interferon alpha 5 in the treatment of viral hepatopathies The invention relates to the use of interferon alpha 5 in the treatment of viral hepatopathies. The invention describes the reduced synthesis of IFNα5 in the livers of patients with hepatitis C in comparison to healthy livers. The sub-type of IFN expressed in said ... | 02/07/2006 |
| 6924270 | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection Ribavirin derivatives represented by the formula II, pharmaceutical compositions containing them as well as methods of using the ribavirin derivatives represented by the formula II for the treatment of susceptible viral infections, for example, chronic hepatitis C i... | 08/02/2005 |
| 6905677 | Combined hepatitis B treatment The invention relates to a method of treating patients infected with hepatitis B virus comprising the adminstration of both a nucleoside analogue and interferon-α over a prolonged period of time. ... | 06/14/2005 |
| 6875742 | Method for treating cytokine mediated hepatic injury A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A th... | 04/05/2005 |
| 6864244 | Anhydrous crystalline 1-[4(S)-azido-2(S),3(R)-dihydroxy-4-(hydroxymethyl)-1(R)-cyclopentyl]cytosine hemisulfate as useful as an antiviral agent The present invention relates to the hemisulfate salt of 1-[4(S)-azido-2(S),3(R)-dihydroxy-4-(hydroxymethyl)-1(R)-cyclopentyl]cytosine (Ia) with improved stability and physical properties which facilitate manufacturing, handling and formulating I and polymorphic cry... | 03/08/2005 |
| 6863904 | Compositions and methods for prophylactic and therapeutic supplementation of nutrition in subjects The present invention relates to compositions without added iron and methods for prophylactic nutritional supplementation and therapeutic nutritional supplementation. Specifically, the method involves administering to an individual a composition comprising carotenoi... | 03/08/2005 |
| 6846810 | Antiviral nucleoside derivatives The present invention relates to nucleoside derivatives for the treatment of Hepatitis C viral infections including compounds of formula I, pharmaceutical compositions comprising these compounds and methods for treatment or prophylaxis of Hepatitis C Virus mediated ... | 01/25/2005 |
| 6787526 | Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides A method and composition for treating a host infected with hepatitis D comprising administering an effective hepatitis D treatment amount of a described 2′-deoxy-β-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof. ... | 09/07/2004 |
| 6703049 | Angiogenesis inhibitor The present invention relates to a novel angiogenesis inhibitor, more particularly, arsenolite (solid As4 O6) and composition containing the same. The arsenolite of the present invention inhibits endothelial cell proliferation and tu... | 03/09/2004 |
| 6685931 | Treatment of hepatitis C virus infections with interleukin-10 The hepatoprotective effect of IL-10 is described, in particular, the use of interleukin-10 in the treatment of liver damage (e.g. fibrosis or cirrhosis) in a difficult-to-treat patient afflicted with chronic hepatitis C virus infection who has failed to ... | 02/03/2004 |
| 6686332 | Method of treating depressed reticuloendothelial system function The present invention provides methods of treating adverse physiological effects associated with depressed reticuloendothelial system function comprising administering to a subject suffering from depressed reticuloendothelial system function an effective ... | 02/03/2004 |
| 6686375 | Composition useful as hepatoprotectants comprising extract of plant Cryptolepis buchanani and a method thereof The present invention relates to a composition useful for hepatoprotection, said composition comprising polar extract of plant Cryptolepis Buchanani and/or fractions of the said extract, and optionally pharmaceutically acceptable additives and a method of... | 02/03/2004 |
| 6673775 | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection Ribavirin derivatives represented by formula I ##STR1## wherein at least one of R2, R3 or R5 is a straight or branched chain polyalkylene oxide polymer conjugate, and pharmaceutical compositions containing them as well as ... | 01/06/2004 |
| 6596700 | Methods of treating hepatitis delta virus infection with ଲ-L-2'-deoxy-nucleosides A method and composition for treating a host infected with hepatitis D comprising administering an effective hepatitis D treatment amount of a described 2'-deoxy-ଲ-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug ther... | 07/22/2003 |
| 6593364 | Triterpene derivatives and remedies for liver diseases A triterpene derivative useful for the treatment of hepatic disorders is disclosed. This compound comprises as an active ingredient a triterpene derivative represented by the following formula (I) or a salt thereof: ##STR1## wherein R1 represen... | 07/15/2003 |
| 6518317 | Antiviral agents An antiviral agent which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-1-one represented by the following formula [I] and an optically active substance and a salt thereof as an effecti... | 02/11/2003 |
| 6479508 | Viral polymerase inhibitors A compound of the formula I: ##STR1## wherein: X is CH or N; Y is O or S; Z is OH, NH2, NMeR3, NHR3 ; OR3 or 5- or 6-membered heterocycle, having 1 to 4 heteroatoms selected from O, N and S, said heterocycle bei... | 11/12/2002 |
| 6472373 | Combination therapy for eradicating detectable HCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection Methods for treating an antiviral treatment naive patient having chronic hepatitis C infection to eradicate detectable HCV-RNA involving administering a therapeutically effective amount of a combination therapy of ribavirin and interferon-alpha for a time... | 10/29/2002 |
| 6461605 | Continuous low-dose cytokine infusion therapy A method is provided for treating conditions that are susceptible of treatment with a cytokine wherein the undesirable side effects normally associated with cytokine administration are diminished or eliminated. The method comprises continuously administer... | 10/08/2002 |
| 6455078 | Medicinal herbal composition for treating liver diseases and HIV The present invention provides a herbal pharmaceutical composition for treating patients with liver diseases and/or HIV. The composition contains fifteen (15) ingredients, which are diffuse hedyotis, bistort rhizome, giant knotweed rhizome, Asiatic moonse... | 09/24/2002 |
| 6455051 | Ameliorant for hepatitis C therapeutic effect and application thereof The present invention provides an ameliorant for enhancing the therapeutic effect of IFN- on hepatitis C; a therapeutic composition for the treatment of hepatitis C which comprises IFN- and IFN-γ as active ingredients and further contains a... | 09/24/2002 |
| 6426098 | Herbal compositions for hepatic disorders Compositions for treating hepatic disorders via oral or parenteral administration include Salvia miltiorrhiza and Polyporus umbellatus in proportions of about 1:1 to about 5:1, and may comprise from about 6% to about 30% of the total weight of the composi... | 07/30/2002 |
| 6410009 | Pharmaceutical composition for treating hepatitis B virus (HBV) infection The invention provides a pharmaceutical composition for the treatment of hepatitis B virus (HBV) infection, comprising an amount of a soluble active agent which interacts with at least one of the binding sites between hIL6 and pS1 and between hIL6 and hep... | 06/25/2002 |
| 6403564 | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection A method for treating a patient having chronic hepatitis C infection to eradicate detectable HCV-RNA involving a combination therapy using a therapeutically effective amount of ribavirin derivative of formula I and a therapeutically effective amount of in... | 06/11/2002 |
| 6387365 | Combination therapy for chronic hepatitis C infection There is disclosed a method for treating chronic hepatitis C infection in patients in need of such treating comprising administering an amount of alpha interferon in association with an amount of ribavirin effective to treat chronic hepatitis C infection ... | 05/14/2002 |
| 6380164 | Method for treating cytokine mediated hepatic injury A method of modulating cytokine mediated hepatic injury by administering deltorphins to a mammal. Deltorphin I SEQ ID NO:1, deltorphin II SEQ ID NO:2 or combinations of deltorphins I SEQ ID NO:1 and II SEQ ID NO:2 may be administered. A deltorphin concent... | 04/30/2002 |
