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| Number | Title | Issue Date |
| 7115592 | Phosphonate substituted pyrimidine compounds and methods for therapy Novel compounds are provided having formula (I) where R1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes f... | 10/03/2006 |
| 6818633 | Antiviral compounds and methods for synthesis and therapy Novel compounds are provided having formula (I) where R1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods fo... | 11/16/2004 |
| 6670342 | Method of treating hepatitis delta virus infection A method for the treatment for hepatitis delta infection in a host, that includes administering an effective amount of a nucleoside or a nucleoside analog that suppresses the expression of the hepatitis B surface or preS1 antigen in the host 100-fold or m... | 12/30/2003 |
| 6645972 | Methods of treating leukemia The present invention provides a novel method for treating leukemia in a host that has been previously treated with a Bcr-Abl tyrosine kinase inhibitor comprising administering to the host a therapeutically effective amount of a compound having the formul... | 11/11/2003 |
| 6444656 | Antiviral phosphonate nucleotides The present invention relates to a novel nucleotide analogue having the general formula (I) and pharmaceutically acceptable salts, esters, or salt of such esters: ##STR1## wherein n, X, Q U R1', R1, Z and R2 are defined here within. The co... | 09/03/2002 |
| 6300356 | Method for decreasing QT dispersion or inhibiting the progression of QT dispersion with an angiotensin II receptor antagonist Angiotensin II receptor antagonists are useful for decreasing QT dispersion or inhibiting the progression of QT prolongation in patients. Also disclosed is a method for monitoring the reduction in die risk of experiencing an adverse cardiac event, such as... | 10/09/2001 |
| 6200961 | Concentrates of organophosphorous insecticides A low volatile organic compound co-solvent system is disclosed for preparing emulsion concentrates of low melting organophosphorous insecticides wherein the bioefficacy of the insecticide active is significantly enhanced. The co-solvent system comprises a... | 03/13/2001 |
| 6201002 | Method for reducing mortality with an angiotensin II antagonist Angiotensin II receptor antagonists are useful in reducing and preventing mortality and sudden cardiac death in symptomatic heart failure patients. Losartan potassium has been shown to reduce mortality and sudden cardiac death in this patient population. ... | 03/13/2001 |
| 5880111 | Therapeutic derivations of diphosphonates Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, and infectious urinary tract stones, are obtained by combining chemically a diphosphonate compound with a therapeut... | 03/09/1999 |
| 5854227 | Therapeutic derivatives of diphosphonates Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, infectious urinary tract stones, and bone cancer, are obtained by combining chemically a diphosphonate compound wit... | 12/29/1998 |
| 5698541 | 2,4-diphosphonoglutaric acid derivatives, processes for their production and pharmaceutical agents containing these compounds The invention concerns compounds of the general formula I ##STR1## in which R denotes a lower alkyl which can be substituted if desired by hydroxy, alkoxy, amino, dialkylamino, alkylmercapto, alkylsulfinyl, alkanesulfonyl, cycloalkyl, aryl or a heter... | 12/16/1997 |
| 5190930 | Araliphatylaminoalkanediphosphonic acids Araliphatylaminoalkanediphosphonic acids of formula ##STR1## wherein R1 is an aromatically substituted aliphatic radical, R2 is hydrogen or a monovalent aliphatic radical and alk is a divalent aliphatic radical, and their salts,... | 03/02/1993 |
| 5133972 | Topically administrable pharmaceutical preparations The invention relates to topically adminstrable pharmaceutical preparations containing pharmaceutically acceptable methanediphosphonic acid derivatives of formula ##STR1## and their salts, wherein each of R1 and R2 is halogen, o... | 07/28/1992 |
| 5098931 | 7-substituted HMG-CoA reductase inhibitors Novel HMG-CoA reductase inhibitors are useful as antihypercholesterolemic agents and are represented by structural formulae (I) and (II): ##STR1##... | 03/24/1992 |
| 4971958 | Diphosphonic acid derivatives, pharmaceutical compositions and methods The present invention provides diphosphonic acid derivatives of the general formula: ##STR1## according to claim 1. These compounds are useful for the treatment or prophylaxis of calcium metabolism disturbance or disease.... | 11/20/1990 |
| 4871720 | Aromatically substituted azacycloalkyl-alkanediphosphonic acids useful for the treatment of illnesses that can be attributed to calcium metabolism disorders Aromatically substituted azacycloalkylalkanediphosphonic acids of the formula ##STR1## in which R represents an aromatically substituted azacycloaliphatyl radical that is bonded to the group alk by way of a nitrogen atom and that optionally cont... | 10/03/1989 |
| 4783313 | Enhancing body defense mechanisms Disclosed is a method of providing immuno-prophylaxis as well as malignant tumor immuno-therapy by administering a malignant-tumor-immunization and recession-provoking antigenic agent of malignant tumor tissue source to a living subject in an effective do... | 11/08/1988 |
| 4584295 | Pyrimidylmethyl thiophosphorus esters useful for the control of insects, mites and nematodes Heterocyclic compounds of the formula ##STR1## wherein R1, R2, R3, R4, R5 and X are as defined hereinafter, process for their preparation, as well as pesticidal compositions containing these comp... | 04/22/1986 |
| 4159323 | O,O'-Dialkyl-4,6-diphosphorylated pyrimidines and compositions and methods for combating arthropods containing them O,O'-Dialkyl-4,6-diphosphorylated pyrimidines of the formula ##STR1## in which R and R2 each independently is alkyl, R1 and R3 each independently is alkyl, alkoxy, alkylthio, alkylamino or phenyl, R4 is hydrogen... | 06/26/1979 |
| 4107301 | O,O'-Dialkyl-O,O'-[2-aminopyrimidin(4,6) diyl]-bis-[(thiono)(thiol)phosphoric(phosphonic) acid esters] O,O'-Dialkyl-O,O'-[2-aminopyrimidin(4,6)diyl]-bis-[(thiono)(thiol)phosphori c(phosphonic) acid esters] of the formula ##STR1## in which R is alkyl, R1 is alkyl, alkoxy or alkylthio, R2 and R3 each independently is alkyl or ... | 08/15/1978 |
| 4059696 | Pyrimidine (4,6)diyl-bis-(thiono)(thiol)-phosphoric(phosphonic)acid esters Pyrimidine (4,6)diyl-bis-(thiono)(thiol)-phosphoric (phosphonic) acid esters of the formula ##STR1## in which R is alkyl with 1 to 6 carbon atoms, R1 is alkyl, alkoxy or alkylmercapto each with 1 to 6 carbon atoms or phenyl, R2 ... | 11/22/1977 |
