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| Number | Title | Issue Date |
| 8173596 | Prouroguanylin, and synthetic analogs or proteolytic cleavage products derived from it, as therapeutic and diagnostic agents for diseases involving salt and/or fluid homeostasis A method for treating a disorder characterized by salt retention, fluid retention, and combinations thereof. A method for determining the presence of or the progression of a disorder characterized by salt retention, fluid retention, salt loss, fluid loss, and combin... | 05/08/2012 |
| 7056524 | Methods of hydrating mucosal surfaces A method of hydrating nasal airway surfaces in a subject in need of such treatment comprises topically applying a sodium channel blocker to a nasal airway surface of the subject in an amount effective to inhibit the reabsorption of water by the surface. The channel ... | 06/06/2006 |
| 6784179 | Tetracyclic derivatives, process of preparation and use A compound of formula (I) and salts and solvates thereof, in which: R0 represents hydrogen, halogen or C1-6 alkyl; R1 represents hydrogen, C1-6alkyl, C2-6 | 08/31/2004 |
| 6503883 | Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis The invention relates to a pharmaceutical preparation, which contains an immunosuppressive active agent in dissolved form in a starch capsule, or hard or soft gelatin capsule which has been coated with one or several polymer films. The invention further r... | 01/07/2003 |
| 6420358 | Vasopressin antagonist and diuretic combination This invention provides methods of increasing urine flow in humans while minimizing the loss of electrolytes or ions, the methods comprising administering to a human in need thereof a combination of N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)ylcarbo... | 07/16/2002 |
| 6369059 | Tetracyclic derivatives, process of preparation and use A compound of formula (I) ##STR1## and salts and solvates thereof, in which: R0 represents hydrogen, halogen or C1-6 alkyl; R1 represents hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, haloC | 04/09/2002 |
| 6329428 | Therapeutic drug for the treatment of micturition disorders The present invention is drawn to a therapeutic drug for micturition disorders and diseases of the lower urinary tract system, containing an organic acid salt of [2-[4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl]ethyl]-dimethylsulfonium. The invention... | 12/11/2001 |
| 5948799 | Method for improving morbidity and/or mortality This invention relates to a method for reducing morbidity and/or mortality in a mammal with congestive heart failure due to non-ischemic etiology comprising administering amlodipine or a pharmaceutically acceptable amlodipine acid addition salt, and, opti... | 09/07/1999 |
| 5914336 | Method of controlling the serum solubility of orally administered torasemide and composition relating thereto A method of controlling the serum solubility of orally administered torasemide is disclosed. A new crystallin modification of torasemide, called modification III which has significantly higher rates of solubilization than the known crystallin form of tora... | 06/22/1999 |
| 5843452 | Immunotherapy composition and method A composition for use in immunosuppression therapy is disclosed. The composition includes an immunosuppressant drug, such as cyclosporin A, and an ethanol extract of the root xylem of Tripterygium wilfordii. The extract is effective alone, or in combinati... | 12/01/1998 |
| 5843476 | Slimming composition for topical treatment, containing two types of liposomes, and use thereof Compositions containing a first dispersion of lipid vesicles which are capable of penetrating into the deep layers of the skin and which contain at least one active agent chosen from lipolytic agents, draining agents and firming agents, for treating these... | 12/01/1998 |
| 5728678 | Method and composition for providing nutrition to a renal failure patient The present invention provides a composition as well as method for providing nutrition to renal patients. Pursuant to the present invention, the enteral composition includes an effective amount of a protein source including whey protein and free amino aci... | 03/17/1998 |
| 5668157 | Cyanoguanidines as K-channel blockers Cyanoguanidine compounds of formula (I) and its pharmaceutically acceptable acid addition salts wherein R1 is hydrogen or methyl; R2 is C1 -C6 alkyl, C2 -C6 alkenyl, C2 -C6... | 09/16/1997 |
| 5565485 | Biphenyl compounds useful or endothelin antagonists Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral... | 10/15/1996 |
| 5508044 | Diltiazem pharmaceutical spheroid formulation A solid oral dosage form comprising diltiazem (or a pharmaceutically acceptable salt thereof) in controlled release form and hydrochlorothiazide in immediate release form. Preferably, the controlled release component comprises a plurality of spheroids com... | 04/16/1996 |
| 5504099 | Injection solutions of azosemide which are ready for injection Aqueous injection solution that is ready-for-injection of a water-soluble, physiologically well-tolerated azosemide salt of an organic amide, which contains an organic solvent and if desired, a physiologically well-tolerated buffer and it concerns a proce... | 04/02/1996 |
| 5475031 | Discovery of a valuable property for succinic acid and other intermediary metabolites This invention relates to the use of the succinic acid molecule to stimulate the Citric Acid Cycle in humans and animals and thus relieve those metabolic disorders caused by a deficiency in the Citric Acid Cycle in humans and animals.... | 12/12/1995 |
| 5422393 | Natriuretic hormone A purified naturally occurring natriuretic compound, identified as Natriuretic Hormone, and a method for isolation of the compound. The natriuretic compound has a molecular weight of about 360, a molecular formula of C21 H28 O5 | 06/06/1995 |
| 5395836 | 8-tricycloalkyl xanthine derivatives There is provided a novel xanthine Compound(I) ##STR1## wherein R1 and R2 are the same or different and each represent hydroxy-substituted, oxo-substituted or unsubstituted lower alkyl, Y is a single bond or alkylene, and Q is ... | 03/07/1995 |
| 5364879 | Medical uses of trioxolane and diperoxide compounds The present invention provides a method of medical treatment for a medical condition in a mammal. In this method, a pharmacologically effective amount for treatment of the condition of a trioxolane or a diperoxide of a non-terpene unsaturated hydrocarbon ... | 11/15/1994 |
| 5266596 | L- or DL-threo-3-(3,4-dihydroxyphenyl)serine for the treatment of urinary incontinence DL- or L-threo-3-(3,4-dihydroxyphenyl)serine is effective for the treatment of urinary incontinence, shows no side effects such as urine discharge disturbance, palpitation and hypertension, and has low toxicity.... | 11/30/1993 |
| 5256687 | Pharmaceutical composition for the treatment of high blood pressure The invention relates to a pharmaceutical composition comprising an angiotensin converting enzyme inhibitor (trandolpril or pamipril) and a loop diuretic (Furosemide or piretanide), and to their use for the treatment of high blood pressure.... | 10/26/1993 |
| 5164401 | Method of diuretic treatment with 3,7-diazabicyclo[3,3,1]nonane compounds A method of treating a mammal in need of diruetic treatment by administering an effective diuretic amount of a diuretically active 3,7,9,9-tetrasubstituted 3,7-diazabicyclo[3,3,1]nonane compound, diuretic pharmaceutical compositions containing an effectiv... | 11/17/1992 |
| 5143937 | Benzenesulfonamides and a process for their preparation Compounds of the formula I ##STR1## where R1 to R5 have the meaning indicated, a process for their preparation and their use as medicaments are described. They are effective lipid-lowering agents with antioxidative properties fr... | 09/01/1992 |
| 5132298 | Diuresis by cyclodextrins and their derivatives A method for improvement in diuresis which comprises administering, to a subject in need of such improvement, a cyclodextrin or a derivative thereof in an amount effective to cause such improvement.... | 07/21/1992 |
| 5124152 | Parenteral formulation of metolazone There are described pharmaceutical compositions comprising aqueous solutions of 7 c l r - ,2,3,4-tetrahydro-2-methyl-3-2-methylphenyl)-4-oxo-6-quinazolinesulfonamid e. ethanol and a cosolvent selected from propylene glycol or polyethylene glycols suit... | 06/23/1992 |
| 5118615 | Peptide and gene coding for same Disclosed is a DNA fragment comprising a base sequence coding for a peptide occurring in human atrium cordis and having diuretic action or a precursor of the peptide, plasmids containing the DNA fragment, microorganisms transformed with the plasmid, and a... | 06/02/1992 |
| 5106630 | Natriuretic hormone A purified naturally occurring natriuretic compound, identified as Natriuretic Hormone, and a method for isolation of the compound. The natriuretic compound has a molecular weight of about 360, a molecular formula of C21 H28 O5 | 04/21/1992 |
| 5106610 | Method for determining the diuretic potency of candidate drugs as inhibitors of the antidiuretic hormone-elicited water channel A method for determining the diuretic potency of candidate drugs as inhibitors of ADH-elicited water channels is disclosed. In a preferred embodiment, such diuretic potency of candidate drugs is determined by suspending vesicles containing ADH water chann... | 04/21/1992 |
| 5104887 | Topical ophthalmic imino substituted 2-imino-3-methyl-delta4-1,3,4-thiadiazoline-5-sulfonamides carbonic anhydrase inhibitors High potency carbonic anhydrase inhibitors derived from methazolamide.... | 04/14/1992 |
| 5100647 | Method and formulations for the therapy of cystic fibrosis, Bartter's syndrome and secretory diarrheas, and for diuretic treatment Methods for the therapy of cystic fibrosis, Bartter's syndrome, and secretory diarrheas, and for diuretic treatment, by administering to a patient dodecahydro-7,14-methano-2H,6H-di-pyrido[1,2-a:1',2'-e][1,5]diazocine or a pharmaceutically acceptable ... | 03/31/1992 |
| 5100646 | NMR glomerular filtration test A method of determining the glomerular filtration rate of a subject comprises (1) obtaining a serum sample Spre and a urine sample Upre from a subject; (2) administering to the subject an amount of a paramagnetic substance that is fi... | 03/31/1992 |
| 5087630 | Method for the treatment of a hyponatremic disease Compounds of formula (Ia), or pharmaceutically acceptable salts or solvates thereof, ##STR1## in which A, together with the nitrogen atom, represents --(CH2)p--, where p is an integer from 3 to 6, or an optionally substituted tetrahyd... | 02/11/1992 |
| 5011688 | Liquid composition for the relief of premenstrual and menstrual discomforts A liquid composition for the relief of premenstrual and menstrual discomfort comprising, as active pharmaceutical agents, an effective amount of an analgesic, an antihistamine, and a diuretic, said active agents being dissolved in a liquid vehicle, said c... | 04/30/1991 |
| 5010092 | Protection against chemically-induced kidney damage by methimazole Drug treatment therapies and kits for use therewith are disclosed. They involve the use of methimazole and/or its pro-drug carbimazole to reduce nephrotoxic effects of chemical exposure. In one embodiment, a patient receives cisplatin and then is treated ... | 04/23/1991 |
| 4981852 | Chemical compounds triamterene and hydrochlorothiazide A diuretic pharmaceutically acceptable solution of triamterene and solutions of triamterene and hydrochlorothiazide to provide an antihypertensive and diuretic effect for those in need thereof. Triamterene is solubilized in a combination of a glycol and l... | 01/01/1991 |
| 4980352 | Gem-dimethyl substituted bicyclic compounds useful as eukalemic diuretics Certain gem-dimethyl substituted bicyclic phenolic pyrazines of formula III possess eukalemic diuretic properties. They are of value in treating those diseases and conditions in which a eukalemic diuretic effect is required, for example in treating edema,... | 12/25/1990 |
| 4973600 | Benzodioxole derivatives, pharmaceutical compositions and use Novel benzodioxole derivative of the formula: ##STR1## wherein R1 is a lower alkyl group, a lower alkoxy-lower alkyl group, phenyl group or pyridyl group, R2 is hydrogen atom or a halogen atom and R3 is hydrogen atom ... | 11/27/1990 |
| 4968673 | Use of a thromboxane receptor antagonist in renal diseases and dysfunction The use is described of [1R-[1(Z),2ଲ,3ଲ,5]]-(+)-7-[5-[[(1,1'-biphenyl)-4-y l]methoxy]-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-heptenoic acid or a physiologically acceptable salt, solvate or cyclodextrin complex thereof in t... | 11/06/1990 |
| 4952583 | Aminophenol derivatives Certain amine containing phenolic pyrazines of formula III possess eukalemic diuretic properties and are of value in treating diseases and conditions in which a eukalemic diuretic effect is required, for example in treating edema, hypertension and/or rela... | 08/28/1990 |
