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| Number | Title | Issue Date |
| 7718633 | Prodrugs of HIV protease inhibitors A compound of the formula is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions for inhibiting HIV protease activity and treating HIV infection are also disclosed. ... | 05/18/2010 |
| 7687480 | Phosphonate compounds The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and th... | 03/30/2010 |
| 7642249 | Dihydrogen phosphate salt of a prostaglandin D2 receptor antagonist The present invention is directed to dihydrogen phosphate salt 2-(3-{6-[2-(2,4-dichloro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenyl)-2-methyl-propionic acid of Formula (III), a pharmaceutical composition comprising... | 01/05/2010 |
| 7511027 | Method of treating hepatitis delta virus infection A method for the treatment for hepatitis delta infection in a host, that includes administering an effective amount of a nucleoside or a nucleoside analog that suppresses the expression of the hepatitis B surface or preS1 antigen in the host 100-fold or more relativ... | 03/31/2009 |
| 7419967 | Sulfonamide inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. T... | 09/02/2008 |
| 7358273 | Inhibitors of caspases The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1β converting enzyme (“ICE”) inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and... | 04/15/2008 |
| 7314862 | Antitumor agent The present invention relates to an antitumor agent containing a histone deacetylase inhibitor and a topoisomerase II inhibitor in combination. This combination has been found to exhibit a synergistic anticancer or antitumor effect compared to administration of eith... | 01/01/2008 |
| 7288624 | Inhibitors of interleukin-1β converting enzyme The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmace... | 10/30/2007 |
| 7273856 | Linear basic compounds having NK-2 antagonist activity and formulations thereof Described herein are compounds of formula (I) useful as antagonists of tachykinins in general, and in particular of neurokinin A; and the pharmaceutical formulations comprising the compounds of formula (I) ... | 09/25/2007 |
| 7252805 | Device for vaporising and diffusing oils A device which uses a heat source for heating and diffusing fragrant oils or insecticidal oils. The oil is contained in a reservoir remote from the heat source and the device comprises means for transferring the oil from a reservoir to a surface of a heat-absorbing ... | 08/07/2007 |
| 7215878 | Chip that comprises an active agent and an integrated heating element Active compound chip and process for the production of an active compound chip comprising an active compound which is bound at room temperature, at least one heating element being located at least partly in the interior of the chip and the heating element having an ... | 05/08/2007 |
| 7208481 | Aminodiphosphonate apolipoprotein E modulators The present invention relates to methods of use of aminodiphosphonate to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease states. ... | 04/24/2007 |
| 7129227 | Lipid analogs for treating viral infections A method of treating viral infections, and in particular HIV-1, hepatitis B virus, and herpesviruses, is disclosed. The method comprises administering to a subject in need of such treatment an infection-combating amount of a phospholipid or phospholipid derivative. | 10/31/2006 |
| 7115592 | Phosphonate substituted pyrimidine compounds and methods for therapy Novel compounds are provided having formula (I) where R1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes f... | 10/03/2006 |
| 7112557 | Electrically conductive oil-based mud An electrically conductive oil mud meeting the fluid requirements for resistive logging tools and a method for preparing such mud is disclosed. The fluid has been optimized to deliver performance in a manner as similar to that of a traditional invert emulsion drilli... | 09/26/2006 |
| 7071176 | Aryl phosphate derivatives of AZT having anti-HIV activity Aryl phosphate derivatives of d4T with para-bromo substitution on the aryl group show markedly increased potency as anti-HIV agents without undesirable levels of cytotoxic activity. In particular, these derivatives are potent inhibitors of HIV reverse transcriptase.... | 07/04/2006 |
| 7060692 | Active ingredient combinations comprising insecticidal and acaricidal properties The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing (a) cyclic ketoenols having the formula in which the gro... | 06/13/2006 |
| 7057012 | PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules Novel parathyroid hormone (PTH) peptides and analogs thereof of the PTH(1–34) fragment are disclosed that combine the N-terminal signaling domain (residues 1–9) and the C-terminal binding domain (residues 15–31) via a linker. Nucleic acid molecules and peptide... | 06/06/2006 |
| 7022663 | Oral, nasal and pulmonary dosage formulations of copolymer 1 Pharmaceutical compositions useful for treating autoimmune diseases in a mammal comprising as an active ingredient a therapeutically effective amount of Copolymer 1, and microcrystalline cellulose are disclosed. Processes for the manufacture of such compositions are... | 04/04/2006 |
| 7022815 | Polypeptide derivatives of parathyroid hormone (PTH) Novel parathyroid hormone(PTH) polypeptide derivatives are disclosed, as are pharmaceutical compositions containing said polypeptides, and synthetic and recombinant methods for producing said polypeptides. Also disclosed are methods for treating mammalian conditions... | 04/04/2006 |
| 7018989 | Chemical compounds Aryl substituted phosphoryl derivatives of the formula In which Ar is phenyl, naphthyl, or pyridyl, Y is O or S, X1 is O, NR3, S, CR3R4, CR3W1 or CW... | 03/28/2006 |
| 7014819 | Device for vaporizing and diffusing oils A device which uses a heat source for heating and diffusing fragrant oils or insecticidal oils. The oil is contained in a reservoir remote from the heat source and the device comprises means for transferring the oil from a reservoir to a surface of a heat-absorbing ... | 03/21/2006 |
| 6967079 | Pyrimidine derivatives for labeled binding partners Compounds having particular interest as labels and various novel uses in diagnostics and therapeutics are provided which have structure (1) wherein R1 is a binding partner, a linker or H; | 11/22/2005 |
| 6943173 | 5-substituted 2-aryl-4-pyrimidinones Arylpyrimidinone compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating diso... | 09/13/2005 |
| 6936602 | Benzazepine derivatives, process for the preparation of the same and uses thereof Compounds of the general formula (I): or salts thereof, which exhibit CCR5 antagonism and exert preventive and therapeutic effects against HIV infections: wherein R1 is a 5- to 6-membered aromatic ring which... | 08/30/2005 |
| 6919347 | Bradykinin B1 receptor antagonists Bradykinin B1-receptor antagonists of formula are disclosed. The compounds are useful for treating diseases associated with inappropriate bradykinin receptor activity, such as diabetic vasculopathy, inflamma... | 07/19/2005 |
| 6919322 | Phenyl Phosphonate Fructose-1,6-Bisphosphatase Inhibitors Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose. ... | 07/19/2005 |
| 6878697 | Phenylamino-pyrimidines and uses thereof This invention relates to compounds of the general formula: in which RA, RB, RC, RD, w, x, y, and z are as defined herein, and to their preparation a... | 04/12/2005 |
| 6835386 | Collar containing a novel gel formulation to control arthropod infestation of animals The present invention provides a device, preferably a collar or ear tag, capable of the controlled, sustained release of an effective amount of an active ingredient that can protect an animal against arthropod pests, comprising a reservoir containing a novel gel for... | 12/28/2004 |
| 6818633 | Antiviral compounds and methods for synthesis and therapy Novel compounds are provided having formula (I) where R1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods fo... | 11/16/2004 |
| 6812247 | Organometallic complex A metal complex and its use for binding or cleaving a nucleic acid. The metal complex has the formula: M is Pt, Pd, Ni, Co, or Cu; X is aryl, heteroaryl, cyclyl, or heterocyclyl; Y is halogen, tosylate, mesylate, trifl... | 11/02/2004 |
| 6787525 | Glyceryl nucleotides, method for the production thereof and their use The invention relates to glyceryl nucleotides of the formula Ia in which a) one of the radicals A1, A2 and A3 is a hydrogen atom or a radical selected from hydroxyl, mercapto, alky... | 09/07/2004 |
| 6756391 | Antiviral compounds The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV-infected cells as well as othe... | 06/29/2004 |
| 6750340 | Bisphosphonate conjugates and methods of making and using the same The present invention is directed to particular bisphosphonate compounds, and in particular, to bisphosphonate conjugates that are useful in the treatment of soft tissues surrounding bone and bone-related diseases, such as bone cancer and osteoporosis. ... | 06/15/2004 |
| 6747036 | Methods of treating leukemia The present invention provides a novel method for treating leukemia and more particularly acute myelogenous leukemia (AML) in a host comprising administering to the host a therapeutically effective amount of a compound having the formula I: ... | 06/08/2004 |
| 6723711 | Propanoic acid derivatives that inhibit the binding of integrins to their receptors A compound of the structure A method for the inhibition of the binding of α4β1 integrin to its receptors, for example VCAM-1(vascular cell adhesion molecule-1) and fibronectin; pharmaceutically ac... | 04/20/2004 |
| 6723712 | Antiviral agent for use in treatment of cancer The invention relates to an antiviral agent for use in combination with an anticancer agent, for the treatment of cancer. Especially, the invention provides means for the treatment of non-virus-associated cancer. ... | 04/20/2004 |
| 6706698 | α-Substituted β-aminoethyl phosphonate derivatives The present invention relates to novel α-substituted-β-aminoethylphosphonate and α-substituted-β-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and ver... | 03/16/2004 |
| 6703396 | Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of the enantiomers. The nucleoside enantiomer (-)-2-hydrox... | 03/09/2004 |
| 6670342 | Method of treating hepatitis delta virus infection A method for the treatment for hepatitis delta infection in a host, that includes administering an effective amount of a nucleoside or a nucleoside analog that suppresses the expression of the hepatitis B surface or preS1 antigen in the host 100-fold or m... | 12/30/2003 |
