Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 7414043 | 9-α-substituted estratrienes as selectively active estrogens This invention describes the new 9α-substituted estratrienes of general formula I in which R3, R7, R7′, R13, R16 as well as R17 and R17′ have... | 08/19/2008 |
| 7297702 | Contraception method using competitive progesterone antagonists and novel compounds useful therein Competitive progesterone antagonists, including two novel steroids, viz., 11β,19-[4-(cyanophenyl)-o-phenylene]-17β-hydroxy-17α-(3-hydroxyprop-1(Z)-enyl)-4-androsten-3-one and 11β,19-[4-(3-pyridinyl)-o-phenylene]-17β-hydroxy-17α-(3-hydroxyprop-1(Z)-enyl)-4-andr... | 11/20/2007 |
| RE39861 | Methods of extended use oral contraception A method of female contraception involves administering a combination of estrogen and progestin for 60-110 consecutive days in which the daily amounts of estrogen and progestin are equivalent to about 5-35 mcg of ethinyl estradiol and about 0.025 to 10 mg of norethi... | 09/25/2007 |
| 7247708 | Modified vitamin K-dependent polypeptides The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described. ... | 07/24/2007 |
| 7220837 | Modified vitamin K-dependent polypeptides The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described. ... | 05/22/2007 |
| 7169402 | Antimicrobial and antiviral polymeric materials The invention provides an antimicrobial and antiviral polymeric material, having microscopic particles of ionic copper encapsulated therein and protruding from surfaces thereof. ... | 01/30/2007 |
| 7029657 | Nasal spray steroid formulation and method The present invention relates to an improvement in a method of contraception, in treatment of benign gynecological disorders, and in hormone replacement. The improved method includes administering intranasally an estrogenic compound and an androgenic compound, and i... | 04/18/2006 |
| 6977250 | Prevention of ovarian cancer by administration of progestin products The present invention relates to methods for preventing the development of epithelial ovarian cancer by administering progestin products, either alone or in combination with other agents such as estrogen products. ... | 12/20/2005 |
| 6960337 | Methods and compositions for treating benign gynecological disorders An improvement in a method of treating benign gynecological disorders is described. In the method, treatment of a benign gynecological disorder with a composition comprised of a gonadotropin releasing hormone (GnRH) compound and an estrogenic compound, and optionall... | 11/01/2005 |
| 6906049 | Contraceptive medicine based on a progestational agent and an oestrogen and preparation method The present invention relates to the field of chemistry and more particularly to that of therapeutic chemistry. The invention relates more particularly to novel contraceptive compositions formed from a progestative agent and an oestrogen. The invention... | 06/14/2005 |
| 6841548 | Pharmaceutical preparations containing estra-1,3,5(10)-triene derivatives The invention concerns pharmaceutical preparations containing estra-1,3,5(10)-triene derivatives as active ingredients which carry a group of the general formula R—SO2—O— at their C3 position wherein... | 01/11/2005 |
| 6797282 | Combination progestin oral contraceptive regimen An oral contraception regimen which comprises sequentially administering two or more progestational agents exhibiting different effects on the human endometrium in combination with an estrogen. The invention is also directed to an extended use oral contraception reg... | 09/28/2004 |
| 6790853 | Contraception method using competitive progesterone antagonists and novel compounds useful therein Competitive progesterone antagonists, including two novel steroids, viz., 11β,19-[4-(cyanophenyl)-o-phenylene]-17β-hydroxy-17α-(3-hydroxyprop-1(Z)-enyl)-4-androsten-3-one and 11β,19-[4-(3-pyridinyl)-o-phenylene]-17β-hydroxy-17α-(3-hydroxyprop-1(Z)-enyl)-4-andr... | 09/14/2004 |
| 6774139 | Dual function microbicides Contraceptive activity as well as anti-microbial, particularly anti-viral protection is provided by contraceptive compositions containing a thiourea compound of the invention exhibiting spermicidal or sperm-immobilizing activity. Preferred compounds of the invention... | 08/10/2004 |
| 6762286 | Modified vitamin K-dependent polypeptides The invention provides vitamin k-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described. ... | 07/13/2004 |
| 6759408 | Combination regimens using progesterone receptor modulators This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds which are antagonists of the progesterone receptor having the general structure: wherein R1 | 07/06/2004 |
| 6753319 | D-mannose contraceptives The present invention concerns the use of D-Mannose to prevent or inhibit uniting of sperm and egg in the conception process. The administration of D-Mannose to a female such that the environment of an egg has sufficient D-Mannose to inhibit interaction of sperm and... | 06/22/2004 |
| 6747003 | Modified vitamin K-dependent polypeptides The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described. ... | 06/08/2004 |
| 6740645 | 17β-acyl-17α-propynyl-11β-(cyclic amino) aryl steroids and their derivatives having antagonist hormonal properties The invention is directed to a novel class of 17β-acyl-17α-propynyl steroids which exhibit potent antiprogestational activity. ... | 05/25/2004 |
| 6693075 | Modified vitamin K-dependent polypeptides The invention provides vitamin k-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.... | 02/17/2004 |
| 6680058 | Compositions and methods for contraception in or sterilization of mammals Amphipathic lytic peptides are ideally suited to use in a ligand/cytotoxin combination to induce sterility or long-term contraception in mammals. The peptides act directly on cell membranes, and need not be internalized. Administering a combination of gon... | 01/20/2004 |
| 6676957 | Non-absorbent substrates for the inhibition of exoprotein production from gram positive bacteria Non-absorbent substrates for use in inhibiting the production of exoproteins from Gram positive bacteria, such as harmful proteins produced by Staphylococcus species, are provided. The substrates are particularly useful for inhibiting the production of TS... | 01/13/2004 |
| 6667050 | Chewable oral contraceptive The present invention relates to a chewable, palatable oral contraceptive tablet, comprising an oral contraceptive agent, a chewable carrier suitable for human consumption, and not comprising a ferrocene compound, as well as use of these tablets in a meth... | 12/23/2003 |
| 6656936 | Carnitine analogues as topical, microbicidal spermicides Acylcarnitine analogues having alkyl side chains of 10 to 30 carbon atoms display excellent spermicidal and anti-HIV activity, a well as being potent inhibitors of the growth of Candida albicans.... | 12/02/2003 |
| 6645953 | Meiosis regulating compounds Sterol derivative compounds, structurally related to natural compounds which can be extracted from bull testes and from human follicular fluid, useful for regulating meiosis in oocytes and in male germ cells. Some of these compounds are useful in the trea... | 11/11/2003 |
| 6610670 | Cyclodextrin-drospirenone inclusion complexes Described are inclusion complexes formed between cyclodextrin and drospirenone. In a specific embodiment of the invention, the cyclodextrin is ଲ-cyclodextrin. The invention further relates to methods of providing such an inclusion complex, and to th... | 08/26/2003 |
| 6552011 | (Androst-5-en-17beta -yl)alkyl sulfoxides and sulfones and their use for control of fertility ##STR1## The invention relates to (androst-5-en-17beta-yl)alkylsulfoxides and sulfones having general formula (I), wherein R1, R2, R3, X and Y are defined in the specification. The compounds of the invention have meiosis inhibiting activity and can be use... | 04/22/2003 |
| 6544546 | Ring-shaped devices A ring-shaped device for controlled release of hormonal compounds comprising a first compartment having a non-medicated core of ethylene-vinyl-acetate copolymer encircled by a steroid hormone loaded ethylene-vinyl-acetate copolymer middle layer and a non-... | 04/08/2003 |
| 6506742 | Soluble contraceptive liquid formulation This invention provides a convenient process for preparing an oral contraceptive liquid formulation having improved solubility, bioavailability and stability useful as a reference standard.... | 01/14/2003 |
| 6500814 | Hormonal contraceptive The present invention relates to a hormonal contraceptive product having two hormonal components, an estrogen and a gestagen, and a process for the combined, continuous administration of the product of the invention.... | 12/31/2002 |
| 6479475 | Oral contraceptive This invention provides a method of contraception which comprises administering to a female of child bearing age for 23-25 consecutive days, a first phase combination of a progestin at a daily dosage of 40-500 μg trimegestone, 250 μg-4 mg dienogest, or 250 Î... | 11/12/2002 |
| 6476079 | Devices for the delivery of drugs having antiprogestinic properties A device for the controlled release over a prolonged period of time of a drug having antiprogestinic properties, the device including a core containing the drug, optionally a membrane encasing the core, where at least one of the core and membrane, when pr... | 11/05/2002 |
| 6451778 | Oral contraceptive This invention provides a method of contraception which comprises administering to a female of child beating age for a combination of a progestin at a daily dosage of 40-500 μg trimegestone, 250 μg-4 mg dienogest, or 250 μg-4 mg drospirenone, and an es... | 09/17/2002 |
| 6444668 | Combination regimens using progesterone receptor modulators This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds which are antagonists of the progesterone receptor having the general structure: ##STR1## wherein R1 and R2 may b... | 09/03/2002 |
| 6355235 | Topical application of antibodies for contraception and for prophylaxis against sexually transmitted diseases Certain antibody molecules are so stable and so potent at immobilizing sperm as well as the pathogens for sexually transmitted diseases (STDs) that they make possible new prophylactic contraceptive methods: (a) for men, a skin lotion containing antibodies... | 03/12/2002 |
| 6340688 | Contraception method using competitive progesterone antagonists and novel compounds useful therein Competitive progesterone antagonists, including two novel steroids, viz., 11ଲ,19-[4-(cyanophenyl)-o-phenylene]-17ଲ-hydroxy-17-(3-hy droxyprop-1(Z)-enyl)-4-androsten-3-one and 11ଲ,19-[4-(3-pyridinyl)-o-phenylene]-17ଲ-hydroxy-1... | 01/22/2002 |
| 6333058 | Process for the preparation of a spermicidal agent A process for preparing a spermicidal agent from neem oil includes (a) mixing neem oil with an aliphatic hydrocarbon solvent so that a precipitate forms, and filtering the mixture to separate the filtrate solution from the precipitate; (b) contacting the ... | 12/25/2001 |
| 6328991 | Composition and method for prevention of sexually transmitted diseases, including aids A chemical composition, method and product for administration into the vaginal canal. The composition, method and product are effective in preventing the spread of sexually transmitted diseases, including the spread of AIDS.... | 12/11/2001 |
| 6312722 | Pharmaceutical combined preparation, kit and method for hormonal contraception The present invention describes a two-stage pharmaceutical combined preparation for hormonal contraception containing at least 30 daily unit doses, which preparation, in its first stage, comprises as hormonal active ingredient a combination of an oestroge... | 11/06/2001 |
| 6281251 | Iodo-nonoxynol-9-derivatives and methods for their use Mono- and di-iodinated nonoxynol-9-derivatives and methods for their use are disclosed.... | 08/28/2001 |