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| Number | Title | Issue Date |
| 7361344 | Co-administration of a thrombolytic and an-anti-CD18 antibody in stroke A method for improving clinical outcome in focal ischemic stroke in a mammal by increasing cerebral blood flow and/or reducing infarct size is described which involves administering an effective amount of an anti-CD18 antibody to the mammal, in the absence of remova... | 04/22/2008 |
| 7316911 | Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases A method is provided for the localized intravascular administration of a fibrinolytic metalloproteinase to a human subject in amounts that are both safe and effective to lyse an occluding fibrin-containing blood clot, while also avoiding the neutralizing effects of ... | 01/08/2008 |
| 7314728 | Methods of treating peripheral arterial occlusions A method is provided for the localized intravascular administration of a fibrinolytic metalloproteinase to a human subject in amounts that are both safe and effective to lyse an occluding fibrin-containing blood clot, while also avoiding the neutralizing effects of ... | 01/01/2008 |
| 7294699 | Modified vitamin K-dependent polypeptides The invention provides vitamin k-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described. ... | 11/13/2007 |
| 7279183 | Method of reducing thrombosis and complications after arterial angioplasty using stent coated with magnesium-based compound Treatment with magnesium produces a inhibition of acute stent thrombosis under high-shear flow conditions without any hemostatic or significant hemodynamic complications. ... | 10/09/2007 |
| 7208288 | Methods for enhancing the lysis of coagulated blood with apolipoprotein E2 phenotype Methods for enhancing the lysis of coagulated blood comprise administering to coagulated blood a combination of clot clysis agent and a lysis enhancing amount of apolipoprotein E2 (Apo E2) or a therapeutic derivative thereof. Methods for reducing the risk of blood c... | 04/24/2007 |
| 7208180 | Method and preparation for the preventing and/or treating vascular disorders and secondary disorders associated therewith The present invention relates to a method for the prevention and/or treatment of vascular disorders and/or secondary disorders associated therewith, such as depression. The method according to the invention comprises the oral administration of a preparation which co... | 04/24/2007 |
| 7186420 | Multi-part substitution infusion fluids and matching anticoagulants A multi-part substitution infusion fluid for an extracorporeal blood treatment and methods for using same are provided. Generally, the multi-part substitution fluid comprises a first solution composed of electrolites but without divalent cations and a second solutio... | 03/06/2007 |
| 7169573 | Method for monitoring coagulability and hypercoagulable states The assay of soluble endothelial protein C receptor (sEPCR) is useful to monitor effective thrombin levels and a hypercoagulable state. An assay for sEPCR is therefore useful to monitor ongoing effectiveness of anticoagulant therapy. A sEPCR ELISA assay is particula... | 01/30/2007 |
| 7033776 | Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases A method is provided for the localized intravascular administration of a fibrinolytic metalloproteinase to a human subject in amounts that are both safe and effective to lyse an occluding fibrin-containing blood clot, while also avoiding the neutralizing effects of ... | 04/25/2006 |
| 7005502 | Pharmaceutical preparation comprising vWF propeptide Described is a pharmaceutical preparation for treating blood coagulation disorders comprising an effective amount of vWf propeptide as well as a method for producing such a prepartion. ... | 02/28/2006 |
| 6958359 | Vanadium compounds as anti-angiogenic agents Vanadium compounds for inhibiting angiogenesis useful for treating or preventing diabetic retinopathy, hemangiomas, cancers with abnormal blood vessel supply, restenosis following vascular injury, and the like. ... | 10/25/2005 |
| 6919374 | Viscosity modulating substance and use thereof It has now been found that N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester (APM) lowers whole blood viscosity in patient, including those suffering from sickle cell disease and plasma cell dyscrasias. Upon in vivo APM treatment patients experienced a significant l... | 07/19/2005 |
| 6908624 | Coating for implantable devices and a method of forming the same Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients. ... | 06/21/2005 |
| 6878388 | Vanadium compounds for treating proliferative cell disorders Vanadium compounds useful to prevent and/or inhibit adhesion, migration, and invasion of proliferative cells into surrounding tissue. ... | 04/12/2005 |
| 6841371 | Protein C derivatives Novel human protein C derivatives are described. These derivatives have increased anti-coagulation activity and resistance to inactivation by serpins, compared to wild-type protein C and retain the biological activity of the wild-type human protein D. These derivati... | 01/11/2005 |
| 6825323 | Compositions for treatment of hemorrhaging with activated factor VIIa in combination with fibrinogen and methods of using same The combination of recombinant factor VIIa and fibrinogen is effective in treatment for bleeding where direct pressure, tourniquets, indirect pressure, surgical ligation, bandaging, and transfusion of blood or plasma products are typically used. The combination of f... | 11/30/2004 |
| 6808706 | Method for keeping the quality of aqueous parenteral solution of thrombomodulin in storage and distribution A method for keeping the quality of an aqueous parenteral solution of thrombomodulin which is not in a frozen or freeze-dried state but in a liquid form in storage and distribution, characterized in that the aqueous thrombomodulin solution containing an effective am... | 10/26/2004 |
| 6743191 | Substitution infusion fluid and citrate anticoagulation The invention relates to a substitution infusion fluid for hemofiltration of a specific composition. The use of said substitution infusion fluid significantly reduces the risk of the occurrence of abnormalities in a patient undergoing pure hemofiltration. The invent... | 06/01/2004 |
| 6645978 | Lipoxin A4 and its analogs for the treatment of dry eye Ophthalmic compositions containing Lipoxin A4 and its analogs and methods of their use for treating dry eve are disclosed.... | 11/11/2003 |
| 6599881 | Antithrombotic materials and methods Antithrombotic materials and methods are provided for the treatment of thrombotic disorders, in which therapeutically effective amounts of BPI protein products are administered.... | 07/29/2003 |
| 6559133 | Use of flavone 8-acetic acid in vascular and cardiovascular interventions and acute coronary syndromes A method for treatment of a vascular or cardiovascular condition or acute coronary syndromes comprises administering an effective amount of a flavone 8-carboxylic acid to a mammal suffering from a vascular or cardiovascular condition or acute coronary syn... | 05/06/2003 |
| 6515020 | Combination of carnitines and resveratrol for prevention or treatment of cerebral and ageing disorders A pharmaceutical product which comprises admixed or separately packaged (A) L-Carnitine or an alkanoyl L-canitine and (B) a trihydroxy- or tetrahydroxystilbene such as resveratrol is useful for the prevention and treatment of pathological neuronal or cere... | 02/04/2003 |
| 6500427 | One-component tissue adhesive and a process for the production thereof A description is given of a one-component tissue adhesive containing, in aqueous solution, fibrinogen, F XIII, a thrombin inhibitor, prothrombin factors, calcium ions and, where appropriate, a plasmin inhibitor and of a process for the production thereof.... | 12/31/2002 |
| 6495530 | Composition for treating a patient susceptible to or suffering from a cardiovascular disorder or disease The present invention is directed to a composition comprising a therapeutically effective amount of exogenous heparin and arginine or physiologically acceptable salts thereof which is used in the treatment and prevention of cardiovascular diseases or diso... | 12/17/2002 |
| 6486205 | Mixture of primary fatty acids obtained from sugar cane wax A new natural mixture of primary fatty acids of high molecular weight ranging from 24 to 38 carbon atoms, especially those ranging between 26 and 36 carbon atoms and more especially those of straight chain of 26, 28, 29, 30, 31, 32, 33, 34, 35 and 36 carb... | 11/26/2002 |
| 6461640 | Local delivery of fibrinolysis enhancing agents A method of preventing adhesions by topical administration of fibrinolysis enhancing agents is described. The method uses a topically applied polymeric matrix for delivery of a fibrinolytic agent, preferably urokinase, tPA, hirudin, or most preferably, an... | 10/08/2002 |
| 6436367 | Aerosol formulations for buccal and pulmonary application A mixed micellar aerosol pharmaceutical formulation includes a micellar proteinic pharmaceutical agent, an alkali metal lauryl sulphate, at least three micelle forming compounds, a phenol and a propellant. The micelle forming compounds are selected from t... | 08/20/2002 |
| 6423334 | Composition and method for enhancing transport across gastrointestinal tract cell layers A composition for enteral administration having a non-ionic vegetable oil GIT absorption enhancer capable of increasing the enteral absorbability of drugs, especially oral absorbability of hydrophilic and macromolecular drugs. The non-ionic vegetable oil ... | 07/23/2002 |
| 6423348 | Anticoagulant compositions What is shown is an animal blood anticoagulant compound useful in the meat packing industry generally, and in slaughterhouse operations, particularly. The anticoagulant is effective when diluted with water at higher dilution ratios than earlier anticoagul... | 07/23/2002 |
| 6413931 | Peptide inhibitor of fibrinogen blood clotting A method of inhibiting fibrin clot formation is provided. The decorin protein, peptide, or related fragments are found to bind fibrinogen in the presence of Zinc (Zn2+), thus preventing the formation of fibrin clots. The decorin protein, peptid... | 07/02/2002 |
| 6399624 | Method and composition for inhibiting post-surgical adhesions A method and compositions for reducing post-surgical adhesion formation/reformation in mammals following surgical injury to a body cavity or organs situated therein. The aqueous compositions comprising pentoxifylline and a polyoxyalkylene block copolymer ... | 06/04/2002 |
| 6391339 | Use of oligosaccharide for preventing blood clotting in extracorporeal blood circuits The invention relates to the use of a certain oligosaccharide for preventing clotting in an extracorporeal blood circuit of a patient undergoing extracorporeal blood treatment.... | 05/21/2002 |
| 6387360 | Anti-jaundice composition for corpses and method An anti-jaundice composition for providing coloration to a corpse, comprising a bleaching agent, a coloring agent, and a fixing agent, mixed and stored at room temperature, and administered internally to a corpse for providing uniform, controlled colorati... | 05/14/2002 |
| 6380260 | Treatment to lower platelet adhesiveness A compound of formula I ##STR1## or a pharmaceutically acceptable salt thereof in which R1 and R2 are independently H or methyl (for example N,N-dimethyl-1-[1-(4-chlorophenyl) cyclobutyl]-3-methylbutyl amine hydrochloride option... | 04/30/2002 |
| 6274553 | Method for stabilizing peptides and freeze-dried medicinal compositions containing peptides obtained by using the method A method is provided for elevating the stability of peptides containing the sequence -Asp-Gly- or -Asn-Gly- by preventing these sequences from changing into succinimide compounds or ଲ-transition compounds. The method comprises adding an organic acid... | 08/14/2001 |
| 6255296 | Composition and method for treating a patient susceptible to or suffering from a cardiovascular disorder or disease A method for inhibiting the effects of cardiovascular disorders and diseases in a host susceptible to or suffering from a cardiovascular disorder or disease comprising administering to the host, a therapeutically effective amount of a first substance char... | 07/03/2001 |
| 6255277 | Localized use of nitric oxide-adducts to prevent internal tissue damage A method for preventing adverse effects associated with the use of a medical device in a patient by introducing into the patient a device of which at least a portion includes a prophylactic or therapeutic amount of a nitric oxide adduct. The nitric oxide ... | 07/03/2001 |
| 6251370 | Tissue adhesive suitable for spray application An adhesive for tissue capable of uniformly forming a high concentration of fibrin so as to provide a high closing effect is disclosed. The adhesive for tissue comprises a fibrinogen solution and a thrombin solution which solutions are separated from each... | 06/26/2001 |
| 6200588 | Blood-compatible composition and medical device using same The present invention provides a blood-compatible composition containing an ionic complex consisting of an organic cationic compound and heparin or a derivative thereof, wherein the organic cationic compound is an ammonium or a phosophonium bound with fou... | 03/13/2001 |
