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| Number | Title | Issue Date |
| 7342048 | Bioabsorbable pharmaceutical formulation A bioabsorbable release-sustaining pharmaceutical formulation using a biodegradable release-sustaining base material which can prevent an effective component drug from being released too rapidly just after administration of the formulation and then allow continued r... | 03/11/2008 |
| RE40119 | Adjunctive therapy A growth such as a tumor, hypertrophied tissue or cyst is biopsied or more completely excised subsequent to the administration of an effective amount of a gonadotropin releasing hormone analog or other inhibitor of ovarian steroid production or action. ... | 02/26/2008 |
| 7288517 | Treatment of dementia and neurodegenerative diseases with intermediate doses of LHRH antagonists The present invention relates to the treatment of dementia and neurodegenerative diseases like Alzheimer's disease with intermediate doses of LHRH antagonists which do not cause a castration. A preferred LHRH antagonist is cetrorelix. ... | 10/30/2007 |
| 6867181 | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing polymer and a free amino group-containing drug which are ionically bonded to each other. ... | 03/15/2005 |
| 6867191 | Preparation and use of oligopeptide lyophilisate for gonad protection A lyophilizate, method of preparation, and use of the lyophilizate for gonad protection is described. The lyophilizate comprises cetrorelix dissolved in 30% (v/v) acetic acid, transferred to water, and freeze-dried. ... | 03/15/2005 |
| 6863891 | Oligopeptide lyophilisate, their preparation and use A novel lyophilizate and method of preparation as well as the use of the lyophilizate to treat female infertility and for gonad protection. Cetrorelix is dissolved in acetic acid 30% v/v, the solution is transferred to water and freeze dried. ... | 03/08/2005 |
| 6703367 | Methods for treating hot flashes and gynaecomastia Methods to inhibit hot flashes or gynaecomastia in a subject are provided. In the methods of the invention, an LHRH antagonist is administered to a subject in need of treatment for hot flashes or gynaecomastia such that hot flashes or gynaecomastia are in... | 03/09/2004 |
| 6699833 | Pharmaceutical formulations for sustained drug delivery Sustained delivery formulations comprising a water-insoluble complex of a peptide and a carrier macromolecule are disclosed. The formulations of the invention allow for loading of high concentrations of peptide in a small volume and for delivery of a phar... | 03/02/2004 |
| 6593096 | Immunotherapeutic agent for cancer containing nucleoidal component of bacterium as active ingredient An agent for cancer immunotherapy with independent use, containing bacterial components as an active ingredient, which induces cancer patients to exhibit immune responsiveness, as indicated by the increase of interferon-γ and CD28 markers in peripheral b... | 07/15/2003 |
| 6423334 | Composition and method for enhancing transport across gastrointestinal tract cell layers A composition for enteral administration having a non-ionic vegetable oil GIT absorption enhancer capable of increasing the enteral absorbability of drugs, especially oral absorbability of hydrophilic and macromolecular drugs. The non-ionic vegetable oil ... | 07/23/2002 |
| 6384017 | Methods for treating sex hormone-dependent conditions with Lhrh antagonists Methods for treating prostate cancer are disclosed. The methods of the invention generally feature administration to a subject of an LHRH-R antagonist, in combination with a second therapy. In one embodiment, this second therapy is performance of a proced... | 05/07/2002 |
| 6303123 | Methods for the treatment of hormone-dependent tumors with immunogens against gonadotropin releasing hormone Immunogenic compositions capable of generating an immune response in mammals against GnRH are disclosed. The immunogenic compositions are effective in methods of treating gonadotropin and gonadal steroid hormone dependent diseases and immunological contra... | 10/16/2001 |
| 6265393 | Prevention of endometriosis signs or symptons Methods and articles of manufacture are provided for the long-term prevention of clinical symptoms and signs produced by endometriosis. Such methods and articles of manufacture involve the continuous coadministration of low doses of an estrogen agent and ... | 07/24/2001 |
| 6221958 | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides Disclosed is a sustained release pharmaceutical composition. The composition includes a polyester containing a free COOH group ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein at least 50% by wei... | 04/24/2001 |
| 6214798 | GnRH antagonists being modified in positions 5 and 6 Peptides are provided which have improved duration of GnRH antagonistic properties. These antagonists may be used to regulate fertility and to treat steroid-dependent tumors and for other short-term and long-term treatment indications. These antagonists h... | 04/10/2001 |
| 6180608 | Pharmaceutical formulations for sustained drug delivery Sustained delivery formulations comprising a water-insoluble complex of a peptidic compound (e.g., a peptide, polypeptide, protein, peptidomimetic or the like) and a carrier macromolecule are disclosed. The formulations of the invention allow for loading ... | 01/30/2001 |
| 6153586 | Methods for treating prostate cancer with LHRH-R antagonists Methods for treating prostate cancer are disclosed. The methods of the invention generally feature administration to a subject of an LHRH-R antagonist, in combination with a second therapy. In one embodiment, this second therapy is performance of a proced... | 11/28/2000 |
| 6132720 | Immunogens against gonadotropin releasing hormone Immunogenic compositions capable of generating an immune response in mammals against GnRH are disclosed. The immunogenic compositions are effective in methods of treating gonadotropin and gonadal steroid hormone dependent diseases and immunological contra... | 10/17/2000 |
| 6106805 | Diagnostic composition containing an LH-RH antagonist for hysteroscopy The invention relates to a diagnostic composition for improving the effectiveness of hysteroscopy, characterized in that it contains an LH-RH antagonist, in particular cetrorelix. The composition is envisaged for use prior to hysteroscopy and/or for prepa... | 08/22/2000 |
| 6034175 | Salts of peptides with carboxy-terminated polyesters This invention relates to novel salts composed of a cation derived from a peptide containing at least one basic group and an anion derived from a carboxy-terminated polyester, processes for the manufacture of such salts, and the use of such salts in the m... | 03/07/2000 |
| 5985834 | Nova- and decapeptides in the preparation of a drug for the treatment of aids Described are LHRH-antagonistic and bombesin-antagonistic nona- and decapeptides suitable for use in the preparation of a drug for the treatment of AIDS and ARC as well as for use in the preparation of an immunostimulation drug.... | 11/16/1999 |
| 5968895 | Pharmaceutical formulations for sustained drug delivery Sustained delivery formulations comprising a water-insoluble complex of a peptide and a carrier macromolecule are disclosed. The formulations of the invention allow for loading of high concentrations of peptide in a small volume and for delivery of a phar... | 10/19/1999 |
| 5929028 | Liquid gonadotropin containing formulations The invention concerns a liquid gonadotropin-containing formulation characterised in that the formulation comprises a gonadotropin and stabilising amounts of a polycarboxylic acid or a salt thereof and of a thioether compound. The particular proteins (e.g... | 07/27/1999 |
| 5889110 | Salts of peptides with carboxy-terminated polyesters This invention relates to novel salts composed of a cation derived from a peptide containing at least one basic group and an anion derived from a carboxy-terminated polyester, processes for the manufacture of such salts, and the use of such salts in the m... | 03/30/1999 |
| 5877148 | Treatment of cancer with human chorionic gonadotropin Methods useful for treating cancers are disclosed. The methods involve administering human chorionic gonadotropin (hCG) or human luteinizing hormone (hLH) to patients having cancers. Articles of manufacture that are useful for carrying out the described m... | 03/02/1999 |
| 5863985 | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides Disclosed is a sustained release pharmaceutical composition. The composition includes a polyester containing a free COOH group ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein at least 50% by wei... | 01/26/1999 |
| 5853740 | Delivery system for pharmaceutical agents encapsulated with oils The present invention provides a uniform dispersion in aqueous medium of droplets comprising: (a) a core comprising water, a non-toxic C2 -C5 alkanol, a water-soluble drug, and a surfactant, and (b) a coating surrounding the core com... | 12/29/1998 |
| 5824548 | Method of increasing survival of cultured primate embryos in medium containing exogenous gonadotrophin releasor hormone Invitro incubation of primate embryos in the presence of gonadotrophin releasor hormone (GnRH) results in enhanced chorionic gonadotrophin production associated with increased survival and attachment of the embryos. Treatment of invitro fertilized embryos... | 10/20/1998 |
| 5783562 | Luteinizing hormone releasing hormone analogs A method is provided for the design and synthesis of Leuteinizing Hormone Releasing Hormone (LHRH) antagonists having exact amino acid sequences and containing 5-100 amino acids. This method can be used to produce peptides useful in treating disorders of ... | 07/21/1998 |
| 5780435 | Methods for treating prostate cancer with LHRH-R antagonists Methods for treating prostate cancer are disclosed. The methods of the invention generally feature administration to a subject of an LHRH-R antagonist, in combination with a second therapy. In one embodiment, this second therapy is performance of a proced... | 07/14/1998 |
| 5767082 | Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists Synthetic nona- and decapeptide LHRH antagonist analogs are disclosed, having a sterically hindered guanidino-substituted arginyl or homoarginyl residue at position 8, with no arginyl substituent at position 6.... | 06/16/1998 |
| 5744450 | GnRH analogs Peptides which include unnatural amino acids and which either promote or inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount of such peptides that are GnRH ... | 04/28/1998 |
| 5712251 | Treatment method A method of treating prostate cancer in warm-blooded animals comprising administering to warm-blooded animals an effective amount of a peptide of Formula I and an anti-androgen.... | 01/27/1998 |
| 5691314 | Adjunctive therapy A growth such as a tumor, hypertrophied tissue or cyst is biopsied or more completely excised subsequent to the administration of an effective amount of a gonadotropin releasing hormone analog or other inhibitor of ovarian steroid production or action.... | 11/25/1997 |
| 5688506 | Immunogens against gonadotropin releasing hormone Immunogenic compositions capable of generating an immune response in mammals against GnRH are disclosed. The immunogenic compositions are effective in methods of treating gonadotropin and gonadal steroid hormone dependent diseases and immunological contra... | 11/18/1997 |
| 5677275 | Treatment of cancer with human chorionic gonadotropin Methods useful for treating cancers are disclosed. The methods involve administering human chorionic gonadotropin (hCG) or human luteinizing hormone (hLH) to patients having cancers. Articles of manufacture that are useful for carrying out the described m... | 10/14/1997 |
| 5672659 | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides A composition including a polyester containing one or more free COOH groups ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein the polyester contains a member selected from the group of L-lactic ac... | 09/30/1997 |
| 5663145 | Products for administering an initial high dose of Cetrorelix and producing a combination package for use when treating diseases For application during the treatment of benign and malign tumour diseases, the product according to the invention containing the initial dose of Cetrorelix acetate and one or more maintenance doses of Cetrorelix acetate, Cetrorelix embonate or a slow-rele... | 09/02/1997 |
| 5643877 | Compounds comprising gonadotropin releasing hormone (GnRH) and methods for controlling reproduction in fish Novel peptide hormones which influence the release of gonadotropins by the pituitary gland in fish are disclosed. Methods in which such peptides may be administered to fish to control their reproduction are also described. Furthermore, novel isolated cDNA... | 07/01/1997 |
| 5593981 | Method and treatment of androgen-related diseases A method of treatment of androgen-related diseases such as prostate cancer in susceptible male animals, including humans, comprises administering novel antiandrogens and/or novel sex steroid biosynthesis inhibitors as part of a combination therapy. Sex st... | 01/14/1997 |
