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| Number | Title | Issue Date |
| 7998945 | Methods for the treatment and amelioration of atopic dermatitis The present invention relates to a method for the treatment and/or amelioration of atopic dermatitis, the method including the administration of a pharmaceutically active dose of a compound selected from miltefosine, edelfosine, perifosine and ilmofosine to a subjec... | 08/16/2011 |
| 7420000 | Amino phosphonate and amino bis-phosphonate derivatives Aminophosphonate and amino bisphosphonate compounds and methods for their preparation are provided. Also provided are pharmaceutical and agricultural compositions containing the compounds. The compounds and compositions are useful in methods for treatment of various... | 09/02/2008 |
| 7288534 | Sphingomyelin enhancement of tumor therapy Cytotoxic tumor therapy in a patient is enhanced by co-administration of sphingomyelin. The invention most likely enhances a tumor cell's ability to undergo ceramide-induced apoptosis by increasing the levels of sphingomyelin in all cellular compartments, thereby pr... | 10/30/2007 |
| 7273604 | Anti-asthmatic combinations comprising surface active phospholipids Disclosed is a combination product for use in treating asthma and other respiratory conditions comprising a medicament comprising a surface active phospholipid composition in the form of a fine powder and an antiasthma drug. The product is arranged to be administere... | 09/25/2007 |
| 7235556 | Methods of treating dry eye disorders Fused pyridazine derivatives are useful for treating dry eye disorders and other disorders requiring the wetting of the eye. ... | 06/26/2007 |
| 7223737 | Method of treating dry eye disorders using glycosides The topical use of glycosides for the treatment of dry eye disorders is disclosed. ... | 05/29/2007 |
| 7208481 | Aminodiphosphonate apolipoprotein E modulators The present invention relates to methods of use of aminodiphosphonate to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease states. ... | 04/24/2007 |
| 7138520 | Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same In part, the present invention is directed to coordination complexes comprising a therapeutic agent. In one aspect, the subject compositions comprise a platinum metal center and a covalently attached therapeutic agent. ... | 11/21/2006 |
| 7112588 | Use of proteasome inhibitors to treat dry eye disorders Proteasome inhibitors are useful for treating dry eye disorders and other disorders requiring the wetting of the eye. ... | 09/26/2006 |
| 7060728 | 11,12-oxidoarachidonic acid derivatives and methods of their use in treating dry eye disorders 11,12-Oxidoarachidonic acid derivatives and methods of their use for treating dry eye are disclosed. ... | 06/13/2006 |
| 7048908 | Particles for inhalation having sustained release properties The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention rel... | 05/23/2006 |
| 7026296 | Methods of treating dry eye disorders Inhibitors of cytokine synthesis in nonimmune, resident ocular surface cells are useful for treating dry eye disorders and other disorders requiring the wetting of the eye. ... | 04/11/2006 |
| 6926836 | Treatment of iron sulphide deposits Treating a water system containing or in contact with a metal sulphide scale to inhibit, prevent, reduce, dissolve or disperse iron sulphide deposits. A solution of tris(hydroxyorgano)phosphines (THP) and tetrakis(hydroxyorgano)phosphonium salts (THP+ sal... | 08/09/2005 |
| 6794371 | Aminoalkylenephosphonates for treatment of bone disorders A method for preventing loss of bone mineral in mammals which method comprises administering to a mammal an amount of an aminoalkylenephosphonate which is effective to prevent or minimize loss of bone material density. The aminoalkylenephophonates of the present inv... | 09/21/2004 |
| 6784168 | Biocidal compositions and treatments A synergistic biocide comprises a tris(hydroxymethyl)phosphine or a tetrakis (hydroxymethyl)phosphonium salt and at least one non-surfactant biopenetrant, such as a polymer or copolymer having a plurality of quaternary ammonium groups, a hydrotrope or a syntan, toge... | 08/31/2004 |
| 6673378 | Phosphatidylserine-containing muscle development diet supplement and anti-catabolic dietary nutrients An anti-catabolic dietary supplement, phosphatidylserine, and diet and exercise programs using phosphatidylserine for lean muscle development and optimized conditioning.... | 01/06/2004 |
| 6624152 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 09/23/2003 |
| 6593312 | Cyclic -amino-γ-hydroxyamide compounds A compound of formula (I): ##STR1## wherein: ##STR2## represents an optionally substituted saturated carbon ring having from 4 to 8 ring members, R1 and R4, which may be identical or different, each represents hydrogen or acyl, ... | 07/15/2003 |
| 6541462 | Sphingomyelin enhancement of tumor therapy Cytotoxic tumor therapy in a patient is enhanced by co-administration of sphingomyelin. The invention most likely enhances a tumor cell's ability to undergo ceramide-induced apoptosis by increasing the levels of sphingomyelin in all cellular compartments,... | 04/01/2003 |
| 6476006 | Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates The present invention provides compacted pharmaceutical composition for oral administration to a patient which expands upon contact with gastric fluid to retain a dosage form in the patient's stomach for an extended period of time, the formulation compris... | 11/05/2002 |
| 6380174 | Slime-removing composition for paper manufacture and method of controlling slime using the same Disclosed is a slime-removing composition comprising polyhexamethyleneguanidine phosphate and 2-bromo-2-nitro-1, 3-propanediol, represented by the following formulas I and II, respectively. With a synergistic effect, the composition has potent sterilizing... | 04/30/2002 |
| 6353022 | Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders Compositions containing one or more HETE derivative(s) and an effective concentration of ethanol and methods of use for treating dry eye are disclosed.... | 03/05/2002 |
| 6348491 | Oil-in-water emulsion for encapsulating paclitaxel An oil-in-water emulsion for encapsulating paclitaxel including (a) triglyceride , (b) emulsifier including phosphatidyl choline (PC), non-ionic surfactant and polyethyleneglycol-modified disteaoyl phosphatidylethanolamine (PEG-M-DSPE), and (c) pharmaceut... | 02/19/2002 |
| 6329352 | Method and composition for treating sleep apnea Application of synthetic or naturally occurring lung surfactant to the posterior pharyngeal region prior to a period of sleep significantly reduces episodes of sleep disturbance resulting in apnea or hypopnea. The present invention provides lung surfactan... | 12/11/2001 |
| 6313106 | Phospholipid derivatives of valproic acid and mixtures thereof The present invention relates to compounds, which are phospholipid derivatives of valproic acid, to compositions comprising said compounds and their use for treating epilepsy, migraine, bipolar disorders and pain.... | 11/06/2001 |
| 6300323 | (Poly)ethereal ammonium salts of herbicides bearing acidic moieties and their use as herbicides A compound ##STR1## Wherein x, y, and z are integers from 0 to 3; and the (poly)ethereal amine is at least one selected from compounds of formula II1 through II5 : ##STR2##... | 10/09/2001 |
| 6162427 | Combination of G-CSF with a chemotherapeutic agent for stem cell mobilization The invention relates to the use of G-CSF in combination with a chemotherapeutic agent (in particular, cyclophosphamide) to produce a pharmaceutical preparation for boosting the mobilization of hematopoietic stem cells from bone marrow in the treatment of... | 12/19/2000 |
| 6077837 | Prodrugs with enhanced penetration into cells The invention relates to a pharmaceutically acceptable prodrug which is a covalent conjugate of a pharmacologically active compound and an intracellular transporting adjuvant, characterized by the presence of a covalent bond which is scission-sensitive to... | 06/20/2000 |
| 6071919 | Zwitterionic compositions and methods as biological response modifiers A method of treating a disease in a mammal by administering a therapeutic effective amount of an amphoteric zwitterion compound as an active ingredient. A pharmaceutical composition which comprises an amphoteric zwitterionic compound as an active ingredie... | 06/06/2000 |
| 5958902 | Method and composition for treating sleep apnea Application of synthetic or naturally occurring lung surfactant to the posterior pharyngeal region prior to a period of sleep significantly reduces episodes of sleep disturbance resulting in apnea or hypopnea. The present invention provides lung surfactan... | 09/28/1999 |
| 5958977 | Phosphoric acid-amino acid complex salt and additive composition containing the salt and used in feed for ruminant mammals A novel phosphoric acid-amino acid complex salt is provided which manifests insolubility in a neutral or alkaline aqueous solution and solubility in an acidic aqueous solution and has a basic amino acid, an alkaline earth metal, and phosphoric acid as mai... | 09/28/1999 |
| 5902804 | Pharmaceutical composition for inhibiting the growth of viruses and cancers This invention is a pharmaceutical composition that inhibits the growth of cancers and tumors in mammals, particularly in human and warm blooded animals. The composition is also effective against viruses. The composition contains N-phosphonoglycine deriva... | 05/11/1999 |
| 5902802 | Cationic amphiphiles Cationic amphiphiles are provided that are alkyl or alkoxyalkyl O-phosphate esters of diacylphosphatidyl zwitterionic compounds such as phosphatidylcholine or phosphatidyl ethanolamine. The amphiphiles can be used as carriers for delivering macromolecules... | 05/11/1999 |
| 5897860 | Method for controlling bleeding and microbial infections by administering thrombin, casein kinase II, and sphingosine The present invention relates to a hemostatic composition comprising at least 0.1 NIH U/ml of thrombin, about 0.01 mU/ml of casein kinase II, and from 10 ng/ml to 100 ng/ml of sphingosine or a sphingosine derivative. The composition is effective in treati... | 04/27/1999 |
| 5888405 | Methods for controlling biofouling using amino methyl phosphonic acids The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one amino methyl phosphonic acid or salt thereof to inhibit bacterial adhesion t... | 03/30/1999 |
| 5869338 | Method for protection against genotoxic mutagenesis A method and pharmaceutical for protecting against mutational damage in mammalian cells, irrespective of the nature of the mutagenic event or source of radiational or chemical insult or the like.... | 02/09/1999 |
| 5854231 | Pharmaceutical composition for inhibiting the growth of cancers This invention is a pharmaceutical composition that inhibits the growth of cancers and tumors in mammals, particularly in human and warm blooded animals. The composition contains N-phosphonoglycine derivatives which are systemic herbicides in combination ... | 12/29/1998 |
| 5753667 | 1-oxo-2- (phenylsulphonylamino) pentylpiperidine derivatives, their preparation and their therapeutic application The present invention provides a compound of formula (I) ##STR1## in which R1 represents a hydrogen atom or a (C1 -C4)alkyl group, R2 represents a hydrogen atom or a straight or branched (C1 -C | 05/19/1998 |
| 5716959 | Method of treating disease with piperazine zwitterion compounds A substituted piperazine zwitterion composition containing, for example, as an active ingredient, HEPES (N-2 Hydroxyethylpiperazine-N'-2 Ethane Sulfonic Acid), and method useful for treatment of cancer, autoimmune, arthritis and other mammalian diseases.... | 02/10/1998 |
| 5681829 | Class of phosphocholine derivatives having antifungal activity Certain phosphocholine derivatives having substantial antifungal therapeutic activity are disclosed. The phosphocholine derivatives may be chemically synthesized, enzymatically prepared or extracted from the plant Irlbachia alata. The phosphocholine deriv... | 10/28/1997 |
