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| Number | Title | Issue Date |
| 8106097 | Composition based on substituted 1,3-diphenylprop-2-en-1-one derivatives, preparation and uses thereof The invention concerns compositions comprising substituted 1,3-diphenylprop-2-en-1-one derivatives designed for therapeutic use. The inventive compositions are useful in particular for preventing or treating cardiovascular diseases, syndrome X, Ia restenosis, diabet... | 01/31/2012 |
| 7745495 | Pyridine ketones with herbicidal effect The invention relates to compounds of formula (I) wherein A1 is C(R1R2)p; A2 is C(R6R7)q; p is 1 or 2; q is 1 or 2; each of R1, R2, R3, R4 | 06/29/2010 |
| 7632870 | Composition based on substituted 1,3-diphenylprop-2-en-1-one derivatives, preparation and uses thereof The invention concerns compositions comprising substituted 1,3-diphenylprop-2-en-1-one derivatives designed for therapeutic use. The inventive compositions are useful in particular for preventing or treating cardiovascular diseases, syndrome X, Ia restenosis, diabet... | 12/15/2009 |
| 7598294 | 3,4-methylenedioxy-substituted chalcones as therapeutic agents The present invention pertains to the use of a compounds for the manufacture of a medicament for use in the treatment of a proliferative condition, wherein the compounds have the following formula: wherein: each of RB2... | 10/06/2009 |
| 7402706 | Polyisoprenylated benzophenones and their isomers as inhibitors of histone acetyltransferases and uses thereof In this patent we describe the purification of prenylated benzophenones from the fruit rinds of Garcinia species and its evaluation as an inhibitor for Histone acetyltransferases p300 and PCAF. We have found that prenylated benzophenones are potent HAT inhibi... | 07/22/2008 |
| 7326734 | Treatment of bladder and urinary tract cancers Compositions of matter and methods wherein chalcone and flavone derivatives are administered to human or veterinary patients for the treatment of bladder or urinary tract cancer. Compounds of the invention include 2′-hydroxy-4,4′,6′-trimethoxychalcone (Flavoka... | 02/05/2008 |
| 7265112 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasse... | 09/04/2007 |
| 7256219 | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to multifluoro-substituted Chalcones and analogs thereof, represented by the general Formula I: wherein Ar and R6-R10 are defined herein. The present invent... | 08/14/2007 |
| 7250437 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and... | 07/31/2007 |
| 7244416 | Stabilized photoprotective composition Sunscreen compositions contain the active ingredients avobenzone, zinc oxide and phenylbenzimidazole sulfonic acid. The phenylbenzimidazole sulfonic acid protects avobenzone against photodegradation. ... | 07/17/2007 |
| 7235587 | Diesters containing two crylene or fluorene moieties, sunscreen compositions containing the same, and methods of photostabilizing a sunscreen compositions containing the same Diesters that include one or more of a crylene and/or a fluorene moiety, and sunscreen compositions including a mixture of a photoactive compound and one or more of a diester that includes one or more of a crylene and/or a fluorene moiety are described herein. Also ... | 06/26/2007 |
| 7226941 | Compound for treating angiogenesis The present invention provides methods and pharmaceutical compositions for inhibiting expressions of HIF and HIF regulated genes, inhibiting angiogenesis, inducing cell cycle arrest in tumor cells, and treating cell proliferating diseases or conditions. ... | 06/05/2007 |
| 7192976 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and... | 03/20/2007 |
| 7112698 | 4-(c2-6alkoxy)-substituted chalcones as therapeutic agents The present invention pertains to compounds of the following formula: (1) wherein: RALK is primary or secondary aliphatic saturated C2-6alkyl; each of RB2, RB3, RB4, and RB5 is independently —H, —... | 09/26/2006 |
| 7101910 | Compounds for the treatment of metabolic disorders Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed. ... | 09/05/2006 |
| 7056952 | Isoflavone metabolites There are disclosed compounds of formulae (I) or (II) in which A is selected from the group consisting of (1), (2), (3) and (4); OH, and one of R1 and R2 is selected from H, OH and OCH3, and the other of R1 and R2 | 06/06/2006 |
| 7030162 | Treatment of migraine headache The invention is directed to pharmaceutical compositions useful in the treatment of migraine. The compositions contain metoclopramide and one or more NSAIDs in unit dosage form. By selecting NSAIDs that are non-acidic or segregating the metoclopramide and NSAID, the... | 04/18/2006 |
| 7014842 | Sunscreen composition There is provided a composition comprising one or more photoactive compounds and one or more optimization agents. Surprisingly, the composition requires a small amount of optimization agent to efficiently optimize the polarity, critical wavelength, SPF, PFA, Star Ra... | 03/21/2006 |
| 6984389 | Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an α-2-macroglobulin (α2M) preparation with a non-vaccine treatment modality. In particular, an HSP preparation or an α2M ... | 01/10/2006 |
| 6919473 | Photostabilizers, UV absorbers, and methods of photostabilizing a sunscreen composition Derivatives of fluorene, including ester derivatives of cyano(9H-fluoren-9-ylidene) acetic acid, and sunscreen compositions including a mixture of a photoactive compound and an ester derivative of cyano(9H-fluoren-9-ylidene) acetic acid are disclosed herein. Also di... | 07/19/2005 |
| 6919324 | Functionalized stilbene derivatives as improved vascular targeting agents Novel stilbenoid compounds and their prodrug forms are disclosed, which serve as potent vascular targeting agents useful for the treatment of solid tumor cancers and other diseases associated with unwanted neovascularization. The novel stilbenoid compounds are tubul... | 07/19/2005 |
| 6916848 | Compounds for the treatment of metabolic disorders Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed. ... | 07/12/2005 |
| 6906059 | Pharmaceutical composition with protective action against oxidative/toxic substances, especially cardiotoxic substances The use of benzazepin-N-acetic acid derivatives which contain an oxo group in the a position to the nitrogen atom and are substituted in the 3 position by a 1-(carboxyalkyl)-cyclopentyl-carbonyl-amino radical, and of their salts and biolabile esters, for the prophyl... | 06/14/2005 |
| 6858602 | Compounds for the treatment of metabolic disorders Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed. ... | 02/22/2005 |
| 6828347 | Anti-viral multi-quinone compounds and regiospecific synthesis thereof This invention provides various biquinone and trimeric quinone derivatives. The invention also provides a method for synthesis of a multi-quinone compound including reacting a hydroxyquinone anion with a first quinone possessing a first directing group at a C-2 of t... | 12/07/2004 |
| 6790463 | Uses of targeted oxidative therapeutic formulation in arteriosclerosis The use of a pharmaceutical formulation in treating coronary arteriosclerosis and a two-component pharmaceutical formulation. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by a... | 09/14/2004 |
| 6787672 | Substituted chalcones as therapeutic compounds This invention pertains to substituted chalcones, specifically substituted 1-(4-methoxyphenyl)-3-(3,5-dimethoxyphenyl)prop-1-en-3-ones, which have therapeutic application, for example, as potent antiproliferative agents and antiinflammatory agents, and which have th... | 09/07/2004 |
| 6774111 | Carbohydrate system and a method for providing nutrition to a diabetic The two carbohydrate mixture of this invention utilizes a source of fructose in combination with at least one readily digestible glucose polymer source. The addition of the fructose significantly decreases the glycemic response when compared to the digestible glucos... | 08/10/2004 |
| 6589997 | Small-molecule modulators of hepatocyte growth factor/scatter factor activities The invention is directed to small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization ... | 07/08/2003 |
| 6462054 | Inhibitors of fatty acid amide hydrolase Potent inhibitors of fatty acid amide hydrolase (FAAH) are constructed having Ki 's below 200 pM and activities 102 -103 times more potent than the corresponding trifluoromethyl ketones. The potent inhibitors combine sever... | 10/08/2002 |
| 6462075 | Chalcone and its analogs as agents for the inhibition of angiogensis and related disease states The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The pres... | 10/08/2002 |
| 6455032 | Composition and method for protecting skin from UV induced immunosuppression and skin damage Compositions and a method of protecting skin from either UV-induced immunosuppression or from UV-induced skin damage using a composition containing an extract of soy or clover, and/or the isoflavone compounds genistein, biochanin, dihydro-diadzein, formon... | 09/24/2002 |
| 6416773 | Cosmetic or dermatological light protection agent preparations The invention relates to cosmetic or dermatological preparations comprising a) 0.1 to 10% by weight of one or more 3,3-diphenylacrylates of the formula I, ##STR1## and b) 0.1 to 10% by weight of one or more dibenzoylmethane derivatives of the formula II, ... | 07/09/2002 |
| 6413998 | Compositions and methods for treating bone deficit conditions Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 Å, are effective in treating condi... | 07/02/2002 |
| 6410587 | Compounds and therapies for the prevention of vascular and non-vascular pathologies The invention provides a method of treating a mammal having, or at risk of, an indication associated with a TGF-beta deficiency comprising administering one or more agents that is effective to elevate the level of TGF-beta. The invention also provides nov... | 06/25/2002 |
| 6391921 | Treatment of inflammation with 2,4,6-trihydroxy--para-methoxyphenylacetophenone, or its pharmaceutically acceptable derivatives 2,4,6-trihydroxy--p-methoxyphenylacetophenone (also identified herein as "D-58"), or its pharmaceutically acceptable derivatives such as salt and ester forms, is administered for inhibiting inflammatory reactions. The treatment can be remedial or p... | 05/21/2002 |
| 6346550 | Hydroxylation activated prodrugs The present invention concerns enzymatic aromatic hydroxylation-activated prodrugs, particularly anti-tumour prodrugs and those which are specifically activated by the hydroxylation activity of the enzyme CYP1B1.... | 02/12/2002 |
| 6248790 | Treatment of inflammation with 2,4,6-trihydroxy-alpha-rho-methoxyphenylacetophenone, or its pharmaceutically acceptable derivatives 2,4,6-trihydroxy--p-methoxyphenylacetophenone (also identified herein as "D-58"), or its pharmaceutically acceptable derivatives such as salt and ester forms, is administered for inhibiting inflammatory reactions. The treatment can be remedial or p... | 06/19/2001 |
| 6235773 | Compositions for regulating skin appearance The present invention relates to methods for preventing or treating skin disorders using flavonoid compounds. The present invention also relates to methods for regulating skin condition.... | 05/22/2001 |
| 6218435 | Reduction of hair growth A method of reducing hair growth in a mammal includes applying, to an area of skin from which reduced hair growth is desired, a dermatologically acceptable composition containing a suppressor of the metabolic pathway for the conversion of glucose to acety... | 04/17/2001 |
