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...that the first rickshaw was invented in 1869 by an American Baptist minister, the Rev. E. Jonathan Scobie, to transport his invalid wife around the streets of Yokohama?
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| Number | Title | Issue Date |
| 7109380 | Cyclopentenedione antifungal compounds and methods for their use Compounds and methods useful in the control, treatment, and prevention of fungal activity, of the following formula: where R1-3 are independently H, alkyl, methyl, acyl, halogen, phenyl, R4 ... | 09/19/2006 |
| 7091241 | Nontoxic potentiation/sensitization of cancer therapy by supplementary treatment with combined vitamins C and K A combination of Vitamin C and a quinone used as a supplemental treatment for a cancer patient. The combination may be administered before, during and after the patient undergoes a conventional cancer treatment protocol. The combination may be administered orally, i... | 08/15/2006 |
| 7064148 | Chloride channel opener Disclosed is a novel use of a prostaglandin compound as a chloride channel opener. According to the instant invention, chloride channels in a mammalian subject can be opened by a prostaglandin compound to facilitate chloride ion transportation. ... | 06/20/2006 |
| 6903238 | Substituted indenones as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure R1, R2, and R3 are as defined in the specification, or a pharmaceutically acceptable salt thereof... | 06/07/2005 |
| 6887904 | Substituted arylcycloalkanes, compositions containing them and use thereof Substituted arylcycloalkanes, compositions containing them and use thereof. The present invention relates especially to substituted arylcycloalkanes with therapeutic activity, which may be used such as in oncology. ... | 05/03/2005 |
| 6806264 | Arylphenyl-substituted cyclic ketoenols The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulp... | 10/19/2004 |
| 6777447 | Derivatives of benzylidene cyclohexanone, benzylidene cyclopentanone, and benzylidene acetone, and therapeutic uses thereof Benzylidene cyclohexanone, cyclopentanone and acteone derivatives and therapeutic methods of using same are disclosed. The compounds are non-toxic and exhibit potent anti-inflammatory, antibacterial and antioxidation activity. Also, certain compounds of the inventio... | 08/17/2004 |
| 6514934 | Imidazoline -adrenergic receptor antagonist compounds in combination with nitric oxide donors, compositions and methods of use The present invention is directed to nitrosated or nitrosylated -adrenergic receptor antagonists, compositions comprising -adrenergic receptor antagonists that are optionally substituted with at least one NO or NO2 moiety and comp... | 02/04/2003 |
| 6251833 | 2-arylcyclopentan-1,3-diones The present invention relates to novel 2-aryl-3-hydroxy-Ɗ2 -cyclopentene-1-one derivatives of the formula (I) ##STR1## in which A, B, D1, D2, G, W, X, Y and Z are each as defined in the description, to processes for their... | 06/26/2001 |
| 6172118 | Compounds This invention relates to ketones, alcohols and amines represented by the likes of of 3-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylethynylcyclobutan-1-one. They are useful as PDE 4 antagonists.... | 01/09/2001 |
| 6150374 | Substituted cycloalkenes, process of preparing them and method of using them as pesticides The invention relates to novel substituted cycloalkenes of the formula (I), ##STR1## to a plurality of processes for their preparation, and to novel intermediates and a plurality of processes for their preparation.... | 11/21/2000 |
| 6121330 | 5-Hydroxyalkyl substituted phenyls and their use in medicaments for the treatment of arteriosclerosis and hyperlipoproteinaemia The novel 5-hydroxy-alkyl-substituted phenyls are prepared by either reacting the corresponding benzaldehydes with the Grignard compounds and subsequently reducing the other functional groups or by reducing the corresponding benzoic esters by customary me... | 09/19/2000 |
| 6107346 | Methods for treating hyperlipidemia The present application relates to a series of compounds, and pharmaceutical formulations thereof, of the formula ##STR1## which provide a method of inhibiting hyperlipidemia, especially hypercholesterolemia, and the pathological sequelae thereof, in... | 08/22/2000 |
| 6075044 | Heterocyclic derivatives as inhibitors of purine salvage phosphoribosyltransferases The use of certain heterocyclic derivatives for treating parasitic protozoa infections in mammals, in particular bovine trichomoniasis and giardiasis, is disclosed.... | 06/13/2000 |
| 6051588 | Nitroso esters of ଲ-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs A compound comprising a non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO group, a pharmaceutical composition including the compounds and methods of treatment of pain and/or inflammation using the compounds and compositi... | 04/18/2000 |
| 6048877 | Tetralone derivatives as antiarrhythmic agents Tetralone derivatives of the formula ##STR1## where R1 is halo, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, (aryl)alkenyl, (aryl)alkynyl, alkoxy, O-alkenyl, O-aryl, O-alkyl(heterocyclo), COO-alkyl,alkanoyl, CO-amino, CO-substituted amino, ... | 04/11/2000 |
| 5994294 | Nitrosated and nitrosylated -adrenergic receptor antagonist compounds, compositions and their uses Disclosed are nitrosated and nitrosylated -adrenergic receptor antagonists, compositions of an -adrenergic receptor antagonist (-antagonist), which can optionally be substituted with at least one NO or NO2 moiety, and a com... | 11/30/1999 |
| 5843869 | Inhibitors of hydroxyphenylpyruvate dioxygenase and an assay for identification of inhibitors There are described a method for enriching the anabolic p-hydroxyphenylpyruvate dioxygenases from plant tissues and a method by means of which the enzymatic activity of the enzyme can be measured in a simple manner without complete purification of the enz... | 12/01/1998 |
| 5840658 | Process for the controlled fixing of scale inhibitor in a subterranean formation A process for fixing of a scale inhibitor in a subterranean formation, which comprises: a) injecting into the formation a solution comprising a polymeric scale inhibitor, a metal cation, a precursor and a weak organic acid, wherein the polymeric scale inh... | 11/24/1998 |
| 5677336 | Non-steroid androgen receptor antagonist compounds and methods Non-steroidal compounds which are high affinity, high specificity ligand antagonists for the androgen receptor are disclosed. Also disclosed are methods for employing the disclosed compounds for modulating processes mediated by the androgen receptor and f... | 10/14/1997 |
| 5665773 | Cloprostenol and fluprostenol analogues and their use to treat glaucoma and ocular hypertension Disclosed is the use of cloprostenol and fluprostenol analogues for the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic compositions comprising said compounds.... | 09/09/1997 |
| 5663180 | Substituted cyclopentenes for the treatment of inflammation A class of 1,2-diarylcyclopentenyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula III: ##STR1## wherein each of R1 and R2 is in... | 09/02/1997 |
| 5618837 | PDGF antagonists III Methods for inhibiting intimal hyperplasia in the vasculature of mammals, including primates, are disclosed. The methods comprise administering to the mammal an effective amount of Brefeldin A or a derivative of Brefeldin A. The methods are useful in redu... | 04/08/1997 |
| 5618547 | Control of ectoparasites A series of 1,3-propanediones having a perfluoroalkyl group or a perfluorocycloalkyl group on one carbonyl, and a 3,5-disubstituted phenyl group on the other, are useful when administered to animals for the control of ectoparasites.... | 04/08/1997 |
| 5455265 | Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors Process of treatment of mammals, including humans to treat diseases or conditions of the type which are normally treated with retinoid-like compounds is disclosed, with pharmaceutical compositions containing an active compound which is a selective agonist... | 10/03/1995 |
| 5149711 | 2-cyclopentenone derivatives A 2-cyclopentenone derivative represented by the following formula ##STR1## wherein R1 represents an alkyl group having 1 to 10 carbon atoms which may be substituted by a substituted or unsubstituted phenyl or phenoxy group, R2,... | 09/22/1992 |
| 5116869 | 2-substituted-2-cyclopentenones 2-Substituted-2-cyclopentenones represented by the formula (I): ##STR1## wherein A is a hydroxyl group or ##STR2## and B is a hydrogen atom or A and B are bonded together to form one bonding arm; R1 represents a substituted or unsubst... | 05/26/1992 |
| 5106407 | Iodones and methods for antimicrobial use The present invention discloses the antimicrobial utility of certain iodonium ylide compounds. The particular iodonium ylide compounds are phenyl iodonium ylides having an ortho substituent that stabilizes the positive charge on the polyvalent iodine by a... | 04/21/1992 |
| 5047420 | 1,3-diaryl cyclopentanes and derivatives thereof as PAF antagonists Novel 1,3-diaryl cyclopentanes of the following general formula were prepared. ##STR1## These compounds were found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and as such useful in the treatment or amelio... | 09/10/1991 |
| 4981872 | Prostaglandin derivatives, their preparation and their therapeutic use Prostaglandin derivatives having an oxo group at specified positions in the side chain have a variety of physiological effects, notably a strong anti-ulcer activity accompanied by a limited ability to inhibit blood platelet aggregation.... | 01/01/1991 |
| 4952401 | Rodenticide for toxic wick A composition and a method of using the same wherein said composition comprises a rodenticide and an additive selected from the group consisting of 1. polyoxyalkylated alkyl phenols; 2. sorbitan fatty acids and polyoxyalkylated derivatives thereof; 3. polyoxya... | 08/28/1990 |
| 4871756 | Leukotriene antagonists Compounds having the formula: ##STR1## are antagonists of leukotrienes of C4, D4, E4 and the slow reacting substance of anaphylaxis. As such, these compounds will be useful as anti-asthmatic, anti-allergic, anti-infla... | 10/03/1989 |
| 4845129 | Diaryl substituted cyclopentane and cyclopentene derivatives The invention discloses certain diaryl substituted cyclopentane and cyclopentene derivatives useful as PAF inhibitors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibi... | 07/04/1989 |
| 4843097 | 10-aryl-1,8-dihydroxy-9-anthrones and their esters, process for preparing same, and use of same in human and veterinary medicine and in cosmetics Mono, di and tri-esters of 1,8-dihydroxy-10-phenyl-9-anthrone or -9-anthranol have the formula ##STR1## wherein p is 0 or 1, (a) when p=0, t=1 and R2 represents hydrogen or --COR3, (b) when p=1, t=0 and R1 and R2 | 06/27/1989 |
| 4829091 | Process for the preparation of ketones and novel insecticides produced therefrom An improved method for the decarbalkoxylation of alkylated ଲ-keto esters to obtain high yields of ketones. In accordane with the method, decarbalkoxylation of alkylated ଲ-keto esters is accomplished by heating the esters in the presence of dil... | 05/09/1989 |
| 4713392 | Pesticides A compound of formula II in which formula: RA represents a group ArCR1 R2 -- in which Ar represents a phenyl or naphthyl group optionally substituted by one or more halogen, alkoxy, haloalkoxy, methylenedioxy or C1 -... | 12/15/1987 |
| 4675341 | [(5,6-dichloro-3-oxo-9a-propyl-2,3,9,9a-tetrahydrofluoren-7-yl)o xy]ethanol and its derivatives The invention relates to novel [(5,6-dichloro-3-oxo-9a-propyl-2,3,9,9a-tetrahydrofluoren-7-yl)oxy]ethanol , its derivatives, and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head tra... | 06/23/1987 |
| 4395417 | Antihyperlipidemic compositions The invention concerns cyclic imides, diones, reduced diones and analogs thereof which are useful as antihyperlipidemic agents to reduce serum cholesterol and trigylcerides.... | 07/26/1983 |
| 4390537 | 1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, compositions and use 1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, a class of compounds possessing anti-allergic properties for use in the treatment of allergic conditions, such as asthma prepared by etherifying an alkanoylphenol with an aminoalkyl halide, conver... | 06/28/1983 |
| 4333948 | Pharmaceutical formulations containing prostaglandin What are disclosed are: a substance, obtained from blood serum and having a molecular weight below 2000, which is suitable for stabilizing prostaglandins, especially those of the A, E, F, or I type; methods for preparing such a stabilizing substance from ... | 06/08/1982 |
