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| Number | Title | Issue Date |
| 8058314 | Conductance of improperly folded proteins through the secretory pathway and related methods for treating disease This invention provides the methodology and agents for treating any disease or clinical condition which is at least partly the result of endoplasmic reticulum-associated retention of proteins. Thus, the methods and agents of the present invention provide for the rel... | 11/15/2011 |
| 7973083 | Pesticidally active compounds A pesticidally active combination comprising an HPPD-inhibiting herbicide in the form of an agrochemically acceptable salt and an insecticide is disclosed, provided that the HPPD inhibiting herbicide is not a compound of formula (A) wherein Ra is C1-... | 07/05/2011 |
| 7820721 | Compounds for the treatment of metabolic disorders Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. wherein n is 1 or 2;... | 10/26/2010 |
| 7723393 | Cycloalkylidene compounds as selective estrogen receptor modulators The present invention relates to compounds of formula (I) with a variety of therapeutic uses, more particularly the substituted cyclic alkylidene compounds are useful for selective estrogen receptor modulation. ... | 05/25/2010 |
| 7608643 | Compounds for inhibiting KSP kinesin activity The present invention relates to compounds of Formula I or pharmaceutically acceptable salts or solvates thereof: The present invention provides compositions comprising these compounds that are useful for treating cellular ... | 10/27/2009 |
| 7345096 | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms The present invention relates to the use of compounds and composition of compounds that modulate norepinephrine levels for the prevention and treatment of vasomotor symptoms, such as hot flush, caused by, inter alia, thermoregulatory dysfunctions. ... | 03/18/2008 |
| 7338960 | Phenylalkanoic acid and phenyloxyalkanoic acid derivatives as hPPAR activators A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, wherein: ... | 03/04/2008 |
| 7129271 | Compounds for pest control and methods for their use Compounds, compositions, and methods that employ an eremophilane sesguiterpene are presented for controlling an arthropod pest population. The compounds have minimal adverse or toxic effects on humans, non-human animals, and the natural environment. The compounds ma... | 10/31/2006 |
| 7056950 | Compositions of biochemical compounds involved in bioenergy metabolism of cells A composition of biochemical compounds involved in bioenergy metabolism of cells and a method of use in prevention and therapy of diseases are disclosed. ... | 06/06/2006 |
| 6949585 | Cyclooctanone derivatives and cyclodecanone derivative, and use thereof The present invention provides a compound which has cytokine production inhibitory activity and is useful for the treatment of diseases which is associated with cytokine. The compound is represented by the following general formula (I) [wherein A represents a cyclic... | 09/27/2005 |
| 6887904 | Substituted arylcycloalkanes, compositions containing them and use thereof Substituted arylcycloalkanes, compositions containing them and use thereof. The present invention relates especially to substituted arylcycloalkanes with therapeutic activity, which may be used such as in oncology. ... | 05/03/2005 |
| 6777564 | Anthraquinone compound A novel compound with anthraquinone structure and having the following foluma (I): wherein R1, R2 and R3 each independently is hydrogen, hydroxy, amino or C1-6 alkyl group; R | 08/17/2004 |
| 6696484 | Method and compositions for regulation of 5-alpha reductase activity Pharmaceutical compositions and methods for treating androgen related disorders. The pharmaceutical compositions may include a 5-reductase inhibitor, such as natural and synthetic flavanoids, catechols, curcumin-related substances, quinones, catech... | 02/24/2004 |
| 6605639 | Ligands of nuclear receptor It has been newly found out that ascochlorin, which is a publicly known fat-soluble antibiotic, and its homologues serve as a ligand of retinoid X receptor and react in vivo with the amino group of serum protein to form Schiff bases without showing any si... | 08/12/2003 |
| 6576660 | Methods and compositions for regulation of 5--reductase activity Compounds that inhibit 5-alpha-reductase are provided. The compounds are used to treat prostate cancer, breast cancer, obesity, skin disorders and baldness.... | 06/10/2003 |
| 6281250 | Retinyl ethers, derivatives and analogues and inhibition of breast carcinogenesis The present invention is directed to retinyl ethers, derivatives and analogues and their use in inhibiting breast carcinogenesis or breast cancer cell growth.... | 08/28/2001 |
| 6251833 | 2-arylcyclopentan-1,3-diones The present invention relates to novel 2-aryl-3-hydroxy-Ɗ2 -cyclopentene-1-one derivatives of the formula (I) ##STR1## in which A, B, D1, D2, G, W, X, Y and Z are each as defined in the description, to processes for their... | 06/26/2001 |
| 6172118 | Compounds This invention relates to ketones, alcohols and amines represented by the likes of of 3-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylethynylcyclobutan-1-one. They are useful as PDE 4 antagonists.... | 01/09/2001 |
| 6159988 | Arylcycloalkyl derivatives, their production and their use Compounds of formula I, ##STR1## and the physiologically tolerable salts thereof, wherein the substituents R1 -R4 have the meanings given in the specifications and show an activity against inflammatory conditions.... | 12/12/2000 |
| 6150374 | Substituted cycloalkenes, process of preparing them and method of using them as pesticides The invention relates to novel substituted cycloalkenes of the formula (I), ##STR1## to a plurality of processes for their preparation, and to novel intermediates and a plurality of processes for their preparation.... | 11/21/2000 |
| 6051588 | Nitroso esters of ଲ-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs A compound comprising a non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO group, a pharmaceutical composition including the compounds and methods of treatment of pain and/or inflammation using the compounds and compositi... | 04/18/2000 |
| 5880162 | Pesticidal fluoroolefins A pesticidal compound of formula I: ##STR1## in which formula: either R1 is hydrogen and R2 represents a cyclopropyl group or R1 and R2 each represent an alkyl group, which alkyl groups may be the same or d... | 03/09/1999 |
| 5840658 | Process for the controlled fixing of scale inhibitor in a subterranean formation A process for fixing of a scale inhibitor in a subterranean formation, which comprises: a) injecting into the formation a solution comprising a polymeric scale inhibitor, a metal cation, a precursor and a weak organic acid, wherein the polymeric scale inh... | 11/24/1998 |
| 5840282 | Light screening compositions Photostable, cosmetic light-screening compositions for the protection of the human epidermis and the hairs against the ultraviolet rays of wavelengths between 320 and 400 nm, and between 320 and 400 nm respectively, comprising, in a cosmetically acceptabl... | 11/24/1998 |
| 5807898 | Antimalarial agents The invention describes a method of killing or inhibiting the growth of the malaria causing pathogen Plasmodium falciparum by exposing the pathogen to a preparation containing methylene-bis-aspidinol, desaspidin, and/or aspidin.... | 09/15/1998 |
| 5760092 | Allocolchinones and uses thereof Disclosed are allocolchinones, which are anti-mitotic agents. Allocolchinones bind to tubulin reversibly and are more effective at inhibiting microtubule formation than colchicine. 7-Acetamido-allocolchinone inhibits the growth of a number of tumor cell ... | 06/02/1998 |
| 5716995 | Anti-osteopathic composition An anti-osteopathic composition comprising as an active ingredient a compound represented by the following formula (I), (II) or (III): ##STR1## which is useful for therapeutic and prophylactic treatment of osteopathia such as osteoporosis and bone fr... | 02/10/1998 |
| 5677336 | Non-steroid androgen receptor antagonist compounds and methods Non-steroidal compounds which are high affinity, high specificity ligand antagonists for the androgen receptor are disclosed. Also disclosed are methods for employing the disclosed compounds for modulating processes mediated by the androgen receptor and f... | 10/14/1997 |
| 5618547 | Control of ectoparasites A series of 1,3-propanediones having a perfluoroalkyl group or a perfluorocycloalkyl group on one carbonyl, and a 3,5-disubstituted phenyl group on the other, are useful when administered to animals for the control of ectoparasites.... | 04/08/1997 |
| 5589514 | Arylcycloalkyl derivatives, their production and their use Compounds of formula I, ##STR1## wherein the substituents R1 -R4 and a have the given meanings and show an activity against inflammatory conditions.... | 12/31/1996 |
| 5492690 | Benzoylacetate esters as non-sensitizing chelating photo-protectants The subject invention relates to pharmaceutical compositions comprising a safe and effective amount of a compound having the structure: ##STR1## wherein n is 3 or 4; each R is independently alkyl or alkoxy; and R' is C1 C20 alky... | 02/20/1996 |
| 5476876 | Di-tert-butylphenol compounds useful as anti-inflammatory agents The subject invention relates to compounds having the structure: ##STR1## wherein (a) X is selected from hydroxy, C1 to about C2 alkanoxy, thiol, C1 to about C2 alkanylthiol, and halo; (b) R and R' are each inde... | 12/19/1995 |
| 5364843 | Agents for potentiating the effects of antitumor agents and combating multiple drug resistance Potentiating agents which enhance the efficacy of antineoplastic agents are disclosed. The potentiating agents disclosed are piperazinyl benzyl compounds such as 1-[-(4-Chlorophenyl)-3-methoxybenzyl]-4-allylpiperazine dihydrochloride.... | 11/15/1994 |
| 5346897 | Agents for potentiating the effects of antitumor agents and combating multiple drug resistance Potentiating agents which enhance the efficacy of antineoplastic agents are disclosed. The potentiating agents disclosed are acrivastine esters and the pharmaceutically acceptable salts thereof.... | 09/13/1994 |
| 5344845 | Compound and use of the same as medicine Disclosed herein is a specific cinnamic acid derivative such as methyl 4-(4-acetoxy-3-methoxycinnamanide)-1-cyclohexanecarboxylate, or a pharmaceutically acceptable salt thereof. These compounds are useful as IV-type allergic reaction-suppressive drugs.... | 09/06/1994 |
| 5208238 | Agents for potentiating the effects of antitumor agents and combating multiple drug resistance Potentiating agents which enhance the efficacy of antineoplastic agents are disclosed. The potentiating agents disclosed are 2-(aminoethylamino) pyridines such as (E)-3-(6-(N-(2-Dimethylaminoethyl)-4-methoxybenzylamino)-2-pyridyl)acrylic acid.... | 05/04/1993 |
| 5106407 | Iodones and methods for antimicrobial use The present invention discloses the antimicrobial utility of certain iodonium ylide compounds. The particular iodonium ylide compounds are phenyl iodonium ylides having an ortho substituent that stabilizes the positive charge on the polyvalent iodine by a... | 04/21/1992 |
| 4985464 | Drug compositions for local treatment of alopecia areata A drug composition for the local treatment of alopecia areata and other dermatological diseases is disclosed. The composition contains as an active ingredient an aliphatic, alkoxy or aryl substituted cyclopropenone. Diphenylcyclopropenone is a particularl... | 01/15/1991 |
| 4829091 | Process for the preparation of ketones and novel insecticides produced therefrom An improved method for the decarbalkoxylation of alkylated ଲ-keto esters to obtain high yields of ketones. In accordane with the method, decarbalkoxylation of alkylated ଲ-keto esters is accomplished by heating the esters in the presence of dil... | 05/09/1989 |
| 4713392 | Pesticides A compound of formula II in which formula: RA represents a group ArCR1 R2 -- in which Ar represents a phenyl or naphthyl group optionally substituted by one or more halogen, alkoxy, haloalkoxy, methylenedioxy or C1 -... | 12/15/1987 |
