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| Number | Title | Issue Date |
| 8163805 | Small molecule antagonists of Bcl-2 family proteins The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of Bcl-2 family proteins. In particular, the present invention provides gossypol compounds (e.g., isomers, enantiomers, racemic compounds, metabolites, derivat... | 04/24/2012 |
| 8093301 | Anti-allergic agent The inventors have found that vitamin K3 and vitamin K5 which may be used in pharmaceuticals and foods or ACNQ, DHNA, or the like which can stimulate the growth of bifidobacteria can inhibit degranulation of basophil-like cells, exhibit a potent degranulation-inhibi... | 01/10/2012 |
| 7947743 | Use of agomelatine in obtaining medicaments intended for the treatment of bipolar disorders The present invention relates to the use of agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, on its own or in association, in obtaining medicaments intended for the treatment of bipolar disorders, especially bipolar disorders of types I and II, and more e... | 05/24/2011 |
| 7851510 | Gossypol derivatives, production method thereof and uses of same The present invention relates to compounds of general formula (1): in which, independently of each other, R1 and R2 represent: —OH, or —CH2—O—R3,... | 12/14/2010 |
| 7745494 | Vitamin K for prevention and treatment of skin rash secondary to anti-EGFR therapy The invention provides methods and compositions for treating and preventing a skin rash secondary to anti-epidermal growth factor receptor (EGFR) therapy, where the method comprises applying a vitamin K analog or a phosphatase inhibitor to the skin. ... | 06/29/2010 |
| 7622506 | Naphthalenedione compounds for treating inflammation related disorders and microbial infection This invention relates to compositions containing a compound of formula (I) shown below: Each variable is defined in the specification. Also disclosed are methods of using these compositions to treat acne, psoriasis, and in... | 11/24/2009 |
| RE40862 | Gossypolone for the treatment of cancer A method for treating cancer in a human, which comprises administering to the human subject an anti-cancer effective amount of a compound selected from gossypol, gossypol acetic acid, gossypolone, metabolites thereof, or physiologically acceptable salts thereof. Als... | 07/21/2009 |
| 7432300 | Gossypol co-crystals and the use thereof This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (... | 10/07/2008 |
| 7432304 | Small molecule antagonists of Bcl-2 family proteins The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of Bcl-2 family proteins. In particular, the present invention provides gossypol compounds (e.g., isomers, enantiomers, racemic compounds, metabolites, derivat... | 10/07/2008 |
| 7417072 | Blockade of Pin1 prevents cytokine production by activated immune cells The invention provides pharmaceutical compositions and methods of treating immunological disorders. The invention also provides pharmaceutical compositions and methods of inducing eosinophil apoptosis, and methods for treating eosinophil-associated disorders compris... | 08/26/2008 |
| 7361691 | Method of treating cancers using β-lapachone or analogs or derivatives thereof Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint activator, which is preferably β-lapachone, or a derivative or analog thereof, combined with an oncogenic kinase modulator, preferably imatinib. This combination of the cell cyc... | 04/22/2008 |
| 7354928 | Small molecule inhibitors targeted at Bcl-2 The present invention relates to small molecule antagonists of Bcl-2 family proteins such as Bcl-2 and/or Bcl-XL. In particular, the present invention provides non-peptide cell permeable small molecules (e.g., tricyclo-dibenzo-diazocine-dioxides) that bin... | 04/08/2008 |
| 7351744 | Naphthalene derivatives as termite repellents and toxicants Several derivatives of naphthalene, including 1′-acetonaphthone, 2′-acetpnaphthone, 1-methoxynaphthalene, and 2-methoxynaphthalene, were discovered to be effective toxicants and repellents of termites, and resulted in significant reduction in termite feeding act... | 04/01/2008 |
| 7342046 | Gossypol co-crystals and the use thereof This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (... | 03/11/2008 |
| 7332181 | Composition for managing diabetes, obesity, and hyperlipidemia and associated methods A nutritional supplement includes a first formulation including minerals: chromium polynicotinate, magnesium glycinate, manganese sulfate, selenium, vanadyl sulfate, zinc gluconate, copper gluconate, iodine, and boron; and vitamins: vitamins C, B1, B2, B3, B6, and B... | 02/19/2008 |
| 7279502 | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions... | 10/09/2007 |
| 7244463 | enhanced animal food product The present invention advances prior art animal food products by providing an animal food product formulated with Garicinia mangostana L., or Mangosteen fruit, from the Mangosteen plant. The addition of Mangosteen to the animal food product of the present inv... | 07/17/2007 |
| 7202273 | Therapeutic methods and compositions involving isoflavones Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (1), in which Z is H, R1 is H, or RACO where RA is C1-10alkyl or an amino acid, R | 04/10/2007 |
| 7166310 | Stable extract from , method for the production thereof and its use as a topical medicament The invention relates to an improved and stable (i.e. color-stable and, optionally, stable with regard to its hyperforin content) extract from the overground parts of Hypericum perforatum L., to a method for the preparation thereof, and to pharmaceutical prep... | 01/23/2007 |
| 7163930 | Pharmaceutical compositions and methods relating to fucans Compositions, methods and the like comprising fucans such as fucoidan to treat surgical adhesions, arthritis, and psoriasis. ... | 01/16/2007 |
| 7119110 | Method and composition for preventing or reducing the symptoms of insulin resistance syndrome A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and administering to them an effective amount of a composition comprising niacin-bo... | 10/10/2006 |
| 7115279 | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer. ... | 10/03/2006 |
| 6994863 | Pharmaceutical and cosmetic carrier and composition for topical application A pharmaceutical or cosmetic carrier or composition for topical application characterized by rheological properties which render the carrier or composition semi-solid at rest and a liquid upon application of shear forces thereto. The composition or carrier are prepa... | 02/07/2006 |
| 6949250 | Selective algaecides for control of cyanochloronta We have now discovered that certain 9,10-anthraquinone derivatives we developed possess potent activity against O. perornata while possessing a sufficiently high level of solubility in water to make their activity against O. perornata viable. These com... | 09/27/2005 |
| 6939896 | Cd45 inhibitors Substituted naphthalenediones in accord with structural diagram (I): compositions thereof and methods for the use thereof, for the treatment of T cell mediated conditions such as autoimmune diseases and organ graft rejection. In compounds of the invention, wherein: ... | 09/06/2005 |
| 6884797 | Targeted oxidative therapeutic formulation Pharmaceutical formulation, its method of preparation, and its use. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by an oxygen-containing oxidizing agent, such as ozone; a pene... | 04/26/2005 |
| 6838583 | Non-halogenated naphthol compounds, antimicrobial compositions containing the same, and the methods of using the same An antimicrobial compound, composition containing such compound, and method of use of the same for reducing the presence of microorganism on a substrate or in a fluid environment comprising an antimicrobial effective carrier and one or more essential antimicrobial c... | 01/04/2005 |
| 6835755 | Naphthoquinone derivatives and their use in the treatment and control of tuberculosis Naphthoquinone derivatives of Formula (1): wherein R, represents an OH group, methyl ether, ethyl ether or a similar ether, R1 represents a methyl, ethyl or similar aliphatic hydrocarbon derivative: R2 and R3 each independently represent hydrogen or a group selected... | 12/28/2004 |
| 6822003 | Aldose reductase inhibitor and process for preparation thereof Aldose redcutase inhibitor and pharmaceutically acceptable derivatives thereof of the formula I below derived from cultures of Aspergillus niger CFR 1046 and useful as a rat lens aldose reductase inhibitor ... | 11/23/2004 |
| 6790463 | Uses of targeted oxidative therapeutic formulation in arteriosclerosis The use of a pharmaceutical formulation in treating coronary arteriosclerosis and a two-component pharmaceutical formulation. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by a... | 09/14/2004 |
| 6777424 | Methods for treating osteoarthritis using an estrogen agonist / antagonist The present invention provides methods and kits for treating osteoarthritis using an estrogen agonist/antagonist. ... | 08/17/2004 |
| 6761912 | Composition for increasing bone density A composition and a method for administering an improved supplement to prevent bone density loss. The composition combines a calcium compound with inulin, and optionally magnesium, Vitamin D3, Vitamin K, Vitamin C, and may combine a soy isoflavone, all in... | 07/13/2004 |
| 6713463 | Methods and compositions for treating and preventing mucositis A method of reducing or inhibiting mucositis in a patient, which includes administering an inflammatory cytokine inhibitor or a mast cell inhibitor, or a combination thereof, is disclosed. ... | 03/30/2004 |
| 6696484 | Method and compositions for regulation of 5-alpha reductase activity Pharmaceutical compositions and methods for treating androgen related disorders. The pharmaceutical compositions may include a 5-reductase inhibitor, such as natural and synthetic flavanoids, catechols, curcumin-related substances, quinones, catech... | 02/24/2004 |
| 6677330 | Fluorides of 4-substituted piperidine derivatives The present invention provides a novel compound having an excellent acetylcholinesterase inhibitory effect. That is, it provides a 4-substituted piperidine compound fluoride represented by the following formula, a pharmaceutically acceptable salt thereof ... | 01/13/2004 |
| 6649659 | Atovaquone pharmaceutical compositions The invention relates to a process for the production of microfluidized particles of atovaquone having improved bioavailability.... | 11/18/2003 |
| 6613806 | Enhancement of the efficacy of benzoylbenzenes The invention relates to method for the enhancement of the activity and/or systemicity of fungicidal compositions containing at least one benzoylbenzene of formula I ##STR1## wherein R1 through R7, m and n are as defined in claim... | 09/02/2003 |
| 6608107 | Methods and compositions to treat conditions associated with neovascularization This invention also provides a method to inhibit neovascularization in tissue by delivering to the cell or tissue an effective amount of gossypol, or a pharmaceutically acceptable salt, derivative or prodrug thereof. Also provided herein is a method for t... | 08/19/2003 |
| 6596064 | Biocidal-antifouling agents with low ecotoxicity index A use of tetralin derivatives as biocidal and antifouling agents for preventing and slowing the growth of algae, molds and microorganisms. In particular, the vitamin derivatives are constituted by salts of menadione bisulfite with the heterocyclic bases t... | 07/22/2003 |
| 6576660 | Methods and compositions for regulation of 5--reductase activity Compounds that inhibit 5-alpha-reductase are provided. The compounds are used to treat prostate cancer, breast cancer, obesity, skin disorders and baldness.... | 06/10/2003 |
