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| Number | Title | Issue Date |
| 7985776 | Iontophoretic delivery of curcumin and curcumin analogs for the treatment of Alzheimer's Disease A method of delivering a curcuminoid to a patient, which includes iontophoretically delivering a charged curcuminoid across the skin of an Alzheimer's Disease patient. ... | 07/26/2011 |
| 7939568 | Use of a composition comprising vitamin K1 oxide or a derivative thereof for the treatment and/or the prevention of mammal dermatological lesions The present invention is related to the use of a composition having an adequate pharmaceutical or cosmetic carrier or diluent and a sufficient amount of vitamin K1 oxide or its derivative for the treatment and/or the prevention of mammal dermatological lesions. ... | 05/10/2011 |
| 7718706 | Arylphenyl-substituted cyclic keto-enols The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkyl... | 05/18/2010 |
| 7288680 | Benzotropolone derivatives and modulation of inflammatory response The present invention provides novel benzotropolone derivatives represented by the general formula: including neotheaflavate B and EGCGCa. The benzotropolone derivatives of the present invention are effective ant... | 10/30/2007 |
| 7279600 | Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents This invention provides estrogen receptor modulators having the structure: wherein R1 to R6 and R8 are as defined in the specification; or a pharmaceutically acceptable salt there... | 10/09/2007 |
| 7256219 | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to multifluoro-substituted Chalcones and analogs thereof, represented by the general Formula I: wherein Ar and R6-R10 are defined herein. The present invent... | 08/14/2007 |
| 7183445 | Cyclohexyl derivatives as selective estrogen receptor modulators The present invention is directed to novel cyclohexyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and diseases mediated by an estrogen receptor. ... | 02/27/2007 |
| 7163930 | Pharmaceutical compositions and methods relating to fucans Compositions, methods and the like comprising fucans such as fucoidan to treat surgical adhesions, arthritis, and psoriasis. ... | 01/16/2007 |
| 7157491 | Aryl-carbaldehyde oxime derivatives and their use as estrogenic agents This invention provides estrogen receptor modulators having the structure where R1–R5 are as defined in the specification; or a pharmaceutically acceptable salt thereof. ... | 01/02/2007 |
| 7138433 | Quinone-based therapeutic agent for hepatopathy With an object of providing an agent for treating hepatic disease by inhibiting occurrence of hepatic disease, in particular portal venous invasion, there is disclosed an agent for treating or preventing hepatic disease containing menatetrenone as an active ingredie... | 11/21/2006 |
| 7091241 | Nontoxic potentiation/sensitization of cancer therapy by supplementary treatment with combined vitamins C and K A combination of Vitamin C and a quinone used as a supplemental treatment for a cancer patient. The combination may be administered before, during and after the patient undergoes a conventional cancer treatment protocol. The combination may be administered orally, i... | 08/15/2006 |
| 7087790 | Benzotropolone derivatives and modulation of inflammatory response The present invention provides novel benzotropolone derivatives represented by the general formula: including neotheaflavate B and EGCGCa. The benzotropolone derivatives of the present invention are effective ant... | 08/08/2006 |
| 7060686 | Anti-inflammatory compounds derived from Methods for treating, preventing, or inhibiting diseases and disorders associated with inflammation, cell-proliferation, and pain comprising the administration of a compound having the structural formula wherein ... | 06/13/2006 |
| 7056525 | Carotenoid formulations, comprising a mixture of β-carotene, lycopene and lutein Carotenoid formulations comprising a mixture of β-carotene, lycopene and lutein, and the use thereof in human and animal foods, cosmetics and pharmaceuticals. ... | 06/06/2006 |
| 6987127 | Regulation of NAD(P)H oxidase growth and transcription in melanoma cells Malignant melanoma cells spontaneously generate reactive oxygen species (ROS) that promote constitutive activation of the transcription factor nuclear factor-kB (NF-kB). Although antioxidants and inhibitors of NAD(P)H oxidases significantly reduce constitutive NF-kB... | 01/17/2006 |
| 6984389 | Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an α-2-macroglobulin (α2M) preparation with a non-vaccine treatment modality. In particular, an HSP preparation or an α2M ... | 01/10/2006 |
| 6956061 | Polyisoprenylbenzophenone derivatives, processes for their preparation and use thereof The present invention relates to compounds of the formula (I): which are produced by the plant Garcinia punctata, chemical derivatives derived therefrom, a process for their preparation, and their use as pharmac... | 10/18/2005 |
| 6946492 | Use of C2-substituted indan-1-one systems for preparing medicaments for the treatment of obesity Embodiments of the invention relate to methods of reducing weight in mammals and for the prophylaxis or treatment of obesity comprising administration of C2-substituted indan-1-one systems and their physiologically acceptable salts and physiologically functional der... | 09/20/2005 |
| 6887904 | Substituted arylcycloalkanes, compositions containing them and use thereof Substituted arylcycloalkanes, compositions containing them and use thereof. The present invention relates especially to substituted arylcycloalkanes with therapeutic activity, which may be used such as in oncology. ... | 05/03/2005 |
| 6855696 | Antitumor agents The present invention provides illudin analogs of the general formula I: wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specif... | 02/15/2005 |
| 6794415 | Biphenyl compounds and their use as oestrogenic agents A method of treating osteoporosis in warm-blooded animals comprising administering to warm-blooded animals in need thereof an effective amount to treat osteoporosis of a compound selected from the group consisting of a compound of the formula: | 09/21/2004 |
| 6790463 | Uses of targeted oxidative therapeutic formulation in arteriosclerosis The use of a pharmaceutical formulation in treating coronary arteriosclerosis and a two-component pharmaceutical formulation. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by a... | 09/14/2004 |
| 6787672 | Substituted chalcones as therapeutic compounds This invention pertains to substituted chalcones, specifically substituted 1-(4-methoxyphenyl)-3-(3,5-dimethoxyphenyl)prop-1-en-3-ones, which have therapeutic application, for example, as potent antiproliferative agents and antiinflammatory agents, and which have th... | 09/07/2004 |
| 6787571 | Anti-inflammatory compounds derived from Pseudopterorgorgia elisabethae Methods for treating, preventing, or inhibiting diseases and disorders associated with inflammation, cell-proliferation, and pain comprising the administration of a compound having the structural formula wherein R1 ... | 09/07/2004 |
| 6777424 | Methods for treating osteoarthritis using an estrogen agonist / antagonist The present invention provides methods and kits for treating osteoarthritis using an estrogen agonist/antagonist. ... | 08/17/2004 |
| 6777447 | Derivatives of benzylidene cyclohexanone, benzylidene cyclopentanone, and benzylidene acetone, and therapeutic uses thereof Benzylidene cyclohexanone, cyclopentanone and acteone derivatives and therapeutic methods of using same are disclosed. The compounds are non-toxic and exhibit potent anti-inflammatory, antibacterial and antioxidation activity. Also, certain compounds of the inventio... | 08/17/2004 |
| 6773727 | Use of gossypol and related terpenes for control of urban and agricultural pests Low concentrations of gossypol and related phyllophage toxins from cotton improve the effectiveness of insecticidal agents against social insects, including cockroaches, and particularly termites and ants. Levels of gossypol and other cotton phyllophage toxins which... | 08/10/2004 |
| 6761912 | Composition for increasing bone density A composition and a method for administering an improved supplement to prevent bone density loss. The composition combines a calcium compound with inulin, and optionally magnesium, Vitamin D3, Vitamin K, Vitamin C, and may combine a soy isoflavone, all in... | 07/13/2004 |
| 6696484 | Method and compositions for regulation of 5-alpha reductase activity Pharmaceutical compositions and methods for treating androgen related disorders. The pharmaceutical compositions may include a 5-reductase inhibitor, such as natural and synthetic flavanoids, catechols, curcumin-related substances, quinones, catech... | 02/24/2004 |
| 6632843 | Treatment of bruxism This invention relates to the use of a composition for local percutaneous delivery of a drug such as a muscle relaxant, more particularly cyclobenzaprine in an organogel cream. The composition is applied by the patient directly to the skin over accessible... | 10/14/2003 |
| 6576660 | Methods and compositions for regulation of 5--reductase activity Compounds that inhibit 5-alpha-reductase are provided. The compounds are used to treat prostate cancer, breast cancer, obesity, skin disorders and baldness.... | 06/10/2003 |
| 6500416 | Pesticide There are described a flowable composition for controlling harmful insects and representatives of the order Acarina, comprising at least one pesticidally active compound, one or more signal substances selected from the group consisting of pheromones, kair... | 12/31/2002 |
| 6482846 | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that d... | 11/19/2002 |
| 6465011 | Formulations comprising lipid-regulating agents The present invention is directed to a solid formulation comprising the lipid-regulating agent dispersed in a hydrophilic, amorphous polymer in which said lipid-regulating agent is present as a meta-stable, amorphous phase.... | 10/15/2002 |
| 6462066 | Method and composition for treatment of ischemic neuronal reperfusion injury Methods and compositions for treatment of, or protection from, neuropathy resulting from reperfusion injury upon reversal of an ischemic condition, comprising treatment or prophylactic treatment of the patient with an antagonist of the type 3 ryanodine re... | 10/08/2002 |
| 6455578 | Aromatic derivatives and iron complexes thereof for the use as normalizing agents of the iron level The present invention is directed to aromatic derivatives of formula (I), wherein: R1 is (a), wherein R3 and R4 are selected from between H and OH, provided that R3 and R4 are not simultaneously H, an... | 09/24/2002 |
| 6436423 | Product and method for improving avian health A product and method for reducing and preventing the ingestion of substrates by avians wherein the substrates are disposed within an avian house. The product is a bird repellent in combination with a substrate disposed within an avian house. As a result o... | 08/20/2002 |
| 6433022 | Spermicide There is provided a method of contraception, comprising exposing a spermicidally sufficient quantity of an agent to spermatozoa. The agent is a quinone represented by the following formula: ##STR1## Each group A is H or an electron releasing moiety. The a... | 08/13/2002 |
| 6433021 | Indane compounds and their pharmaceutical use Indane compounds of general formulae (1) to (4) and their pharmaceutical use, particularly to achieve mast cell stabilising activity and/or anti-inflammatory activity are described. In these formulae R1 to R7 may be selected from: H,... | 08/13/2002 |
| 6323181 | Antitumor agents The present invention provides illudin analogs of the general formula I: ##STR1## wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically ... | 11/27/2001 |
