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| Number | Title | Issue Date |
| 7820720 | Topical terbinafine formulations and methods of administering same for the treatment of fungal infections The present invention relates to topical antifungal formulations terbinafine or a pharmaceutically acceptable salt thereof, a lipid, and a surfactant, and uses thereof for the treatment of skin and nail fungal infections. ... | 10/26/2010 |
| 7365231 | Compound with antitumor activity and preparation method therefor The present invention provides the diaminophenyladamantane derivatives with antitumor activities and the preparation method therefore. The method includes a step of reacting an aromatic diol with at least one 5-halo-2-nitrophenol in the presence of at least one inor... | 04/29/2008 |
| 7338972 | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma Substituted 1-alkylamino-1H-indazoles for lowering intraocular pressure and treating glaucoma are disclosed. ... | 03/04/2008 |
| 7273889 | NMDA receptor antagonist formulation with reduced neurotoxicity The present invention is directed to pharmaceutical compositions of effective amounts of NMDA receptor antagonists and preservative for the administration to a patient in need of effective analgesia and anesthesia. The compositions of the invention advantageously do... | 09/25/2007 |
| 7268131 | Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma Substituted [1,4]oxazino[2,3-g]indazols for lowering intraocular pressure and treating glaucoma are disclosed. ... | 09/11/2007 |
| 7208512 | Benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma The present invention provides benzodifuran imidazoline derivatives and benzofuran imidazoline derivatives for lowering intraocular pressure and providing ocular neuroprotection. ... | 04/24/2007 |
| 7186863 | Sertraline compositions An acid salt of sertraline, wherein the acid is citric acid, fumaric acid, malic acid, maleic acid, malonic acid, phosphoric acid, succinic acid, sulfuric acid, L-tartaric acid, HBr, acetic acid, benzoic acid, benzenesulfonic acid, ethanesulfonic acid, lactic acid, ... | 03/06/2007 |
| 7157078 | Devices and methods for eliminating termite colonies This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to ... | 01/02/2007 |
| 7129257 | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma Pyrazolo[3,4-e]benzoxazoles and analogues thereof for lowering intraocular pressure and treating glaucoma are disclosed. ... | 10/31/2006 |
| 7081238 | Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level A method of diagnosing attention deficient-hyperactivity disorder (ADHD) in a human patient by assessing the level of dopamine transporter in at least one region of the patient's central nervous system, where an elevated level of dopamine transporter in the patient ... | 07/25/2006 |
| 7071225 | Arylaminopropane analogues and their use for the treatment of glaucoma Arylaminopropane analogues are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the prese... | 07/04/2006 |
| 7071194 | Method for improving respiratory function and inhibiting muscular degeneration The present invention provides a method for improving respiratory function and inhibiting muscular degeneration (e.g., dystrophy and atrophy). Alternative embodiments of the invention provide a method of inhibiting motor neuron apoptosis and the subsequent muscular ... | 07/04/2006 |
| 7071195 | Amine and amide derivatives as ligands for the neuropeptide Y Y5 receptor useful in the treatment of obesity and other disorders Amine and amide derivatives of the formula: which are ligands for the neuropeptide Y Y5 (NPY5) receptor, methods of preparation and pharmaceutical compositions containing amines and amides of formula A as the act... | 07/04/2006 |
| 7067524 | Substituted phenyl naphthalenes as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4, R5, R... | 06/27/2006 |
| 7049337 | Derivatives of 2-aminotetralins and pharmaceutical analogs thereof exhibiting differential CNS receptor activity and behavior Aminotetralin derivatives and pharmacological analogs thereof which contain an N-propynyl group exhibit differential dopaminergenic receptor activity. The subject compounds are useful in affecting dopamine receptor activity, particularly in exhibiting differing acti... | 05/23/2006 |
| 7041703 | 2-aminotetralines and pharmaceutical compositions for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies 2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or autoimmune pathologies in which the aetiopathogenic role of inflammatory ... | 05/09/2006 |
| 6982286 | Carbocyclic hydrazino inhibitors of copper-containing amine oxidases The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-I (VAP-1... | 01/03/2006 |
| 6974839 | Method of delaying ejaculation The invention provides a method of delaying ejaculation. The method comprises administering an effective amount of a tramadol material to a human male prior to sexual intercourse. The method is particularly useful for treating premature ejaculation. ... | 12/13/2005 |
| 6960608 | Fused indazoles and indoles and their use for the treatment of glaucoma Novel fused indazoles and indoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of th... | 11/01/2005 |
| 6956129 | Polyhalogen-substituted cinnamic acids and cinnamic acid derivatives and a process for the preparation of polyhalogen-substituted cinnamic acids and cinnamic acid derivatives Polyhalogenated cinnamic acids and cinnamic acid derivatives are prepared by reacting diazonium salts accessible from polyhalogenated anilines with acrylic acid or acrylic acid derivatives in the presence of a homogeneous, palladium-containing catalyst at about −5... | 10/18/2005 |
| 6956060 | Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also provides methods of treating a subject afflicted with Parkinson's disease, ... | 10/18/2005 |
| 6951868 | Azabicyclic-phenyl-fused-heterocyclic compounds for treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is any of: These compounds may be in the form of pharmaceutical salts or compositions, and racemic mixtu... | 10/04/2005 |
| 6949575 | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using aminoindane derivatives The present invention provides compounds of Formula (I) and a method of treating Alzheimer's disease using a compound of Formula (I), wherein: R1 and R2 include alkyl and phenylalkyl; R3 is hydrogen or alkyl; and R4 and R | 09/27/2005 |
| RE38761 | Styryl compounds which inhibit EGF receptor protein tyrosine kinase A method of inhibiting cell proliferation in a patient suffering from such disorder comprising administering to said patient an effective amount of a composition comprising, in admixture with a pharmaceutically acceptable carrier, a compound, or a pharmaceutically a... | 07/19/2005 |
| 6914074 | Substituted phenyl naphthalenes as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4, R5, R6, R7, R | 07/05/2005 |
| 6911543 | Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is These compounds may be in the form of pharmaceutical salts or co... | 06/28/2005 |
| 6890959 | Aminomethyl-phenyl-cyclohexanone derivatives Aminomethyl-phenyl-cyclohexanone derivatives of formula I or Ia, their diastereomers, enantiomers and salts formed with a physiologically tolerated acid. Also disclosed are processes for preparing the same, pharmaceuti... | 05/10/2005 |
| 6878721 | Beta2-adrenoceptor agonists Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2... | 04/12/2005 |
| 6858652 | Sertraline hydrochloride polymorphs, processes for preparing them, compositions containing them and methods of using them The present invention is directed to novel polymorphic Forms XI, XII, XIII, XIV, XV and XVI of sertraline hydrochloride, to processes for preparing them, methods of using them to treat disease, methods of using them to make other sertraline hydrochloride forms, and ... | 02/22/2005 |
| 6849663 | 2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies 2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or autoimmune pathologies in which the aetiopathogenic role of inflammatory ... | 02/01/2005 |
| 6844368 | Compounds useful in pain management The present invention relates to novel oxo-aminotetralin compounds of the formula (I) wherein X, R1, R2, R3, R4, R5, and R6 are defined herein. ... | 01/18/2005 |
| 6784210 | Compound and a novel process for their preparation The present invention is directed to a procedure for making an enantiomerically enriched compound containing a hydronaphthalene ring structure. The process involves reacting oxabenzonorbornadienes with nucleophiles using rhodium as a catalyst and in the presence of ... | 08/31/2004 |
| 6753429 | 1,4-disubstituted benzenes as insecticides Compounds of formula I: wherein A, B, D, and R are as defined herein and their agriculturally acceptable salts are disclosed as effective insecticides. In addition, compositions comprising an insecticidally effective amo... | 06/22/2004 |
| 6720314 | Use of a vital dye for facilitating surgical procedures for cataract extraction Methods for performing a capsulorhexis are disclosed wherein a dye is used to stain a lens capsule of an eye. The dye is capable of staining tissue without diffusing through the tissue. Compositions including dyes that are useful in the methods are also disclosed. | 04/13/2004 |
| 6716421 | Devices and methods for eliminating termite colonies This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to about 50 to about 100% of te... | 04/06/2004 |
| 6710089 | Substituted N-fused-phenyl-N-benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscle... | 03/23/2004 |
| 6703424 | Dispersible compositions containing L-DOPA ethyl ester The present invention relates to a dispersible pharmaceutical composition comprising a therapeutically effective amount of L-DOPA ethyl ester, a therapeutically effective amount of a decarboxylase inhibitor, a filler, a disintegrant, and a lubricant. The ... | 03/09/2004 |
| 6696430 | Use of vital dye for facilitating surgical procedures for vitreo-retinal surgery A method for performing retinal membrane removal is disclosed using vital dyes which are applied to the membrane. Compositions including vital dyes which are useful in the retinal membrane removal methods are also disclosed.... | 02/24/2004 |
| 6670387 | Thrombopoietin mimetics Non-peptide TPO mimetics are disclosed, as well as a method of treating thrombocytopenia, in a mammal, including a human, in need thereof, which comprises administering to such mammal an effective amount of a selected hydroxy-1-azo-naphthalene derivative.... | 12/30/2003 |
| 6649614 | Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent for treatment of depression or anxiety The present invention relates to the treatment of depression and/or anxiety by the administration of a combination of a specific class of NK-1 receptor antagonists and an antidepressant or anti-anxiety agent.... | 11/18/2003 |
