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| Number | Title | Issue Date |
| 8106031 | Hydrolytically-resistant boron-containing therapeutics and methods of use Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said ag... | 01/31/2012 |
| 8101588 | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of... | 01/24/2012 |
| 8058262 | Proteasome inhibitors and methods of using the same The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating disease... | 11/15/2011 |
| 8039450 | Boron-containing small molecules as anti-inflammatory agents Compounds and methods of treating anti-inflammatory conditions are disclosed. ... | 10/18/2011 |
| 8039451 | Boron-containing small molecules This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow t... | 10/18/2011 |
| 7947663 | Inhibitors of fatty acid amide hydrolase The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). The present invention also provides methods for treating an FAAH mediated disease, disorder or ... | 05/24/2011 |
| 7932239 | Methods of and compositions for reducing neuronal cell death Methods and compositions involving a class of boron-protected phenylphosphine agents having increased cell permeability and having improved chemical stability for treating or for preventing neuronal cell death-related diseases or conditions in a human or a non-human... | 04/26/2011 |
| 7915236 | Proteasome inhibitors and methods of using the same The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating disease... | 03/29/2011 |
| 7858598 | Reagents for detection of hypochlorous acid Provided herein are compounds or hypochlorous acid probes which can be used as reagents for measuring, detecting and/or screening, directly or indirectly, hypochlorous acid or hypochlorite. Provided also herein are methods that can be used to measure, directly or in... | 12/28/2010 |
| 7825104 | Methods and compositions for treating fungal infections Phenylboronic acid and water soluble derivatives thereof and related boronic acid compounds are used for treating fungal and bacterial infections. ... | 11/02/2010 |
| 7816344 | Boron-containing small molecules This invention provides, among other things, novel oxaboroles which are monosubstituted at the 3-, 6-, or 7-position, or disubstituted at the 3-/6- or 3-/7- positions, which are useful for treating bacterial infections, pharmaceutical compositions containing such ox... | 10/19/2010 |
| 7816343 | Wood preservative composition A wood preservative composition comprising a mixture of a fungicide which is a combination of a boric acid ester, which is soluble in an organic solvent and has a sterically hindered di-alcohol or tri-alcohol group, such as trihexylene glycol biborate, an organo-iod... | 10/19/2010 |
| 7767657 | Boron-containing small molecules This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow t... | 08/03/2010 |
| 7652000 | Boron-containing compounds and methods of use Methods of treating and/or preventing surface infections, such as acne, in an animal, such as a human being, using antibiotics incorporating borinic acid complexes, especially picolinic acid derivatives, are disclosed, along with compositions of these antibiotics. | 01/26/2010 |
| 7582621 | Boron-containing small molecules This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow t... | 09/01/2009 |
| 7531526 | Boronic ester and acid compounds, synthesis and uses Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and... | 05/12/2009 |
| 7456156 | Aryl boronic acids for treating obesity Disclosed is a phenyl boronic acid compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aryl group. Z and Z′ are independently —O—, —NH— or... | 11/25/2008 |
| 7442830 | Proteasome inhibitors The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases. ... | 10/28/2008 |
| 7427608 | Protection against and treatment of hearing loss The present invention provides a method for protecting against or treating hearing loss in a subject. This method involves administering an effective amount of a protein tyrosine kinase inhibitor to the subject to protect against or to treat hearing loss. ... | 09/23/2008 |
| 7405304 | Methods for the preparation of alkyl diaryl borinates and complexed diarylboronic acids The present invention provides methods for preparing complexed diaryl boronic acids from alkyl diarylborinates. ... | 07/29/2008 |
| 7371729 | Boronic acid salts useful in parenteral formulations Salts of a peptide boronic acid drug, for example of Cbz-(R)-Phe-(S)-Pro-(R)-Mpg-B(OH)2. The counter-ion to the boronate may be an alkali metal or derived from a strongly basic organic nitrogen-containing compound. ... | 05/13/2008 |
| 7368439 | Dinucleoside poly(borano)phosphate derivatives and uses thereof The present invention provides dinucleoside boranophosphate derivatives of the general formula I: wherein X and X′ each independently is an unsubstituted or substituted purine or pyrimidine residue; Y and Y′ each independ... | 05/06/2008 |
| 7326695 | Anti-bacterial agents based upon oxoanion binding Compounds of the structure I: are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T1 and T2 are each independen... | 02/05/2008 |
| 7317109 | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV The present invention is directed to pyrrolidinylaminoacetyl pyrrolidine boronic acid compounds that display selective, potent dipeptidyl peptidase IV inhibitory activity. These compounds are useful for the treatment of disorders that can be regulated or normalized ... | 01/08/2008 |
| 7301046 | Boronate esters The present invention relates to optically active boronate derivatives which are useful as intermediates for the synthesis of HMG-CoA enzyme inhibitors such as atorvastatin, cerivastatin rosuvastatin, pitavastatin, and fluvastatin. ... | 11/27/2007 |
| 7288533 | Topical application for treating toenail fungus A topical applications is used to treat and prevent the spread of nail infections or onychomycosis caused by bacteria, fungi and other pathogens. The topical application has a composition that comprises, as an active ingredient, at least one species selected from th... | 10/30/2007 |
| 7282491 | Prokaryotic proteasomal proteases of (MTB) as targets for antibiotic therapy The present invention relates to methods of treating Mycobacterium pathogen infection in a subject that involve: inhibiting proteasomal activity in a pathogen under conditions effective to make the pathogen susceptible to antibacterial host defenses; inhibiti... | 10/16/2007 |
| 7279502 | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions... | 10/09/2007 |
| 7267990 | Chelation of charged and uncharged molecules with porphyrin-based compounds Porphyrins containing one or more neutral or negatively-charged, closo- or nido-carborane substituents are useful as chelators. The carbon-carbon bonds linking the boron-containing groups to the porphyrin ring make the compounds highly resistant to hydrolysis. These... | 09/11/2007 |
| 7259138 | Anti-tumor agents A method for treating subjects with abnormal cell proliferation is provided. The method involves administering to subjects in need of such treatment an effective amount of an agent of Formula I, to inhibit cell proliferation such as that associated with tumor growth... | 08/21/2007 |
| 7241459 | Polymers containing bioactive glass with antimicrobial effect The method of protecting a polymeric plastic from attack by bacteria and fungi includes providing bioactive glass particles having a mean particles size preferably less than 2 μm as an additive incorporated into the polymeric plastic. The bioactive glass particles ... | 07/10/2007 |
| 7235564 | Vinorelbine derivatives The present invention relates to novel vinorelbine derivatives. Pharmaceutical compositions containing these compounds as well as processes of preparation and processes of use for treatment of various conditions are also disclosed. ... | 06/26/2007 |
| 7223745 | Proteasome inhibitors and methods of using the same The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating disease... | 05/29/2007 |
| 7220732 | Compounds useful as photodynamic therapeutic agents The present invention relates to compounds of the formula or a salt, metal complex or hydrate or other solvate thereof, wherein: M is a chelating agent; R1, R2, R | 05/22/2007 |
| 7217701 | Intracellular calcium concentration increase inhibitors An intracellular calcium concentration increase inhibitor containing as the active ingredient (1) a boron compound represented by the formula (I). The compound represented by the formula (I) inhibits the increase o... | 05/15/2007 |
| 7217695 | Peptidomimetic inhibitors of post-proline cleaving enzymes The present invention relates to inhibitors of post-proline cleaving enzymes, such as inhibitors of dipeptidyl peptidase IV, as well as pharmaceutical compositions thereof, and methods for using such inhibitors. In particular, the inhibitors of the present invention... | 05/15/2007 |
| 7214696 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective... | 05/08/2007 |
| 7183267 | β-lactamase inhibitors and methods of use thereof The invention provides novel non-β-lactam inhibitors of β-lactamases. In particular, the invention provides boronic acid-based compounds set forth in the specification. These compounds may be used with β-lactam antibiotics to bacterial infection, particularly, β... | 02/27/2007 |
| 7144913 | Dihydropyrrolo[1,2-a]indole and tetrahydropyrido[1,2-a]-indole derivatives as prostaglandin d2 receptor antagonists Dihydropyrroloindoles and tetrahydropyridoindoles are prostaglandin receptor antagonists useful for the treatment of prostaglandin-mediated diseases such as allergic rhinitis, nasal congestion and asthma. ... | 12/05/2006 |
| 7129225 | Protection against and treatment of hearing loss The present invention provides a method for protecting against or treating hearing loss in a subject. This method involves administering an effective amount of a protein tyrosine kinase inhibitor to the subject to protect against or to treat hearing loss. ... | 10/31/2006 |
