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| Number | Title | Issue Date |
| 7994225 | Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections Efflux pump inhibitors are co-administered with antimicrobial agents for the treatment of ophthalmic or otic infections. The agents may be co-administered directly to the site of infection (e.g., the eye or ear). ... | 08/09/2011 |
| 7973080 | Method for inhibiting the growth of antibiotic resistant of bacteria by using pentane-1,5-diol A method for inhibiting the growth of multiple-resistant bacteria comprises the topical administration of a pharmaceutical composition comprising 15% by weight or more of pentane-1,5-diol and a pharmaceutical acceptable carrier. Also disclosed is a method of prepari... | 07/05/2011 |
| 7348319 | Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same The present invention relates to nitric oxide-releasing amidine diazeniundiolates, compositions comprising same, methods of using same, and a method for preparing same from imidate diazeniumdiolates and primary or secondary amines. ... | 03/25/2008 |
| 7258850 | Methods and compositions for treating erectile dysfunction Methods are provided for increasing libido and/or treating erectile dysfunction in a man. The methods include the administration of a formulation testosterone alone, another fast-acting drug to treat erectile dysfunction or a combination of the testosterone and the ... | 08/21/2007 |
| 7157017 | Fungicidal compositions and methods using cyanodithiocarbimates The invention relates to control fungal growth on tanned hides, using cyanodithiocarbimates of formula (I): X is a halogen; R is a substituted or unsubstituted C1–... | 01/02/2007 |
| 7115665 | Inhibitors of endo-exonuclease activity for treating cancer The present invention relates to the treatment of cancer with compounds that inhibit the activity of endo-exonuclease. Endo-exonuclease has been shown to be necessary for the repair of damaged DNA. Compounds that inhibit the activity of endo-exonuclease have been sh... | 10/03/2006 |
| 7115666 | Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain Disclosed are nitrone compounds and pharmaceutical compositions containing such compounds. The nitrone compounds have one to six additional carbons bridging between the nitrone functionality and the nitrone aryl ring. The disclosed compositions are useful as therape... | 10/03/2006 |
| 6929685 | Alkylamine derivatives as antifouling agents The invention relates to methods for preventing the attachment of aquatic organisms to surfaces that are submerged for extension periods of time in water. More particularly, this invention relates to the protection of submerged surfaces with alkylamine derivatives a... | 08/16/2005 |
| 6914078 | Triarylmethane derivatives and their use as photochemotherapeutic agents Disclosed are compounds having one of the following structures: wherein R and R′ are hydrogen or substituted or unsubstituted C1 to C6 linear or branched alkyl, and at least one X is a halogen a... | 07/05/2005 |
| 6911478 | Nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same The present invention relates to nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions comprising such compounds, methods of using such compounds and compositions, and to a method for the preparation of nitric oxide-releasing amidine- a... | 06/28/2005 |
| 6908948 | DNA-cleaving antitumor agents A chemical composition and method of use of the composition is described. The chemical composition includes an aza-enediynes, aza-enyne allenes, or an aza-diallenes. These compound are preferably non-hydrolyzable, cationic compounds that bind to nucleic acids. In ad... | 06/21/2005 |
| 6903100 | USE OF REGULARLY SCHEDULED HIGH DOSE INTRAVENOUS METHOTREXATE THERAPY, WITH INTERIM ADMINISTRATION OF IMMUNOMODULATORY AGENTS, TO TREAT MULTIPLE SCLEROSIS AND OTHER DISEASES OF THE CENTRAL NERVOUS SYSTEM The present invention is directed to the treatment of multiple sclerosis by periodically administering a high dose of methotrexate at a level sufficiently high to cross the blood brain barrier. The methotrexate administration is accompanied by leucovorin rescue of t... | 06/07/2005 |
| 6852889 | Antioxidant nitroxides and nitrones as therapeutic agents The invention provides novel adamantane compounds having one of the following formulas: wherein: R1 and R3 are H, OH, alkyl, cycloalkyl, amino or aryl, an... | 02/08/2005 |
| 6815425 | Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same A nueroprotectant composition wherein the active ingredient is pGLU-GLU-PRO-NH2 or a combination of pGLU-GLU-PRO-NH2 (EEP) and N-tert-Butyl-α-(2-sulfophenyl)nitrone (SPBN) or other nitrone. A method of treating and preventing diseases and inju... | 11/09/2004 |
| 6750254 | Nitric oxide-releasing amidine—and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same The present invention relates to nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions comprising such compounds, methods of using such compounds and compositions, and to a method for the preparation of nitric oxide-releasing amidine- a... | 06/15/2004 |
| 6686345 | DNA-cleaving antitumor agents A chemical composition and method of use of the composition is described. The chemical composition includes an aza-enediyne, aza-enyne allene, or an aza-diallene. These compound are preferably non-hydrolyzable, cationic compounds that bind to nucleic acid... | 02/03/2004 |
| 6653350 | Methods of treating osteoarthritis with inducible nitric oxide synthase inhibitors Methods of treating osteoarthritis by administering an therapeutically effective amount of NOS inhibitor are provided.... | 11/25/2003 |
| 6569902 | Nitrone inhibition of cancer development PBN (-phenyl-tert-butylnitrone), and its derivatives nitrone-based free radical traps, significantly reduce preneoplastic nodule development as well as inhibit hepatocellular carcinoma (HCC) formation at very low levels. The involvement of reactive... | 05/27/2003 |
| 6559185 | Nitromethyl ketone compounds having aldose reduction inhibiting properties and methods for their use The present invention relates to the compounds of formula: ##STR1## in which R1, R2, R3, E, A, X, Z, p and n are as defined herein. These compounds are aldose reductase inhibitors.... | 05/06/2003 |
| 6545055 | Inhibitors of factor Xa Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.... | 04/08/2003 |
| 6511991 | Nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same The present invention relates to nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions comprising such compounds, methods of using such compounds and compositions, and to a method for the preparation of nitric oxide-releasing... | 01/28/2003 |
| 6462056 | Oxazolidines as 5-HT2A-antagonists The invention relates to novel oxazolidine derivatives of the formula ##STR1## in which R1, R2 and R3 have the meanings stated in claim 1, their salts and processes for preparing the compounds according to the invention. T... | 10/08/2002 |
| 6410600 | Azine used as fungicides The invention relates to novel azines, to a process for their preparation and to their use as fungicides.... | 06/25/2002 |
| 6395783 | Treatment of PCP addiction and PCP addiction-related behavior The present invention provides a method for changing addiction-related behavior of a mammal suffering from addiction to phencyclidine (PCP). The method includes administering to the mammal an effective amount of gamma vinylGABA (GVG) or a pharmaceutically... | 05/28/2002 |
| 6297284 | DNA-cleaving antitumor agents A chemical composition and method of use of the composition is described. The chemical composition includes an aza-enediyne, aza-enyne allene, or an aza-diallene. These compound are preferably non-hydrolyzable, cationic compounds that bind to nucleic acid... | 10/02/2001 |
| 6043281 | Nitromethyl ketones, process for preparing them and compositions containing them The present invention relates to the compounds of formula: ##STR1## in which R1, R2, R3, E, A, X, Z, p and n are as defined herein. These compounds are aldose reductase inhibitors.... | 03/28/2000 |
| 6020374 | Biologically active synthetic dye compounds A pharmaceutical composition comprising, in admixture with a pharmaceutically acceptable carrier, a therapeutically effective amount of a polyaromatic ring-containing compound, capable of mimicking the physiological activity of insulin or insulin-like gro... | 02/01/2000 |
| 6015828 | Chemical modification of chloride channels as a treatment for cystic fibrosis and other diseases This invention relates generally to medical treatment methods. Specifically, the invention relates to methodology for the correction of defective chloride transport by activation of chloride channels of the lung and other epithelia using genetic or chemic... | 01/18/2000 |
| 5985303 | Shelf-life extender for food use The invention provides a shelf-life extender for upholding the freshness of food, such as meat, vegetables, fruits, etc., in retail packages or in a refrigerator for an extended period of time. An isothiocyanic acid compound is supported on a matrix such ... | 11/16/1999 |
| 5981168 | Method and composition for modulating amyloidosis Methods and compositions, useful in the treatment of amyloidosis and conditions and diseases associated therewith, such as Alzheimer's Disease (AD). These methods involve administering to a subject a pharmaceutical composition including one or more agents... | 11/09/1999 |
| 5861435 | Method for preventing settlement of aquatic fouling organisms A method for preventing settlement of aquatic fouling organisms on surface of an aquatic structure without environmental hazard is provided. The method is based upon absolutely novel concept to prevent the settlement by means of thick slime layer, i.e. bi... | 01/19/1999 |
| 5728736 | Reduction of hair growth Mammalian hair growth is reduced by applying to the skin a dermatologically acceptable composition including an inhibitor of arginase.... | 03/17/1998 |
| 5650444 | Substituted biphenyl derivatives A compound of the following structure: ##STR1## wherein, when R8 =H: R1 =alkyl, cycloalkyl, arylalkyl, aryl; R2 =cycloalkyl, aryl, C3 -C10 alkyl; X,Y=O, S(O)n, NH; Z=CHO, CO2 R3 | 07/22/1997 |
| 5594012 | Amino acid derivatives and anti-active oxygen agents A novel anti-active oxygen agent which comprises as active ingredient an amino acid derivative represented by the following general formula (I): ##STR1## wherein Ar represents a 2-hydroxyphenyl, 2-hydroxy-1-naphthyl or pyridyl group, and one or more ... | 01/14/1997 |
| 5591760 | Synergistic microbicidal combinations containing 4,5-dichloro-2-octyl-3-isothiazolone and certain commercial biocides Synergistic microbicidal compositions are disclosed, comprising 4,5-dichloro-2-octyl-3-isothiazolone and one or more known microbicides for more effective, and broader control of microorganisms in various systems.... | 01/07/1997 |
| 5576316 | Method for inhibiting tumor growth rate using creatine or creatine analogs A method for inhibiting tumor growth rate using creatine or creatine analogs is described. The creatine or creatine analogs are administered to subjects such that tumor growth rate is inhibited. Pharmaceutical compositions containing the creatine or creat... | 11/19/1996 |
| 5543433 | Azine-substituted phenylacetic acid derivatives and fungicides containing these Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH3, CHOCH3 or NOCH3, R is hydrogen or alk... | 08/06/1996 |
| 5489590 | Method of treating with therapeutic composition comprising photoactive compound A therapeutic composition derived from a pre-activated photoactive compound and a conveyor for destroying tumor or other pathogenic biological contaminants infecting animal body tissues. The conveyor can either be a matrix support or an antibody. The acti... | 02/06/1996 |
| 5470586 | Antifouling coating and method for using same A method of controlling the attachment of organisms to an underwater surface is disclosed. The method comprises contacting the organisms with a compound of Formula I ##STR1## wherein R1, R2 and R3 are each independent... | 11/28/1995 |
| 5409954 | -arylacrylic acid derivatives, their preparation and their use for controlling pests and fungi -arylacrylic acid derivatives of the general formula I ##STR1## where X is ethylene or ethenylene; Y is a direct bond or oxygen; R1 is a mononuclear or dinuclear aromatic system substituted by C1 -C4 -alkyl, their p... | 04/25/1995 |
