Did You Know...
...that the x-ray was discovered purely by accident? When German physicist Wilhelm Konrad von Roentgen was experimenting with cathode rays in 1895, he put an activated Crookes tube in a book and went out to lunch. When he returned, he discovered that a key that had also been placed in the book showed up as an image on the developed film!
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| Number | Title | Issue Date |
| 8183296 | Pesticide phenyloxy substituted phenylamidine derivatives The present invention relates to 2,5-di-substituted-4-phenyloxy-substituted-phenyl-amidine derivatives of formula (I) in which the substituents are as in the description, their process of preparation, their use as fungicide or insecticide active agents, particularly... | 05/22/2012 |
| 7947741 | Use and administration of bacterial efflux pump inhibitors This invention provides for efflux pump inhibitors to be co-administered with antimicrobial agents for the treatment of infections caused by drug resistant pathogens, novel efflux pump inhibitors, combined dosage forms of efflux pump inhibitors with an antimicrobial... | 05/24/2011 |
| 7592374 | Insecticidal nitromethylene compounds A composition of matter is disclosed that comprises a compound of the formula: wherein R1 is selected from the group consisting of unsubstituted and substituted biphenyl moieties, unsubstituted and substi... | 09/22/2009 |
| 7365196 | Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ... | 04/29/2008 |
| 7351743 | Therapeutic guanidines The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines. ... | 04/01/2008 |
| 7273856 | Linear basic compounds having NK-2 antagonist activity and formulations thereof Described herein are compounds of formula (I) useful as antagonists of tachykinins in general, and in particular of neurokinin A; and the pharmaceutical formulations comprising the compounds of formula (I) ... | 09/25/2007 |
| 7262223 | Amidine derivatives for treating amyloidosis The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a t... | 08/28/2007 |
| 7220781 | Meta-benzamidine derivatives as serine protease inhibitors Compounds of formula I in which R1, R2, R3, each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted... | 05/22/2007 |
| 7157078 | Devices and methods for eliminating termite colonies This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to ... | 01/02/2007 |
| 7122535 | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them A method of treating pain in a warm-blooded animal comprising administering to anwarm-blooded animal in need thereof an amount of a compound of the formula wherein the substituents are defined in accordance with the di... | 10/17/2006 |
| 7078400 | 20-HETE synthase inhibitor The present invention relates to an inhibitor for production of 20-hydroxyeicosatetraenoic acid, comprising, as an effective ingredient, specific hydroxyformamidine derivatives or pharmaceutically-acceptable salts thereof. The inhibitors according to the present inv... | 07/18/2006 |
| 7074934 | Serine protease inhibitors Compounds of formula (I) where R2, each X, L, Y, Cy, Lp, D and n are as defined in the specification, are serine protease inhibitors useful as antithrombotic agents. ... | 07/11/2006 |
| 7041704 | Methods of treating gastrointestinal tract disorders using sodium channel modulators The invention relates to methods of using sodium channel modulators, particularly TTX-R sodium channel modulators and/or activity dependent sodium channel modulators to treat a gastrointestinal tract disorders, particularly inflammatory bowel disorders and irritable... | 05/09/2006 |
| 7019025 | Derivatives of amidines, their preparation and their use as medicaments Compounds of the formula wherein R1 is alkyl and R2 is alkenyl, alkynyl, allenyl or cyanoalkyl, n is 0 or 1, k is an integer from 1 to 3, X is —(CH2)m— ... | 03/28/2006 |
| 6936597 | Prodrugs of anticancer agents employing substituted aromatic acids Polymeric prodrugs of the formula: wherein B is selected from the group consisting of OH, leaving groups, residues of amine-containing moieties and a residues of hydroxyl-containing m... | 08/30/2005 |
| 6936719 | Biaryl compounds as serine protease inhibitors Compounds of formula (I) are useful as inhibitors of trypsin like serine protease enzymes such as thrombin, factor VIIa, factor Xa, TF/FVIIa, and trypsin. These compounds could be useful to treat and/or prevent clotting disorders, and as anticoagulating agents. ... | 08/30/2005 |
| 6921752 | Use of LTB4 antagonists in veterinary medicine The invention relates to the use of LTB4 antagonists for preparing a pharmaceutical composition for the treatment or prevention of respiratory diseases in companion and domesticated animals. ... | 07/26/2005 |
| 6916957 | Serine protease inhibitors Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents. ... | 07/12/2005 |
| 6906076 | Compounds and methods of use to treat infectious diseases The present invention concerns alkyl aryl carbonyl compounds that possess anti-infective activity. The compounds of the invention can be used to target specific nuclear localization signal, thereby blocking importation of specific proteins or molecular complex into ... | 06/14/2005 |
| 6864254 | Inhibitor for 20-hete-yielding enzyme An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is useful especially as a remedy for kidney diseases, cerebrovascular dis... | 03/08/2005 |
| 6852761 | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade The invention relates to polycyclic aryl and heteroaryl substituted benzene compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety ... | 02/08/2005 |
| 6825231 | Substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics, and a medicament comprising them The application discloses substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics and a medicament comprising them Substituted norbornylamino derivatives having exo-configured nitrogen and an endo-fused... | 11/30/2004 |
| 6809088 | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them The invention relates to new derivatives of 2-(iminomethyl)amino-phenyl which are NO synthase inhibitors and can trap reactive oxygen species. These compounds can notably be used for the treatment of stroke, of neurodegenerative diseases and of ischemic or hemorragi... | 10/26/2004 |
| 6767548 | Gel inhibited liquid carrier for a biocide containing a carbodiimide and an emulsifier mixture This invention relates to a biocidal composition resistant to the formation of a gel and to the method for stabilizing a concentrate containing, in addition to the biocide, a carbodiimide, a lipophilic/hydrophilic emulsifier mixture having a HLB of 6 to 20 and optio... | 07/27/2004 |
| 6740682 | Meta-benzamidine derivatives as serine protease inhibitors The novel compound 3-amidinobenzoyl-D-phenylglycine-3-phenylanilide is useful as a serine protease inhibitor. ... | 05/25/2004 |
| 6740653 | Shelf life extension of microemulsions containing active aza biocide This invention relates to the stabilization of o/w microemulsions containing an active aza biocide by addition of an alkaline, water soluble buffering agent in an amount sufficient to adjust the pH to between 6 and 14 and to the use of said o/w microemulsions to con... | 05/25/2004 |
| 6737077 | Proteinaceous animal chew with dentally therapeutic cation This invention relates to chewable objects for animals which contain, as a dentally therapeutic ingredient, one or more cationic substances. The inventive therapeutic animal chews are of sufficient durability to allow for a chewing cycle long enough for the release ... | 05/18/2004 |
| 6716421 | Devices and methods for eliminating termite colonies This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to about 50 to about 100% of te... | 04/06/2004 |
| 6706745 | Biphenylamidine derivatives The present invention relates to a biphenylamidine derivative of the general formula (1): or a pharmaceutically acceptable salt thereof, which is a novel compound functioning as a clinically applicable FXa inhibitor.... | 03/16/2004 |
| 6664295 | Fungicidal phenylamidine derivatives The invention provides fungicidal compounds of formula I and salts thereof: ##STR1## wherein the various radicals and substituents are as defined in the description, fungicidal compositions containing them and method for combating fungi which comprises... | 12/16/2003 |
| 6641800 | Pressurized aerosol compositions comprising powdered medicament dispersed in hydrofluoroalkane Pressurized aerosol composition for administration by inhalation comprising a liquefied hydrofluoroalkane, a powdered medicament dispersed therein, and a suspending agent comprising a polymer soluble in the liquefied hydrofluoroalkane which is selected fr... | 11/04/2003 |
| 6635668 | Imidazoline receptor binding compounds Pentamidine and analogs thereof have activity as imidazoline receptor binding compounds. A method of binding the imidazoline receptor, comprises contacting a bis-benzene to said imidazoline receptor in an amount effective to bind to said receptor, wherein... | 10/21/2003 |
| 6576669 | Use of an LTB4 antagonist for the treatment or prevention of diseases caused by increased expression of mucin genes Medicaments and pharmaceutical kits comprising an LTB4 antagonist of formula (I) ##STR1## a tautomer thereof or a pharmaceutically acceptable salt thereof, and methods of treating or preventing cystic fibrosis, diseases caused by increased... | 06/10/2003 |
| 6545055 | Inhibitors of factor Xa Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.... | 04/08/2003 |
| 6534546 | Aniline derivatives possessing an inhibitory effect of nitric oxide synthase Compounds represented by the general formula (1): ##STR1## (where R1 is SR6 or NR7 R8, where R6 is typically an alkyl group having 1-6 carbon atoms, R7 is a hydrogen atom, an alkyl group having ... | 03/18/2003 |
| 6534543 | Oxa acids and related compounds for treating skin conditions The present invention is directed to the use of compounds of Formula (I), as active principals for treating skin conditions and compositions containing these compounds ##STR1## wherein R4 is (CR5 R6 -CR7 R8... | 03/18/2003 |
| 6528491 | Pyranoside derivatives The present invention relates to new pyranoside derivatives of general formula I, processes for preparing them as well as their use as medicaments: ##STR1##... | 03/04/2003 |
| 6500823 | Unsaturated hydroximic acid derivatives as per abstract inhibitors ##STR1## The object of the invention consists of novel unsaturated hydroximic acid derivatives, the process for their preparation and as active substance such as compounds containing pharmaceutical compositions. The novel compounds possess valuable pharma... | 12/31/2002 |
| 6489365 | Amidine derivatives, the preparation and use thereof as medicaments with Itb4 antagonistic effect Compounds of the formula ##STR1## which is explained more fully in the specification, may be prepared by conventional methods and used therapeutically in conventional galenic preparations.... | 12/03/2002 |
| 6479524 | Substituted aryl and heteroaryl derivatives, their production and their use as medicines Compounds that prolong thrombin time. Exemplary are: (a) rac-4-{3-[5-ethoxycarbonylmethyl-2-methyl-4-(2-methyl-pyrrolidinocarbonyl) -phenyl]-propargylamino}benzamidine, (b) rac-4-{3-[2,5-dimethyl-4-(2-methyl-pyrrolidinocarbonyl)-phenyl]-propargyla mino... | 11/12/2002 |
