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| Number | Title | Issue Date |
| 8053477 | Inhibitors of the S100-p53 protein-protein interaction and method of inhibiting cancer employing the same Compounds that bind S100 and inhibit the S100-p53 protein-protein interaction and activate the tumor suppressor activity of p53, and thus which have an antineoplastic effect are disclosed, as well as methods for identifying these compounds, compositions comprising t... | 11/08/2011 |
| 7262223 | Amidine derivatives for treating amyloidosis The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a t... | 08/28/2007 |
| 7229961 | Compositions and methods for enhancing drug delivery across and into ocular tissues This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including into and across ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, ... | 06/12/2007 |
| 6960588 | Tryptase inhibitors Compounds of formula (I) in which M, B1, B2, B3, B4, B5, B6, A1, A2, A3, A4, A5, A6, K1 and K2 have the meanings as indicated in the description, are novel effective tryptase inhibitors. ... | 11/01/2005 |
| 6949567 | Compounds for the treatment of protozoal diseases The invention relates to new diphenylurea having the formula (I) or a salt thereof, where Y is C═O, C═S, C═NH, (C═O)2 or SO2; and to pro... | 09/27/2005 |
| 6794545 | Conformationally restricted polyamine analogs as disease therapies Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. Also provided is a method of d... | 09/21/2004 |
| 6706764 | Use of creatine or creatine analogs for the treatment of diseases of the nervous system The present invention relates to the use of creatine compounds including creatine, creatine phosphate or analogs of creatine, such as cyclocreatine, for treating diseases of the nervous system. Creatine compounds can be used as therapeutically effective agents again... | 03/16/2004 |
| 6677377 | Structure based discovery of inhibitors of matriptase for the treatment of cancer and other conditions The present invention relates to a method of inhibiting carcinoma progression wherein matriptase plays a role in a subject in need of such inhibition including administering to a subject an effective amount of a compound comprising two positively charged ... | 01/13/2004 |
| 6669951 | Compositions and methods for enhancing drug delivery across and into epithelial tissues This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, ocular tissues and the like. The compositions and methods are al... | 12/30/2003 |
| 6641800 | Pressurized aerosol compositions comprising powdered medicament dispersed in hydrofluoroalkane Pressurized aerosol composition for administration by inhalation comprising a liquefied hydrofluoroalkane, a powdered medicament dispersed therein, and a suspending agent comprising a polymer soluble in the liquefied hydrofluoroalkane which is selected fr... | 11/04/2003 |
| 6635668 | Imidazoline receptor binding compounds Pentamidine and analogs thereof have activity as imidazoline receptor binding compounds. A method of binding the imidazoline receptor, comprises contacting a bis-benzene to said imidazoline receptor in an amount effective to bind to said receptor, wherein... | 10/21/2003 |
| 6635650 | Substituted dimeric compounds The invention relates to compounds of formula (I): wherein: A represents NR1 C(Q)R2, C(Q)NR2 R3 or NR1 C(Q)NR2 R3, B represents NR1 C(Q)R2, C(Q)NR2... | 10/21/2003 |
| 6593292 | Compositions and methods for enhancing drug delivery across and into epithelial tissues This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, and the like. The compositions and methods are also useful for d... | 07/15/2003 |
| 6569853 | Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders The invention features a method for treating a patient having a cancer or other neoplasm, by administering to the patient (i) chlorpromazine or a metabolite or analog thereof; and (ii) pentamidine or a metabolite or analog thereof simultaneously or within... | 05/27/2003 |
| 6248787 | Guanylhydrazones and their use to treat inflammatory conditions This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the inv... | 06/19/2001 |
| 6180676 | Guanylhydrazones and their use to treat inflammatory conditions This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the inv... | 01/30/2001 |
| 6114392 | Agmatine, and polyaminoguanidine-bound heterocyclic compounds for neurotrauma and neurodegenerative diseases The invention relates to the use of agmatine, in the treatment of acute neurotrauma (such as stroke) and degenerative disorders of the central and peripheral nervous system (such as dementia). The invention further provides novel compounds of general formula I... | 09/05/2000 |
| 6022900 | Guanylhydrazones and their use to treat inflammatory conditions This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the inv... | 02/08/2000 |
| 6008255 | Guanylhydrazones and their use to treat inflammatory conditions This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the inv... | 12/28/1999 |
| 5990174 | Aqueous composition A aqueous medium containing a biguanide, particularly a biguanide oligomer, and having a pH of less than 5. The biguanide oligomer may be a poly(hexamethylene biguanide) having up to 15 repeat units. The medium has improved storage stability compared to c... | 11/23/1999 |
| 5958983 | Polyaromatic antiviral compositions The present invention relates to polyaromatic compounds having useful antiviral activity against viruses of the herpes family, to a composition containing them, and to a method of using them for the treatment of herpes viruses infections.... | 09/28/1999 |
| 5922693 | Cleaning compositions containing biostatic agent The present invention relates to an aqueous cleaning composition containing (a) 1 to 10 weight % of at least one surfactant selected from the group consisting of anionic surfactants and ethoxylated nonionic surfactants and mixtures thereof; (b) 0.2 to 10 weigh... | 07/13/1999 |
| 5859062 | Guanylhydrazones and their use to treat inflammatory conditions This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the inv... | 01/12/1999 |
| 5854289 | Guanylhydrazones and their use to treat inflammatory conditions This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the inv... | 12/29/1998 |
| 5849794 | Guanylhydrazones and their use to treat inflammatory conditions This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the inv... | 12/15/1998 |
| 5830917 | L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors There is disclosed a novel amino alcohol amine derivatives of L-N6 -(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular their use as nitric oxide synthase inhibitors.... | 11/03/1998 |
| 5753684 | Guanylhydrazones and their use to treat inflammatory conditions This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the inv... | 05/19/1998 |
| 5728737 | N-alkoxy-amidine derivatives The present invention relates to novel N-alkoxy-arnidine derivatives of the formula (I), to a process for their preparation and to their use as pesticides. In addition, the invention also relates to novel intermediates and to a process for their preparati... | 03/17/1998 |
| 5719192 | Use of terbinafine for the therapeutic treatment of pneumocystosis A method of use comprising administering terbinafine for the primary and secondary prophylaxis and treatment of Pneumocystis carinii pneumonia, including oral administration of terbinafine at does of 3 to 20 mg/kg/day, to a subject suffering from this typ... | 02/17/1998 |
| 5637621 | Methods and compositions for treating Botrytis infections The invention provides fungicidal compounds having the general formula: X1 -A1 -B1 -C-B2 -A2 -X2 (I) wherein X1 is an amidine, a guanidine, or an imidazole group. A1 is either a ... | 06/10/1997 |
| 5629348 | Methods and compositions for treating septoria infections The invention provides fungicidal compounds having the general formula: X1 -A1 -B1 -C-B2 -A2 -X2 (I) wherein X1 is an amidine, a guanidine, or an imidazole group. A1 is either a... | 05/13/1997 |
| 5334374 | Pharmaceutical compositions containing pentamidine Pharmaceutical compositions suitable for administration by inhalation and containing pentamidine, or pharmaceutically acceptable salt thereof, in powder form. Such compositions include pressurized aerosol compositions and nonpressurized power compositions... | 08/02/1994 |
| 5321030 | Creatine analogs having antiviral activity The present invention relates to the use of analogs of creatine, such as cyclocreatine, as antiviral agents. Analogs of creatine can be used as antiviral agents against a variety of viruses, particularly DNA viruses, such as Herpes viruses (e.g., HSV-1, H... | 06/14/1994 |
| 5302598 | Method and compositions for treating Pneumocystic carinii infections The present invention provides methods for treating and preventing the onset of Pneumocystis carinii pneumonia (PCP) comprising administering to a mammal in need of such treatment or prevention an effective amount of a pharmaceutically acceptable iron che... | 04/12/1994 |
| 5262157 | Method of preventing Pneumocystis carinii pneumonia using pentamidine in an aerosol form Pneumocystis carinii pneumonia may be prevented in a subject susceptible to infection by Pneumocystis carinii by administering to the subject an amount of a pentamidine in aerosol form effective to prevent infection by Pneumocystis carinii and thus preven... | 11/16/1993 |
| 5206236 | Method for the treatment of malaria A method for treating malaria which comprises to an afflicted host patient a therapeutically effective amount of a compound have the structure of formula I: ##STR1## wherein X is O or NH; R1 is H or two R1 groups on the same ... | 04/27/1993 |
| 5204113 | Pharmaceutical compositions containing pentamidine Pharmaceutical compositions suitable for administration by inhalation and containing pentamidine, or pharmaceutically acceptable salt thereof, in powder form. Such compositions include pressurized aerosol compositions and non-pressurized powder compositio... | 04/20/1993 |
| 5202320 | Method for treating leishmaniasis This invention relates to a method for treating leishmaniasis which comprises administering to an afflicted host patient, a therapeutically effective amount of a compound having the following structure; ##STR1## wherein X is O or NH; R1 is... | 04/13/1993 |
| 5135942 | Fungicidal active compound combinations A fungicidal composition comprising A) at least one of 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-batan-2-ol of the formula ##STR1## and 1-(4-phenyl-phenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl(butan-2-ol of the formula ##STR2#... | 08/04/1992 |
| 5126360 | Fungicidal active compound combinations A fungicidal composition comprising A) 1-(4-chlorophenyl)-4,4-dimethyl-3-(1,2,4-triazol-1-yl-methyl)-pentan-3-ol of the formula ##STR1## and B) at least one guanidated aliphatic polyamine of the formula ##STR2## in which R1 repr... | 06/30/1992 |
