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| Number | Title | Issue Date |
| 8173709 | Anti-infective methods for treating pathogen-induced disordered tissues Compositions, methods and systems for treating disordered epithelial tissues, such as is caused by pathogens and/or by toxins produced thereby. The invention relates to the use of an anti-infective and/or antimicrobial active agent in a carrier, with vigorous agitat... | 05/08/2012 |
| 8148429 | Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands The present invention relates to the use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is H or OH; R1, R2, R3, R4 and R5 are the same or different and are selected... | 04/03/2012 |
| 8084502 | Use of agmatine for protection of retinal ganglion cells A use method of agmatine or a pharmaceutically allowable salt thereof, and a pharmaceutical composition comprising the same are disclosed. The method and pharmaceutical composition of the present invention can effectively cure or prevent eye diseases preferably incl... | 12/27/2011 |
| 8071652 | Method of treating irritable bowel syndrome A treatment to differentially regulate the expression of genes related to irritable bowel syndrome is provided. ... | 12/06/2011 |
| 8058311 | Imaging 18F or 11C-labelled alkylthiophenyl guanidines The invention provides a compound of formula (I); or a salt or solvate thereof, wherein: R1 is hydrogen or C1-4 alkyl; R2 and R4 are each independently selected from C1-4 alkyl, [11C]C1-4 a... | 11/15/2011 |
| 8008352 | Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them Pentafluorosulfanylbenzoylguanidines, of the formula I and II in which R1 to R4 have the meanings stated in the claims, are suitable as antiarrhythmic medicaments with a cardioprotective component for the prophylaxis of inf... | 08/30/2011 |
| 7829596 | Methods of treatment A method of treating weight loss due to underlying disease in a patient, the method comprising administering to the patient an effective amount of an agent which reduces sympathetic nervous system activity. A method of treating weight loss due to underlying disease ... | 11/09/2010 |
| 7820719 | Cytostatic drug composition A drug composition containing as a drug substance a polymeric guanidine derivative based on a diamine containing oxyalkylene chains between two amino groups, with the guanidine derivative representing a product of polycondensation between a guanidine acid addition s... | 10/26/2010 |
| 7528173 | Plasma carboxypeptidase B inhibitors Compounds of the following formula (I), for example: (1), wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, meth... | 05/05/2009 |
| 7521479 | Methods of treating prion disease in mammals The invention is related to the treatment of prion-related diseases such as the transmissible spongiform encephalopathies (TSEs) in mammals by administering chaotropic agents to or inducing a hyperthermia state in the affected mammals. ... | 04/21/2009 |
| 7432397 | Imaging compounds The invention relates to compounds of formula: (I) or a salt or solvate thereof, wherein: R1 is —11CH2R5 or [18F]—C1-4 fluoroalkyl wherein R5 is hydrogen or C1-4 alkyl; R | 10/07/2008 |
| 7368605 | Variously substituted derivatives of guanidine, and their use as medicines with anti-diabetes and/or anti-obesity activity Formula (I) compounds are described where the groups are as identified in the text, and their use as medicines, particularly as anti-diabetes, serum glucose-lowering and anti-obesity agents. They are useful for the prophyla... | 05/06/2008 |
| 7351743 | Therapeutic guanidines The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines. ... | 04/01/2008 |
| 7335639 | IGF-1 composition and its use A highly concentrated, low salt-containing, biologically active syrup form of IGF-I or variant thereof and methods for its preparation are provided. This novel syrup form of IGF-I has an IGF-I concentration of at least about 250 mg/ml, a density of about 1.0 g/ml to... | 02/26/2008 |
| 7326730 | Aminoadamantane derivatives as therapeutic agents The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases using the derivatives and composi... | 02/05/2008 |
| 7322369 | Methods of detaching microorganisms from, or of inhibiting microbial attachment to, animal or poultry carcasses or seafood or parts thereof Methods of detaching microorganisms (e.g., bacteria) from, or of inhibiting microbial (e.g., bacterial) attachment to, animal or poultry carcasses or seafood or parts thereof, wherein the method involves contacting animal or poultry carcasses or seafood or parts the... | 01/29/2008 |
| 7316810 | Foaming composition for washing and treating hair and/or scalp based on an active principle The invention concerns a foaming composition for washing and treating hair and/or scalp essentially characterized in that it contains in an aqueous medium: at least an active principle selected among corticoids and retinoids; at least an anionic surfactant; at least... | 01/08/2008 |
| 7316665 | Method and device for the delivery of a substance including a covering An abrasion device and method for delivery of substances into the skin using a microabrader for delivering a substance into the skin are disclosed. An abrasion device with a cover is also disclosed. Such devices and methods can be effectively used to deliver bioacti... | 01/08/2008 |
| 7285682 | Terphenyl guanidines as β-secretase inhibitors The present invention provides terphenyl guanidine compounds of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibril... | 10/23/2007 |
| 7279502 | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions... | 10/09/2007 |
| 7261701 | Skin antiseptic composition dispenser and methods of use Skin antiseptic composition dispensers and methods of use are disclosed. The skin antiseptic composition dispenser may include a container with one or more walls that are substantially impermeable to ethylene oxide gas during normal ethylene oxide sterilization proc... | 08/28/2007 |
| 7262222 | Synergistic mixtures of o-phenylphenol and other nitrogen and aldehyde microbiocides Ortho phenylphenol or its sodium salt is shown to form synergistic antimicrobial mixtures with nitrogen and aldehyde-containing microbiocides. ... | 08/28/2007 |
| 7262168 | Compositions providing for increased IGF-I solubility Novel IGF-I compositions are described. The compositions include a solubilizing compound comprising a guanidinium group that provides for IGF-I compositions in which IGF-I is highly soluble at pHs of about 5.5 or greater and at refrigerated temperatures. ... | 08/28/2007 |
| 7229961 | Compositions and methods for enhancing drug delivery across and into ocular tissues This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including into and across ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, ... | 06/12/2007 |
| 7229986 | Melanin-concentrating hormone antagonist A melanin-concentrating hormone antagonist comprising a compound of the formula: wherein R is hydrogen atom or a cyclic group which may be substituted; X is a bond or a spacer having a main chain of 1 to 10 atoms... | 06/12/2007 |
| 7208521 | Selective inhibitors of the urokinase plasminogen activator The present invention relates to novel selective inhibitors of the urokinase plasminogene activator (uPA, EC3,4.21.31) of the aryl guanidine type. ... | 04/24/2007 |
| 7202253 | Cycloalkyl inhibitors of potassium channel function Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating... | 04/10/2007 |
| 7202280 | Methods for the treatment and prevention of pancreatitis and for induction of liver regeneration Novel methods for treating and preventing acute and/or chronic pancreatitis are described. Additionally, novel methods for inducing liver regeneration are described. The methods may comprise administering to a patient an effective amount of a metabolically stable an... | 04/10/2007 |
| 7199159 | Use of biguanide derivatives for making a medicine having a wound healing effect The present invention relates to the use of biguanide derivatives of general formula I below: in which: the groups R1 and R2 represent, independently of each other, a hydrogen a... | 04/03/2007 |
| 7186748 | N-phenylpyrrole guanidine derivatives as melanocortin receptor ligands The present invention provides novel compounds of the general Formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is (CH2)n... | 03/06/2007 |
| 7169814 | Guanidinium transport reagents and conjugates Transport reagents and conjugates of therapeutic agents linked to transport reagents are described. In particular, the transport reagents have a plurality of guanidinium moieties that are either contiguous or spaced along a backbone, but are sufficiently removed fro... | 01/30/2007 |
| 7153881 | Compounds acting as melanocortin receptor ligands The present invention provides novel compounds and use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: Wherein X and Y are independently chosen from O, N, S and (CH2 | 12/26/2006 |
| 7153887 | Use of 15-deoxyspergualin for the treatment of ANCA associated vasculitis The invention describes the use of deoxyspergualin (DSG) or an analogue thereof for the preparation of a medicament for the treatment of and/or prophylaxis against hyperreactive inflammatory diseases and autoimmune diseases, wherein the treatment is performed in cyc... | 12/26/2006 |
| 7145037 | Adamantane derivatives with neuroprotective, antidepressant and anti-ischaemic activities, and process for preparing them The invention describes compounds represented by the general formula (I) given below: in which: n is an integer between 1 and 4; R1 and R2 | 12/05/2006 |
| 7122505 | Composition for controlling the growth of algae, fungi and pathogenic organisms in water A stable aqueous concentrate comprising a polymeric biguanide, a chelating agent and a water-miscible organic solvent for controlling the growth of algae, fungi and pathogenic organisms in water. ... | 10/17/2006 |
| 7115665 | Inhibitors of endo-exonuclease activity for treating cancer The present invention relates to the treatment of cancer with compounds that inhibit the activity of endo-exonuclease. Endo-exonuclease has been shown to be necessary for the repair of damaged DNA. Compounds that inhibit the activity of endo-exonuclease have been sh... | 10/03/2006 |
| 7109329 | Neurologically active compounds and compounds with multiple activities This invention provides pharmacologically active compounds having neurological and other bio-active capability. These active compounds comprise the derivatives of guanidino, aminoguanidino, 2-imadazolino, 2-hydrazinoimidazolino or 2-guanidinobenzimidazolino groups. | 09/19/2006 |
| 7102013 | Methods of making amidino compounds useful as nitric oxide synthase inhibitors Method of making an alpha-amino acid compound having the structure of Formula 32: comprising treating under hydrolyzing conditions a hydantoin compound having the structure of Formula 33: | 09/05/2006 |
| 7091229 | Tricyclic lactam and sultam derivatives and their use as histone deacetylase inhibitors A compound of formula (I) wherein A and B are optionally substituted cyclohexenyl or phenyl groups, X is carbonyl or sulfonyl, and Y is 5–7 atoms-linker, is useful as histone deacetylase inhibitors, particularl... | 08/15/2006 |
| 7087559 | Non-foaming cleaning and conditioning hair care compositions There are disclosed non-foaming cleaning compositions, and non-foaming cleaning and conditioning compositions for the hair. The compositions have at least one non-ionic surfactant and, optionally, at least one conditioning ingredient. Preferably, the compositions ha... | 08/08/2006 |
