Did You Know...
...When G.G. Hubbard learned of his future son-in-law's invention, he called it "only a toy." His daughter was engaged to a young man named Alexander Graham Bell.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7863334 | Guanylhydrazone compounds, compositions, methods of making and using The present invention relates to compounds having the formula: salts thereof; compositions comprising one or more of the compounds and/or salts thereof; methods of using; and methods of making.... | 01/04/2011 |
| 7741372 | Guanylhydrazones useful for treating diseases associated with T cell activation There is disclosed a method for treating diseases and disorders involving T cell activation and HIV-infection using the p38 mitogen activated protein kinase (MAPK) signaling pathway as a target for intervention. There is further disclosed a use for guanylhydrazone-s... | 06/22/2010 |
| 7326730 | Aminoadamantane derivatives as therapeutic agents The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases using the derivatives and composi... | 02/05/2008 |
| 7291647 | Guanylhydrazone compounds, compositions, methods of making and using The present invention relates to compounds having the formula: salts thereof; compositions comprising one or more of the compounds and/or salts thereof; methods of using; and methods of m... | 11/06/2007 |
| 7118873 | Polynucleotides encoding cellular transporters and methods of use thereof This disclosure encompasses the Indy gene, polypeptides encoded by the Indy gene and fragments thereof. This disclosure also encompasses homologs of the Indy gene both from Drosophila and other organisms. In addition, this disclosure encompasses the use of In... | 10/10/2006 |
| 7083799 | No-synthase inhibitors The use of an effective amount of at least one nitric oxide synthase inhibitor in a cosmetic composition or for making a pharmaceutical composition is disclosed, said inhibitor or pharmaceutical composition being intended to reduce the skin irritant effect of topica... | 08/01/2006 |
| 6936637 | Prevention of apoptosis in non-cancerous cells Treatment of normal, non-cancerous, animal cells with an agent that depletes polyamines within the cells results in an inhibition of apoptosis when the cells are exposed to an inducer of apoptosis. This inhibition of apoptosis is not observed, or is observed to a le... | 08/30/2005 |
| 6849662 | Therapeutic uses for nitric oxide inhibitors The present invention is based on the discovery that nitric oxide (NO) is an important growth regulator in an intact developing organism. In particular, the present invention relates to a method of increasing in a mammal a population of hematopoietic stem cells whic... | 02/01/2005 |
| 6809117 | Therapeutic uses of nitric oxide inhibitors The present invention is based on the discovery that nitric oxide (NO) is an important growth regulator in an intact developing organism. In particular, the present invention relates to a method of increasing in a mammal a population of hematopoietic stem cells in b... | 10/26/2004 |
| 6747062 | Regulation of wound healing by nitric oxide The present invention provides methods and compositions for promoting healing of damaged tissue that result in an increased level of nitric oxide in the vicinity of the damaged tissue. Also provided are methods and compositions for inhibiting unwanted wound healing ... | 06/08/2004 |
| 6689813 | Process for the preparation of pharmaceutical compositions possessing neurogenic or non-neurogenic anti-inflammatory as well as analgetic effects The invention relates to the use of peptide amides of formula (I) ##STR1## and phenylamino-oxoacetic acid derivatives of formula (II) ##STR2## as well as the salts of the above compounds as active substances for the preparation of pharmaceutical compositi... | 02/10/2004 |
| 6673777 | Guanylhydrazones useful for treating diseases associated with T cell activation There is disclosed a method for treating diseases and disorders involving T cell activation and HIV-infection, using the p38 mitogen activated protein kinase (MAPK) signaling pathway as a target for intervention. There is further disclosed a use for guany... | 01/06/2004 |
| 6605447 | Methods and means of detecting nitric oxide synthase Methods for identifying and monitoring increased or decreased levels of inducible nitric oxide synthase in biological samples are provided. A collection device for detecting inducible nitric oxide synthase in biological samples is also provided. Detection... | 08/12/2003 |
| 6593372 | Therapeutic uses for nitric oxide inhibitors The present invention is based on the discovery that nitric oxide (NO) is an important growth regulator in an intact developing organism. In particular, the present invention relates to a method of increasing in a mammal a population of hematopoietic stem... | 07/15/2003 |
| 6498192 | Prevention of apoptosis in non-cancerous cells Treatment of normal, non-cancerous, animal cells with an agent that depletes polyamines within the cells results in an inhibition of apoptosis when the cells are exposed to an inducer of apoptosis. This inhibition of apoptosis is not observed, or is obser... | 12/24/2002 |
| 6444706 | Guanidine derivatives, processes for preparing them and their use as pharmaceutical compositions The invention concerns new guanidine derivatives of formula (I), methods of preparing them and their use in drugs containing such compounds. ##STR1##... | 09/03/2002 |
| 6433019 | Neurotrophic factor secretion promoters The present invention relates to a neurotrophic factor secretagogue, in particular, to a BDNF (brain-derived neurotrophic factor) secretagogue, which comprises as an active ingredient an NO donor. The medicament of the present invention promotes the secre... | 08/13/2002 |
| 6410598 | Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis The present invention relates generally to the non-enzymatic glycosylation of amyloidogenic proteins and the consequent formation of advanced glycosylation endproducts (AGEs). It has been found that formation of AGE-amyloidogenic proteins can enhance amyl... | 06/25/2002 |
| 6372796 | Therapeutic uses for nitric oxide inhibitors The present invention is based on the discovery that nitric oxide (NO) is an important growth regulator in an intact developing organism. In particular, the present invention relates to a method of increasing in a mammal a population of hematopoietic stem... | 04/16/2002 |
| 6339082 | Tricyclic compounds, preparation method and said method intermediates, application as medicines and pharmaceutical compositions containing same A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as set forth in the specification and its salts with non-toxic pharmaceutically acceptable acids and bases useful for treating loss of... | 01/15/2002 |
| 6284798 | Guanidine derivatives, methods of preparing them and their use as drugs The invention concerns new guanidine derivatives of formula (I), methods of preparing them and their use in drugs containing compounds, of formula (I), wherein ##STR1## wherein x is --NH--NH--CH2 R1 and R1 denotes C8 | 09/04/2001 |
| 6248787 | Guanylhydrazones and their use to treat inflammatory conditions This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the inv... | 06/19/2001 |
| 6180676 | Guanylhydrazones and their use to treat inflammatory conditions This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the inv... | 01/30/2001 |
| 6143728 | Guanylhydrazones useful for treating diseases associated with T cell activation There is disclosed a method for treating diseases and disorders involving T cell activation and HIV-infection, using the p38 mitogen activated protein kinase (MAPK) signaling pathway as a target for intervention. There is further disclosed a use for guany... | 11/07/2000 |
| 6133320 | Treatment of osteoporosis and metabolic bone disorders with nitric oxide substrate and/or donors Primary and secondary osteoporosis in a female or a male mammal is treated by administering thereto a nitric oxide synthase substrate, a nitric oxide donor or both, optionally; in further combination with one or more of an estrogen, a progestin, an anabol... | 10/17/2000 |
| 6114392 | Agmatine, and polyaminoguanidine-bound heterocyclic compounds for neurotrauma and neurodegenerative diseases The invention relates to the use of agmatine, in the treatment of acute neurotrauma (such as stroke) and degenerative disorders of the central and peripheral nervous system (such as dementia). The invention further provides novel compounds of general formula I... | 09/05/2000 |
| 6022900 | Guanylhydrazones and their use to treat inflammatory conditions This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the inv... | 02/08/2000 |
| 6008255 | Guanylhydrazones and their use to treat inflammatory conditions This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the inv... | 12/28/1999 |
| 5977181 | Therapeutic uses for nitric oxide inhibitors The present invention is based on the discovery that nitric oxide (NO) is an important growth regulator in an intact developing organism. In particular, the present invention relates to a method of increasing in a mammal a population of hematopoietic stem... | 11/02/1999 |
| 5965529 | Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in further combination with one or more of a cyclo... | 10/12/1999 |
| 5962413 | Treatment of uterine contractility disorders with a nitric oxide synthase substrate and/or donor, or a nitric oxide inhibitor Dysmenorrhea, disfunctional uterine bleeding, preterm labor and postpartum labor in female mammals are treated by inhibiting uterine contractility by administering thereto a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in comb... | 10/05/1999 |
| 5891909 | Amidinohydrazones as protease inhibitors Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R1 -R4, R6 -R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically ac... | 04/06/1999 |
| 5869534 | Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom The in vivo oxidation of lipids and lipid-containing molecules has been discovered to be initiated by the concurrent reaction of such lipid materials with reducing sugars such as glucose, advanced glycosylation endproducts such as AGE-peptides, or a compo... | 02/09/1999 |
| 5859062 | Guanylhydrazones and their use to treat inflammatory conditions This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the inv... | 01/12/1999 |
| 5854289 | Guanylhydrazones and their use to treat inflammatory conditions This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the inv... | 12/29/1998 |
| 5849794 | Guanylhydrazones and their use to treat inflammatory conditions This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the inv... | 12/15/1998 |
| 5837737 | Hydrazinedicarboximidamide compounds and pharmaceutical composition comprising same Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use o... | 11/17/1998 |
| 5753684 | Guanylhydrazones and their use to treat inflammatory conditions This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the inv... | 05/19/1998 |
| 5693673 | Process of preparing 2,2'-(1-methyl-1,2-ethanediylidene)bis›hydrazine caroximidamide! Process for the preparation of 2,2'-(1-methyl 1,2-ethanediylidene)bis›hydrazine carboximidamide! by: a) reacting aminoguanidine hydrochloride with methylglyoxal aldehyde or methylglyoxal dimethyl acetal; and b) purifying the 2,2'-(1-methyl-1,2-ethanediylidene... | 12/02/1997 |
| 5686495 | Substituted hydrazinedicarboximidamides and methods of use thereof Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use o... | 11/11/1997 |
