Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 7750050 | Chaperone-based therapy for Niemann-Pick disease The present invention provides a method for treating individuals affected with the acid sphingomyelinase-deficient forms of Niemann-Pick disease (i.e., Type A or Type B Niemann-Pick) by administering small molecules as specific molecular “chaperones” for the def... | 07/06/2010 |
| 7439394 | Cyclohexyl-1,4-diamine compounds Novel cyclohexyl-1,4-diamine compounds corresponding to formula I, processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing pharmaceutical compositions including the... | 10/21/2008 |
| 7432302 | Composition containing polyamine transport inhibitor and use thereof Proliferative cutaneous disease states or conditions are treated by administering a polyamine transport inhibitor R-X-L-polyamine wherein R is a straight or branched C10-50 saturated or unsaturated aliphatic, carboxyalkyl... | 10/07/2008 |
| 7419972 | 2-substituted estra-1,3,5(10)-trien-17-ones as inhibitors of 17β-hydroxy steroid dehydrogenase type 1 The invention relates to new 2-substituted estra-1,3,5(10)-trien-17-ones of formula I as well as their pharmaceutically acceptable salts, their methods of manufacture and use as medicaments for prophylaxis and/or therapy of... | 09/02/2008 |
| 7411091 | N-acyl-N′-benzyl-alkylendiamino derivatives This invention is related to compounds and use of N-Acyl-N′-benzyl-alkylendiamino derivatives of the following general formula (I), wherein A is a straight or branched C2-C8 alkyl chain; X is a methylene, oxygen, sulphur or a NR7 g... | 08/12/2008 |
| 7402697 | Antibacterial agents D-(threo)-1-aryl-2-disubstitutedacylamido-3-fluoro-1-propanol compounds compounds and analogues thereof (“Fenicol Compounds”), compositions comprising an effective amount of a Fenicol Compound, and methods for treating or preventing a bacterial infection in an a... | 07/22/2008 |
| RE40360 | Methods for inhibition of angiogenesis with a composition comprising 3-hydroxythalidomide The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs, metabolites and hydrolysis products have been shown to inhibit angiogene... | 06/03/2008 |
| 7381416 | Selenohydroxy acids and their derivatives, applications in nutrition, cosmetics and pharmaceutics The purpose of this invention is: new selenohydroxy acid compounds and their derivatives; their process for the preparation; use of the new compounds as precursors of L(+)-selenomethionine and/or s... | 06/03/2008 |
| 7378446 | Compound having anti-HCV activity and process for producing the same The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its having a high degree of replication inhibitory activity against HCV,... | 05/27/2008 |
| 7378444 | Analogues of lipid mediators derived from omega-3 PUFAs and methods of use The present invention is directed to compounds that are analogues of lipid mediators derived from a fish oil-derived fatty acid, eicosapentaenoic acid [C20:5 ω-3; EPA], but with a longer tissue half-life and enhanced bioactivity. These analogues may be used to trea... | 05/27/2008 |
| 7371368 | Odor control composition and process The disclosure of this invention relates to odor control and more particularly, to a process and composition whereby household, institutional and industrial odors are eliminated wherein these odors are incorporated in a variety of substrates or are emitted from indu... | 05/13/2008 |
| 7316815 | Polyamino acid derivatives and use thereof in compositions for treating keratin fibers The invention concerns the use in a cosmetic composition of at least a poly-aminoacid of general formula (I) in which X is —O—, —S— or —NR3; R1 represents in particular a hydrogen atom or a C1-C40 alkyl radical; ... | 01/08/2008 |
| 7304092 | Compounds and methods for treating tumors, cancer and hyperproliferative diseases The present invention relates to novel compounds, pharmaceutical compositions and methods for treating tumors, cancer and hyperproliferative diseases including psoriasis, genital warts and hyperproliferative cell growth diseases, including hyperproliferative keratin... | 12/04/2007 |
| 7230018 | Substituted propane-1,3-diamine derivatives and the pharmaceutical use thereof Substituted propane-1,3-diamine derivatives, methods for producing such derivatives, and medicaments and pharmaceutical compositions containing such derivatives useful for the treatment or prophylaxis of pain, urinary incontinence, itching, tinitus aurium, or diarrh... | 06/12/2007 |
| 7208528 | Polyamine analogues as therapeutic and diagnostic agents Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine t... | 04/24/2007 |
| 7205261 | Use of certain N-acylethanolamines to achieve ethylene- and cytokinin-like effects in plants and fungi N-acylethanolamines (NAEs) that can deliver an ethylene- or cytokinin-like effect to a plant, plant part or fungus are disclosed. Also disclosed are methods of using the NAEs. ... | 04/17/2007 |
| 7201929 | Aspirin formulation for cardiovascular health The invention relates generally to an aspirin formulation which may comprise additional vitamins, minerals, herbs and supplements and methods for using the same for maintaining cardiovascular health. The aspirin formulation may comprise supplements such as vitamin B... | 04/10/2007 |
| 7202229 | Aspirin formulation for cardiovascular health The invention relates generally to an aspirin formulation which may comprise additional vitamins, minerals, herbs and supplements and methods for using the same for maintaining cardiovascular health. The aspirin formulation may comprise supplements such as vitamin B... | 04/10/2007 |
| 7202277 | Benzamidine derivatives having anti-inflammatory and immunosuppressive activity Compounds which can be represented by the general formula (I) indicated below: and in which: A is selected independently from the carboxamide group, the thiocarboxamide group, a... | 04/10/2007 |
| 7160334 | Composition for bleaching human hair A water-free composition for the bleaching and brightening of human hair at the same time with a simultaneous conditioning effect is disclosed. The particularly exceptional effects of the bleaching agent is that improvement of shine and elasticity. The bleaching age... | 01/09/2007 |
| 7161035 | Substituted biphenyl derivatives, method for preparing same and pharmaceutical compositions containing same The invention relates to compounds of formula (I): wherein: B represents a hydrogen atom, a COOR group, a CONRR′ group, or a (C1–C6)alkyl group substit... | 01/09/2007 |
| 7160923 | Polyamine analogues as therapeutic and diagnostic agents Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine t... | 01/09/2007 |
| 7157103 | Pharmaceutical formulation containing irritant Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse; and an effective amount of an irritant to impart an irritating sensation to an abuser upon administration of said dosage form after ... | 01/02/2007 |
| 7148260 | Water-based emulsifier wax gels including free sphingoid bases and oil in-water emulsion including the same Water-based emulsifier wax gels are provided that include skin-identical sphingolipids The present invention also provides a process for the preparation of such gels, the use of such gels for the preparation of oil-in-water emulsions, and the resulting emulsions tha... | 12/12/2006 |
| 7144587 | Pharmaceutical formulation containing opioid agonist, opioid antagonist and bittering agent Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of an opioid analgesic; an opioid antagonist; and a bittering agent in an effective amount to impart a bitter taste to an abuser upon administration of the dosage f... | 12/05/2006 |
| 7144897 | Hydroxy alkyl amines Disclosed are compounds of formula X, which are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising compounds of formula X and methods of preparing the compou... | 12/05/2006 |
| 7141250 | Pharmaceutical formulation containing bittering agent Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse; and an effective amount of a bittering agent to impart a bitter taste to an abuser upon administration of said dosage form after tam... | 11/28/2006 |
| 7138546 | Compounds and compositions for delivering active agents Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well. ... | 11/21/2006 |
| 7115624 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 The present invention provides a method of inhibiting a member of a family of Protein Tyrosine Phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTPα, PTPε, PTPμ, PTPδ, PTPσ, PTPζ, PTPβ, PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR, and HePTP ... | 10/03/2006 |
| 7108867 | Process for preparing particles A process for preparing particles of a substance, such as a protein or polypeptide, comprising: (a) preparing a first liquid comprising water, the substance and a modulator, wherein the modulator has a solubility in water which decreases with increasing temperature;... | 09/19/2006 |
| 7067127 | GIcNAc phosphotransferase of the lysosomal targeting pathway The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme. ... | 06/27/2006 |
| 7034058 | Anti-tumor pharmaceutical composition comprising N-vanillyl fatty acid amide The present invention provides an anti-tumor pharmaceutical composition having a high anti-tumor effect with low side-effects. The anti-tumor pharmaceutical composition comprises a N-vanillyl fatty acid amide of formula (1): ... | 04/25/2006 |
| 7011843 | Method for protecting a human being against health impairment by ingestion of a transdermal therapeutic system A method for the protection of a human being against any health impairment as a result of the ingestion of the whole or parts of a transdermal therapeutic system containing at least one pharmacologically active ingredient, which is toxic or induces nausea or addicti... | 03/14/2006 |
| 6969732 | Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, a method for their synthesis and pharmaceutical compositions containing them The present invention relates to racemic propylisopropyl acetic acid and propylisopropyl acetamide and their isomers in their racemic and stereospecific forms, for use in treatment of neurological and psychotic disorders, and affective disorders and to treat pain, h... | 11/29/2005 |
| RE38761 | Styryl compounds which inhibit EGF receptor protein tyrosine kinase A method of inhibiting cell proliferation in a patient suffering from such disorder comprising administering to said patient an effective amount of a composition comprising, in admixture with a pharmaceutically acceptable carrier, a compound, or a pharmaceutically a... | 07/19/2005 |
| 6905856 | Soluble GlcNAc phosphotransferase The present invention relates to a soluble GlcNAc phosphotransferase, a method of making the same and a method of phosphorylating with the same. ... | 06/14/2005 |
| 6888015 | Sphingolipid synthesis inhibitor A inhibitor of sphingolipids synthesis comprising a compound represented by general formula A. Desirably, a novel inhibitor of sphingolipids synthesis comprising (1R, 3R) N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl) alkaneamide, wherein carbon number of alkanoyl gro... | 05/03/2005 |
| 6884907 | Hydroxamic acids and acyl hydroxamines as naaladase inhibitors This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neurona... | 04/26/2005 |
| 6864285 | Covalent derivatives of alkanolamides of monocarboxylic and dicarboxylic acids functionally active on the CB2 cannabinoid receptor The present invention relates to novel covalent derivatives of alkanolamides of monocarboxylic and dicarboxylic acids with aminoalcohols of general formula (I) which can usefully be used as agonists of the CB2 cannabinoid receptor and hence as drugs active in pathol... | 03/08/2005 |
| 6846940 | Ceramides, compositions thereof and methods of use thereof Novel ceramide compounds, compositions containing them and the use of these compounds, in particular for strengthening the lipid barrier of the epidermis. ... | 01/25/2005 |
