Did You Know...
...that the x-ray was discovered purely by accident? When German physicist Wilhelm Konrad von Roentgen was experimenting with cathode rays in 1895, he put an activated Crookes tube in a book and went out to lunch. When he returned, he discovered that a key that had also been placed in the book showed up as an image on the developed film!
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| Number | Title | Issue Date |
| 7432302 | Composition containing polyamine transport inhibitor and use thereof Proliferative cutaneous disease states or conditions are treated by administering a polyamine transport inhibitor R-X-L-polyamine wherein R is a straight or branched C10-50 saturated or unsaturated aliphatic, carboxyalkyl... | 10/07/2008 |
| 7414152 | N-substituted p-menthane carboxamides Cooling compounds are provided having the formula: wherein, m is 0 or 1, Y and Z are selected independently from the group consisting of H, OH, C1-C4 straight or branched alkyl, and a C1-C4 straight or branched alkoxy, X is... | 08/19/2008 |
| 7208510 | Fungicidal combinations of active substances The present invention relates to fungicidally active compound combinations of a fluorobenzothiazole derivative of the formula (I) and at least one of the compounds listed in the disclosure. ... | 04/24/2007 |
| 7205331 | Fungicidal carboxamides Compounds of Formula I are disclosed which are useful as fungicides wherein X is —O—, —CH(R11)—or ═C(R11 | 04/17/2007 |
| 7115593 | Fungicidal combinations of active substances The present invention relates to active compound combinations of a fluorobenzo-thiazole of the formula (I) and at least one of the compounds listed herein. The active compound combinations of the present inventio... | 10/03/2006 |
| 7074833 | Use of the (1S,2R) enantiomer of milnacipran for the preparation of a drug A method for treating or preventing a disorder or a condition by double inhibition of serotonin (5-HT) and noradrenaline (NA) reuptake in a subject in need thereof, while limiting the risks of cardiovascular disturbances and/or organ and/or tissue toxicity, comprisi... | 07/11/2006 |
| 7053071 | Induction of apoptosis in cancer cells The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of... | 05/30/2006 |
| 7038085 | Stereoisomers of p-hydroxy-milnacipran, and methods of use thereof The present invention relates generally to the enantiomers of para-hydroxy-milnacipran or congeners thereof. Biological assays revealed that racemic para-hydroxy-milnacipran is approximately equipotent in inhibiting serotonin and norepinephrine uptake (IC50 | 05/02/2006 |
| 7034057 | Compounds for the treatment of inflammatory disorders This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-α or combi... | 04/25/2006 |
| 7005452 | Use of the dextrogyral enantiomer of milnacipran for the preparation of a drug The present invention concerns the use of a mixture of enantiomers enriched in the dextrogyral enantiomer of milnacipran and/or of at least one of its metabolites, as well as their pharmaceutically-acceptable salts, for the preparation of a drug intended to prevent ... | 02/28/2006 |
| 6995285 | ABCA-1 elevating compounds The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery dis... | 02/07/2006 |
| 6960687 | Derivatives and pharmaceutical compositions of n-hydroxyalkyl tetramethylcyclopropane-carboxamide, having anti-epiletic, neurological, and CNS activity, and method for their preparation New derivatives of N-Hydroxyalkyl-tetramethylcyclopropane carboxamide, pharmaceutical compositions thereof, methods for their preparation, and use thereof for the treatment of epilepsy, neurological, affective and psychotic disorders and for the treatment of pain an... | 11/01/2005 |
| 6872751 | Composition and method for augmenting or restoring the production of fetal protein in patient in need thereof The present invention relates to methods for prevention and/or treatment of diseases or conditions caused by deficiency in the adult isoform of a given protein wherein said method comprises administering to a patient in need thereof a composition containing NO or at... | 03/29/2005 |
| 6730635 | Microcapsule suspensions The invention relates to microcapsule suspensions containing (A) a particulate disperse phase of microcapsules comprising: (1) sleeves that are reaction products of mixtures of toluylene diisocyanate and 4,4′-methylenebis-(cyclohexyl isocyanate) with... | 05/04/2004 |
| 6703379 | Benzene derivatives and pharmaceutical use thereof The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammat... | 03/09/2004 |
| 6683114 | Treatment of psoriasis Norepinephrine reuptake inhibitors are used to treat psoriasis.... | 01/27/2004 |
| 6670400 | Phenoxyethylamine derivatives having high affinity for the 5-HT1A receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said derivatives Phenoxyethylamine derivatives of general formula (I) having high affinity for the 5-HT1A receptor, methods for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as gastric acid secretion inhib... | 12/30/2003 |
| 6602911 | Methods of treating fibromyalgia The present invention provides a method of treating fibromyalgia syndrome (FMS), chronic fatigue syndrome (CFS), and pain in an animal subject. The method generally involves administering a therapeutically effective amount of a dual serotonin norepinephri... | 08/05/2003 |
| 6441044 | Cycloalkyl carboxylic acid amides, their production and their use as fungicides in agriculture The present invention relates to cycloalkylcarboxamides of formula I ##STR1## where: A is optionally substituted C3 -C6 -cycloalkyl; Alk is straight-chain or branched C1 -C6 -alkylene; R1 is optionally substitu... | 08/27/2002 |
| 6313163 | 2,4-pentadienoic acid derivatives having retinoid-like biological activity Compounds of formula 1 ##STR1## wherein Z is selected from the group consisting of the radicals shown in Formula 2 and in Formula 3, ##STR2## Y is cyclopropyl optionally substituted with one or two R4 groups, the divalent Y radical being s... | 11/06/2001 |
| 6262104 | Diarylalkenylamine derivatives Compounds, or solvates or salts thereof, of formula (I): ##STR1## selective delta opioid agonists and antagonists and may be of therapeutic utility as analgesics, immunosuppressants to prevent rejection in organ transplant and skin graft, anti-allergic an... | 07/17/2001 |
| 6262091 | Process and agents for controlling harmful fungi Compositions for controlling harmful fungi, containing in a solid or liquid carrier a) at least one p-hydroxyaniline derivative of the formula I ##STR1## b) at least one amide compound of the formula II A--CO--NR8 --R9 (II) where the sub... | 07/17/2001 |
| 6251947 | Fungicidal carboxamides ##STR1## Compounds of Formula (I) are disclosed which are useful as fungicides, wherein Q is: (Q-1) or (Q-2), Z is (Z-1); (Z-2); (Z-3) or (Z-4); X is --O--, --CH(R11)-- or .dbd.C(R11)--; R1 is H or C1 -C | 06/26/2001 |
| 6235789 | Benzocycloalkene compounds, their production and use A compound of the formula ##STR1## wherein R1 and R2 are H, a hydrocarbon group or a heterocyclic group, or R1 and R2 are combinedly a spiro ring; R3 is a hydrocarbon group, a substituted amino group,... | 05/22/2001 |
| 6214869 | Heterocyclic cis cyclopropane derivatives as melatonergic agents There is provided a novel series of cis cyclopropane compounds of Formula I ##STR1## wherein R1, R2, R3, R4, X, Y, Z and m are as defined herein which bind to the human melatonin receptor and therefore are useful ... | 04/10/2001 |
| 6143789 | Naphthalene compounds Compound of formula (I): ##STR1## wherein: T represents alkylene, A and B together form a naphthalene, dihydronaphthalene, or tetrahydronaphthalene group, R represents hydrogen, hydroxy, R' or OR', R' being as defined in the description, G1 | 11/07/2000 |
| 6090854 | Aryloxyanilides and related compounds There is provided novel aryloxyanilides and related compounds of the formula ##STR1## wherein R1 is --OR, --CO2 R, or halogen with R being C1-4 alkyl; R2 is R, cyclopropyl, C2-4 alkenyl or --CH | 07/18/2000 |
| 6028112 | Spirocyclopropyl fluorenes as melatonergic agents There is provided novel spirocyclopropyl fluorene derivatives having the general Formula I ##STR1## wherein R, R1 and X are as defined herein which are useful as melatonergic agents.... | 02/22/2000 |
| 5965621 | Methods and compositions for reducing or maintaining body weight in a mammal A method for reducing or maintaining the level of adipose tissue formation in a mammal includes the step of administering a pantethine composition to the mammal in an amount and for a period of time sufficient to achieve a desired body weight. Composition... | 10/12/1999 |
| 5962413 | Treatment of uterine contractility disorders with a nitric oxide synthase substrate and/or donor, or a nitric oxide inhibitor Dysmenorrhea, disfunctional uterine bleeding, preterm labor and postpartum labor in female mammals are treated by inhibiting uterine contractility by administering thereto a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in comb... | 10/05/1999 |
| 5929119 | Fungicidal composition A composition which is suitable for controlling fungal pests, comprising conventional additives and an effective amount of a p-hydroxyaniline derivative of the general formula I ##STR1## where the substituents have the following meanings: R1 | 07/27/1999 |
| 5925674 | Cycloalkylcarboxanilides This invention relates to cycloalkylcarboxanilides of the formula ##STR1## which are used to combat pests.... | 07/20/1999 |
| 5922771 | Benzocycloalkene compounds, their production and use A compound of the formula ##STR1## wherein R1 and R2 independently represent H or an optionally substituted hydrocarbon group; R3 represents an optionally substituted hydrocarbon group; R4 represents H or a... | 07/13/1999 |
| 5885621 | Treatment of a hemoglobinopathy Disclosed are methods for treating a patient identified as having a hemoglobinopathy that is characterized by a reduced affinity of hemoglobin for oxygen. The methods involve providing gaseous nitric oxide and/or carbon monoxide for (i) inhalation by the ... | 03/23/1999 |
| 5880157 | Derivatives of tetramethylcyclopropane The present invention relates to derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid (TMCA) of general formula (I), ##STR1## wherein R is lower alkyl group (C1 -C6), an aryl group, an aralkyl group or an amide of... | 03/09/1999 |
| 5780512 | Alkylated (hetero) cyclic compounds The invention relates to a compounds selected from these of formula (I): ##STR1## in which: R1, R2, R3 and A are as defined in the description, and a medicinal product containing the same useful for treating a melaton... | 07/14/1998 |
| 5763466 | Fungicidal active compound combinations A novel fungicidal composition comprising a fungicidally effective amount of a combination consisting of (i) N-1-(4-chloro-phenyl)-ethyl!-2,2-dichloro-1-ethyl-3-methyl-cyclopropaneca rboxamide of the formula ##STR1## and (ii) (A) a triazole de... | 06/09/1998 |
| 5753709 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics Certain N-acyl 2-aryl cyclopropylmethylamine derivatives are useful as melatonergic agents.... | 05/19/1998 |
| 5736578 | Ethylamido fluorenes and improved method of making same Novel substituted fluorene compunds of Formula I are active as melatonergic agents: ##STR1## wherein: X=H, halogen, OH or OZ; Z=C1-6 alkyl; --(CH2)m --CF3 (m=0-2); CD3 ; or ##STR2## n=1 or 2... | 04/07/1998 |
| 5696150 | Fungicidal active compound combinations A novel fungicidal composition comprising a fungicidally effective amount of a combination consisting of (i) N-1-(4-chloro-phenyl)-ethyl!-2,2-dichloro-1-ethyl-3-methyl-cyclopropaneca rboxamide of the formula ##STR1## and (ii) (A) a triazole de... | 12/09/1997 |
