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| Number | Title | Issue Date |
| 8133915 | Interleukin-1 and tumor necrosis factor-α modulators; syntheses of such modulators and methods of using such modulators Described herein are chemical compounds and pharmaceutical compositions, including novel chemical compounds and pharmaceutical compositions thereof, useful in the treatment of various diseases and disease states. Also described are methods of synthesizing natural pr... | 03/13/2012 |
| 7432302 | Composition containing polyamine transport inhibitor and use thereof Proliferative cutaneous disease states or conditions are treated by administering a polyamine transport inhibitor R-X-L-polyamine wherein R is a straight or branched C10-50 saturated or unsaturated aliphatic, carboxyalkyl... | 10/07/2008 |
| 7244768 | Compositions and methods comprising prostaglandin related compounds and trefoil factor family peptides for the treatment of glaucoma with reduced hyperemia Compositions, methods, and pharmaceutical products related to prostaglandin-related compounds and trefoil factor family peptides are disclosed herein. Of particular interest are compositions and methods useful for the treatment of glaucoma with a reduced occurrence ... | 07/17/2007 |
| 7229473 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 06/12/2007 |
| 7202277 | Benzamidine derivatives having anti-inflammatory and immunosuppressive activity Compounds which can be represented by the general formula (I) indicated below: and in which: A is selected independently from the carboxamide group, the thiocarboxamide group, a... | 04/10/2007 |
| 7179943 | Bicyclic derivatives that modulate voltage-gated potassium channels and methods of use thereof Bicyclic amide derivatives of formula (I) or tautomers or pharmaceutically acceptable salts thereof or both are provided: Also provided are processes for preparing the bicyclic amide derivatives as well as pharma... | 02/20/2007 |
| 7138546 | Compounds and compositions for delivering active agents Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well. ... | 11/21/2006 |
| 7132457 | Adamantane derivatives The invention provides adamantane derivatives of formula (I), a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy. In formula (I) D represents CH2 ... | 11/07/2006 |
| 7053071 | Induction of apoptosis in cancer cells The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of... | 05/30/2006 |
| 7041702 | Pharmaceutically active compounds and methods of use The present invention relates to pharmaceutically acceptable compounds, including acylguanidine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly usefu... | 05/09/2006 |
| 6995285 | ABCA-1 elevating compounds The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery dis... | 02/07/2006 |
| 6963010 | Hydrophobic polyamine analogs and methods for their use The disclosed invention provides new polyamine analogs and derivatives containing a hydrophobic region and a polyamine region as well as methods and compositions for their use. ... | 11/08/2005 |
| 6906069 | LXR modulators The invention provides compounds, compositions and methods for modulating the effects of LXRα in a cell. The compounds and compositions are useful both as diagnostic indicators of LXRα function and as pharmacologically active agents. The compounds and compositions... | 06/14/2005 |
| 6756504 | Sphingolipids The invention relates to compounds of the general formula (I), as defined, and to pharmaceutical compositions containing them. The compounds of formula (I) are inhibitors of various lipid-related enzymes. They can be used in reducing accumulation of sphingoli... | 06/29/2004 |
| 6713650 | ABCA-1 elevating compounds The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery dis... | 03/30/2004 |
| 6713463 | Methods and compositions for treating and preventing mucositis A method of reducing or inhibiting mucositis in a patient, which includes administering an inflammatory cytokine inhibitor or a mast cell inhibitor, or a combination thereof, is disclosed. ... | 03/30/2004 |
| 6710081 | Erection insufficiency remedies Therapeutic agents for erectile dysfunction containing as the active ingredient prostaglandin derivatives of formula (I) (wherein symbols have the same meanings as described in the description), nontoxic salts thereof, o... | 03/23/2004 |
| 6670400 | Phenoxyethylamine derivatives having high affinity for the 5-HT1A receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said derivatives Phenoxyethylamine derivatives of general formula (I) having high affinity for the 5-HT1A receptor, methods for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as gastric acid secretion inhib... | 12/30/2003 |
| 6613771 | Method of treatment of viral infection including HIV using water soluble fullerenes A water soluble derivative of buckministerfullerene (C60) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieti... | 09/02/2003 |
| 6593312 | Cyclic -amino-γ-hydroxyamide compounds A compound of formula (I): ##STR1## wherein: ##STR2## represents an optionally substituted saturated carbon ring having from 4 to 8 ring members, R1 and R4, which may be identical or different, each represents hydrogen or acyl, ... | 07/15/2003 |
| 6562782 | Oligocycloalkanoid compounds and methods of use The present invention related to an oligocycloalkanoid compound comprising formula (I) ##STR1## wherein m, n, and o are independently an integer from 0 to 2; A1 through A10 are independently a direct link, alkylene, alkylene-O--, ... | 05/13/2003 |
| 6262091 | Process and agents for controlling harmful fungi Compositions for controlling harmful fungi, containing in a solid or liquid carrier a) at least one p-hydroxyaniline derivative of the formula I ##STR1## b) at least one amide compound of the formula II A--CO--NR8 --R9 (II) where the sub... | 07/17/2001 |
| 6242470 | Adamantane derivatives The invention provides adamantane derivatives, a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy.... | 06/05/2001 |
| 6235780 | ω-cycloalkyl-prostaglandin E1 derivatives (wherein R1 is OH etc.; X is Cl, F; R2 is H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl which may be substituted; n is 0-4.), non-toxic salts thereof or cyclodextrin clathrates thereof can strongly bind on EP2 subtype receptor... | 05/22/2001 |
| 6225353 | Method and composition for selectively inhibiting melanoma A composition and method of preventing or inhibiting tumor growth, and of treating malignant melanoma, without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, which is topically ap... | 05/01/2001 |
| 6214869 | Heterocyclic cis cyclopropane derivatives as melatonergic agents There is provided a novel series of cis cyclopropane compounds of Formula I ##STR1## wherein R1, R2, R3, R4, X, Y, Z and m are as defined herein which bind to the human melatonin receptor and therefore are useful ... | 04/10/2001 |
| 6096784 | Inhibitors of oleamide hydrolase Inhibitors of oleamide hydrolase, responsible for the hydrolysis of an endogenous sleep-inducing lipid (1, cis-9-octadecenamide) were designed and synthesized. The most potent inhibitors possess an electrophilic carbonyl group capable of reversibly formin... | 08/01/2000 |
| 6090853 | Fungicidally active carboxylic acid amides Carboxamides of the formula I ##STR1## where the substituents have the following meanings: R1 is unsubstituted or substituted bicycloalkyl, tricycloalkyl or bicycloalkenyl; R2,R3 and R4 are each, independen... | 07/18/2000 |
| 6060509 | Antifungal agents A pine root (Deutero mycetes) fungal metabolite and analogs thereof having antifungal activity.... | 05/09/2000 |
| 6048877 | Tetralone derivatives as antiarrhythmic agents Tetralone derivatives of the formula ##STR1## where R1 is halo, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, (aryl)alkenyl, (aryl)alkynyl, alkoxy, O-alkenyl, O-aryl, O-alkyl(heterocyclo), COO-alkyl,alkanoyl, CO-amino, CO-substituted amino, ... | 04/11/2000 |
| 5929119 | Fungicidal composition A composition which is suitable for controlling fungal pests, comprising conventional additives and an effective amount of a p-hydroxyaniline derivative of the general formula I ##STR1## where the substituents have the following meanings: R1 | 07/27/1999 |
| 5925674 | Cycloalkylcarboxanilides This invention relates to cycloalkylcarboxanilides of the formula ##STR1## which are used to combat pests.... | 07/20/1999 |
| 5880160 | Colchicine derivatives, the use thereof and formulations containing them The present invention relates to novel colchicine derivatives having antiproliferative, antineoplastic, antiinflammatory and muscle relaxant activities; said derivatives include novel colchine nitrogen amides for use either as such or after derivatization... | 03/09/1999 |
| 5827891 | HIV protease inhibtors HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain the... | 10/27/1998 |
| 5780512 | Alkylated (hetero) cyclic compounds The invention relates to a compounds selected from these of formula (I): ##STR1## in which: R1, R2, R3 and A are as defined in the description, and a medicinal product containing the same useful for treating a melaton... | 07/14/1998 |
| 5760023 | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations.... | 06/02/1998 |
| 5703129 | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of ଲ-amyloid protein production A series of 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives of Formula I have been synthesized. ##STR1## As inhibitors of the production of ଲ-amyloid protein from ଲ-amyloid precursor protein, these compounds are expected to be ... | 12/30/1997 |
| 5693630 | Phenylethyl and phenylpropylamines Compounds of the general formula ##STR1## or pharmaceutically acceptable salts thereof, wherein Z is a saturated or unsaturated 3 to 6 carbon chain, m is 2 or 3, R1 is a hydrogen atom, or a straight or branched C1-4 alkyl group,... | 12/02/1997 |
| 5684049 | HIV-inhibiting benzeneacetamide derivatives A compound for use as a medicine having the formula ##STR1## a pharmaceutically acceptable acid addition salt form or a stereochemically isomeric form thereof, wherein R1 and R2 each independently are hydrogen, C1-6 a... | 11/04/1997 |
| 5658947 | Method and composition for selectively inhibiting melanoma using betalinic acid A composition and method of inhibiting tumor growth and treating malignant melanoma without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, which is topically applied to the situs ... | 08/19/1997 |
