Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 7226948 | Treatment of neurodegenerative conditions with nimesulide The present invention relates to the use of nimesulide and structurally related compounds in the prevention and/or treatment of neurodegenerative conditions. It is based, at least in part, on the discovery that nimesulide exhibits a neuroprotective effect against β... | 06/05/2007 |
| 7115624 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 The present invention provides a method of inhibiting a member of a family of Protein Tyrosine Phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTPα, PTPε, PTPμ, PTPδ, PTPσ, PTPζ, PTPβ, PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR, and HePTP ... | 10/03/2006 |
| 6538016 | -sulfin-and -sulfonamino acid amides The invention relates to -sulfin- and -sulfonamino acid amides of the general formula I ##STR1## including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R1 is C1 -C12... | 03/25/2003 |
| 6482860 | Pentafluorobenzenesulfonamides and analogs The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of dis... | 11/19/2002 |
| 6476011 | Methods for introducing an estrogenic compound The invention pertains to methods for introducing an estrogenic compound into a subject in need thereof involving administering an effective amount of a ring system compound having the formula (II) ##STR1## wherein each of R1 and R2 ... | 11/05/2002 |
| 6436925 | Substituted benzamides, their production and their use as cysteine protease inhibitors Benzamides of the formula I ##STR1## and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings: R1 --C1 -... | 08/20/2002 |
| 6432986 | Compositions, kits, and methods for inhibiting cerebral neurovascular disorders and muscular headaches Methods, kits, and compositions for inhibiting a cerebral neurovascular disorder or a muscular headache in a human patient are provided. The methods comprise intranasally administering to the patient a pharmaceutical composition comprising a local anesthe... | 08/13/2002 |
| 6391918 | N-sulphonyl and N-sulphinyl phenylglycinamide Novel -amino acid amides of formula (I) as well as possible isomers and mixtures of isomers thereof, wherein the substituents are defined as follows: n is the number zero or one; R1 is optionally substituted alkyl, alkenyl, alkynyl, cycl... | 05/21/2002 |
| 6387954 | Alkenyl sulphonamide derivatives The present invention provides certain alkenyl sulphonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.... | 05/14/2002 |
| 6194463 | N-sulphonyl and N-sulphinyl amino acid amides as microbicides -Amino acid amides of formula (I) wherein the substituents are defined as follows: n is a number zero or one; R1 to R7 are as defined herein; R8 is C1 -C6 alkyl, C3 -C6 al... | 02/27/2001 |
| 6057322 | Basically-substituted benzoylguanidines, a process for preparing them, their use as a medicament or diagnostic agent, and a medicament containing them Compounds of the formula I ##STR1## and the pharmaceutically tolerated salts thereof, are described. A process for their preparation and their use as medicaments in cardiovascular diseases are also described.... | 05/02/2000 |
| 6031003 | Calcium receptor-active molecules The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can m... | 02/29/2000 |
| 5985930 | Treatment of neurodegenerative conditions with nimesulide The present invention relates to the use of nimesulide and structurally related compounds in the prevention and/or treatment of neurodegenerative conditions. It is based, at least in part, on the discovery that nimesulide exhibits a neuroprotective effect... | 11/16/1999 |
| 5756498 | Sulfonylalkanoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Sulfonylalkanoylamino hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. In accordance with the present invention, compounds of Formula (I) are disclosed ... | 05/26/1998 |
| 5708034 | Substituted sulfonimidamides, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them Substituted sulfonimidamides, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them Sulfonimidamides of the formula I ##STR1## in which at least one of the three substituents R(1), R(2) and R(3) is a ... | 01/13/1998 |
| 5607931 | 1,2-disubstituted ethly amides as inhibitors of ACAT Amides of the formula ##STR1## wherein: R1 is A and R2 is B; R1 is B and R2 is A; or R1 and R2 are independently selected from the group B; A is phenyl, substituted phenyl, heteroaryl, or s... | 03/04/1997 |
| 5470834 | Sulfoximine and suldodiimine matrix metalloproteinase inhibitors Novel sulfoximine and sulfodiimine matrix metalloproteinase inhibitors of the formula, ##STR1## wherein: R1 is selected from the group consisting of lower-alkyl, hydroxy lower-alkyl, amino lower-alkyl, carbamoyl lower-alkyl, lower-alkyl ... | 11/28/1995 |
| 5459149 | Penta-2,4-dienamides and use as pesticides The present Application discloses pesticidally active compounds of formula (I): Q(CH2)a (O)b Q1 CR2 =CR3 CR4 =CR5 CXNR1 Rx or a salt or propesticide t... | 10/17/1995 |
| 5368867 | Process for the accelerated production of stable solutions, in equilibrium, of peracetic acid in low concentrations The production of dilute equilibrium, storage stable solutions of peracetic acid from mixtures of aqueous hydrogen peroxide and acetic acid, or by dilution of more concentrated peracetic acid solutions, takes a long time because of the low concentrations ... | 11/29/1994 |
| 5270043 | Arthropodicidal composition comprising thiodicarb and a phenylpyrazole The invention provides arthropodicidal compositions comprising an arthropodicidally effective amount of (A) 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethyl sulfinylpyrazole and (B) thiodicarb, and methods of controlling arthropod... | 12/14/1993 |
| 5258406 | Sulfonimidamides This invention provides certain sulfonimidamide compounds, formulations and method of use of these compounds in treating susceptible neoplasms.... | 11/02/1993 |
| 4402980 | Sulphonic acid cycloalkylamides and their use as microbicides A N-sulphenylated sulphonic acid cyclohexylamide of the formula ##STR1## wherein R1 denotes lower alkyl, chloroalkyl or dialkylamino, R2 denotes a cycloalkyl radical which is optionally substituted by lower alkyl and X1, X... | 09/06/1983 |
| 4369192 | Animal feed and process A process for increased productivity in healthy animals comprising the administration of a compound of the formula ##STR1## or a pharmacologically acceptable acid addition salt thereof wherein R1 and R2 are the same or different... | 01/18/1983 |
| 4356194 | Animal feed and process A process for increased productivity in healthy animals comprising the administration of a compound of the formula ##STR1## or a pharmacologically acceptable acid addition salt thereof, wherein R1 is lower alkyl of from 1 to 4 carbon atoms... | 10/26/1982 |
| 4309425 | Miticidal, insecticidal, ovicidal and fungicidal N-(N',N'-diarylaminothio)sulfonamides Sulfonamides, such as N-[N-(2-chloro-5-(trifluoromethyl)phenyl]-N-[2,4-dinitro-6-(trifluoromethy l)phenyl]aminothio]-N,4-dimethylbenzenesulfonamide, are useful for control of arthropod pests of plants and animals and fungus disease of plants.... | 01/05/1982 |
| 4105795 | Antispasmodic substituted sulphoximides This invention provides compounds of the general formula I ##STR1## wherein R1 and R2 independently represent groups selected from the group consisting of straight chain alkyl groups; branched chain alkyl groups; aryl groups; op... | 08/08/1978 |
| 4066765 | Arthropodicidal formamidines Novel pesticidal compounds of the formula: ##STR1## wherein R1 is lower alkyl of from 1 to 4 carbon atoms; R2 is hydrogen, halogen or lower alkyl of from 1 to 4 carbon atoms; R3 and R4 are the same or diffe... | 01/03/1978 |
| 4034112 | Ethanolamine derivatives having ଲ-adrenergic blocking activity Novel 1-aryl-2-amidoalkylaminoethanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess ଲ-adrenergic blocking activity. Repre... | 07/05/1977 |
| 4020153 | Cyclic sulphonamides and sulphinamides having a physiological cooling effect Compositions are disclosed having a physiological cooling action on the skin. The compositions contain, as the active ingredient certain cyclic sulphonamides and sulphinamides.... | 04/26/1977 |
| 4004031 | Bis-(O-1-alkylthio-ethylimino)-N-methyl-carbamic acid)-N,N'-sulphide insecticides Compounds of the formula I ##STR1## wherein R represents a C1 -C5 -alkyl radical their manufacture and their use as pest control agents.... | 01/18/1977 |
| 3947591 | Pesticidal N,N"-thio and dithio bis(substituted phenyl formamidines) Novel pesticidal compounds of the formula: ##SPC1## Wherein R1 and R2 are the same or different and are selected from the group consisting of lower alkyl of from 1 to 4 carbon atoms; R3 and R4 are the same or di... | 03/30/1976 |
