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| Number | Title | Issue Date |
| 8183204 | Methods and compositions for increasing skin remodeling Skin remodeling is stimulated at the site of blemished skin using an ionic metal-peptide complex to diminish or remove the skin imperfection. The blemish can be a scar, especially surgical or wound scars, acne scars, keloid scars, and the like, or a skin tag, callus... | 05/22/2012 |
| 8129338 | Nitric oxide-blocked cross-linked tetrameric hemoglobin The present invention includes compositions containing carboxamidomethylated cross-linked hemoglobin where the cysteine moiety of the hemoglobin includes a thiol protecting group and where the hemoglobin has a reduced ability to bind with nitric oxide. Preferably, t... | 03/06/2012 |
| 8097585 | Methods of treating inflammation by administration of heme oxygenase-1 and products of heme degradation The present invention relates to the treatment of disorders using heme oxygenase-1 and heme degradation products. ... | 01/17/2012 |
| 8030272 | Lactoferrin compositions and methods of wound treatment The present invention relates to lactoferrin compositions and methods of using the compositions to treat wounds. The compositions can be administered alone or in combination with other standard wound healing therapies. ... | 10/04/2011 |
| 7906480 | Use of a parathyroid hormone peptide analogs for the treatment of vaginal atrophy The invention features methods for the treatment of vaginal atrophy by administering a parathyroid hormone peptide or peptide analog and formulations thereof. ... | 03/15/2011 |
| 7893024 | Enhancement of iron chelation therapy The present invention provides methods of enhancing the rate of iron release from ferritin. By increasing the amount of iron available for chelation, the invention also provides methods of treating conditions associated with iron overload. The invention also provide... | 02/22/2011 |
| 7759306 | Methods of treating acute blood loss The present invention relates to novel methods of using blood substitutes to treat acute blood loss and novel pharmaceutical compositions comprising blood substitutes. Blood substitutes useful for the methods of the present invention can (1) induce expression of ery... | 07/20/2010 |
| 7754684 | Macromolecular platinum chelates The present invention relates to platinum complex chemotherapeutic compounds having the generic structure: wherein n is 0 or 1 and, preferably, one of R1, R2, R3 or R8 is a -(link... | 07/13/2010 |
| 7691809 | Lactoferrin for age related disorders in humans The method of the present invention provides a novel use of lactoferrin to modulate the molecular events during development of age-related disorders in humans. More specifically, the present invention is directed to the use of lactoferrin to treat or prevent autoimm... | 04/06/2010 |
| 7655620 | Use of one or more metal carriers to selectively kill mammalian cells Compositions and methods for decreasing the viability of cells, particularly aberrant non-healthy cells, and most particularly cancer cells, are disclosed. The primary agent that causes cell death is a toxic metal atom or ion. Embodiments of the invention provide co... | 02/02/2010 |
| 7642233 | Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein The present disclosure relates to the use of AHSP to stabilize the α subunit of rHb. AHSP may be co-expressed with the hemoglobin genes. AHSP stabilization may be used to increase the production of intact rHb in various systems, such as E. coli, other microo... | 01/05/2010 |
| 7638487 | Lactoferrin in the reduction of pain The present invention relates to methods of using lactoferrin (LF) to reduce pain in conditions associated with severe or intractable pain by administering a composition of lactoferrin either alone or in combination with other therapy for pain. ... | 12/29/2009 |
| 7622439 | Method to enhance hemodynamic stability using oxygen carrying compositions The present invention relates to methods for enhancing the hemodynamic stability of an individual undergoing surgery by administering a composition comprising a hemoglobin-based oxygen carrier. In one embodiment, the present invention relates to the use of polyalkyl... | 11/24/2009 |
| 7598220 | Use of hyperpolymeric hemoglobin for the treatment of pulmonary edema This invention relates to the use of hypo-oncotic aqueous solutions of molecularly dispersed chemically modified high molecular weight crosslinked hemoglobins, namely so-called hemoglobin hyperpolymers, to prepare agents for the symptomatic, primarily life-saving tr... | 10/06/2009 |
| 7528108 | Compositions and methods for treating or preventing overweight or obesity with zinc-charged protein fragments Compositions and methods for treating or preventing, for example, overweight or obesity are provided. Compositions provided comprise zinc-charged, protease digested serum or milk proteins. Compositions are administered in a therapeutically effective amount to treat ... | 05/05/2009 |
| 7524814 | Lactoferrin compositions and methods of wound treatment The present invention relates to lactoferrin compositions and methods of using the compositions to treat wounds. The compositions can be administered alone or in combination with other standard wound healing therapies. ... | 04/28/2009 |
| 7521417 | Method and apparatus for preparing an acellular red blood cell substitute A process is disclosed for the preparation of an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin. Also disclosed is an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin product cap... | 04/21/2009 |
| 7504377 | Nitric oxide-blocked cross-linked tetrameric hemoglobin The present invention includes compositions containing carboxamidomethylated cross-linked hemoglobin where the cysteine moiety of the hemoglobin includes a thiol protecting group and where the hemoglobin has a reduced ability to bind with nitric oxide. Preferably, t... | 03/17/2009 |
| 7494974 | Carboxymethylated cross-linked tetrameric hemoglobin The present invention includes compositions containing carboxymethylated cross-linked hemoglobin where the cysteine moiety of the hemoglobin includes thiol protecting group and where the hemoglobin is incapable of binding with the nitric oxide. Preferably, the hemog... | 02/24/2009 |
| 7435795 | Stabilized hemoglobin solutions A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system furt... | 10/14/2008 |
| 7417023 | Targeted delivery of bioaffecting compounds for the treatment of cancer A homogeneous conjugate for targeting and treating diseased cells wherein the conjugate comprises an anti-cancer drug and a targeting protein, wherein said anti-cancer drug is selected from the group consisting of heat sensitizers, photosensitizers and apoptosis ind... | 08/26/2008 |
| 7411044 | Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer t... | 08/12/2008 |
| 7396814 | Metallopeptide compositions for treatment of sexual dysfunction Metallopeptide compositions are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. The metallopeptides include at least one, and preferably two, aromatic amino acid... | 07/08/2008 |
| 7384916 | Methods and compositions for preventing and treating aging or photodamaged skin Disclosed are methods for treating aging and photodamaged skin employing topical application of compositions which comprise at least one peptide manganese complex. Also disclosed are methods wherein the composition further comprises retinol, at least one retinol der... | 06/10/2008 |
| 7375080 | Immobilized lactoferrin (Im-LF) antimicrobial agents and uses thereof Disclosed is a composition of matter comprising a defined dispersion of lactoferria immobilized on a naturally occuring substrate via the N-terminus region of the lactoferrin. Compositions comprising immobilized lactoferrin (Im-LF) are used in a method for reducing ... | 05/20/2008 |
| 7371411 | Methods for production of the oxidized glutathione composite with CIS-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells The present invention relates to a composite for the treatment of a variety of medical conditions, the composite comprising an oxidized glutathione-based compound, which has a disulfide bond, and a metal material, in particular where the metal is either platinum or ... | 05/13/2008 |
| 7371728 | Prostate-specific antigen probes for optical imaging This invention provides a novel probe, which contains a prostate peptide substrate. The probe can be used as a prostate diagnostic agent for optical imaging. An 11 amino acid peptide substrate is synthesized for specific prostate-specific antigen (PSA). This protect... | 05/13/2008 |
| 7368099 | MRI contrast agents An MRI contrast agent enables direct detection and imaging of exfoliated vascular endothelial sites. The MRI contrast agent includes an imaging unit which contains an unpaired electron-carrying atom and/or molecule and is capable of amplifying or reducing MRI signal... | 05/06/2008 |
| 7368141 | Process of isolating lactoferrin A process for isolating lactoferrin from milk or a casein-containing component or product containing lactoferrin, comprising subjecting a precipitate of casein obtained from the milk of the casein-containing component or product, with which precipitate at least part... | 05/06/2008 |
| 7357914 | Use of metal chelates in human or animal feeding The present invention relates to the use in human and animal nutrition (monogastric and polygastric animals) of known chelates of bivalent metal Mg, Ca, Mn, Co, Cu, Zn and Fe with methionine hydroxy analogue. The present invention further relates to a method for pre... | 04/15/2008 |
| 7351690 | Knockout identification of target-specific sites in peptides The invention provides methods for identification and determination of target-specific sites in peptides and proteins, including a method for determining the primary sequence of a secondary structure within a known parent polypeptide that binds to the target of inte... | 04/01/2008 |
| 7332158 | Compositions and treatments for myelosuppression by ex vivo activated immune cells The disclosure includes protocols of activating and administering human blood cells to myelosuppressed patients, including patients treated for cancer, e.g., by chemotherapy or radiation. The protocol may include culturing blood cells in the presence of a cytokine a... | 02/19/2008 |
| 7332320 | Protease producing an altered immunogenic response and methods of making and using the same The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that encode novel variants, host cells comprising DNA encoding novel variants... | 02/19/2008 |
| 7329402 | Methods of imaging and treatment Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The... | 02/12/2008 |
| 7329641 | Blood substitutes The functional characteristics of heme proteins can be modified to produce hemoglobins that can be used as blood substitutes in different therapeutic applications. Stable polymers of tetrameric hemoglobin, and of myoglobin molecules, are provided for use in the bloo... | 02/12/2008 |
| 7326775 | Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions A method of preparing an ultra-cleansed lactoferrin preparation, termed treatment for contaminant reduction (TCR) is provided which includes the steps of treating commercial lactoferrin preparation with at least one each of surfactants, antioxidants and polyphenols ... | 02/05/2008 |
| 7323443 | Lactoferrin in the reduction of pain The present invention relates to methods of using lactoferrin (LF) to reduce pain in conditions associated with severe or intractable pain by administering a composition of lactoferrin either alone or in combination with other therapy for pain. ... | 01/29/2008 |
| 7323442 | Agents for alleviating symptoms accompanied by inflammation The present invention provides agents for alleviating symptoms resulting from inflammation, which have an activity to alleviate inflammatory symptoms caused by bacterial infection, particularly accumulation of body fluid such as bronchocavemous plasma exudation, asc... | 01/29/2008 |
| 7318931 | Sustained release formulation A composition comprises a protein, a polyol, and a metal. The protein is stabilized by the polyol and the metal, and is protected from denaturing when in contact with an organic solvent. The polyol may be a hydrocarbon containing two or more hydroxyl groups (—OH) ... | 01/15/2008 |
| 7319092 | Methods of suppressing microglial activation Methods of suppressing the activation of microglial cells in the Central Nervous System (CNS), methods of ameliorating or treating the neurological effects of cerebral ischemia or cerebral inflammation, and methods of combating specific diseases that affect the CNS ... | 01/15/2008 |
