Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 8461208 | Bis(thio-hydrazide amide) salts for treatment of cancers Disclosed are bis(thio-hydrazide amide) disalts and pharmaceutical compositions thereof. Also disclosed are methods of using bis(thio-hydrazide amide) disalts to treat cancer. ... | 06/11/2013 |
| 8394858 | Cyclohexane derivatives and uses thereof The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active a... | 03/12/2013 |
| 8148426 | Bis(thio-hydrazide amides) for increasing Hsp70 expression A method of treating a Hsp70-responsive disorder in a subject includes administering to the subject an effective amount of a compound represented by Structural Formula I, or a pharmaceutically acceptable salt or solvate thereof. ... | 04/03/2012 |
| 8048925 | Bis(thio-hydrazide amide) salts for treatment of cancers Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I): Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R1-R4 are inde... | 11/01/2011 |
| 7939564 | Combination with bis(thiohydrazide amides) for treating cancer Disclosed herein are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with hyperthermia treatment. Also disclosed are ... | 05/10/2011 |
| 7795313 | Bis(thio-hydrazide amide) salts for treatment of cancers Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I): Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R1 | 09/14/2010 |
| 7763658 | Treatment for cancers One embodiment of the present invention is a method of treating a subject with a multi-drug resistant cancer. The method comprises administering to the subject an effective amount of a compound represented by Structural Formula (I): ... | 07/27/2010 |
| 7678832 | Bis(thio-hydrazide amide) formulation Disclosed herein are compositions comprising a compound represented by structural formula (I): 2 g of which is reconstitutable in 10 mL of a water in less than 10 minutes, and methods for preparing these compositions. ... | 03/16/2010 |
| 7671092 | Paclitaxel enhancer compounds Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken... | 03/02/2010 |
| 7632865 | Thioamides and salts thereof and cytokine production inhibitors containing both To provide cytokine production inhibitors useful as preventive or therapeutic medicines for diseases accompanied by hyperactivated immune functions. A cytokine production inhibitor containing, as an active ingredient, a thioamide compound represented by the f... | 12/15/2009 |
| 7425649 | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia. ... | 09/16/2008 |
| 7385084 | Bis(thio-hydrazide amide) salts for treatment of cancers Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I): Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R1-R4 are inde... | 06/10/2008 |
| 7368473 | Paclitaxel enhancer compounds One embodiment of the present invention is a compound represented by the Structural Formula (I): Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with b... | 05/06/2008 |
| 7345094 | Paclitaxel enhancer compounds Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken... | 03/18/2008 |
| 7303792 | Diaminobenzene derivative, polyimide precursor and polyimide obtained therefrom, and aligning agent for liquid crystal The present invention provides a novel diamine which is especially useful as a material for a resin for a liquid crystal alignment film, a polyimide precursor and a polyimide synthesized by using the diamine, and a treating agent for liquid crystal alignment contain... | 12/04/2007 |
| 7288262 | Composition comprising a cyclohexane-based compound, compound and use of said compound to structure a composition Compositions, in particular cosmetic compositions, comprising a cyclohexane-based compound defined by formula (I): wherein: R, which may be identical or different, are each chosen from hydrogen atoms an... | 10/30/2007 |
| 7282599 | Dithiocarbamate antiviral agents and methods of using same The invention discloses a use of dithiocarbamate compounds having the structural formula R1R2NCS2H, in which R1 and R2, independently of each other, represent a straight or branched C1-C4 a... | 10/16/2007 |
| 7253175 | Method for treating athlete's foot A method of treating a patient having a fungal infection comprises administering an effective fungal infection treatment amount of an antiviral agent, such as valacyclovir, to eliminate the symptoms of the fungal infection. ... | 08/07/2007 |
| 7138140 | Suplatast tosilate crystals Provided are a suplatast tosilate crystal showing characteristic peaks in powder X-ray diffraction diffraction angles (20±0.1°) of 5.6°, 9.0°, 11.0°, 15.3°, 16.5°, 17.2°, 17.9°, 19.2°, 19.9°, and 21.5°; and a preparation process of the crystal. Owing to ... | 11/21/2006 |
| 7135465 | Sustained release beadlets containing stavudine Extended dosage forms of stavudine are provided comprising beadlets formed by extrusion-spheronization and coated with a seal coating. The beadlets are also coated with a modified release coating such that a hard gelatin capsule containing such beadlets will provide... | 11/14/2006 |
| 7105545 | N-p-propargyloxyphenethyl-thioacetic acid amides The invention relates to N-propargyloxy-phenethyl thioacetic acid amide derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R | 09/12/2006 |
| 7074952 | Synthesis of taxol enhancers Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound. The hydrazide starting compound is represented by Structural Formula (I): The thiohydrazide product compound... | 07/11/2006 |
| 7049317 | CCR-3 receptor antagonists The invention provides compounds of Formula (I): wherein R1–R4 have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions containi... | 05/23/2006 |
| 7037940 | Taxol enhancer compounds Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, t... | 05/02/2006 |
| 7005546 | Acetamidobenzamide compounds for neurodegenerative disorders A group of benzamide compounds are disclosed which are useful for treating neurodegenerative disorders. Methods for making these compounds are provided. These materials are formed into pharmaceutical compositions for oral or intravenous administration to patients su... | 02/28/2006 |
| 7001923 | Taxol enhancer compounds One embodiment of the present invention is a compound represented by the Structural Formula (I): Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together wi... | 02/21/2006 |
| 6977070 | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system Buccal aerosol sprays or capsules using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention co... | 12/20/2005 |
| 6969508 | Buccal, polar and non-polar spray or capsule containing drugs for treating pain Buccal aerosol sprays or capsules using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention co... | 11/29/2005 |
| 6939855 | Anti-inflammatory compositions and method The disclosed invention includes pharmaceutical compositions and methods for treating inflammatory conditions, particularly those that are characterized by increased binding of alpha-9 integrin to one or more of its ligands. Also disclosed are methods for selecting ... | 09/06/2005 |
| RE38761 | Styryl compounds which inhibit EGF receptor protein tyrosine kinase A method of inhibiting cell proliferation in a patient suffering from such disorder comprising administering to said patient an effective amount of a composition comprising, in admixture with a pharmaceutically acceptable carrier, a compound, or a pharmaceutically a... | 07/19/2005 |
| 6825235 | Synthesis of taxol enhancers Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound. The hydrazide starting compound is represented by Structural Formula (I): The thiohydrazide product compound is re... | 11/30/2004 |
| 6762204 | Taxol enhancer compounds One embodiment of the present invention is a compound represented by the Structural Formula (I): Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together w... | 07/13/2004 |
| 6740681 | Pharmaceutical compositions comprising thiram Thiram (tetramethyliuram disulfide) is shown to inhibit angiogenesis and/or inflammation and to be useful in the treatment of angiogenesis-dependent disorders, including neoplasms, and in the inhibition, treatment and allevation of inflammation associated with sever... | 05/25/2004 |
| 6716881 | Carbanilides used as pesticides The present invention provides carbanilides of formula (I), wherein A, Q, R, X, Z and m are as defined herein. A plurality of processes for preparing these compounds is provided, along with methods of using the compounds... | 04/06/2004 |
| 6710086 | Protected forms of pharmacologically active agents and uses therefor In accordance with the present invention, there are provided conjugates of dithiocarbamates “DC”) and pharmacologically active agents (e.g., NSAIDs). Invention conjugates provide a new class of pharmacologically active agents (e.g., anti-inflammatory agents) whi... | 03/23/2004 |
| 6656971 | Trisubstituted carbocyclic cyclophilin binding compounds and their use The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invention further relate... | 12/02/2003 |
| 6596770 | Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor The present invention provides a novel dithiocarbamamte disulfide dimer useful in various therapeutic treatments, either alone or in combination with other active agents. In one method, the disulfide derivative of a dithiocarbamate is coadministered with ... | 07/22/2003 |
| 6589991 | Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor The present invention provides a novel dithiocarbamamte disulfide dimer useful in various therapeutic treatments, either alone or in combination with other active agents. In one method, the disulfide derivative of a dithiocarbamate is coadministered with ... | 07/08/2003 |
| 6573284 | Method of treating melanoma Novel pro-drugs and assay reagents are provided which are useful as therapeutic agents especially for delivery and targetting therapeutically active agents to melanoma cells. The pro-drugs and assay reagents are substrates for tyrosinase and may be repres... | 06/03/2003 |
| 6509379 | Phenylacetic acid derivatives, process and intermediate products for their preparation, and their use as fungicides and pesticides Phenylacetic acid derivatives of the formula I ##STR1## where the variables are as disclosed herein, their salts, processes and intermediates for their preparation, and their use for controlling harmful fungi and animal pests.... | 01/21/2003 |
