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| Number | Title | Issue Date |
| 7863332 | Biaromatic compound activators of PPARγ receptors and cosmetic/pharmaceutical compositions comprised thereof Novel biaromatic compounds having the general formula (I): and cosmetic/pharmaceutical compositions comprised thereof are useful in human or veterinary medicine (in dermatology and also in the fields of cardiovascular disea... | 01/04/2011 |
| 7825162 | Abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease A method for treating cardiovascular disease, including hyperlipidemia and atherosclerosis, using abietane diterpenoid compound or terpenoid compound isolated from Torreya nucifera as an effective ingredient. The abietane diterpenoid compound or terpenoid com... | 11/02/2010 |
| 7612113 | Hydroxy tetrahydro-naphthalenylurea derivatives This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as VR1 antagonist and us... | 11/03/2009 |
| 7423175 | Hydroxy-tetrahydro-naphthalenylurea derivatives This invention relates to hydroxy-tetrahydro-naphthalenylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The hydroxy-tetrahydro-naphthalenylurea derivatives of the present invention have an excellent activity... | 09/09/2008 |
| RE39866 | Nonpeptide insulin receptor agonists Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula wherein ... | 10/02/2007 |
| 7172803 | Laser markable carrier unit The present invention relates to the laser inscription of a flexible inner support layer of a multilayered support unit, which is distinguished by the fact that the laser inscription of the inner support layer is carried out through one or more flexible outer laser-... | 02/06/2007 |
| 7115664 | Peptidomimetic ligands for cellular receptors and ion channels One aspect of the present invention relates to novel peptidomimetic compounds. A second aspect of the present invention relates to the use of the novel peptidomimetic compounds as ligands—agonists or antagonists—for various cellular receptors, e.g., G-protein-co... | 10/03/2006 |
| 7109243 | Inhibitors of cathepsin S The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme (e.g., cathespin K). The present inven... | 09/19/2006 |
| 7105567 | 3-substituted urea derivatives and medicinal use thereof The present invention relates to a urea derivative of the formula (1) wherein each symbol is as described in the specification, a pharmaceutically acceptable salt thereof and pharmaceutical use thereof. The compo... | 09/12/2006 |
| 6992106 | Anti-tumor composition The present invention provides composition having as active ingredients a stilbene derivative and a platinum coordination compound which is highly efficacious and highly safe for treating tumors, particularly for the treatment of solid or malignant tumors and thus m... | 01/31/2006 |
| RE38915 | Nonpeptide insulin receptor agonists Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula wherein ... | 12/06/2005 |
| 6933272 | Use of non-peptidyl compounds for the treatment of insulin related ailments The present invention relates to the use of at least a non-peptidyl compound as a biological modulator of insulin activity or insulin-related activity, which compound possesses ionic and hydrophobic chemical moieties spatially located so as to mimic at least an ioni... | 08/23/2005 |
| 6933320 | Combination comprising combretastatin and anticancer agents An antitumor combination comprising a stilbene derivative and an anticancer compound selected from the group consisting of taxanes, alkylating agents, antimetabolites, vinca alkaloids, platinum compounds, epidophylloptoxins, and antibiotics as the active ingredients... | 08/23/2005 |
| 6864380 | Benzylcycloalkyl amines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of inflammatory diseases such as asthma and other allergic diseases. | 03/08/2005 |
| 6852738 | Acyl sulfamides for treatment of obesity, diabetes and lipid disorders A class of acyl sulfamides comprises compounds that are potent ligands for PPAR gamma and generally have antagonist or partial agonist activity. The compounds may be useful in the treatment, control or prevention of obesity, non-insulin dependent diabetes mellitus (... | 02/08/2005 |
| 6838472 | Substituted urea retinoid agonists The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders and methods for de... | 01/04/2005 |
| 6822001 | Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents Combination therapies are provided for the treatment of proliferative disorders which use a pentafluorobenzenesulfonamide of formula I and an antineoplastic agent such as gemcitabine or paclitaxel. ... | 11/23/2004 |
| 6815556 | Compounds having fungicidal activity and processes to make and use same A compound according to formula one that is useful as a fungicide is provided. Additionally, processes to make and use same are provided. ... | 11/09/2004 |
| 6777561 | Compounds Compounds of general formula I are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy... | 08/17/2004 |
| 6696487 | Fungicidal phenyl(thio)urea and phenyl(thio)carbamate derivatives The invention relates to compounds of formula (I), and also to salts thereof, which have fungicidal activities: ##STR1## in which the various radicals and substituents are as defined in the description, and also to the fungicidal compositions containing t... | 02/24/2004 |
| 6670400 | Phenoxyethylamine derivatives having high affinity for the 5-HT1A receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said derivatives Phenoxyethylamine derivatives of general formula (I) having high affinity for the 5-HT1A receptor, methods for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as gastric acid secretion inhib... | 12/30/2003 |
| 6664259 | Il-8 receptor antagonists This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).... | 12/16/2003 |
| 6624117 | Heat sensitive recording material A heat sensitive recording material, comprising a) at least one colour forming compound, and b) at least one developer of the formula ##STR1## wherein R1 is unsubstituted or substituted phenyl, naphthyl or C1 -C20 | 09/23/2003 |
| 6608052 | Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds of the formula(I) wherein G, E, W, Ar, X, Y and Z. The compounds are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceut... | 08/19/2003 |
| 6569895 | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders Tetrahydrofurans, tetrahydrothiophenes, pyrrolidines and cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune res... | 05/27/2003 |
| 6566304 | Biogenic control and limitation of the reproduction of parasitic earth nematodes in stock culture The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a) to (b) as a soil additive for biologically controlling pla... | 05/20/2003 |
| 6525091 | Substituted diarylureas as stimulators for Fas-mediated apoptosis Substituted diarylureas, pharmaceutical compositions containing them, and their use for stimulating Fas-mediated apoptosis. The compounds, as single stereoisomers or mixtures of stereoisomers, their pharmaceutically acceptable salts, and pharmaceutical co... | 02/25/2003 |
| 6515021 | Bicyclic aromatic compounds The invention relates to novel bicyclic aromatic compounds which have the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumati... | 02/04/2003 |
| 6492428 | Compounds having MIF antagonist activity There are disclosed methods of use and pharmaceutical compositions for two related genera of low molecular weight compounds comprising optionally substituted iminoquinone or orthoquinone ring systems. The compounds have MIF (macrophage migration inhibitor... | 12/10/2002 |
| 6492419 | Aqueous insecticidal pour-on formulation A topically acceptable aqueous pour-on formulation adapted for localized external application to an animal, which format includes an effective amount of a water insoluble insect growth regulator (IGR), a suspending agent, a surfactant or mixture of surfac... | 12/10/2002 |
| 6479519 | Substituted anilides The invention is directed to physiologically active compounds of formula (I): ##STR1## wherein: R1 is hydrogen, halogen, hydroxy, lower alkyl or lower alkoxy; X1, X2 and X6 independently represent N or CR10 | 11/12/2002 |
| 6462087 | Anti-tumor composition The present invention provides composition having as active ingredients a stilbene derivative and a platinum coordination compound which is highly efficacious and highly safe for treating tumors, particularly for the treatment of solid or malignant tumors... | 10/08/2002 |
| 6387906 | 2,4,4-trisubstituted-1,3-dioxolane antifungals The present invention concerns novel compounds of formula ##STR1## a N-oxide form, a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein n is zero, 1, 2 or 3; X is N or CH; each R1 independently i... | 05/14/2002 |
| 6329431 | Nonpeptide insulin receptor agonists Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula ##STR1## wherein each A is independently a ... | 12/11/2001 |
| 6316478 | IL-8 receptor antagonists This invention relates to novel spiro compound derivatives of benzoisothiazolyl-urea and -thiourea and compositions thereof. These compounds are useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).... | 11/13/2001 |
| 6310074 | Substituted dimeric compounds The invention relates to compound of formula (I): A--G1 --Cy--G2 --Cy'--G3 --B (I) wherein: A represents a grouping NR1 C(Q)R2, C(Q)NR2 R3 or NR1 C(Q)NR2 R3 | 10/30/2001 |
| 6150415 | Epoxide hydrolase complexes and methods therewith Biologically stable inhibitors of soluble epoxide hydrolases are provided. The inhibitors can be used, for example, to selectively inhibit epoxide hydrolase in therapeutic applications such as treating inflammation, for use in affinity separations of the ... | 11/21/2000 |
| 6147116 | Polyaromatic antiviral compositions The present invention relates to polyaromatic compounds having useful antiviral activity against viruses of the herpes family, to a composition containing them, and to a method of using them for the treatment of herpes viruses infections.... | 11/14/2000 |
| 6133319 | IL-8 receptor antagonists This invention relates to the use of phenyl ureas of formulas (I) and (II) in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8). The variables of (I) and (II) are defined herein. ##STR1##... | 10/17/2000 |
| 6103761 | Agents acting at cholecystokinin receptors The invention concerns a series of novel bis-urea derivatives, nonpeptides, which show good binding affinity for the CCK-B receptor. The compounds, compositions containing them, methods of preparation, and utilities including anxiety, gastric acid secreti... | 08/15/2000 |
