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| Number | Title | Issue Date |
| 8110607 | Process for producing 1,4-dihydroxy-2-naphthoic acid A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This comp... | 02/07/2012 |
| 8101662 | Treatment of cancer with specific RXR agonists A method of treating cancer is disclosed comprising administering to a patient in need of such treatment a RXR agonist at a level below the RAR activating threshold and at or above the RXR effective dose. ... | 01/24/2012 |
| 8076375 | Methods of inhibiting poxvirus growth This disclosure ascribes new functions to derivatives of tetralin, anthraquinone, naphthylamine, tri-amino-pyrimidine, xanthen-3-one, and/or cinnamic acid (including, for example, NSC270718R, NSC117285R, NSC170008Y, NSC306711P, NSC119913X, NSC119915Z, NSC119911V, NS... | 12/13/2011 |
| 8044099 | Synthetic bifunctional molecules containing drug moiety and pharmacokinetic modulating moiety Bifunctional molecules and methods for their use are provided. The subject bifunctional molecules are conjugates of a drug moiety and a pharmacokinetic modulating moiety, where these two moieties are optionally joined by a linking group. The bifunctional molecules a... | 10/25/2011 |
| 7868044 | Method for the treatment of acne using compositions comprising 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid Dermatological disorders having an inflammatory or proliferative component, notably common acne, are treated with topically applicable pharmaceutical compositions containing about 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) o... | 01/11/2011 |
| 7838558 | Administration of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid for the treatment of dermatological disorders Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) or salt thereof, formulated into p... | 11/23/2010 |
| 7834060 | Administration of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphtoic acid for the treatment of dermatological disorders Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) or salt thereof, formulated into p... | 11/16/2010 |
| 7834061 | Process for producing 1,4-dihydroxy-2-naphthoic acid A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This comp... | 11/16/2010 |
| 7795311 | Methods and compositions for the management of soil-borne fungal diseases Improved methods and compositions for protecting plants or seeds from soil-borne fungal diseases. The composition may include a triterpenoid isolated from Glycyrrhiza glabra and a polymer. The triterpenoid may be Carbenoxolone disodium salt, and the polymer m... | 09/14/2010 |
| 7754767 | Method for treatment of premature ejaculation in humans The present invention belongs to the fields of pharmacology, medicine and medicinal chemistry, and provides methods and compositions for treating sexual dysfunction; more particularly, the invention relates to treatment of premature ejaculation in humans. ... | 07/13/2010 |
| 7737181 | Pharmaceutical compositions comprising 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid for the treatment of dermatological disorders Dermatological disorders having an inflammatory or proliferative component, notably common acne, are treated with topically applicable pharmaceutical compositions containing about 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) o... | 06/15/2010 |
| 7655699 | Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to members of the subclass of Retinoi... | 02/02/2010 |
| 7642288 | Topical application of adapalene for the long-term treatment of acne vulgaris Administration of adapalene in a topical medicament to a patient so as to sustain its biological response in the treatment of acne vulgaris, wherein the administration pattern of the topical medicament comprises topically applying onto the afflicted skin area a ther... | 01/05/2010 |
| 7579377 | Administration of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid for the treatment of dermatological disorders Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) or salt thereof, formulated into p... | 08/25/2009 |
| 7517910 | Alkoxyphenylpropanoic acid derivatives The present invention aims at provision of a novel compound having a GPR40 receptor function modulating action, which is useful as an insulin secretagogue, an agent for the prophylaxis or treatment of diabetes and the like. The compound represented by the formula: | 04/14/2009 |
| 7511075 | Therapeutic malonic acid/acetic acid Ctri-adducts of buckminsterfullerene and methods related thereto Disclosed and claimed herein are e,e,e malonic acid/acetic acid tri-adducts of buckminsterfullerene of the general formula C60R3, wherein each R is independently selected from groups of the formula ═CR1R2 wherein each R | 03/31/2009 |
| 7442808 | Antidiabetic bicyclic compounds Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful a... | 10/28/2008 |
| 7432300 | Gossypol co-crystals and the use thereof This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (... | 10/07/2008 |
| 7414042 | Method and composition for selectively inhibiting melanoma Compositions and methods are disclosed for treating melanoma wherein a betulinic acid derivative is the active compound in the composition to be administered. The compositions are optionally applied topically is inserted therefor. ... | 08/19/2008 |
| 7384654 | Anti-Allergy composition and related method An composition and related method that prevents, inhibits and/or mitigates an allergic response by down regulating the production of IgE, down regulating the binding of IgE antibodies to receptors on cells, and/or inhibiting allergy mediators, for example, histamine... | 06/10/2008 |
| 7374915 | Process for producing 1,4-dihydroxy-2-naphthoic acid A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This comp... | 05/20/2008 |
| 7355074 | Compounds having aromatic rings and side-chain amide-functionality and a method for transporting monovalent anions across biological membranes using the same A compound containing at least two aromatic rings covalently bonded together, with each aromatic ring containing at least one oxyacetamide-based side chain, the compound being capable of forming a chloride ion channel across a lipid bilayer, and transporting chlorid... | 04/08/2008 |
| 7348449 | Ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof Novel ligand antagonists of the RAR receptors have the following structural formula (I): in which A is a CH2, CHOH, C═O or C═N—OH radical or a sulfur or selenium atom; B is a radical selected from among tho... | 03/25/2008 |
| 7342046 | Gossypol co-crystals and the use thereof This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (... | 03/11/2008 |
| 7338977 | Anti-viral compounds Compounds of formula I wherein at least one R1 is H and the remainder are CH2CO2K; R2 is and L is H are described. The compounds are us... | 03/04/2008 |
| 7332516 | Geminally di-substituted NSAID derivatives as Aβ42 lowering agents The present invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a derivative thereof, X is ... | 02/19/2008 |
| 7318930 | Control methods for boring bark beetles A composition which causes adult boring bark beetles to discontinue boring, discontinue laying eggs and become disoriented and bore out of the tree or cease boring altogether and die is described. Additional tests have shown that beetles will not infest a tree which... | 01/15/2008 |
| 7312031 | Alpha-complementation viral fusion assay The present invention relates to the use of an alpha complementation assay as a quick, effective, and safe method for the detection of cell fusion mediated by viral proteins. Additionally, the method disclosed herein permits the identification of inhibitors of cell ... | 12/25/2007 |
| 7312205 | Methods and compositions for inhibiting tumor growth The present invention relates to novel betulinic acid derivatives with increased activity for the treatment of carcinomas and HIV diseases, a method for preparing such novel betulinic acid derivatives as well as their use as pharmaceuticals. ... | 12/25/2007 |
| 7279479 | Method for the treatment of heart failure A combination therapy for the treatment of heart failure, particularly acute heart failure, comprises administering a combination of levosimendan or a pharmaceutically acceptable salt thereof and a calcium ion source and/or an intracellular calcium increasing agent ... | 10/09/2007 |
| 7262180 | Compositions and methods for the treatment of inflammatory conditions of mucosae, skin and the eye The present invention relates to compositions comprising telmesteine, glycyrrhetinic acid, and a proanthocyanidin, as well as methods for using such compositions in the treatment of an inflammatory condition of the skin including, but not limited to, atopic dermatit... | 08/28/2007 |
| 7259188 | Methods and pharmaceutical compositions for treatment of anti-estrogen resistant breast cancer using RXR modulators Methods and compositions for the treatment of anti-estrogen resistant breast cancer using retinoid compounds which are modulators of Retinoid X Receptors. ... | 08/21/2007 |
| 7241809 | Method for treating inflammatory bowel diseases The present invention relates to a method for treating an inflammatory bowel disease, including administering an effective amount of 1,4-dihydroxy-2-naphthoic acid or a salt thereof. ... | 07/10/2007 |
| 7199140 | Vinyl phenyl derivatives as GLK activators The invention relates to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein A, R1, R2, R3, n and m are described in the specification, useful in the treatment of ... | 04/03/2007 |
| 7186749 | Pyrrolo-naphthyl acids and methods for using them The present invention relates to pyrrolo-naphthyl compounds of the formula and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders. ... | 03/06/2007 |
| 7166611 | Pharmaceutical compositions having appetite suppressant activity A pharmaceutical composition contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for obtaining the extract and a process for synthesizing compound (1... | 01/23/2007 |
| 7166641 | Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same The present invention provides pharmaceutically acceptable salts having local anesthetic and anti-inflammatory activities. The preferred pharmaceutically acceptable salt is a diclofenac salt of lidocaine. Diclofenac is a non-steroidal anti-inflammatory drug (“NSAI... | 01/23/2007 |
| 7163956 | Substituted fullerene compositions and their use as antioxidants This patent discloses a substituted fullerenes, compositions comprising the same, and their use as antioxidants. The substituted fullerenes comprise a fullerene core (Cn) and at least one of: (i) from 1 to 6 (>CX1X2) groups bonded to the fuller... | 01/16/2007 |
| 7153886 | Method for treatment of peripheral inflammation of a loop ileal artificial anus The present invention provides a novel agent for prophylaxis or treatment of inflammatory bowel diseases for oral administration or intra-intestinal infusion, which comprises as an active ingredient a compound of the formula (I): | 12/26/2006 |
| 7148245 | Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them Compounds of formula (I): in which: Ar represents an aromatic or a heteroaromatic radical optionally substituted, in particular, with an alkyl or a carboxyl group, ... | 12/12/2006 |
