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| Number | Title | Issue Date |
| 8048917 | Prodrugs of GABA analogs, compositions and uses thereof The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pha... | 11/01/2011 |
| 8026279 | Crystalline form of γ-aminobutyric acid analog A crystalline form of a γ-aminobutyric acid analog, and methods of preparing same, are provided. ... | 09/27/2011 |
| 8003695 | IKK-beta serine-threonine protein kinase inhibitors Compounds of formula (IA) or (IB) are inhibitors of IkB kinase (IKK) activity, and are useful in the treatment of autoimmune and inflammatory diseases: Formula (A) and (B) wherein R7 is hydrogen or optionally substituted (C1-C6)alkyl... | 08/23/2011 |
| 8003694 | Crystal of hydroxynorephedrin derivative hydrochloride ¼ hydrate The present invention provides ethyl (−)-2-[4-[2-[[1S,2R]-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-2,5-dimethylphenoxyacetate hydrochloride ¼ hydrate or a crystal thereof which can be determined by characteristic diffraction peaks of the powder X-... | 08/23/2011 |
| 7968599 | Fast release solid formulation, preparation and use thereof The present invention relates to a chemically stable formulation of florfenicol, (and structurally related compounds) in compositions such as soluble blended powders, granules, fast-dissolving tablets or pellets suitable for rapid release of the drug in water, and t... | 06/28/2011 |
| 7855231 | High concentration topical insecticide containing insect growth regulator A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The insecticide contains an insecticide and an insect growth regulator effective for killing fleas, flea larvae and flea ... | 12/21/2010 |
| 7645793 | Injectable pharmaceutical formulations The present invention relates to a process for suppressing the foaming which may occur at the time of the preparation of a solution or a suspension. Particularly, the present invention relates to pharmaceuticals, foods, and the like wherein the foaming at the time o... | 01/12/2010 |
| 7563821 | Levodopa prodrug mesylate, compositions thereof, and uses thereof (2R)-2-Phenylcarbonyloxypropyl(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate and crystalline form thereof, methods of making the same, pharmaceutical compositions thereof, and methods of using the same to treat diseases or disorders such as Parkinson's dise... | 07/21/2009 |
| 7550506 | Amino acid derived prodrugs of propofol, compositions and uses thereof The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as m... | 06/23/2009 |
| 7465755 | Hydrazide derivatives as prostaglandin receptors modulators The present invention relates to hydrazide derivatives of Formula I notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such hydrazide derivatives. Said hydrazide derivatives are useful in the treatment of prete... | 12/16/2008 |
| 7423170 | Anticancer agents based on regulation of protein prenylation Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is effected by the prenylation reaction, whereby a hydrophobic group (e.g.... | 09/09/2008 |
| 7419974 | Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an —S(O)z... | 09/02/2008 |
| 7419970 | Cosmetic compositions comprising N-acylamino amides The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing, whether chronobiologic or light-induced, and in particular skin agei... | 09/02/2008 |
| 7393873 | Arylsulfonamide derivatives N-aryl arylsulfonamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. ... | 07/01/2008 |
| 7361686 | Compounds for the treatment of metabolic disorders Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyper-lipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Formula (I) wherein n is 1 or 2; m is 2 or 3; ... | 04/22/2008 |
| 7342127 | Substituted anilide ligands for the thyroid receptor Novel thyroid receptor ligands are provided having the general formula I wherein X, R1, R2, R3, R4, R5, R6, R7,... | 03/11/2008 |
| 7317023 | Diaryl ether β2 adrenergic receptor agonists The invention provides novel β2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β2 adrenergic receptor... | 01/08/2008 |
| 7314620 | Methods for diagnosis and treatment of PH domain signal transduction disorders Methods for treatment, diagnosis, and screening are provided for diseases or conditions characterized by an abnormality in a signal transduction disorder. The signal transduction pathway involves an interaction between a PH domain and a PH domain binding partner. | 01/01/2008 |
| 7311893 | Amyloid targeting imaging agents and uses thereof Amyloid-targeting imaging agents such as radiolabeled amyloid targeting molecules and amyloid targeting molecule-chelator conjugates for imaging, e.g., amyloid plaques in vivo, and/or for the treatment of amyloidosis disorders. The invention provides amyloid-targeti... | 12/25/2007 |
| 7309719 | Stabilized pharmaceutical preparation of gamma-aminobutyric acid derivatives and process for preparing the same The present invention provides a stabilized pharmaceutical preparation of a 4-amino-3-substituted-butanoic acid derivative which can be obtained by incorporating an amino acid as a stabilizer. ... | 12/18/2007 |
| 7300956 | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analog... | 11/27/2007 |
| 7265136 | Substituted stilbene compounds with vascular damaging activity A compound for use in inducing necrosis in vascular tissue of a tumor in an animal. The compound contains a first moiety which is a cis-stilbene moiety and a second moiety which is an inhibitor of the formation or action of nitric acid. Also, a method for inducing n... | 09/04/2007 |
| 7256215 | Crystals of 5-hydroxycarbamimidoyl-2-hydroxybenzenesulfonamide derivative The present invention provides a novel crystalline form of n-butyl[4-[2-[2-hydroxy-5-(N-hydroxycarbamimidoyl) benzenesulfonylamino]ethyl]-2′-methanesulfonyl-3-yloxy] acetate hydrochloride, pharmaceutical compositions containing the same and their uses, which exhib... | 08/14/2007 |
| 7247653 | Pharmaceutical composition The present invention relates to a pharmaceutical composition containing a cycloalkene compound, a salt thereof or a prodrug thereof, and a nonionic surfactant and/or a cyclodextrin derivative readily soluble in water, and a method for improving solubility, s... | 07/24/2007 |
| 7244848 | Biphenylcarboxamides useful as lipid lowering agents Biphenylcarboxamide compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyp... | 07/17/2007 |
| 7238680 | Topical compositions for veterinary uses A method of treating a non-human dermatological disorder, wherein the method comprises topically administering to a non-human dermatological disorder a therapeutically effective amount of a topical composition containing: (1) an active component comprising at least ... | 07/03/2007 |
| 7235583 | Fatty acid-anticancer conjugates and uses thereof The invention provides conjugates of fatty acids and anticancer agents useful in treating cancer, and compositions and formulations thereof. Methods for using the conjugates also are provided. ... | 06/26/2007 |
| 7235258 | Sustained-release formulations for treating CNS-mediated disorders Sustained-release compositions for delivering therapeutic concentrations of isovaleramide, isovaleric acid, and certain structurally related compounds are provided for the treatment for a variety of pathological conditions, including epilepsy and spasticity, which a... | 06/26/2007 |
| 7220875 | Amino acid derived prodrugs of propofol, compositions and uses thereof The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as m... | 05/22/2007 |
| 7217706 | Propanolamine derivatives This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympatho... | 05/15/2007 |
| RE39593 | 1-phenyl-3-dimethylaminopropane compounds with a pharmacological effects 1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions. ... | 04/24/2007 |
| 7202275 | Malonamic acids and derivatives thereof as thyroid receptor ligands The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula I, which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias... | 04/10/2007 |
| 7192628 | Magnetically interactive substrates A substrate is printed with areas of magnetizable ink. The magnetizable ink is compressed into the surface of the substrate, and overprinted to hide it. Suitable inks for the purpose are disclosed. The ink may be permanently magnetized in any of a variety of pattern... | 03/20/2007 |
| 7185657 | Method and device for treating gastroesophageal reflux disease Disclosed is a delivery device for controllably delivering a prosthetic bulking device below a tissue surface such as below the mucosa to treat gastroesophageal reflux disease. The delivery device may be embodied in a deployment catheter, an endoscope, or an endosco... | 03/06/2007 |
| 7147864 | Methods for preventing photodamaged skin by administering selegiline or desmethylselegiline The present invention is directed to methods that can be used in the treatment of wounds, burns, and photodamaged skin. Methods can be used for both humans and animals and involve the administration of compositions containing selegiline and/or desmethylselegiline. | 12/12/2006 |
| 7135586 | Biphenylcarboxamides useful as lipid lowering agents Biphenylcarboxamide compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyp... | 11/14/2006 |
| 7129379 | 3-amino-propoxphenyl derivatives (l) Compounds of formula (Ia) as potent, β1-specific beta blockers with a short duration of action in the systemic circulation, wherein R is 3′,4′-dimethoxyphenyl, R1 is hydrogen, and R2 is selected from methyl, ethyl, propyl, isobu... | 10/31/2006 |
| 7115258 | Vesicular monoamine transporter gene therapy in parkinson's disease The present invention provides methods and compositions for the therapeutic intervention of Parkinson's disease. More particularly, methods of making and sequestering dopamine are disclosed. Additionally, methods of genetically modifying donor cells by gene transfer... | 10/03/2006 |
| 7115767 | Tetraline derivatives as ghrelin receptor modulators The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the comp... | 10/03/2006 |
| 7101880 | Peptidic compounds as cysteine protease inhibitors The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compo... | 09/05/2006 |
