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| Number | Title | Issue Date |
| 8163798 | Methods and devices for providing prolonged drug therapy Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are pro... | 04/24/2012 |
| 7989496 | Transdermal delivery of ketoprofen polar derivatives A topical or transdermal composition including a polar derivative of ketoprofen and a pharmaceutically acceptable topical or transdermal carrier, wherein the polar derivative of ketoprofen comprises a polarity that is greater than that of ketoprofen. ... | 08/02/2011 |
| 7981931 | Pharmaceutical compositions of short-acting sedative hypnotic agent The invention provides pharmaceutical compositions comprising a phenylacetic acid ester compound useful for inducing or maintaining general anesthesia or sedation in mammals, methods for preparing such compositions, and methods for inducing or maintaining anesthesia... | 07/19/2011 |
| 7855230 | Derivatives of 3,3-diphenylpropylamines The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodr... | 12/21/2010 |
| 7691904 | pH sensitive prodrugs of 2,6-diisopropylphenol The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby providing an alternative to the water-insoluble 2,6-diisopropylpheno... | 04/06/2010 |
| 7615574 | Synergistic composition for treating leukemia The present invention provides a method of treating acute and chronic myeloid leukemia (AML & CML) and lymphoid leukemia, said method comprising administering a pharmaceutical composition comprising pharmaceutically effective amount of chlorogenic acid (CA) and 3-o-... | 11/10/2009 |
| 7572829 | Pharmaceutical compositions useful in prevention and treatment of Beta-amyloid protein-induced disease The invention provides methods for treating beta-Amyloid protein-induced disease, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture of a medicament for treating the same. More particularly, the inventio... | 08/11/2009 |
| 7495029 | Prodrugs of (2R)-2-propyloctanoic acid for the treatment of stroke Disclosed are prodrugs of (2R)-2-propyloctanoic acid, and pharmaceutical compositions comprising them, which may be effective in modulating multiple events in the biochemical cascade of stroke. Also disclosed are methods of treating patients who have had a stroke, o... | 02/24/2009 |
| 7417059 | Substituted aromatic-ring compounds, process for producing the same and use The present invention is directed to a class of cyclohexene derivatives bearing sulfamoyl and ester groups which have an inhibitory activity on nitric oxide (NO) production and cytokine production, and are useful as an agent for the prophylaxis and/or treatment of d... | 08/26/2008 |
| 7407985 | Compounds that abrogate DNA damage induced cell cycle G2 checkpoint and/or augment anti-cancer activity of DNA-damaging treatments The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to... | 08/05/2008 |
| 7407648 | Merocyanine derivatives for cosmetic use The use is described of merocyanine derivatives of formula (1), wherein R1 and R2 are each independently of the other hydrogen; C1-C22alkyl; cyclo-C3C8alkyl; or unsubstituted or C1-C5 | 08/05/2008 |
| 7396953 | Angiogenesis inhibitors and pharmaceutical/cosmetic applications thereof Novel derivatives of fumagalone have the general formula (I): and are useful angiogenes is inhibitors; these can be formulated into pharmaceutical compositions suited for human or veterinary medicine, or can be formulated i... | 07/08/2008 |
| 7368478 | Methods for inhibiting angiogenesis and tumor growth Angiogenesis, tumor growth, and metalloproteinase 2 (MMP2) interaction with integrin-αvβ3 are inhibited by an inhibitor compound of formula: wherein G1 and G2 are each independe... | 05/06/2008 |
| 7368593 | Method of selective esterification A method of preparing a compound of formula I wherein R is a hydrocarbon and n is an integer from 1 to 5, including the steps of: contacting a compound of formula II with a compou... | 05/06/2008 |
| 7361686 | Compounds for the treatment of metabolic disorders Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyper-lipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Formula (I) wherein n is 1 or 2; m is 2 or 3; ... | 04/22/2008 |
| 7320966 | Synergistic and residual pesticidal compositions containing plant essential oils Synergistic and residual pesticidal compositions containing synergistic and residual mixtures of plant essential oils and/or their constituents, plant essential oils and/or their constituents in admixture with known active pesticidal compounds or plant essential oil... | 01/22/2008 |
| 7314888 | Compounds and medicinal use thereof A compound or a salt thereof having the atom corresponding to N3 and the two or more atoms selected from N1, N2, N4 and N5, said atoms constitute the pharmacophore represented by the following formula: | 01/01/2008 |
| 7307102 | Method of preventing or treating estrogen-dependent diseases and disorders The present invention relates, in general, to the treatment of estrogen-dependent diseases and disorders and, in particular, to a method of treating estrogen-dependent cancers, particularly breast cancer, with antiestrogens. ... | 12/11/2007 |
| 7297817 | Thio-substituted arylmethanesulfinyl derivatives The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein ... | 11/20/2007 |
| 7288271 | Chlorogenic acid and an analog thereof for immune system stimulation The present invention relates to a preparation for stimulating or enhancing an immune system comprising one or more agents that stimulate T-lymphocytes in vivo. Such a preparation can be sued in the prophylaxis and/or treatment of a medical condition. The invention ... | 10/30/2007 |
| 7282520 | External preparation An external preparation characterized by comprising, as selected from gallic acid derivatives of the following formula (I), wherein R1 represents a hydrogen atom, an alkali metal, an alkaline earth met... | 10/16/2007 |
| 7279600 | Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents This invention provides estrogen receptor modulators having the structure: wherein R1 to R6 and R8 are as defined in the specification; or a pharmaceutically acceptable salt there... | 10/09/2007 |
| 7265245 | Compounds useful for the treatment of diseases associated with the formation of amyloid fibrils The present invention provides new amyloidogenesis inhibiting compounds of formula (I): in which R1 is a —NRaRb group, where Ra and... | 09/04/2007 |
| 7256215 | Crystals of 5-hydroxycarbamimidoyl-2-hydroxybenzenesulfonamide derivative The present invention provides a novel crystalline form of n-butyl[4-[2-[2-hydroxy-5-(N-hydroxycarbamimidoyl) benzenesulfonylamino]ethyl]-2′-methanesulfonyl-3-yloxy] acetate hydrochloride, pharmaceutical compositions containing the same and their uses, which exhib... | 08/14/2007 |
| 7253302 | Mixed esters of dicarboxylic acids for use as pigment dispersants Novel mixed esters of dicarboxylic acids with monohydric fatty alcohols and propoxylated fatty alcohols show unexpected superior properties as pigment dispersants, especially for inorganic pigments used in foundations, make-ups, lipsticks and physical sunscreens. Th... | 08/07/2007 |
| 7244859 | Method for producing δ-aminopentadienoate derivatives The invention is a method for producing δ-aminopentadienoate derivatives of formula (1), the method comprising reacting a streptocyanine derivative of formula (2) with an ester derivative of formula (3) in the presence of an organic base. In formulae (1) to (3), R | 07/17/2007 |
| 7244759 | Isoindoline compounds and methods of making and using the same The invention encompasses isoindoline compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment, prevention or management of various diseases and disorders. Examples include, but are not limited to, cancer, inflammatory bowel... | 07/17/2007 |
| 7244763 | Compounds that modulate PPAR activity and methods of preparation This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic... | 07/17/2007 |
| 7238680 | Topical compositions for veterinary uses A method of treating a non-human dermatological disorder, wherein the method comprises topically administering to a non-human dermatological disorder a therapeutically effective amount of a topical composition containing: (1) an active component comprising at least ... | 07/03/2007 |
| 7230003 | Aromatic prodrugs of propofol, compositions and uses thereof Prodrugs of propofol, methods of making prodrugs of propofol, pharmaceutical compositions of prodrugs of propofol and methods of using prodrugs of propofol and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pa... | 06/12/2007 |
| 7226946 | Substituted phenol compounds useful for anesthesia and sedation The invention provides substituted phenol compounds and pharmaceutical compositions containing substituted phenol compounds which are useful for inducing or maintaining anesthesia or sedation in a mammal. This invention also provides methods for inducing or maintain... | 06/05/2007 |
| 7217424 | Compositions containing esters of aromatic alkoxylated alcohols and fatty carboxylic acids A personal care or cosmetic product composition that includes from about 0.1% to about 99% of at least one ester of alkoxylated aromatic alcohol and fatty carboxylic acid, and from about 0.1% to 60% of at least one functional ingredient is provided. The functional i... | 05/15/2007 |
| 7214677 | Benzamide, heteroarylamide and reverse amides The present invention relates to novel to P2X7 inhibitors of formula I and to processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them, an... | 05/08/2007 |
| 7214710 | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof. ... | 05/08/2007 |
| 7208520 | Crystals of hydroxynorephedrine derivative The present invention provides ethyl (−)-2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-2,5-dimethylphenoxy]acetate hydrochloride, crystalline forms thereof and pharmaceutical compositions containing them, which have excellent β3 | 04/24/2007 |
| 7205006 | Mahonia aquifolium extract, extraction process and pharmaceutical composition containing the same A skin treatment composition comprising a Mahonia aquifolium extract in a liposome delivery system. The Mahonia aquifolium extract is present in the skin treatment composition in a range of from 5% to 20% by weight of the total composition. The skin tr... | 04/17/2007 |
| 7192981 | 3,4-dihydroxyhydrocinnamic acid derivative According to the invention, there is provided a novel 3,4-dihydroxyhydrocinnamic acid derivative, designated DHH105, having blood glucose lowering effects in vivo as a result of the enhancement of glucose transport mediated by the increase of insulin receptor signal... | 03/20/2007 |
| 7179941 | Carbonylamino-substituted acyl phenyl urea derivatives, process for their preparation and their use The invention relates to compounds of the formula I in which the radicals are defined as specified, and also to their physiologically tolerated salts. The compounds are suitable, for example, as medicaments for p... | 02/20/2007 |
| 7166726 | Aryl substituted 3,4-dihydroanthracene derivatives having retinoid antagonist or retinoid inverse agonist type biological activity Disclosed herein are compounds of the formula wherein R1 is independently H or alkyl of 1 to 6 carbons; R2 is optional and is defined as lower alkyl of 1 to 6 carbons, F, Cl, Br... | 01/23/2007 |
| 7163956 | Substituted fullerene compositions and their use as antioxidants This patent discloses a substituted fullerenes, compositions comprising the same, and their use as antioxidants. The substituted fullerenes comprise a fullerene core (Cn) and at least one of: (i) from 1 to 6 (>CX1X2) groups bonded to the fuller... | 01/16/2007 |
