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| Number | Title | Issue Date |
| 7851503 | Thrombopoetin receptor activator and process for producing the same A preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective or a platelet increasing agent, which contains a thrombopoietin receptor activator represented by the formula (1): | 12/14/2010 |
| 7250525 | Stilbene derivatives and their use for binding and imaging amyloid plaques This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregat... | 07/31/2007 |
| 6713509 | Controlled release formulation for treating COPD This invention relates to a controlled or sustained release formulation designed to deliver a PDE4 inhibitor for treating an inflammatory disease such as asthma or COPD and the like. ... | 03/30/2004 |
| 6656968 | (Z)-styryl acetoxyphenyl sulfides as cyclooxygenase inhibitors Compounds of the formula ##STR1## are provided wherein R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, C1 -C8 alkyl, C1 -C | 12/02/2003 |
| 6610282 | Polymeric controlled release compositions Disclosed are compositions containing biologically active compounds that slowly release the biologically active compound. These compositions may be directly incorporated into the locus to be protected or may be applied to a structure in a coating.... | 08/26/2003 |
| 6525092 | Pesticidal bis-oxime compounds Bis-oxime compounds of the general formula (I) are provided ##STR1## wherein X, Y, R1, R2 R3 and n are as defined in the specification. The bis-oxime compounds possess pesticidal activity, which may provide plants with pro... | 02/25/2003 |
| 6518304 | Fungicidal composition The present invention provides a fungicidal composition characterized by containing as active ingredients (a) a compound represented by the formula I: ##STR1## (wherein Ar is a substituted or unsubstituted phenyl group, Y is an oxygen atom, an oxymethylen... | 02/11/2003 |
| 6475766 | Human osteoclast-derived cathepsin Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses an... | 11/05/2002 |
| 6426366 | Pharmaceutical compositions comprising tyrphostins Compounds useful for countering undesired toxic effects to cells, tissues or organs having formula (I) wherein: Ar is a group of formulae (i) or (ii), n is 0 or, when Ar has formula (i) above, then n may also be 1, R is CN, --GC(S)NH2, --C(O)NH... | 07/30/2002 |
| 6410572 | Fungicidal mixtures based on amide compounds and tetrachloroisophthalonitrile Fungicidal mixtures comprise as active components a) an amide compound of the formula I A--CO--NR1 R2 in which A is an aryl group or an aromatic or non-aromatic, 5- or 6-membered heterocycle which has from 1 to 3 hetero atoms which are select... | 06/25/2002 |
| 6409809 | Pigmented coatings exhibiting reduced fading A method for preventing the fading of pigmented coatings, especially water based acrylic paints, includes incorporating therein a biocide containing a mixture of from about 1% to about 99% by weight of a halogenated benzonitrile compound and from about 1%... | 06/25/2002 |
| 6387682 | Human osteoclast-derived cathepsin Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses an... | 05/14/2002 |
| 6262091 | Process and agents for controlling harmful fungi Compositions for controlling harmful fungi, containing in a solid or liquid carrier a) at least one p-hydroxyaniline derivative of the formula I ##STR1## b) at least one amide compound of the formula II A--CO--NR8 --R9 (II) where the sub... | 07/17/2001 |
| 6245804 | Nonsteroidal gestagens This invention describes the new, nonsteroidal gestagens of general formula I ##STR1## in which A, B, Ar, R1, R2 and R3 have the meanings that are indicated in more detail in the description. The new compounds show a very ... | 06/12/2001 |
| 6225346 | Tyrphostin like compounds The present invention relates to molecules capable of modulating tyrosine signal transduction to prevent and treat cell proliferative disorders or cell differentiation disorders associated with particular tyrosine kinases by inhibiting one or more abnorma... | 05/01/2001 |
| 6194453 | Protein kinase inhibitor Disclosed herein are compounds of the formula I ##STR1## wherein A and C are independently H, alkyl of 1-6 carbon atoms, hydroxy, or alkoxy of 1-6 carbon atoms; B is hydroxy or alkoxy of 1-6 carbon atoms; and Y is cyano, ##STR2## --C(NR1 R | 02/27/2001 |
| 6136840 | Fungicidal mixtures The present invention relates to a fungicidal mixture which comprises a) a carbamate of the formula I: ##STR1## where X is CH and N, n is 0, 1 or 2 and R is halogen, C1 -C4 -alkyl and C1 -C4 -haloalkyl, it being... | 10/24/2000 |
| 6121198 | Synergistic composition of biocides The invention is directed to a biocidal composition for inhibition fungal, bacterial and algae growth which comprises a mixture of tetrachloroisophthalonitrile and 3-iodo-2-propynly butyl carbamate.... | 09/19/2000 |
| 6121197 | Biocidal composition The invention is directed to a biocidal composition for inhibiting fungal and algae growth which comprises a mixture of tetrachloroisophthalonitrile and N-cyclopropyl-N'(1,1 -dimethylethyl)-6-(methylthio)-1,3,5-triazine-2,4-dismine.... | 09/19/2000 |
| 6117868 | Treatment of gastrointestinal ulcers or gastritis caused by microbial infection A method and composition for the treatment of infectious gastrointestinal ulcer disease or infectious gastritis disease of microbially infected gastrointestinal tissue in a mammal involves administration of an antimicrobial amount of an antimicrobial medi... | 09/12/2000 |
| 6114382 | Methods for treating inflammatory bowel disease The present invention provides novel compositions and methods relating to the treatment of Inflammatory Bowel Disease ("IBD"), most notably, Ulcerative Colitis, Crohn's Disease, Colitis and Diverticulitis. The invention relates to the discovery of a paras... | 09/05/2000 |
| 6103768 | Fatty acid based compositions and methods for the control of plant infections and pests The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination treatments whereby fatty acids are used to enhance or aug... | 08/15/2000 |
| 6051605 | Method of treating psychosis and schizophrenia This invention relates to compounds that are antagonists of dopamine D4 receptors, and to methods of treating psychosis and schizophrenia using a compound that is an antagonist of dopamine D4 receptors.... | 04/18/2000 |
| 5981569 | Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction and particularly KDR/FLK-1 receptor signal transduction in order to regulate and/or modulate vasculogenesis and angiogenesis. The invention is bas... | 11/09/1999 |
| 5981582 | Compositions and methods of combatting fungi When used in admixture with mancozeb, chlorothalonil, a copper salt, folpet, fluazinam or cymoxanil (it being possible for the latter to be used also together with one of the other five components), metalaxyl having a high R-enantiomer content of more tha... | 11/09/1999 |
| 5981561 | Fungicide mixtures A fungicidal mixture comprising a) (2RS,3SR)-1-[3-(2-chlorophenyl)-2,3-epoxy-2-(4-fluorophenyl)-propyl]-1H-1, 2,4-triazole ##STR1## or a salt or adduct thereof, and b) tetrachloroisophthalonitrile II ##STR2## in a synergistically active amou... | 11/09/1999 |
| 5968977 | Ketonitrile derivatives and antibacterial agent and drugs containing the same The present invention is directed to a ketonitrile derivative represented by the following formula (1): ##STR1## (wherein R1 is a hydrogen atom or a lower alkyl group; each of R2, R3, R4, and R5,... | 10/19/1999 |
| 5932614 | Sulfonic stilbene compounds in the treatment of viral diseases Sulfonic acid stilbenes block the infection of cells by HIV and these compounds can be used to prevent viral infection.... | 08/03/1999 |
| 5922762 | Fungicidal active compound combinations There are described new active compound combinations of a compound of the formula (I) ##STR1## with known fungicidal active compounds, and their use for the control of phytopathogenic fungi.... | 07/13/1999 |
| 5906961 | Alkanolamide spreader-sticker surfactant combination An adjuvant composition containing at least an alkanolamide surfactant and optionally other surfactants or pesticides or formulation aids. The surfactant preferably is reacted with a fatty acid. The process preferably takes places without the use of alkox... | 05/25/1999 |
| 5861435 | Method for preventing settlement of aquatic fouling organisms A method for preventing settlement of aquatic fouling organisms on surface of an aquatic structure without environmental hazard is provided. The method is based upon absolutely novel concept to prevent the settlement by means of thick slime layer, i.e. bi... | 01/19/1999 |
| 5854285 | Protein kinase inhibitor A compound of the formula I ##STR1## wherein A and C are independently H, alkyl of 1-6 carbon atoms, hydroxy, or alkoxy of 1-6 carbon atoms; B is hydroxy or alkoxy of 1-6 carbon atoms; and Y is cyano, ##STR2## --C(NR1 R2).dbd.C(... | 12/29/1998 |
| 5798384 | Microbicidal composition There is disclosed a microbicidal composition comprising as active ingredients: (I) a dithiocarbonimide compound represented by the general formula: ##STR1## wherein Z represents CH group or nitrogen atom, R1 and R2 are the same... | 08/25/1998 |
| 5780390 | Agricultural spray adjuvant comprising coconut diethanolamide and polyalkylene glycol An agricultural spray adjuvant composition that can be added to an agricultural spray to enhance the deposition of the agricultural spray by preventing evaporation, reducing surface tension, stabilizing dynamic surface tension and enhancing stickability c... | 07/14/1998 |
| 5767151 | 3,3-(disubstituted) cyclohexan-1-ylidine acetate dimers and related compounds The present invention relates to novel 3,3-(disubstituted)-cyclohexan-1-ylidene acetate dimers of Formula (I): ##STR1## and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammateor... | 06/16/1998 |
| 5763364 | Thixotropic aqueous plant protection agent suspensions The invention relates to thixotropic aqueous suspension concentrates of plant protection agents. The invention furthermore relates to the use of these agents in plant protection and the use of saponites as auxiliaries in the preparation of plant protectio... | 06/09/1998 |
| 5633254 | Synergistic fungicidal mixtures for the control of plant diseases Synergistic mixtures which include dimethomorph and cymoxonil in a fungicidially effective aggregate amount, and the use of such mixtures in the control of plant diseases. In certain embodiments, a contact fungicide is included, along with the dimethomorp... | 05/27/1997 |
| 5631286 | Compounds useful for treating allergic or inflammatory diseases Novel cyclohexanes of formulas (I) and (II) are described herein. They inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production: these compounds are also useful in the medi... | 05/20/1997 |
| 5627207 | Arylethenylene compounds which are useful as tyrosine kinase inhibitors The present invention provides compounds of the formula ##STR1## wherein Y is a naphthyl, tetrahydronaphthyl, pyridyl, quinolyl, isoquinolyl or indolyl ring system, R is a moiety which is an acrylic acid, a CN-substituted acrylic acid, acrylamide, ac... | 05/06/1997 |
| 5591727 | Insecticidal composition The invention relates to an insecticidal composition which comprises at least one pyrethroid, at least one UV absorbing agent and at least one antioxidant from the group consisting of tocopherol derivatives and citric acid esters. This insecticidal compos... | 01/07/1997 |
