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| Number | Title | Issue Date |
| 8173702 | Pesticidal composition and method for controlling harmful insects A pesticidal composition containing: 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl 3-(2-cyano-1-propenyl)-2,2-dimethylcyclopropanecarboxylate, a saturated hydrocarbon having an initial boiling point of 150° C. or higher and a 95%-distillation temperature of 300° C. or... | 05/08/2012 |
| 8158678 | Photoabsorbing, highly conjugated compounds of cyanoacrylic esters, sunscreen compositions and methods of use Novel derivatives of α-cyano-β-naphthyl acrylates, sunscreen compositions including one or more α-cyano-β-naphthyl acrylate derivatives are described herein. Also disclosed are methods for stabilizing a sunscreen composition and methods of filtering out ultra-vi... | 04/17/2012 |
| 8153688 | Esters of 2-phenylalkanenitriles and antifungal compositions containing them Esters of 2-phenylalkanenitriles, such as 3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitrile and 3-acetoxy-2-(4-chlorophenyl)propanenitrile, and compositions containing such esters, are useful as fungicides at very low concentrations. ... | 04/10/2012 |
| 8063102 | Tetrahydronaphthalen-2-ol derivatives The present invention relates to novel tetrahydronaphthalen-2-ol derivatives, to pharmaceutical compositions comprising these compounds and to their use in therapy, in particular to their use for the manufacture of a medicament for the prevention or treatment of low... | 11/22/2011 |
| 7989495 | Compositions and methods for inhibiting NF-κB mediated tumorigenicity and adhesion dependent survival of cancer cells Disclosed are compositions and methods for inhibiting NF-κB mediated cellular proliferation and metastasis. ... | 08/02/2011 |
| 7649018 | Mono- and di-phosphates of 3-(3-fluoro-4-hydroxy-phenyl)-7-hydroxy-naphthalene-1-carbonitrile Compounds of formula II wherein each R1 and R2 is independently selected from H and —P(O)(R3)(R4), provided that at least one of R1 and R | 01/19/2010 |
| 7402704 | Arylsulfones and uses related thereto Aryl sulfone compounds of formula I and II are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: ... | 07/22/2008 |
| 7390833 | Method for treating ADAMTS-5-associated disease The present invention relates to methods of treating ADAMTS-5-associated diseases and particularly osteoarthritis comprising administering an agent capable of modulating ADMATS-5 activity to a subject afflicted with the disease. The agent is preferably a biaryl sulf... | 06/24/2008 |
| 7371747 | Cyanoalkylamino derivatives as protease inhibitors The present invention is directed to novel cyanoalkylamino derivatives that are inhibitors of cysteine protease such as cathepsins K, S, B and L, in particular cathepsin K Pharmaceutical composition comprising these compounds, method of treating diseases mediated by... | 05/13/2008 |
| 7368479 | Alpha-sulfonylamino-acetonitriles The invention relates to α-sulfonylamino-acetonitrile derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein Ar1, and Ar2 independently of each other stand for an optionally substitut... | 05/06/2008 |
| 7317066 | Liquid crystal polymers Liquid crystal polyester derived from phenylene-naphthalene monomers and one or more comonomers display an improved balance of properties, including low melt viscosity, fast cycle time in molding, very low mold shrinkage, high tensile and/or flexural strength, solve... | 01/08/2008 |
| 7300670 | Oral suspension formulation An aqueous pharmaceutical suspension for oral administration of a drug, which suspension maintains its content uniformity for prolonged period. ... | 11/27/2007 |
| 7253318 | Benzyloxy derivatives as MAOB inhibitors The invention relates to compounds of the formula and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5, n, m, and o are... | 08/07/2007 |
| 7250518 | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes Compounds of the formula: useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils. ... | 07/31/2007 |
| 7235587 | Diesters containing two crylene or fluorene moieties, sunscreen compositions containing the same, and methods of photostabilizing a sunscreen compositions containing the same Diesters that include one or more of a crylene and/or a fluorene moiety, and sunscreen compositions including a mixture of a photoactive compound and one or more of a diester that includes one or more of a crylene and/or a fluorene moiety are described herein. Also ... | 06/26/2007 |
| 7196081 | Compounds with hydroxycarbonyl-halogenoalkyl side chains The present invention provides a compound consisting of a moiety and a group chemically bonded to said moiety, wherein said moiety contains a compound having low activity following oral administration or its parent scaffold and said group has the following general f... | 03/27/2007 |
| 7196119 | Development of new selective estrogen receptor modulators The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen receptor. Methods for making and using the disclosed SERMs are disclos... | 03/27/2007 |
| 7183293 | Ether derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds of the formula wherein j is 1; k is 0 or 1; m is 1, 2 or 3; n is 1 or 2; W1 and W2 are independently —O— or —S(═O)t—, where t i... | 02/27/2007 |
| 7148255 | Amidoacetonitrile compounds The invention relates to compounds of formula I wherein R1, R2, R3, R4, R5, R6, R8, R8′, R9, W, X, A1 | 12/12/2006 |
| 7138495 | Human phosphodiesterase IV isozymes This invention relates to novel nucleic acid sequences encoding three novel human phosphodiesterase (hPDE IV) isozymes. It also relates to polypeptides encoded by such sequences. This invention also relates to an assay method for detecting the presence of suc... | 11/21/2006 |
| 7115258 | Vesicular monoamine transporter gene therapy in parkinson's disease The present invention provides methods and compositions for the therapeutic intervention of Parkinson's disease. More particularly, methods of making and sequestering dopamine are disclosed. Additionally, methods of genetically modifying donor cells by gene transfer... | 10/03/2006 |
| 7109238 | Calcilytic compounds Novel calcilytic compounds and methods of using them are provided. ... | 09/19/2006 |
| 7109214 | Substituted cyclopentene compounds The present invention relates to substituted cyclopentene compounds of the general formula I, to a process for the production thereof, to pharmaceutical preparations containing these compounds and to the use thereof for the production of pharmaceutical preparations.... | 09/19/2006 |
| 7105699 | Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine and its formamide Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-n... | 09/12/2006 |
| 7102026 | Process for preparing and isolating -bicalutamide and its intermediates The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide intermediates including ethyl-[2-{... | 09/05/2006 |
| 7087734 | Human phosphodiesterase IV isozymes This invention relates to novel nucleic acid sequences encoding three novel human phosphodiesterase (hPDE IV) isozymes. It also relates to polypeptides encoded by such sequences. This invention also relates to an assay method for detecting the presence of suc... | 08/08/2006 |
| 7087785 | Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine and its formamide Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-n... | 08/08/2006 |
| 7053245 | N-acylamino benzyl ether derivatives This invention relates to N-acylamino aryl derivatives of the formula where R1, R21, R22, R23, R24, R3, R4, R5, R | 05/30/2006 |
| 7049271 | Phenyl-substituted 2-enamino-ketonitriles The present invention relates to novel phenyl-substituted 2-enamino-ketonitriles of the formula (I): in which Ar, X, Z, Y and K are each as defined in the description, to a plurality of pro... | 05/23/2006 |
| 7019030 | Immunotherapeutic agents Cyano and carboxy derivatives of substituted styrenes are inhibitors of tumor necrosis factor α, nuclear factor κB, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical em... | 03/28/2006 |
| 7019031 | Anticancer agents based on regulation of protein prenylation Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is effected by the prenylation reaction, whereby a hydrophobic group (e.g.... | 03/28/2006 |
| 7012075 | Cathepsin cysteine protease inhibitors This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, s... | 03/14/2006 |
| 6962610 | Hair dye composition Provided is a hair dye composition containing a dissociative direct dye represented by the following formula (1): wherein, R1 to R4 each represents H or substituent, X represents OH or —NHSO | 11/08/2005 |
| 6953810 | Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes Compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructuive pulmonary disease, of the formula: ... | 10/11/2005 |
| 6949669 | Organic compounds Compounds of general formula (I) wherein the substituents are as defined in claim 1 are suitable for use as herbicides ... | 09/27/2005 |
| 6946426 | Process to prepare aqueous formulations Provided is a method of formulating hydrophobic pesticides comprising emulsifying an aqueous phase and a water-immiscible phase to form a formulation; wherein the aqueous phase is comprised of water and optionally a freeze/thaw agent, one or more emulsifiers, or com... | 09/20/2005 |
| 6914133 | Human phosphodiesterase IV isozymes This invention relates to novel nucleic acid sequences encoding three novel human phosphodiesterase (hPDE IV) isozymes. It also relates to polypeptides encoded by such sequences. This invention also relates to an assay method for detecting the presence of suc... | 07/05/2005 |
| 6881248 | Paint composition A paint composition containing an insecticide and piperonyl butoxide as a synergist. ... | 04/19/2005 |
| 6838484 | Formulations comprising selective androgen receptor modulators The present invention relates to pharmaceutical compositions and formulations comprising a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents defi... | 01/04/2005 |
| 6831099 | Enzyme inhibition Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited b... | 12/14/2004 |
