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| Number | Title | Issue Date |
| 8420697 | Treatment of acute exacerbation of asthma and reduction of likelihood of hospitalization of patients suffering therefrom The invention provides a method of improving one or more clinical outcomes of an individual experiencing an acute respiratory attack. The acute respiratory attack may include acute reversible bronchospasm, severe acute bronchospasm, or acute exacerbation of asthma. ... | 04/16/2013 |
| 8389573 | Glycyrrhetinic acid derivatives The present invention relates to novel derivatives of glycyrrhetinic acid, compositions comprising said derivatives and their use in the treatment of conditions or diseases that benefit from an upregulation of PPAR&ggr; and/or a downregulation of the expression or a... | 03/05/2013 |
| 8362073 | Acylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals The present invention relates to compounds of the formula I, wherein A, Y, Z, R3 to R6, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable... | 01/29/2013 |
| 8314145 | High purity 17α-cyanomethyl-17β-hydroxy-estra-4,9-diene-3-one and process for the synthesis thereof The invention relates to a new process for the synthesis of high purity 17α-cyanomethyl-17β-hydroxy-estra-4,9-diene-3-one (further on dienogest) of formula (I) from 3-methoxy-17-hydroxy-estra-2,5(10)-diene of formula (V). The invention relates also to the high pur... | 11/20/2012 |
| 8309601 | Forms of CDDO methyl ester A triterpenoid compound, methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous crystalline form that can prepared, for example, from a saturated methanol solution. The glassy form displays... | 11/13/2012 |
| 8202903 | Use of aminaphtone for the preparation of a medicament for treating arteriopathies The subject of the present invention is the use of aminaphtone for the preparation of a medicament for treating arteriophaties, in particular arteriophaties of a degenerative inflammatory type. Preferably, said medicament is formulated for oral administration. ... | 06/19/2012 |
| 8129429 | Synthetic triterpenoids and methods of use in the treatment of disease The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second tr... | 03/06/2012 |
| 8088824 | Forms of CDDO methyl ester A triterpenoid compound, methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous crystalline form that can prepared, for example, from a saturated methanol solution. The glassy form displays... | 01/03/2012 |
| 7968596 | Preparation and diabetic use of Gibberellins The present invention relates to application of compounds of formula (1) (Gibberellins) and their derivatives for the preparation of a pharmaceutical composition or medicaments for the treatment of diabetes, its complications and associated conditions, including obe... | 06/28/2011 |
| 7910623 | Synthesis of scabronines and analogues thereof A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, t... | 03/22/2011 |
| 7795306 | Triterpene derivatives for the treatment of cancer and inflammatory disease by inhibition of NF-κB The present invention relates to the use of triterpenes of the formula (I): which are inhibitors of nuclear factor kappa B (NF-κB for use in the treatment of inflammatory diseases and for cancers susceptible to an NF-κB inhibitor. The present... | 09/14/2010 |
| 7795305 | CDDO-compounds and combination therapies thereof CDDO-compounds in combination with other chemotherapeutic agents induce and potentiate cytotoxicity and apoptosis in cancer cell. One class of chemotherapeutic agents include retinoids. Cancer therapies based on these combination therapies are provided. Also provide... | 09/14/2010 |
| 7728035 | Ester derivatives of rhein and their therapeutic use Compounds that may have anti-inflammatory activity are of general formula (I); wherein X1, is H or COR1, and X2 is H or COR2 but X1, and X2 are not both H; R1 and R2 are the same... | 06/01/2010 |
| 7625947 | Analogs of 3-O-acetyl-11-keto-β-boswellic acid This invention relates to novel AKBA analogs of the formula I given below: Where in R1, R2, R3, R4 and R5 in each of the said analogs are: 1. R1... | 12/01/2009 |
| 7488753 | Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof This invention provides composition comprising a triterpenoidal saponin, comprising two side groups attached to carbon 21, and 22 of triterpenoidal saponin backbone. This invention provides a composition for inhibiting skin or ovarian tumor cell growth... | 02/10/2009 |
| 7435755 | CDDO-compounds and combination therapies thereof CDDO-compounds in combination with other chemotherapeutic agents induce and potentiate cytotoxicity and apoptosis in cancer cell. One class of chemotherapeutic agents include retinoids. Cancer therapies based on these combination therapies are provided. Also provide... | 10/14/2008 |
| 7435756 | Preparation and diabetic use of gibberellins The present invention relates to application of compounds of formula (1) (Gibberellins) and their derivatives for the preparation of a pharmaceutical composition or medicaments for the treatment of diabetes, its complications and associated conditions, including obe... | 10/14/2008 |
| 7407985 | Compounds that abrogate DNA damage induced cell cycle G2 checkpoint and/or augment anti-cancer activity of DNA-damaging treatments The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to... | 08/05/2008 |
| 7384977 | Water soluble paclitaxel prodrugs Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for ... | 06/10/2008 |
| 7378442 | Chemical entities with multiple modes of anti-inflammatory action The invention relates to methods of treatment and pharmaceutical compositions of new chemical compounds that inhibit the various enzymes in the arachidonic acid pathway implicated in inflammatory disease conditions. ... | 05/27/2008 |
| 7371780 | Use of calphostin C to treat drug-resistant tumor cells Calphostin C is used to treat subjects for cancer which is resistant to treatment by other forms of chemotherapeutic drugs, for example breast or uterine cancer, or other cancers characterized by tumor cells that have a defect in an apoptotic regulatory pathway whic... | 05/13/2008 |
| 7358364 | Substituted carboxylic acids The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds inclu... | 04/15/2008 |
| 7348449 | Ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof Novel ligand antagonists of the RAR receptors have the following structural formula (I): in which A is a CH2, CHOH, C═O or C═N—OH radical or a sulfur or selenium atom; B is a radical selected from among tho... | 03/25/2008 |
| 7342125 | Method of treating inflammation with acanthoic acid derivatives Novel compounds are disclosed that have the chemical structure of Formula (II), and its prodrug esters and acid-addition salts, and that are useful as Interleukin-1 and Tumor Necrosis Factor-α modulators, and thus are useful in the treatment of various listed disea... | 03/11/2008 |
| 7326730 | Aminoadamantane derivatives as therapeutic agents The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases using the derivatives and composi... | 02/05/2008 |
| 7323192 | Immediate release tablet An immediate release tablet is provided. The tablet comprises at least 60 weight % of an active ingredient and powdered wax having a melting point greater than about 90° C. The tablet may advantageously be produced by direct compression. Although the wax is hydroph... | 01/29/2008 |
| 7323015 | Oxidation dyeing composition for keratin fibers comprising a cationic poly(vinyllactam) and at least One C-C fatty alcohol, methods and devices for oxidation dyeing The disclosure relates to a composition for the oxidation dyeing of keratin fibers, for example human keratin fibers, such as hair, comprising, in an appropriate dyeing medium, at least one oxidation dye, at least one C10-C14 fatty alcohol and ... | 01/29/2008 |
| 7314637 | Method of administering liposomal encapsulated taxane Liposomal-encapsulated taxane or an antineoplastic derivative thereof or a mixture thereof is provided which is used to effect a therapeutically enhanced method of treating cancer. The liposomal encapsulated paclitaxel allows for administration to a patient, particu... | 01/01/2008 |
| 7309504 | Extract of for the treatment or prevention of hepatitis or the liver protective drug The disclosure concerns an extract of Acanthopanax koreanum and its use. More particularly, it concerns the extract of Acanthopanax koreanum comprising 1) the extract of Acanthopanax koreanum extracted from water, 2) among the water extract, the... | 12/18/2007 |
| 7297691 | Treatment of sleep disorders with cholinesterase inhibitors The present invention is concerned with treatment of sleep disorders by administering a cholinesterase inhibitor, and in particular, by administering galantamine or a pharmaceutically acceptable salt thereof. Also in particular, cholinesterase inhibitors that are ac... | 11/20/2007 |
| 7291650 | Cancer treatment composition and method using natural plant essential oils Pharmaceutical compositions containing plant essential oils, natural or synthetic, or mixtures or derivatives thereof, for the prevention and treatment of soft tissue cancer in mammals. ... | 11/06/2007 |
| 7288526 | Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4 Disclosed are compounds which bind VLA-4. Certain of these compounds aslo inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, su... | 10/30/2007 |
| 7288609 | Coatings for drug delivery devices based on poly (orthoesters) A polymer coating for implantable medical devices based on polyorthoesters and methods for fabricating the coating are disclosed. The implantable medical devices made of polyorthoesters and methods for fabricating thereof are also disclosed. ... | 10/30/2007 |
| 7273948 | Process of preparing esters and ethers of probucol and derivatives thereof A probucol or a probucol derivative can be efficiently converted to a monoester or monoether of probucol by reacting the free hydroxyl-containing probucol or a derivative thereof (by which is meant a probucol compound with at least one substituent that is different ... | 09/25/2007 |
| 7268162 | Aloe-emodin derivatives and their use in the treatment of neoplasias The invention relates to aloe-emodin (AE) derivatives and their use as anticancer drugs. Saids derivatives show a specific cytotoxicity to tumour cells, also of neuroectodermal origin, to which they may in particular act as aloe-emodin prodrugs. Said pharamcological... | 09/11/2007 |
| 7265220 | Amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative Compound of formula (I): wherein: R1 represents aryl, heteroaryl or alkyl which is optionally substituted, or a group of formula —(CO)—CR6R7NR8R9 ... | 09/04/2007 |
| 7256217 | Prodrugs of excitatory amino acids This invention relates to synthetic excitatory amino acid prodrugs according to formula (I) and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurolo... | 08/14/2007 |
| 7253206 | Phenalenone derivatives, processes for preparation and use thereof The present invention provides novel phenalenone derivatives of formula (I) which are formed by the microorganism Penicillium herquei Bainer & Sartory, DSM 14142, during fermentation. A process for their preparation, their use as pharmaceutical compositions, ... | 08/07/2007 |
| 7217706 | Propanolamine derivatives This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympatho... | 05/15/2007 |
| 7196115 | Pharmaceutical composition containing brevifoliol for use in chemotherapeutic treatment of human beings, method therefor The present invention relates to the bioactivity of taxanes isolated from the leaves of Himalayan Yew tree Taxus wallichiana against human cancer cell lines grown in-vitro and subsequent identification of brevifoliol [1] as anticancer agent useful in the trea... | 03/27/2007 |
