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| Number | Title | Issue Date |
| 8173701 | Pesticidal composition and method for controlling harmful insects A pesticidal composition containing: 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl 3-(2-cyano-1-propenyl)-2,2-dimethylcyclopropanecarboxylate, a saturated hydrocarbon having an initial boiling point of 150 C or higher and a 95%-distillation temperature of 300 C or lower... | 05/08/2012 |
| 8088823 | Tuberculosis treatment using pleuromutilin derivatives A method of preventing or treating diseases caused by Mycobacterium, comprising administering to a subject in need of such treatment an effective amount of a pleuromutilin. ... | 01/03/2012 |
| 8030348 | Natural marine source phospholipids comprising polyunsaturated fatty acids and their applications A phospholipid extract from a marine or aquatic biomass possesses therapeutic properties. The phospholipid extract comprises a variety of phospholipids, fatty acid, metals and a novel flavonoid. ... | 10/04/2011 |
| 8026277 | Flavor composition or fragrance composition, product containing the flavor composition or fragrance composition, and novel ester compound Disclosed is a 2-methyl-2-pentenyl ester represented by the general formula (1) [wherein R represents a hydrogen atom or a hydrocarbon group having 1 to 9 carbon atoms which may have a substituent]. The compound has a new-type, unprecedented aroma and/or flavor, par... | 09/27/2011 |
| 7763651 | Treating pain using selective antagonists of persistent sodium current The present invention provides methods of treating chronic pain in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transie... | 07/27/2010 |
| 7728034 | Treating neurological disorders using selective antagonists of persistent sodium current The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative ... | 06/01/2010 |
| 7718696 | Methods of treating diabetes using carnitine conjugates as dual prodrugs Compounds of Formula 1 are dual prodrug compounds of the formula The various terms in Formula 1 are selected to optimize the physiochemical and biological properties such as, lipophilicity, bioavailability, and pharmacokineti... | 05/18/2010 |
| 7563819 | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy The invention provides compounds for use in photochemotherapy or diagnosis, said compounds being branched alkyl esters or substituted alkyl esters of 5-aminolevulinic acid, or derivatives or pharmaceutically acceptable salts thereof. In particular, the invention pro... | 07/21/2009 |
| 7479507 | Anti-inflammatory substituted phenols and elastomeric compositions for oral delivery of drugs 3,5-di-substituted-4-hydroxybenzylidene phosphonates and sulfonates useful in treating inflammatory disease, particularly osteoarthritis, and elastomeric particles for oral delivery of drugs are disclosed. ... | 01/20/2009 |
| 7473705 | Hexafluoroisopropanol substituted ether derivatives The invention is concerned with novel hexafluoroisopropanol substituted ether derivatives of formula (I): wherein R1 to R3 are as defined in the description and in the claims, as well as physiologicall... | 01/06/2009 |
| 7435408 | Porous particles comprising excipients for deep lung delivery Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm... | 10/14/2008 |
| 7417070 | Compounds and methods for delivery of prostacyclin analogs This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing ... | 08/26/2008 |
| 7407648 | Merocyanine derivatives for cosmetic use The use is described of merocyanine derivatives of formula (1), wherein R1 and R2 are each independently of the other hydrogen; C1-C22alkyl; cyclo-C3C8alkyl; or unsubstituted or C1-C5 | 08/05/2008 |
| 7407779 | Modification of solid 3-sn-phosphoglycerides Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structur... | 08/05/2008 |
| 7407987 | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth. ... | 08/05/2008 |
| 7405233 | Ureido substituted benzoic acid compounds and their use for nonsense suppression and the treatment of disease The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions. ... | 07/29/2008 |
| 7399786 | Derivatives of amino acids for treatment of obesity and related disorders Novel amino acid derivatives are provided that are useful for management of disorders such as obesity and immunological diseases. The derivatives are also useful in lowering blood glucose levels in hyperglycemic disorders and for treating related disorders such as b... | 07/15/2008 |
| 7388029 | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth. ... | 06/17/2008 |
| 7387789 | Transdermal delivery of non-steroidal anti-inflammatory drugs The present invention provides a transdermal drug delivery system which comprises: a therapeutically effective amount of a non-steroidal anti-inflammatory drug; at least one dermal penetration enhancer, which is a safe skin-tolerant ester sunscreen ester; and at lea... | 06/17/2008 |
| 7384978 | Compounds and methods for delivery of prostacyclin analogs This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing ... | 06/10/2008 |
| 7378442 | Chemical entities with multiple modes of anti-inflammatory action The invention relates to methods of treatment and pharmaceutical compositions of new chemical compounds that inhibit the various enzymes in the arachidonic acid pathway implicated in inflammatory disease conditions. ... | 05/27/2008 |
| 7368478 | Methods for inhibiting angiogenesis and tumor growth Angiogenesis, tumor growth, and metalloproteinase 2 (MMP2) interaction with integrin-αvβ3 are inhibited by an inhibitor compound of formula: wherein G1 and G2 are each independe... | 05/06/2008 |
| 7365098 | N'-cyano-N-methyl-imidamide derivatives The present invention relates to novel N′-cyano-N-methylimidamide derivatives of the general formula (I) in which n represents 2, 3, 4 or 5, R represents optional... | 04/29/2008 |
| 7358276 | 2-Oxo-1-pyrrolidine derivatives, processes for preparing them and their uses The invention concerns 2-oxo-1-pyrrolidine derivatives of formula I, wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention are particul... | 04/15/2008 |
| 7345174 | Cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof The present invention provides the compound having the formula: wherein each of R1 and R2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino, t-buty... | 03/18/2008 |
| 7316815 | Polyamino acid derivatives and use thereof in compositions for treating keratin fibers The invention concerns the use in a cosmetic composition of at least a poly-aminoacid of general formula (I) in which X is —O—, —S— or —NR3; R1 represents in particular a hydrogen atom or a C1-C40 alkyl radical; ... | 01/08/2008 |
| 7311893 | Amyloid targeting imaging agents and uses thereof Amyloid-targeting imaging agents such as radiolabeled amyloid targeting molecules and amyloid targeting molecule-chelator conjugates for imaging, e.g., amyloid plaques in vivo, and/or for the treatment of amyloidosis disorders. The invention provides amyloid-targeti... | 12/25/2007 |
| 7309269 | Method of fabricating light-emitting device and apparatus for manufacturing light-emitting device In this embodiment, an interval distance between a desposition source holder 17 and an object on which deposition is performed (substrate 13) is reduced to 30 cm or less, preferably 20 cm or less, more preferably 5 to 15 cm, and a deposition source hol... | 12/18/2007 |
| 7303760 | Method for treating multi-drug resistant tumors Methods for administering mitomycin C to a multi-drug resistant cell and for reducing the toxicity of the compound are described. In the methods, mitoymic C is provided in the form of a prodrug conjugate, where the drug is linked to a hydrophobic moiety, such as a l... | 12/04/2007 |
| 7300955 | Method and materials for treatment of Alzheimer's disease The invention provides the combined use of an inhibitor of formation or release of β-amyloid and a nitric oxide releaser for the treatment or prevention of Alzheimer's disease. ... | 11/27/2007 |
| 7294739 | Basic amine esters or oleic acid and their use as anti-inflammatory or immunobodulatory agents This invention is directed to compounds of the following formula (I): wherein R is either: | 11/13/2007 |
| 7268210 | PEG-LHRH analog conjugates PEG-LHRH analog conjugates, where a PEG moiety is covalently bound to a serine residue of a LHRH analog, and methods for producing these conjugates are provided in the present invention. Also provided are a pharmaceutical composition and a method for treating pathol... | 09/11/2007 |
| 7250396 | Juvenile hormone compositions and methods for making same The present invention relates to hormone coating layers having desirable hormone delivery characteristics and product lifetime. In one embodiment, the invention is a hormone composition including a substrate having an external surface, and a coating layer disposed o... | 07/31/2007 |
| 7250157 | Dermatological compositions and methods Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds,... | 07/31/2007 |
| 7223406 | Methods and compositions for preventing and treating male erectile dysfunction and female sexual arousal disorder The invention provides a method for preventing or treating male erectile dysfunction or female sexual arousal disorder by administering an effective amount of one or more factors from a group of factors including vascular endothelial growth factor, brain-derived neu... | 05/29/2007 |
| 7223784 | Compounds for the modulation of the glycolysis enzyme and/or transaminase complex The invention relates to compounds for the modulation of the glycolysis enzyme complex and of the transaminase complex, pharmaceutical compositions containing such compounds as well as uses of such compounds for preparing pharmaceutical compositions for treating var... | 05/29/2007 |
| 7217736 | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy The invention provides compounds for use in photochemotherapy or diagnosis, said compounds being branched alkyl esters or substituted alkyl esters of 5-aminolevulinic acid, or derivatives or pharmaceutically acceptable salts thereof. In particular, the invention pro... | 05/15/2007 |
| 7214710 | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof. ... | 05/08/2007 |
| 7204994 | Juvenile hormone compositions and methods for making same The present invention relates to hormone coating layers having desirable hormone delivery characteristics and product lifetime. In one embodiment, the invention is a hormone composition including a substrate having an external surface, and a coating layer disposed o... | 04/17/2007 |
| 7199141 | Drugs for chronic pains Nitro-oxyderivative compounds or salts thereof having the following general formula (I): A—(B)b0—(C)c0—NO2 wherein: c0 is an integer and is 0 or 1, b0 is an integer and is 0 or 1, A=R—T1—, wherein R is the radica... | 04/03/2007 |
