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| Number | Title | Issue Date |
| 8153687 | Gallium complexes with polyalcohols and methods of use Provided are complexes of gallium and polyalcohols. Also provided are pharmaceutical compositions comprising such complexes and methods of their use. Methods of preparing the complexes are also provided. ... | 04/10/2012 |
| 8088822 | Use of fenretinide or bioactive derivatives thereof and pharmaceutical compositions comprising the same The present invention relates to a new medical use of fenretinide or bioactive derivatives thereof, particularly to the use of fenretinide or bioactive derivatives thereof in the preparation of a medicament for eliminating or killing tumor stem cells in a subject or... | 01/03/2012 |
| 8076371 | Gallium compositions for the treatment of liver cancer and methods of use Provided are compositions and methods to treat liver cancer and related disorders in human or veterinary individuals. Primary liver cancers, including those metastatic to other parts of the body, as well as cancers metastatic to the liver cancer, can be treated and/... | 12/13/2011 |
| 8048915 | Biologically active complex The invention relates to an aqueous solution containing at least one species selected from the group consisting of a 1:1 molar complex of TeO2 with a moiety of formula (A) and ammonium salts thereof: HO—X—OH (A) where X is an... | 11/01/2011 |
| 7977381 | Platinum complexes and methods for inhibiting tumor cell proliferation The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of... | 07/12/2011 |
| 7977382 | Therapeutic bio platinum complex A novel bio platinum complex which increases the therapeutic applicability and effectiveness of platinum used as a cancer treatment in humans and animals especially in anti tumor treatments and to prevent the spread of cancer without fear of high toxicity. The prese... | 07/12/2011 |
| 7973076 | Anti-tumor composition The present invention provides compositions having, as active ingredients, a stilbene derivative and a platinum coordination compound which is highly efficacious and highly safe for treating tumors, particularly for the treatment of solid or malignant tumors and thu... | 07/05/2011 |
| 7935728 | Cyclic palladium compounds having coordinated thereto bis (diphenylphosphine) ferrocene ligands which inhibit the activity of proteins and enzymes and treatment of diseases and disorders associated therewith The invention relates to cyclopalladated compounds containing bis-diphenylphosphine-ferrocene ligands and their analogues which are active inhibitors of proteins and enzymes, for example, those of the serine peptidase, cysteine-protease, metalo-protease and endopept... | 05/03/2011 |
| 7888389 | Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies Disclosed are copper-binding compounds with improved properties and methods of using such compounds in the prevention and treatment of angiogenic diseases, such as cancer. Advantages of the invention include the enhanced stability of the compounds, which is achieved... | 02/15/2011 |
| 7888390 | Preparation of platinum(II) complexes The invention relates to a method for the preparation of platinum (II) complexes, in particular dicarboxylatoplatinum (II) complexes containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a bis-dicarboxylatoplatinate (II... | 02/15/2011 |
| 7888311 | Uranium-chelating peptides and uses thereof The invention concerns uranium-chelating peptides as well as their uses for decontaminating soils and water, and for detecting and treating people contaminated by uranium. Said peptides have a helix-loop-helix type structure comprising the sequence of a calmodulin l... | 02/15/2011 |
| 7842725 | Foaming alcohol compositions with selected dimethicone surfactants Foaming alcohol compositions with selected dimethicone surfactants are disclosed. The dimethicone surfactants are PEG-8 to PEG-12 linear dimethicone surfactants and in particular PEG-10 linear dimethicone surfactant. The compositions are useful as antimicrobial prod... | 11/30/2010 |
| 7842724 | Pharmaceutical gallium compositions and methods Novel pharmaceutical gallium compositions, including gallium complexes having increased oral bioavailability relative to uncomplexed gallium salts are disclosed. Such compositions are useful in the treatment of conditions and diseases in which inhibition of abnormal... | 11/30/2010 |
| 7812052 | Stable aqueous formulation of a platin derivative Disclosed is a stable aqueous formulation of a platin derivative, particularly oxaliplatin. The selected stabilizing additive is effective even in very small concentrations. ... | 10/12/2010 |
| 7767709 | Pharmaceutical composition for oral administration An oral pharmaceutical composition characterized in that it consists of a suspension of a platinum complex of general formula I, wherein A and A′ independently of one another are an NH3 group or an amino or diamino group containing 1 to 18 carbon atoms,... | 08/03/2010 |
| 7700649 | Phosphaplatins and their use in the treatment of cancers resistant to cisplatin and carboplatin The present invention provides phosphaplatins, stable isolated monomeric phosphate complexes of platinum (II) and (IV), and methods of use thereof for treating cancers, including cisplatin- and carboplatin-resistant cancers. Unlike cisplatin, these complexes do not ... | 04/20/2010 |
| 7674824 | Stable oxaliplatin formulation A storage stable pharmaceutical composition comprising a solution of Oxaliplatin in water and a catalytic amount of a carbohydrate. A process for forming such pharmaceutical composition comprising dissolving a known amount of Oxaliplatin in water; adding an amount o... | 03/09/2010 |
| 7655697 | Oral pharmaceutical composition for targeted transport of a platinum complex into the colorectal region, method for producing and use as medicament thereof An oral pharmaceutical composition for targeted transport of a platinum complex into the colorectal region, includes a mixture of platinum complex of general formula I wherein A each independently is an —NH3 gr... | 02/02/2010 |
| 7655696 | Anti-tumor composition The present invention provides composition having as active ingredients a stilbene derivatively and a platinum coordination compound which is highly efficacious and highly safe for treating tumors, particularly for the treatment of solid or malignant tumors and thus... | 02/02/2010 |
| 7651979 | Coordination complexes, and methods for preparing by combinatorial methods, assaying and using the same The present invention relates to novel coordination complexes, methods for synthesizing and identifying coordination complexes, using combinatorial techniques, and assaying their activity. In certain embodiments, the invention relates to a library comprising a plura... | 01/26/2010 |
| 7638555 | Photocatalytic nano-crystalline TiOthin films, method for preparing the same and use thereof The preferred embodiments provide for a process for preparing a TiO2 thin film. The preferred embodiments also provide for TiO2 thin films prepared by the process herein, and a method of using TiO2 thin films for killing bacteria and... | 12/29/2009 |
| 7632863 | 3,4,5,4′-tetramethoxyl-α,β-diphenylethane-3′-O-sodium sulphate and its use This invention relates to a compound of formula (I), 3,4,5,4′-tetramethoxyl-α,β-diphenylethane-3′-O-sodium sulphate, and its use in the preparation of antineoplastic pharmaceutical. ... | 12/15/2009 |
| 7576126 | Platinum (II) complexes, preparation and use The invention relates to a method for the preparation of platinum (II) complexes, in particular dicarboxylatoplatinum (II) complexes containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a bis-dicarboxylatoplatinate (II... | 08/18/2009 |
| 7569606 | Platinum complexes with mononitrile-containing ligands Disclosed herein are novel platinum-based complexes possessing one nitrile substituent group (mononitrile) covalently-bonded to the platinum, one or more nitrogen donor ligands capable of forming hydrogen bonds with the bases in DNA or RNA and leaving groups (i.e., ... | 08/04/2009 |
| 7563818 | Photosensitizer functionalised nanoparticles The present invention relates to self-assembly of a photosensitizer on a nanoparticle. The invention also provides methods for production of functionalized (eg. stabilized) nanoparticles. The nanoparticles may be used in Photodynamic Therapy (PDT). The invention can... | 07/21/2009 |
| 7459482 | Agent for treatment of cisplatin-resistant cancer Preparation of a lipophilic platinum complex being dissolved or suspended in an iodized poppyseed oil fatty acid ethyl ester is useful as an agent for treatment of cisplatin-resistant cancers. ... | 12/02/2008 |
| 7456215 | Pharmaceutical gallium compositions and methods Novel pharmaceutical gallium compositions, including gallium complexes having increased oral bioavailablity relative to uncomplexed gallium salts are disclosed. Such compositions are useful in the treatment of conditions and diseases in which inhibition of abnormall... | 11/25/2008 |
| 7435380 | Pseudo-plastic or thixotropic liquid deodorant product for ostomy pouches A pseudo-plastic or thixotropic carrier having anti-malodorous components dissolved or suspended therein is sprayed on the internal surfaces of an ostomy bag or pouch. The viscoelastic properties of the carrier allow the composition to be conveniently dispensed from... | 10/14/2008 |
| 7435408 | Porous particles comprising excipients for deep lung delivery Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm... | 10/14/2008 |
| 7432403 | Cyclic palladium compounds having coordinated thereto bis (diphenylphosphine) ferrocene ligands which inhibit the activity of proteins and enzymes and treatment of diseases and disorders associated therewith The invention relates to cyclopalladated compounds containing bis-diphenyiphosphine-ferrocene ligands and their analogues which are active inhibitors of proteins and enzymes, for example, those of the serine peptidase, cysteine-protease, metalo-protease and endopept... | 10/07/2008 |
| 7427416 | Methods of treating conditions using metal-containing materials Methods of treating conditions using metal-containing materials are disclosed. Exemplary conditions include bacterial conditions, biofilm conditions, microbial conditions, inflammatory conditions, fungal conditions, viral conditions, autoimmune conditions, idiopathi... | 09/23/2008 |
| 7410655 | Anticancer agent An anticancer agent containing platinum preparation, humic substances, water and sodium chloride. Potassium tetrachloroplatinate is used as a platinum compound and lignohumic acid ammonium salts are used as humic substances taken in the following ratio of com... | 08/12/2008 |
| 7396814 | Metallopeptide compositions for treatment of sexual dysfunction Metallopeptide compositions are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. The metallopeptides include at least one, and preferably two, aromatic amino acid... | 07/08/2008 |
| 7393871 | Anionic and neutral complexes of ruthenium (II) with nitrogen oxide A class of anionic and neutral complexes of ruthenium (II) containing nitrogen oxide (NO) and optionally a nitrogen ligand is described; a process for their preparation is also described. The preparation process includes the use of starting complexes of ruthenium (I... | 07/01/2008 |
| 7390915 | Phosphine transition metal complex having ferrocene skeleton, process for making the same, and anti-cancer agent An anti-cancer agent contains a phosphine transition metal complex having a ferrocene skeleton, the complex being represented by general formula (3) below: (wherein R1, R2, R | 06/24/2008 |
| 7384916 | Methods and compositions for preventing and treating aging or photodamaged skin Disclosed are methods for treating aging and photodamaged skin employing topical application of compositions which comprise at least one peptide manganese complex. Also disclosed are methods wherein the composition further comprises retinol, at least one retinol der... | 06/10/2008 |
| 7381428 | Stabilized lanthanum carbonate compositions Stabilized lanthanum carbonate compositions containing a monosaccharide or disaccharide stabilizing agent are disclosed. Subjects having hyperphosphatemia can be treated by administering a pharmaceutical composition containing a therapeutically effective amount of t... | 06/03/2008 |
| 7378077 | High dose radionuclide complexes for bone marrow suppression The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi... | 05/27/2008 |
| 7368440 | Methods for the administration of amifostine and related compounds The present invention provides methods of administering amifostine, WR-1065, or a combination thereof, to patients receiving radiation therapy or chemotherapy in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compound... | 05/06/2008 |
| 7354952 | Pharmaceutical gallium compositions and methods Novel pharmaceutical gallium compositions, including gallium complexes having increased oral bioavailability relative to uncomplexed gallium salts are disclosed. Such compositions are useful in the treatment of conditions and diseases in which inhibition of abnormal... | 04/08/2008 |
