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| Number | Title | Issue Date |
| 7790766 | Pharmaceutical compositions of short-acting sedative hypnotic agent The invention provides pharmaceutical compositions comprising a phenylacetic acid ester compound useful for inducing or maintaining general anesthesia or sedation in mammals, methods for preparing such compositions, and methods for inducing or maintaining anesthesia... | 09/07/2010 |
| 7335365 | HIV-encoded chemoattractant The combination of HIV proteins Tat and Nef is chemotactic for CD4+ cells. Utilizing the capacity of Tat and Nef to modulate CD4+ cell trafficking and infiltration, the invention provides various treatment modes for individuals infected with HIV. The invention furth... | 02/26/2008 |
| RE39593 | 1-phenyl-3-dimethylaminopropane compounds with a pharmacological effects 1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions. ... | 04/24/2007 |
| 7192965 | 4-(3,3-dihalo-allyloxy)phenoxy alkyl derivatives Compounds of formula wherein A1, A2 and A3 are each independently of the others a bond or a C1–C6alkylene bridge; A4 i... | 03/20/2007 |
| 7173059 | Intermediates useful in the synthesis of HIV-protease inhibitors and methods for preparing the same Optically active 3-amino-butene and 1,2-dihydroxy-3-amino-butane intermediate compounds, useful in the synthesis of HIV-protease inhibitors and methods of preparing these intermediate compounds are disclosed. ... | 02/06/2007 |
| 7078436 | Carbamate compounds for use in preventing or treating anxiety disorders This invention is directed to a method for preventing or treating anxiety disorders comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II): | 07/18/2006 |
| 6972292 | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors The present invention relates to certain substituted polyketides of formula I, wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds ... | 12/06/2005 |
| 6967242 | Antimicrobial 2-deoxystreptamine compounds The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the invention c... | 11/22/2005 |
| 6965048 | Hydroxyalkylamide derivatives The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, X, W, m and n are as defined hereinabove. The compounds are useful for the treatment and/or ... | 11/15/2005 |
| 6852738 | Acyl sulfamides for treatment of obesity, diabetes and lipid disorders A class of acyl sulfamides comprises compounds that are potent ligands for PPAR gamma and generally have antagonist or partial agonist activity. The compounds may be useful in the treatment, control or prevention of obesity, non-insulin dependent diabetes mellitus (... | 02/08/2005 |
| 6825224 | Prodrugs of carbamate inhibitors of IMPDH The present invention relates to novel compounds, methods of preparing these compounds, and pharmaceutical compositions comprising these compounds. These compounds are carbamate prodrugs that convert to active inhibitors of the IMPDH enzyme in vivo. The compounds an... | 11/30/2004 |
| 6589985 | Carbamate compounds for use in preventing or treating movement disorders This invention is directed to a method for preventing or treating movement disorders comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II):... | 07/08/2003 |
| 6521607 | (R)-chiral halogenated substituted N-phenoxy N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and m... | 02/18/2003 |
| 6498188 | Methods of treatment for cancer or viral infections Methods for the treatment of cancers or viral infections in mammals are disclosed that include administration of an N-chlorophenylcarbamate, or an N-chlorophenylthiocarbamate, or a salt thereof. Such compounds may be used in combination with a chemotherap... | 12/24/2002 |
| 6426359 | Prevention and treatment of skeletal disorder with EP2 receptor subtype selective prostaglandin E2 agonists This invention relates to the use of EP2 receptor subtype selective prostaglandin E2 agonists to augment bone mass including the prevention and treatment of skeletal disorders in mammals, including humans.... | 07/30/2002 |
| 6416789 | Synergistic combination of fungicides to protect wood and wood-based products from fungal decay, mold and mildew damage A wood treatment material having a synergistic combination of fungicides including boron-containing compounds, organo-iodine compounds and amine-oxides is provided. This combination is shown to be especially effective in providing resistance to decay, mol... | 07/09/2002 |
| 6406691 | Potentiator of Bacillus pesticidal activity The present invention relates to a factor that potentiates the pesticidal activity of a Bacillus related pesticide as well as methods for isolating and identifying said factor. The invention further relates to pesticidal compositions comprising the factor... | 06/18/2002 |
| 6395763 | Prodrugs of carbamate inhibitors of IMPDH The present invention relates to novel compounds, methods of preparing these compounds, and pharmaceutical compositions comprising these compounds. These compounds are carbamate prodrugs that convert to active inhibitors of the IMPDH enzyme in vivo. The c... | 05/28/2002 |
| 6297275 | Method for controlling fungi using phenylhydrazine derivatives A method for controlling fungi using a phenylhydrazine derivative compound of the formula: ##STR1## wherein: X is phenyl, phenylalkoxy, phenoxy, or benzyl, alone or in combination with one or more halogen, alkyl, or alkylthio; Y is hydrogen, alkanoyl, hal... | 10/02/2001 |
| 6248737 | 1-phenyl-3-dimethylaminopropane compounds with a pharmacological effects 1-phenyl-3 -dimethylaminopropane compounds corresponding to the formula I ##STR1## a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions.... | 06/19/2001 |
| 6211201 | Multivalent salts of pyridostigmine and related compounds A quaternary ammonium cholinergic agent is complexed with a multivalent anion, or with multiple monovalent anions. The complex may be administered orally to a patient to treat pain, or for some other purpose. Numerous modifications are contemplated, inclu... | 04/03/2001 |
| 6177460 | Method of treatment for cancer or viral infections Methods for the treatment of cancers or viral infections in mammals are disclosed that include administration of an N-chlorophenylcarbamate, or an N-chlorophenylthiocarbamate, or a salt thereof. Such compounds may be used in combination with a chemotherap... | 01/23/2001 |
| 6172108 | Hydrazide compounds Compounds of formula (I): R--NH--A--CO--NH--NH--(W)n --Z (I) wherein: n is 0 or 1, W represents --CO-- or S(O)r wherein r is 0, 1 or 2, Z represents a group selected from aryl, arylalkyl, heteroaryl and heteroarylalkyl, each optionally substi... | 01/09/2001 |
| 6140361 | Use of 2-deoxystreptamine as a molecular scaffold for the preparation of functionally and spatially diverse molecules and pharmaceutical compositions thereof 2-Deoxystreptamine is an aminocyclitol whose structural stability and abundant functionality make it an attractive scaffold for the combinatorial generation of small molecules. The ability to selectively functionalize the various positions of 2-deoxystrep... | 10/31/2000 |
| 6060484 | Anti-viral method The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.... | 05/09/2000 |
| 6043284 | Anti-atherosclerotic diaryl compounds The present invention is concerned with diaryl compounds of formula (I) and their use in medical therapy, particularly in the prophylaxis or treatment of a clinical condition for which an ACAT inhibitor is indicated, such as hyperlipidaema or atherosclero... | 03/28/2000 |
| 6034124 | Fungicidal toxins from biocontrol bacteria A biocontrol bacteria, Bacillus cereus ATCC 53522, has been found to naturally synthesize two antibiotics, here designated zwittermicin A and antibiotic B. Zwittermicin A is a 396 dalton linear aminopolyol, a class of metabolite previously unknown in B. c... | 03/07/2000 |
| 5977170 | Elevation of HDL cholesterol by 4-[(aminothioxomethyl)hydrazono]-4-arylbutyl carbamates This invention relates to the treatment of atherosclerosis via raising the level of HDL cholesterol by administration of a compound of the formula ##STR1## wherein R1, R2, and R3 are independently hydrogen, C1 ... | 11/02/1999 |
| 5968975 | Elevation of HDL cholesterol by 2-[(aminothioxomethyl)-hydrazono]-2-arylethyl carbamates This invention relates to the treatment of atherosclerosis via raising the level of HDL cholesterol by administration of a compound of the formula ##STR1## wherein: R1, R2, and R3 are independently hydrogen, C1 ... | 10/19/1999 |
| 5952386 | Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production The present invention provides dihalopropene compounds of the general formula: ##STR1## wherein R1 is C1 -C10 alkyl or the like; L is C(.dbd.O)NH or the like; R2, R3 and R4 are indepen... | 09/14/1999 |
| 5942541 | Substituted amino acid amide derivatives their preparation and use as fungicides There are described new amino acid amide derivatives, some of which are known, of the formula (I) ##STR1## in which R1 to R8 have the meaning given in the description, and a process for their preparation. The amino acid amide de... | 08/24/1999 |
| 5852054 | Fungicidal toxins from biocontrol bacteria A biocontrol bacteria, Bacillus cereus ATCC 53522, has been found to naturally synthesize two antibiotics, here designated zwittermicin A and antibiotic B. Zwittermicin A is a 396 dalton linear aminopolyol, a class of metabolite previously unknown in B. c... | 12/22/1998 |
| 5811449 | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturat... | 09/22/1998 |
| 5807884 | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturat... | 09/15/1998 |
| 5792787 | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty... | 08/11/1998 |
| 5783596 | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty... | 07/21/1998 |
| 5773209 | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturat... | 06/30/1998 |
| 5750351 | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturat... | 05/12/1998 |
| 5709890 | Polyaspartic acid and its analogues in combination with insecticides An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small amount of a water soluble non-aromatic polyorganic acid or... | 01/20/1998 |
| 5688817 | Di(aromatic) compounds and their use in human and veterinary medicine and in cosmetics Di(aromatic) compounds corresponding to the following formula: ##STR1## in which: Ar represents either ##STR2## n=1 or 2 or: ##STR3## X represents a divalent radical, Z represents O, S or a divalent radical, and R1, R2 | 11/18/1997 |
