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| Number | Title | Issue Date |
| 7192965 | 4-(3,3-dihalo-allyloxy)phenoxy alkyl derivatives Compounds of formula wherein A1, A2 and A3 are each independently of the others a bond or a C1–C6alkylene bridge; A4 i... | 03/20/2007 |
| 7045512 | Fungicidal phenoxyphenylhydrazine derivatives A fungicidally active compound of the formula: a) wherein Q is —NY—NH—, —N═N—, or X is oxygen... | 05/16/2006 |
| 6828106 | Methods and compositions using coiled binding partners The present invention relates to a polypeptide multimer comprising a first polypeptide having associated therewith a label and a second polypeptide, wherein a) at least one of the polypeptides is susceptible to protease digestion; b) association of the polypeptides ... | 12/07/2004 |
| 6476027 | N-hydroxy 4-sulfonyl butanamide compounds An N-hydroxy sulfonyl butanamide compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated N-hydroxy sulfonyl butanamide compound in a MMP enzyme-inhibiting effect... | 11/05/2002 |
| 6416789 | Synergistic combination of fungicides to protect wood and wood-based products from fungal decay, mold and mildew damage A wood treatment material having a synergistic combination of fungicides including boron-containing compounds, organo-iodine compounds and amine-oxides is provided. This combination is shown to be especially effective in providing resistance to decay, mol... | 07/09/2002 |
| 6297275 | Method for controlling fungi using phenylhydrazine derivatives A method for controlling fungi using a phenylhydrazine derivative compound of the formula: ##STR1## wherein: X is phenyl, phenylalkoxy, phenoxy, or benzyl, alone or in combination with one or more halogen, alkyl, or alkylthio; Y is hydrogen, alkanoyl, hal... | 10/02/2001 |
| 6291520 | Hydroxamic acid and N-hydroxyurea derivatives and their use Certain novel hydroxamic acid derivatives having the structure ##STR1## inhibit the enzyme lipoxygenase. These compounds, and the pharmaceutically acceptable salts thereof, are useful in the treatment or alleviation of inflammatory diseases, allergic cond... | 09/18/2001 |
| 6197817 | Phenylpropionic acids and esters: compounds and methods for inducing beta-blockade for the treatment of cardiac disorders Disclosed are compounds of the formula: ##STR1## R represents hydrogen or is a C-3 to C-6 cycloalkyl or C-4 to C-10 straight or branched carbon chain alkyl-cycloalkyl or a group --B--D, where B is C-2 to C-10 straight or branched carbon chain alkyl and D ... | 03/06/2001 |
| 6172108 | Hydrazide compounds Compounds of formula (I): R--NH--A--CO--NH--NH--(W)n --Z (I) wherein: n is 0 or 1, W represents --CO-- or S(O)r wherein r is 0, 1 or 2, Z represents a group selected from aryl, arylalkyl, heteroaryl and heteroarylalkyl, each optionally substi... | 01/09/2001 |
| 6158438 | Model of heart failure A method of chronically instrumenting an animal enabling one to simulate congestive heart failure. This invention also relates to method for assessing the effects of a test compound on cardiac function and systemic vascular dynamics.... | 12/12/2000 |
| 6133261 | Amino acid derivatives useful to treat stroke The invention provides a therapeutic method for treating or preventing stroke and other ischemic disorders, as well as novel compounds and pharmaceutical compositions useful for carrying out such methods.... | 10/17/2000 |
| 6013649 | Thiol sulfone metalloprotease inhibitors This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfone inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, pro... | 01/11/2000 |
| 5952386 | Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production The present invention provides dihalopropene compounds of the general formula: ##STR1## wherein R1 is C1 -C10 alkyl or the like; L is C(.dbd.O)NH or the like; R2, R3 and R4 are indepen... | 09/14/1999 |
| 5948778 | Difluoro statone antiviral analogs This invention relates to novel statone antiviral analogs, to the processes and intermediates useful for their preparation and to their use as antiviral agents.... | 09/07/1999 |
| 5927283 | Allosteric modifiers of hemoglobin A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The effect has particular application in a wide variety of treatments including hypoxia, hypothermia, ischemia, stroke, ARDS, COPD, surgic... | 07/27/1999 |
| 5906207 | Method for simulating heart failure A method of chronically instrumenting an animal enabling one to simulate congestive heart failure. A method for assessing the effects of a test compound on cardiac function and systemic vascular dynamics.... | 05/25/1999 |
| 5824705 | Carbamates and crop protection agents containing them Carbamates of the formula I ##STR1## where the substituents have the following meanings: Z is methoxy, NH2, NHCH3, N(CH3)2, CH3, C2 H5, CF3 or CCl3, X ... | 10/20/1998 |
| 5811456 | Monoamine oxidase B inhibitors, processes for their preparation and use thereof Novel monoamine oxidase B inhibitors of formula (I), wherein R1 .dbd.H, an optionally substituted benzyloxy or phenylethoxy group; p=0-3; R3 .dbd.H, a CN, OH, CCH group, a C1 -C3 alkoxy-carbonyl group, or a C | 09/22/1998 |
| 5773469 | Diaryl antimicrobial agents The invention relates to diaryl antimicrobial compounds of the general formula: ##STR1## where G, E L, J, q, m, X, Ar, W, p, n and A are as described herein, pharmaceutical compositions containing the compounds, methods for their production and ... | 06/30/1998 |
| 5753697 | Method and pharmaceutical compositions containing rosmanol derivatives Novel pharmaceutical compositions containing an active substance of formula (I), wherein R1, R2 and R3, which are the same or different are H, CH3 or C2 H5. The compositions have useful ant... | 05/19/1998 |
| 5733935 | Hydroxylamine derivatives and fungicides containing the same A hydroxylamine derivatives of formula (I): ##STR1## wherein R represents ##STR2## in which R1 and R2 represents alkyl group, alkenyl group, alkynyl group, cycloalkyl group, haloalkyl group, haloalkynyl group, alkoxy -... | 03/31/1998 |
| 5728729 | 3-methoxy-2-phenylacrylic acid esters used as pest-control agents, especially as fungicides 3-Methoxy-2-phenyl-acrylic esters of the formula ##STR1## in which R represents optionally substituted alkyl, cycloalkyl or aryl and n represents a number 0 or 1, a process for their preparation and their use as pesticides.... | 03/17/1998 |
| 5709890 | Polyaspartic acid and its analogues in combination with insecticides An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small amount of a water soluble non-aromatic polyorganic acid or... | 01/20/1998 |
| 5705521 | Use of allosteric hemoglobin modifiers in combination with radiation therapy to treat carcinogenic tumors A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The effect has particular application in radiation oncology applications. The compounds are capable of acting on hemoglobin in whole blood... | 01/06/1998 |
| 5677330 | Medical uses of allosteric hemoglobin modifier compounds in patient care A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The effect has particular application in a wide variety of treatments including hypoxia, hypothermia, ischemia, stroke, ARDS, COPD, surgic... | 10/14/1997 |
| 5661182 | Method for lowering oxygen affinity of hemoglobin in redcell suspensions, in whole blood and in vivo Drug compounds are used as allosteric modifiers of hemoglobin present in red blood cells. The compounds bind to only a single pair of symmetry related sites in the central water cavity of hemoglobin at the Lys 99, Arg 141, and Asn 108 ³... | 08/26/1997 |
| 5654301 | Amino acid derivative anticonvulsant The present invention relates to compounds of the formula ##STR1##... | 08/05/1997 |
| 5650397 | Antioccidial method The present invention is directed to anticoccidial methods, animal feed premixes, and animal feeds, employing a specified o-phenylenediamine or benzimidazole. The present invention is also directed to anticoccidial methods, animal feed premixes, and anima... | 07/22/1997 |
| 5648375 | Use of hydrophobic compounds and anesthetics in combination with allosteric hemoglobin modifiers Allosteric hemoglobin modifier compound activity on p50 is potentiated by using the compound in combination with a hydrophobic compound such as an anesthetic.... | 07/15/1997 |
| 5646133 | Polyaspartic acid and its analogues in combination with insecticides An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small amount of a water soluble non-aromatic polyorganic acid or... | 07/08/1997 |
| 5631293 | Preparation of amino acid-substituted benzoylguanidines as diagnostic agents Amino acid-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent and a medicament containing them Benzoylguanidines of the formula I ##STR1## in which the radicals R(1) to R(5) have the meanings... | 05/20/1997 |
| 5574029 | Method for treating anxiety The present invention provides a method for treating anxiety in a human in need thereof, comprising administering an antianxiety amount of a muscarinic agonist compound of the general formula ##STR1## wherein X R43, R44, R4... | 11/12/1996 |
| 5559140 | Difluoro statone analogs This invention relates to novel difluoro statone analogs, to the processes and intermediates useful for their preparation and to their use as anti-viral agents.... | 09/24/1996 |
| 5432191 | Allosteric hemoglobin modifiers to decrease oxygen affinity in blood A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood dur... | 07/11/1995 |
| 5393776 | Tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia This invention relates to structurally novel acyclic tocotrienol analogs, which are useful for cholesterol/lipid lowering in cases of hypercholesterolemia and hyperlipidemia, and for atherosclerosis. Also provided are pharmaceutical compositions and a met... | 02/28/1995 |
| 5378729 | Amino acid derivative anticonvulsant The present invention relates to compounds exhibiting central nervous system (CNS) activity which are useful in the treatment of epilepsy and other CNS disorders. The compounds of this invention have the following general formula: ##STR1## and p... | 01/03/1995 |
| 5356931 | Use of -arylacrylic derivatives for controlling pests Alpha-Arylacrylic acid derivatives of the general formula I ##STR1## where X is ethylene or ethenylene; n is 0 or 1; m is 0, 1, 2, 3 or 4; R1 is cyano, cyanato, thiocyanato, nitro, hydroxyl, carboxyl, haloalkyl, haloalkoxy, unsubstituted or sub... | 10/18/1994 |
| 5344845 | Compound and use of the same as medicine Disclosed herein is a specific cinnamic acid derivative such as methyl 4-(4-acetoxy-3-methoxycinnamanide)-1-cyclohexanecarboxylate, or a pharmaceutically acceptable salt thereof. These compounds are useful as IV-type allergic reaction-suppressive drugs.... | 09/06/1994 |
| 5290803 | Using allosteric hemoglobin modifiers to decrease oxygen affinity in blood A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood dur... | 03/01/1994 |
| 5272144 | Aryloxy-, arylthio-, heteroaryloxy-, heteroarylthio-alkenylene derivatives of amines and pharmaceutical use Aryloxy- and heteroaryloxy-alkylene derivatives of amines of formula ##STR1## wherein each of A and B is a group of formula (i) to (iii): ##STR2## wherein Y is --O--, --S-- or --NR-- in which R is hydrogen or C1 -C6 alkyl;... | 12/21/1993 |
