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| Number | Title | Issue Date |
| 8076370 | Antimicrobial agents Provided herein are substituted aromatic compounds, which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds described herein can be used for the treatment or prevention of a condition caused by or contributed to by gram positiv... | 12/13/2011 |
| 7897639 | Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents Carbamoyl esters inhibit cholinesterase activity and, upon hydrolysis release a pharmacologically active agent. In one embodiment, the carbamoyl ester has the following structure: wherein A is selected from the group consis... | 03/01/2011 |
| 7632862 | Pharmaceutical compositions that modulate HPTPbeta activity HPTPbeta is useful as a target in screening agents effective for the treatment of angiogenesis mediated disorders. ... | 12/15/2009 |
| 7579373 | Targeted bisplatinum polyamines as pro-drugs: selective release of platinum Pro-drug forms of linear polyamine-bridged platinum compounds and methods for their production and use are provided. The polyamine-bridge portion of the compounds is based on spermine or spermidine, and the central amines of the polyamine-bridge are chemically bonde... | 08/25/2009 |
| 7566738 | Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use Acyloxyalkyl carbamate prodrugs of 3-aminopropylsulfinic acid and analogs thereof, pharmaceutical compositions of 3-aminopropylsulfinic acid and analogs thereof, methods of making prodrugs of 3-aminopropylsulfinic acid and analogs thereof, methods of using prodrugs ... | 07/28/2009 |
| 7534813 | Levodopa prodrugs, and compositions and uses thereof Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. ... | 05/19/2009 |
| 7465754 | Method of potentiating chemotherapy and treating solid tumors This invention provides a method of treating solid tumors which comprises administering an effective amount of a combination of (1) a bioresponse modifier and (2) a chemotherapeutic agent. This invention also provides a method of potentiating the effects of a chemot... | 12/16/2008 |
| 7439257 | Aryloxyalkylcarbamate-type derivatives, preparation method thereof and use of same in therapeutics The invention relates to a compound of formula (I): Wherein m, n, X, Y, R1, R2, R3 and R4 are as defined herein. The invention also relates to the use of same in therapeutics. | 10/21/2008 |
| 7405194 | Therapeutic agents and methods of use thereof for the treatment of melanoma The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present i... | 07/29/2008 |
| 7388105 | Compounds and use to reduce the formation of malodour Malodour formation reducing compounds alpha-N-(3-Methyl-5-phenylpentanoxycarbonyl)-L-glutamine, alpha-N-(2-Methyl-5-phenylpentanoxycarbonyl)-L-glutamine, and alpha-N-(2,4-Dimethyl-4-phenylbutanoxycarbonyl)-L-glutamine, and their salts, compositions comprising such c... | 06/17/2008 |
| 7373207 | Treatments for a patient with congestive heart failure The invention is directed to devices for two minimally invasive therapeutic procedures, particularly for patients with congestive heart failure. One procedure involves providing a valve to form a passageway through the patient's left ventricular wall at the apex of ... | 05/13/2008 |
| 7368478 | Methods for inhibiting angiogenesis and tumor growth Angiogenesis, tumor growth, and metalloproteinase 2 (MMP2) interaction with integrin-αvβ3 are inhibited by an inhibitor compound of formula: wherein G1 and G2 are each independe... | 05/06/2008 |
| 7361701 | Aliphatic polyester composition, a molded article thereof and a method for controlling biodegradation rate using the same composition A biodegradable plastic composition which can be stably adjusted in biodegradation rate, and has greatly improved resistance to hydrolysis and weather, in particular the former, and durability resulting from the improved resistances; a molded article thereof; and a ... | 04/22/2008 |
| 7348307 | Methionine aminopeptidase-2 inhibitors and methods of use thereof The present invention provides methods of treating a lymphoma (e.g., a T-cell lymphoma or a B-cell lymphoma) in a subject by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention, for example, compounds of f... | 03/25/2008 |
| 7312244 | Polyamine analog-amino acid conjugates useful as anticancer agents Conjugates in which polyamine analogs are conjugated to an amino acid are provided, as well as compositions comprising these conjugates. Methods of using these conjugates as anticancer treatments are also provided. ... | 12/25/2007 |
| 7312360 | Substituted hydroxyethylamines Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein the variables G, L, A, W, E, R2, R3, R4, R5, RN, and Rc are defined herein. These compounds i... | 12/25/2007 |
| 7310552 | Apparatus for indirectly stimulating the vagus nerve with an electrical field An apparatus for indirectly stimulating a vagus nerve of a patient includes electrodes positioned within the esophagus, trachea, or a jugular vein of a patient, on the neck of the patient, or in combinations of these locations. The apparatus further includes a means... | 12/18/2007 |
| 7297193 | Wax-biocide wood treatment A method for preserving wood by contacting wood with an aqueous composition comprising a paraffin wax, at least one nonionic surfactant, and at least one organic wood preservative. ... | 11/20/2007 |
| 7288555 | Fungicidal composition based on a pyridylmethylbenzamide derivative and a valinamide derivative Fungicidal compositions comprising: a) at least one pyridylmethylbenzamide derivative of formula (I), in which the various radicals are as defined in the description, and b) at least one compound (II) of the valina... | 10/30/2007 |
| 7279494 | Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues The present invention provides certain [3.1.0] bicyclic oxazolidinone derivatives of formula I or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents, pharmaceutical compositions c... | 10/09/2007 |
| 7269457 | Method and system for vagal nerve stimulation with multi-site cardiac pacing A method of performing a medical procedure is provided. The medical procedure includes stimulation of a patient's heart while stimulating a nerve of the patient in order to modulate the patient's inflammatory process. More particularly, the medical procedure include... | 09/11/2007 |
| 7268111 | Therapeutic agents and methods of use thereof for the modulation of angiogenesis The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present i... | 09/11/2007 |
| 7262209 | Carbonyloxy-cyanomethyl compounds as antiparasitic agents The invention relates to compounds of the general formula wherein Ar1, Ar2, R4, R5, R6, R7, R8, W, X, a and b have the significances gi... | 08/28/2007 |
| 7253318 | Benzyloxy derivatives as MAOB inhibitors The invention relates to compounds of the formula and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5, n, m, and o are... | 08/07/2007 |
| 7250401 | Therapeutic compositions A method is provided for the preparation of compounds of the formula (R1)(R2)NC(═X)S(O)nR3 or (R1)(R2)NC(═X)OS(O)nR3, wherein R1, R2 and R3, ... | 07/31/2007 |
| 7226440 | Method and device for accessing a pericardial space A method for accessing a pericardial space of a heart of a mammalian patient is disclosed comprising: guiding a catheter through a coronary sinus of the heart and to a cardiac vein; advancing said catheter to a distal segment of the cardiac vein; intentionally punct... | 06/05/2007 |
| 7225019 | Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated in order to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ.... | 05/29/2007 |
| 7192980 | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors The present invention relates to certain substituted polyketides of formula I, wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said comp... | 03/20/2007 |
| 7184829 | Method and system for nerve stimulation prior to and during a medical procedure A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated in order to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ.... | 02/27/2007 |
| 7179224 | Organ manipulator and positioner and methods of using the same Devices and methods are provided for manipulating and supporting an organ. The subject devices are characterized by having an inflatable annular member having a central opening and an organ contacting surface, a vacuum distribution element configured to create a dif... | 02/20/2007 |
| 7166744 | Retinoid derivatives and methods for producing said compounds and anti-cancer pharmaceutical composition comprising said compounds The present invention relates to a novel retinoid derivative compound represented by the formula I: wherein X, R1, R2 and R3 are as defined herein or pharmaceutically acceptalbe s... | 01/23/2007 |
| 7157102 | Multi-layered microcapsules and method of preparing same A multi-layered microcapsule containing one or more active ingredients and process for preparing the same is disclosed. The multi-layered microcapsule comprises an inner solid microparticle core, typically composed of a biodegradable polymer, and having one or more ... | 01/02/2007 |
| 7157420 | Therapeutic agents and methods of use thereof for the modulation of angiogenesis The present invention provides methods of treating an autoimmune disorder (e.g., lupus erythematosus, multiple sclerosis, myasthenia gravis, vasculitis and diabetes mellitus) in a subject by administering to the subject a therapeutically effective amount of one or m... | 01/02/2007 |
| 7141570 | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives The present invention provides antibacterial agents having the formula I described herein. ... | 11/28/2006 |
| 7142910 | Methods of indirectly stimulating the vagus nerve with an electrical field Controlled cessation of heart beat during coronary bypass surgery and other cardiac surgeries on a beating heart improves surgical technique, and is achieved typically by electrical stimulation of the vagus nerve and administration of a combination of drugs. ... | 11/28/2006 |
| 7135465 | Sustained release beadlets containing stavudine Extended dosage forms of stavudine are provided comprising beadlets formed by extrusion-spheronization and coated with a seal coating. The beadlets are also coated with a modified release coating such that a hard gelatin capsule containing such beadlets will provide... | 11/14/2006 |
| 7119229 | Alkaloid derivative and a pharmaceutical composition containing the same Colchicine derivatives represented by the formula (I) with a halogen or nitric ester group, or pharmaceutically acceptable salts thereof, are described. Pharmaceutical compositions containing the same as effectiv... | 10/10/2006 |
| 7115660 | Methods for inhibiting angiogenesis and tumor growth Angiogenesis, tumor growth, and metalloproteinase 2 (MMP2) interaction with integrin-αvβ3 are inhibited by an inhibitor compound of formula (I): wherein G1 and G2 are each independently NH—C(O)—O—R1, —... | 10/03/2006 |
| 7105569 | Fungicidal active compound combinations New active compound combinations of valinamide derivatives of the formula (I) in which R1 and R2 has the meaning given in the description, with k... | 09/12/2006 |
| 7105482 | Methionine aminopeptidase-2 inhibitors and methods of use thereof The present invention provides methods of treating, parasitic infections, thymoma, and lymphoid malignancies in a subject by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention. ... | 09/12/2006 |
