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An armor with rollers is provided that enables a user to move in all positions by rolling on a hard and smooth surface while constantly varying his bearing points on the ground.
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| Number | Title | Issue Date |
| 8138225 | Histone deacetylase inhibitors based on alpha-ketoepoxide compounds Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, for example, an alpha-ketoepoxide group, such as an alpha-ketothio group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene e... | 03/20/2012 |
| 8124654 | Derivatives of hypoestoxide and related compounds Novel diterpene compounds, in particular, hypoestoxide-related compounds, are provided in pure form or as contained in the native plant source, for treatment and prophylaxis of cancer, inflammatory diseases, hyperlipidemias, malaria, and diabetes mellitus. Embodimen... | 02/28/2012 |
| 8022103 | Ester prodrugs of prostratin and related phorbol compounds Ester prodrugs of phorbol compounds for the treatment of viral infections, neoplastic diseases, inflammatory reactions, and use as analgesics, wherein the phorbol compounds are derivatized with a -x-o-c(o)-R′ group linked to the 6-carbon of the phorbol residue. | 09/20/2011 |
| 8013014 | Aza-peptide epoxides Methods for treatment and/or prevention of nerve degeneration in mammals using aza-peptide epoxide caspase inhibitors are provided. Aspects of the present disclosure include aza-peptide epoxide compositions to treat or prevent diseases, for example stroke, Alzheimer... | 09/06/2011 |
| 7718695 | Inclusion compounds of fumagillol derivative or its salt, and pharmaceutical compositions comprising the same The present invention relates to an inclusion compound of fumagillol derivative or its salt with hydroxypropyl-β-cyclodextrin or sulfobutylether-7-β-cyclodextrin, and pharmaceutical compositions comprising the same. The inclusion compound according to the present ... | 05/18/2010 |
| 7666905 | Compositions comprising hepoxilin analogs and their use in the treatment of cancer Methods and pharmaceutical compositions comprise at least one hepoxilin analog of the formula (I) wherein X and R3 are as defined herein. The methods are directed to treatment of a cancer and for promotion of a a... | 02/23/2010 |
| 7579372 | Histone deacetylase inhibitors based on alpha-ketoepoxide compounds Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, for example, an alpha-ketoepoxide group, such as an alpha-ketothio group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene e... | 08/25/2009 |
| 7557139 | Triptolide analogs for the treatment of autoimmune and inflammatory disorders The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of triptolide alone or in combination or alternation with other anti-autoimmune... | 07/07/2009 |
| 7528168 | Inhibitors of the fatty acid oxidation for the prophylaxis and/or the treatment of chronic and/or atopic skin diseases The invention relates to a method of preventing and/or treating a chronic and/or an atopic skin disease by administering an inhibitor of fatty acid oxidation to a patient in a pharmacologically effective amount. Furthermore, the invention relates to the use of at le... | 05/05/2009 |
| 7524883 | Eponemycin and epoxomicin analogs and uses thereof The present invention provides compounds having formula (1): wherein R1-R6, A, J, D, E, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and met... | 04/28/2009 |
| 7521478 | Total synthesis of myriaporones Compounds of the general formula (I) or a pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereof are provided: wherein the substituent groups defined by R are each independently selected from the group consisting of H, SiR′3, SOR... | 04/21/2009 |
| 7411000 | Process of inhibiting cell death in injured cartilage Processes for inhibiting apoptotic cell death and glycosaminoglycan release from injured cartilage is provided. Inhibition is accomplished using caspase inhibitors. ... | 08/12/2008 |
| 7405194 | Therapeutic agents and methods of use thereof for the treatment of melanoma The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present i... | 07/29/2008 |
| 7355063 | Shogaol compound and tyrosinase activity inhibitor comprising the compound The compound represented by the following formula (1): wherein A, B, R1, R2, R3 and Z are as defined in the specification is analogous to shogaol and gingerol useful in the fields of foods, medicines, quasi-drugs, cosmetics... | 04/08/2008 |
| 7351739 | Bioactive compounds and methods of uses thereof In one aspect, the present invention provides compounds having formula I or IV as shown below: as further defined herein. In additional aspects, the present invention provides compositions and kits comprising the compounds ... | 04/01/2008 |
| 7348307 | Methionine aminopeptidase-2 inhibitors and methods of use thereof The present invention provides methods of treating a lymphoma (e.g., a T-cell lymphoma or a B-cell lymphoma) in a subject by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention, for example, compounds of f... | 03/25/2008 |
| 7345046 | Heteroaryl-fused pyrimidinyl compounds as anticancer agents Heteroaryl-fused pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the heteroaryl-fused pyrimidinyl compounds, either alone or in combination with at lea... | 03/18/2008 |
| 7332523 | TNP-470 polymer conjugates and use thereof The present invention relates to conjugates of water-soluble polymers and o(chloracetyl-carbamoyl) fumagillol (TNP-470) and use of those conjugates as specific intracellular carriers of the TNP-470 into tumor vessels. The present invention further relates to use of ... | 02/19/2008 |
| 7312237 | Combination of epothilone analogs and chemotherapeutic agents for the treatment of prolilferative diseases Compositions and methods are disclosed which are useful of the treatment and prevention of proliferative disorders. ... | 12/25/2007 |
| 7282562 | Compositions and methods for the treatment of immune related diseases The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases. ... | 10/16/2007 |
| 7268111 | Therapeutic agents and methods of use thereof for the modulation of angiogenesis The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present i... | 09/11/2007 |
| 7259188 | Methods and pharmaceutical compositions for treatment of anti-estrogen resistant breast cancer using RXR modulators Methods and compositions for the treatment of anti-estrogen resistant breast cancer using retinoid compounds which are modulators of Retinoid X Receptors. ... | 08/21/2007 |
| 7250157 | Dermatological compositions and methods Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds,... | 07/31/2007 |
| 7232818 | Compounds for enzyme inhibition Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited b... | 06/19/2007 |
| 7229979 | Hypoestoxides, derivatives and agonists thereof for use as stent-coating agents Methods of treating a host suffering from restenosis are provided. The methods include delivery of a stent coated with a hypoestoxide, hypoestoxide derivative or hypoestoxide agonist compound to a vessel. The methods further include the administration of a chemother... | 06/12/2007 |
| 7217706 | Propanolamine derivatives This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympatho... | 05/15/2007 |
| 7214701 | Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ... | 05/08/2007 |
| 7204994 | Juvenile hormone compositions and methods for making same The present invention relates to hormone coating layers having desirable hormone delivery characteristics and product lifetime. In one embodiment, the invention is a hormone composition including a substrate having an external surface, and a coating layer disposed o... | 04/17/2007 |
| 7186861 | Z-substituted acrylamides, methods for production thereof and agents comprising the same Z-substituted acrylamides of formula (I), where the substituents have the following meanings: X═H, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, with X in the 3- or 4-position, n=1 or 2, where X can be different if n=2, R1=alkyl, haloalkyl, cycloalkyl,... | 03/06/2007 |
| 7183420 | Method for the preparation of 11(12)-pentadecen-15-olides The invention relates to an improved method for the preparation of 11(12)-pentadecen-15-olides. ... | 02/27/2007 |
| 7166726 | Aryl substituted 3,4-dihydroanthracene derivatives having retinoid antagonist or retinoid inverse agonist type biological activity Disclosed herein are compounds of the formula wherein R1 is independently H or alkyl of 1 to 6 carbons; R2 is optional and is defined as lower alkyl of 1 to 6 carbons, F, Cl, Br... | 01/23/2007 |
| 7157420 | Therapeutic agents and methods of use thereof for the modulation of angiogenesis The present invention provides methods of treating an autoimmune disorder (e.g., lupus erythematosus, multiple sclerosis, myasthenia gravis, vasculitis and diabetes mellitus) in a subject by administering to the subject a therapeutically effective amount of one or m... | 01/02/2007 |
| 7148007 | Method for evaluating immunotoxicity of test substance The present invention discloses a method of evaluating the immunotoxicity of a hydrophobic test substance, comprising (1) culturing immunocompetent cells in a culture system containing a hydrophobic test substance and a surfactant, (2) obtaining a survival rate of t... | 12/12/2006 |
| 7144917 | Inhibitors of matrix metalloproteinases The invention provides compounds that inhibit MMPs; methods for treating or preventing cancer, angiogenesis, arthritis, connective tissue disease, cardiovascular disease, inflammation or autoimmune disease in a mammal; a method for inhibiting a matrix metalloprotein... | 12/05/2006 |
| 7129271 | Compounds for pest control and methods for their use Compounds, compositions, and methods that employ an eremophilane sesguiterpene are presented for controlling an arthropod pest population. The compounds have minimal adverse or toxic effects on humans, non-human animals, and the natural environment. The compounds ma... | 10/31/2006 |
| 7125854 | Bicyclic carbohydrates as antiprotozoal bioactive for the treatment of infections caused by parasites The use of bicyclic carbohydrates for the treatment of parasite infections is described. Different bicyclic carbohydrates have been tested in vitro against a number of protozoa. These compounds also have been screened against viruses, tumors, bacteria and fungi. Com... | 10/24/2006 |
| 7115720 | Therapeutic and diagnostic compounds, compositions, and methods The invention provides a complex comprising a) a compound formula I: wherein R1, X and n have any of the values described in the specification, or a pharmaceutically acceptable salt thereof; and b) a r... | 10/03/2006 |
| 7115640 | Heterocyclic modulators of nuclear receptors Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X receptor (FXR), liver X receptor (LXR) and/or orphan nuclear receptors. I... | 10/03/2006 |
| 7109238 | Calcilytic compounds Novel calcilytic compounds and methods of using them are provided. ... | 09/19/2006 |
| 7105172 | Treatment of rosacea Disclosed herein are methods for the treatment or prevention of rosacea in a patient, including administering a compound that inhibits one or more components of the bradykinin activation pathway in an amount sufficient to reduce or prevent one or more symptoms of ro... | 09/12/2006 |
