Did You Know...
...that it was melting ice cream that inspired the invention of the outboard motor? It was a lovely August day and Ole Evinrude was rowing his boat to his favorite island picnic spot. As he rowed, he watched his ice cream melt and wished he had a faster way to get to the island. At that moment the idea for the outboard motor was born!
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| Number | Title | Issue Date |
| 8188145 | Synthetic lactone formulations and method of use Natural and synthetic compounds having a lactone structure methods for alleviation of pain, especially pain associated with disorders such as melanoma, leukemia, breast cancer, lung cancer, ovarian cancer, colon cancer, esophagus cancer, liver cancer, and lymphatic ... | 05/29/2012 |
| 8158677 | Treatment of viral infections by modulation of host cell metabolic pathways Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral ... | 04/17/2012 |
| 8084495 | Composition of labdane diterpenes extracted from andrographis paniculata, useful for the treatment of autoimmune diseases, and alzheimer disease by activation for PPR-gamma receptors The diterpenic labdane 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,ha-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-dihydro-4-hydroxy-2(3h)-furanone, chemically diagrammed as inhibits the synthesis of pro-inflammatory c... | 12/27/2011 |
| 7956088 | Synthetic lactone formulations and methods of use Natural and synthetic compounds having a lactone structure methods for using and making the compounds have been disclosed. The compounds are useful as anti-bacterial, anti-fungal and anti-inflammatory agents, and for treating proliferation disorders such as melanoma... | 06/07/2011 |
| 7884130 | Gamma-undecenolactone, method for the preparation and use thereof for cosmetics and in the form of food additives The invention relates to a gamma-undecenolactone of formula (i), wherein a lactonic cycle can carry an unsaturation between carbon No. 2 and carbon No. 3 and is preferably saturated, RI is a possibly substituted C7 alkenyl or alkynyl group having at least... | 02/08/2011 |
| 7649016 | Antitumor medicine There is provided an antitumor medicine comprising 1,5-D-anhydrofructose and/or ascopyrone. The antitumor medicine has effects of ascopyrone in inhibiting the growth and metastasis of tumors, is expected to inhibit inflammation and exerts an excellent effect on prog... | 01/19/2010 |
| 7625945 | Andrographolide and analogues as inhibitors of TNFα and IL-1β expression This invention relates to a method of inhibiting the expression of TNFα or IL-1β with a compound of the following formula: wherein R1 and R2 are defined herein. It also relates to is a method of trea... | 12/01/2009 |
| 7592368 | Sulphonamide derivatives as prodrugs of aspartyl protease inhibitors The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl protease inhibitors characterized by favorable aqueous solubility, hig... | 09/22/2009 |
| 7547726 | AI-2 compounds and analogs based on LsrB structure This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in Salmonella typhimurium. ... | 06/16/2009 |
| 7538139 | Sugar derivatives comprising oxiranes or α, β-unsaturated γ-lactones, process for their preparation and their utilisation as pesticides A method for controlling pests, the method comprising applying an effective amount to pests or their locus of one or more compounds of general formula (I) wherein R1 and R2 represent, independently fro... | 05/26/2009 |
| 7459481 | Stimulation of CPT-1 as a means to reduce weight This invention provides methods and compositions for inducing weight loss and maintaining optimum weight comprising administering an agent that stimulates carnitine palmitoyl transferase-1 (CPT-1) activity to the patient in need, including human patients. These meth... | 12/02/2008 |
| 7375133 | Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid analog or derivative, either alone or ... | 05/20/2008 |
| 7371855 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 05/13/2008 |
| 7361664 | Vitamin D receptor antagonists and related compositions and methods of use A compound of formula: wherein X is a C2-10 spacer, and R is a substituted or unsubstituted C6-30 aryl, a substituted or unsubstituted C5-30 heteroaryl, or ... | 04/22/2008 |
| 7351734 | Aminoindane derivatives as serotonin and norepinephrine uptake inhibitors The present invention relates to aminoindane derivatives having the formula I wherein X, Y, U, R1-2, R13-16 and R are as defined in the claims, or an acid addition salt thereof. The compounds of the invention posses the combined effect of serot... | 04/01/2008 |
| 7345091 | Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid analog or derivative, either alone or ... | 03/18/2008 |
| 7339078 | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to ... | 03/04/2008 |
| 7326542 | Compositions and methods for regulating bacterial pathogenesis The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimul... | 02/05/2008 |
| 7323495 | Synthetic lactone formulations and method of use Natural and synthetic compounds having a lactone structure methods for using and making the compounds have been disclosed. The compounds are useful as anti-bacterial, anti-fungal and anti-inflammatory agents, and for treating proliferation disorders such as melanoma... | 01/29/2008 |
| 7320997 | Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid analog or derivative, either alone or ... | 01/22/2008 |
| 7320439 | Self-contained insect repelling and killing apparatus An apparatus for the purpose of dispensing a chemical agent whose function is to detract or alternatively attract and destroy, insects, in particular, flying insects. The apparatus consists of a chemical source, a connection to a fluid source, usually water, a reser... | 01/22/2008 |
| 7317008 | Carotenoid ester analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury A method of treating ischemic reperfusion injury in a subject. The method may include administering to the subject an effective amount of a pharmaceutically acceptable formulation. The pharmaceutically acceptable formulation may include a synthetic analog or derivat... | 01/08/2008 |
| 7300948 | Alkynyl compounds as non nucleoside reverse transcriptase inhibitors Inhibitors of HIV reverse transcriptase which are useful for the treatment of HIV infection. Exemplars of the invention are compounds of the formula wherein the substituents are as defined in the following table ... | 11/27/2007 |
| 7288567 | Inhibitors of histone deacetylase The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and cond... | 10/30/2007 |
| 7285571 | Herbal chemical composition for the treatment of cancer The present invention relate to a novel synergistic composition of lignans exhibiting anticancer activities for breast, cervix, neuroblastoma, colon, liver, lung, mouth, ovary and prostate cancer obtained from the plant extract of Cedrus deodra, said composit... | 10/23/2007 |
| 7262219 | Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gamma-hydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorde... | 08/28/2007 |
| 7230013 | C10 carbamoyloxy substituted taxane compositions Compositions comprising a taxane having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents. ... | 06/12/2007 |
| 7223792 | Cytotoxic annonaceous acetogenins from Acetogenins isolated from Annona muricata of the family Annonaceae are described. The substantially pure compounds of the invention exhibit to human tumor cell lines as well as selective cytotoxicity for various human tumor cell lines. ... | 05/29/2007 |
| 7208612 | Crystals of LuxP and complexes thereof A crystal comprising LuxP is obtained, and a binding site for autoinducer-2 (AI-2) identified. The X-ray crystallographic data for LuxP and a LuxP-AI-2 complex is determined and used in a drug discovery method. Pharmaceutical compositions comprising ligands identifi... | 04/24/2007 |
| 7205289 | Combinations of active ingredients with insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain cyclic ketoenols and certain insecticidally active compounds that together have very good insecticidal and acaricidal properties. ... | 04/17/2007 |
| RE39530 | 3-amino-3-arylpropan-1-ol-compounds, their preparation and use 3-amino-3-arylpropan-1-ol compounds corresponding to the formula I in which R1 to R5, A and X have the meanings according to claim 1, and their preparation and use as medicaments. ... | 03/27/2007 |
| 7192736 | Nucleic acid molecules encoding cytotoxic conjugates that contain a chemokine receptor targeting agent Nucleic acid moleucles that encode conjugates containing as a ligand a chemokine receptor targeting agent, such as a chemokine, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, ... | 03/20/2007 |
| 7189753 | Preemptive prophylaxis of migraine A method of preventing the headache phase of migraine in a human comprises administration of a 5HT1 receptor agonist or administration of an over-the-counter or nonprescription drug to said human exhibiting prodrome symptoms of migraine. Suitably, the met... | 03/13/2007 |
| 7183316 | Treatment of HPV caused diseases Human papillomavirus (HPV) protein expression is downregulated in patients infected with HPV by administration of PPARγ ligand, selective inhibitor of cyclooxygenase-2 (COX-2), diaryl heterocycle, inhibitor of HPV protein from a natural source and/or certain non-st... | 02/27/2007 |
| 7173055 | Pyrazolecarboxamide and pyrazolethioamide as fungicide Novel pyraole derivatives of formula (I), wherein: X is oxygen or sufu, R1 is C1–C3alkyl, C1–C3haloalkyl, C1–C3alkoxy-C1–C3alkyl or C1–C3 | 02/06/2007 |
| 7166702 | Cytotoxic conjugates comprising a chemokine receptor targeting agent Conjugates containing as a ligand chemokine receptor targeting agents, such as chemokines, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, proliferation and migration of immune... | 01/23/2007 |
| 7161033 | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to ... | 01/09/2007 |
| 7157489 | HIV protease inhibitors Compounds useful for inhibiting HIV protease are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating wild-type HIV and of multidrug-resistant strains of HIV, also are disclosed. ... | 01/02/2007 |
| 7157418 | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders Conjugates containing as a ligand a chemokine receptor targeting agents, such as chemokines, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, proliferation and migration of immu... | 01/02/2007 |
| 7153859 | Condensed polycyclic compounds The present invention provides a novel a condensed polycyclic compound useful as a phosphodiesterase 4 inhibitor, which is shown by the formula [I]: or a pharmaceutically acceptable salt thereof and a pharmaceuti... | 12/26/2006 |
