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"I watched his countenance closely, to see if he was not deranged ... and I was assured by other senators after he left the room that they had no confidence in it."
U.S. Senator Smith of Indiana ; After seeing Samuel Morse demonstrate the telegraph.
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| Number | Title | Issue Date |
| 8183287 | Pharmaceutical formulations and compositions of a selective antagonist of either CXCR2 or both CXCR1 and CXCR2 and methods of using the same for treating inflammatory disorders The present invention provides compositions as well as kits and methods based on a selective antagonist of either CXCR2 or both CXCR1 and CXCR2 that are useful for treating inflammatory disorders. ... | 05/22/2012 |
| 8163796 | Treatment of cancer by oxidation-reduction potentiation of cancerostatic dicarbonyls A novel treatment regimen is described for the control and elimination of cancer cell populations including cancer stem cells. The disclosed protocol consists of a pretreatment step followed by a treatment step. The pretreatment step sensitizes cancer cells to apopt... | 04/24/2012 |
| 7910622 | Modulation of bacterial quorum sensing with synthetic ligands The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sensing ligands in a ligand-prote... | 03/22/2011 |
| 7371779 | Synergistic compositions of N-acylhomoserine lactones and 4-quinolones A composition having immunosuppressant activity comprises at least one compound of the formula (I) in which R is an acyl group of the formula (II) wherein one of R1 and R2 is H and the other is selected from OR4, SR4 and N... | 05/13/2008 |
| 7202274 | Cyclic hemiacetal derivative and use thereof A compound represented by the following formula (I) wherein R1 is a lower alkyl group, R2 is a hydrogen, a halogen, a cyano group, a lower alkyl group or a lower alkoxy group, and n is 0 or ... | 04/10/2007 |
| 7176201 | Modulation of anxiety through blockade of anandamide hydrolysis Fatty acid amide hydrolase inhibitors of the Formula: are provided wherein X is NH, CH2, O, or S; Q is O or S; Z is O or N; R is an aromatic moiety selected from the group consisting of substituted or ... | 02/13/2007 |
| 7160913 | Methods and kit for treating Parkinson's disease The efficacy of levodopa therapy in patients being treated for Parkinson's disease is enhanced by administering high doses of a partial glycine agonist. The frequency and severity of levodopa-induced side effects in Parkinson's disease patients are also reduced by a... | 01/09/2007 |
| 7132448 | High concentration topical insecticide containing insect growth regulator A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The insecticide contains an insecticide and an insect growth regulator effective for killing fleas, flea larvae and flea ... | 11/07/2006 |
| 7109243 | Inhibitors of cathepsin S The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme (e.g., cathespin K). The present inven... | 09/19/2006 |
| 7049338 | Antiproliferative agents This invention relates to certain dioxodihydropyridine derivatives and certain methacrylic acid and furan derivative precursors thereof, processes for their preparation, pharmaceutical compositions containing such compounds and their use as anti-proliferative agents... | 05/23/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 6984662 | High concentration topical insecticide containing insect growth regulator A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The insecticide contains an insecticide and an insect growth regulator effective for killing fleas, flea larvae and flea ... | 01/10/2006 |
| 6956055 | Substituted γ-lactone compounds as NMDA-antagonists The invention relates to substituted γ-lactone compounds, to methods for the production thereof, to medicaments containing these compounds and to the use of these compounds for producing medicaments. ... | 10/18/2005 |
| 6936719 | Biaryl compounds as serine protease inhibitors Compounds of formula (I) are useful as inhibitors of trypsin like serine protease enzymes such as thrombin, factor VIIa, factor Xa, TF/FVIIa, and trypsin. These compounds could be useful to treat and/or prevent clotting disorders, and as anticoagulating agents. ... | 08/30/2005 |
| 6916814 | Methods of treating cytokine mediated diseases Disclosed are methods of treating certain cytokine mediated diseases or conditions using novel aromatic heterocyclic compounds of the formula(I) wherein Ar1,Ar2,L,Q and X are described herein. ... | 07/12/2005 |
| 6894074 | Synergistic insecticidal mixtures The invention relates to insecticidal mixtures comprising compounds of the formula (I) in which X′, Y′, Z′, n, G′, A′ and B′ are as defined above and agonists and/or antagonists of nicotinic acety... | 05/17/2005 |
| 6864283 | Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity Compounds of formula (I) wherein R1is selected from H, C(═O)R′, P(═O)R′R″, S(═O)R′R″, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubs... | 03/08/2005 |
| 6864380 | Benzylcycloalkyl amines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of inflammatory diseases such as asthma and other allergic diseases. | 03/08/2005 |
| 6849634 | Potassium channel inhibitors Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described. ... | 02/01/2005 |
| 6838471 | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytok... | 01/04/2005 |
| 6822001 | Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents Combination therapies are provided for the treatment of proliferative disorders which use a pentafluorobenzenesulfonamide of formula I and an antineoplastic agent such as gemcitabine or paclitaxel. ... | 11/23/2004 |
| 6790866 | Sulfonamide and carboxamide derivatives and drugs containing the same as the active ingredient The sulfonamide or carboamide derivatives of the formula (I) and a pharmaceutical composition which comprise them as an active ingredient: (wherein A ring, B ring is carbocyclic ring, heterocyclic ring; Z1 is ... | 09/14/2004 |
| 6774144 | Methods and formulations for the treatment of infectious bursal disease in avian subjects In one aspect, the invention relates to a method of treating infectious bursal disease (IBD) in an avian subject in need of such treatment. The method comprises administering to the subject a compound of the formulas (I) through (IV) or a pharmaceutically acceptable... | 08/10/2004 |
| 6762183 | Active substance combinations having insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties. ... | 07/13/2004 |
| 6737440 | Synthesis and antimicrobial activity of novel dicationic “reversed amidines” The present invention relates to novel 2,5-bis {[alkyl(or aryl)imino]aminophenyl}furans and thiophenes of the general formula in which R1, R2, R3 and R4 are each independently ... | 05/18/2004 |
| 6726898 | Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease The present invention relates to compositions and methods of treating periodontal disease and related disorders utilizing a sustained, controlled release targeted delivery method to effectively disrupt and inhibit bacterial biofilms at periodontal treatment sites. | 04/27/2004 |
| 6713506 | Tea polyphenol esters and analogs thereof for cancer prevention and treatment Disclosed herein are ester-bond containing tea polyphenols that has a susceptibility to nucleophilic attack, their analogs and pharmaceutically acceptable salts, method for inhibiting proteasomal chymotrypsin-like activity in vivo and in vitro, methods for cancer tr... | 03/30/2004 |
| 6706290 | Methods for eradication of nanobacteria Nanobacteria contribute to pathological calcification in the human and animal body, including diseases such as kidney stones, salivary gland stones, dental pulp stones and atherosclerosis. The present invention provides methods for sterilizing articles contaminated ... | 03/16/2004 |
| 6677353 | Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 01/13/2004 |
| 6677341 | (R)-Chiral halogenated substituted heteroaryl benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and m... | 01/13/2004 |
| 6660732 | Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such c... | 12/09/2003 |
| 6660769 | N substituted 3-amino-2,2-di-c-alkyl-1,4-butyrolactones and 1,4-thiobutyrolactones for use as promoter of γ-aminobutyric acid activity and for treating nervous disorders and preparation method The invention concerns compounds represented by general formula (I) wherein: Z represents a sulfur or oxygen atom; the groups R1 and R2, identical or different, represent each a alkyl group or an alkenyl group; X represents a CO, a CO2, an SO, ... | 12/09/2003 |
| 6656933 | Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such c... | 12/02/2003 |
| 6610713 | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflamm... | 08/26/2003 |
| 6608061 | Bisaryl compound and medicament for cancer treatment comprising the same A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar1 --S--R1 --S--Ar2 wherein R1 represents a nonmetal bridging... | 08/19/2003 |
| 6602905 | N-acyl homoserine lactones for the treatment of cardiac tachyarrhythmias, ischaemic heart disease or congestive heart failure Compounds having anti-fibrotic effects are provided. Also provided is a method for treating disorders, diseases or conditions associated with pathological fibrotic states. The compounds useful in the present invention are homocysteine thiolactone and sele... | 08/05/2003 |
| 6586433 | Substituted N-heteroaryl-N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 07/01/2003 |
| 6569895 | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders Tetrahydrofurans, tetrahydrothiophenes, pyrrolidines and cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune res... | 05/27/2003 |
| 6566373 | Protease inhibitors The invention relates to 3-hydroxy-and 3-keto-cyclohetero-substituted leucine compounds that are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor. The 3-hy... | 05/20/2003 |
| 6541512 | Prevention of pest feed harm on a fibrous product The present invention provides a method of preventing pest feed harm on a fibrous product, a composition preventing pest feed harm on a fibrous product and uses of 1-methyl-2-nitro-3-[(3-tetrahydrofuryl)methyl]guanidine for preventing pest feed harm ... | 04/01/2003 |
