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| Number | Title | Issue Date |
| 8183286 | EP2 and EP4 agonists as agents for the treatment of influenza a viral infection The present invention is directed to the use of EP2 and/or EP4 agonists as therapeutics for the treatment of diseases associated with influenza A viruses, such as for example H5N1 and mutations thereof. ... | 05/22/2012 |
| 8173699 | Compounds for the treatment of inflammatory diseases Compounds of formula 1 and hetero derivatives thereof and the pharmacologically acceptable salts, enantiomers, racemates, hydrates, or solvates thereof, which are suitable for the treatment of respiratory or gastrointestina... | 05/08/2012 |
| 8084494 | Substituted aminophenylsulfonamide compounds as HIV protease inhibitor The present invention concerns substituted aminophenylsulfonamide compounds, their use as protease inhibitors, in particular as broad-spectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits compris... | 12/27/2011 |
| 8067463 | Protease inhibitor precursor synthesis The present invention provides a compound having the structure (I) and processes for the production thereof and the intermediates used in such process. ... | 11/29/2011 |
| 7981929 | Benzofuran derived HIV protease inhibitors Resistance-repellent and multidrug resistant retroviral protease inhibitors are provided. Pharmaceutical composition comprising such compounds, and methods of using such compounds to treat HIV infections in mammals, are also provided. ... | 07/19/2011 |
| 7964638 | Skin cosmetic and wrinkle-reducing agent The present invention is to provide skin cosmetics and anti-wrinkle agents which are excellent in reducing effect on wrinkle caused by photoaging. Skin cosmetics and anti-wrinkle agents which comprise isosorbide represented by the following formula (1). | 06/21/2011 |
| 7923470 | Benzooxazoles as orexin antagonists The present invention is concerned with novel sulfonamides of formula I wherein R1, R2, Ar, Hetaryl, m and n are as described in the description and claims. The compounds are orexin receptor antagonist... | 04/12/2011 |
| 7846967 | Cosmetic composition for skin whitening comprising senkyunolide A as active ingredient The present invention relates to cosmetic compositions and more particularly to skin-whitening cosmetic compositions comprising senkyunolide A as an active ingredient. The present invention discloses the novel inhibitory function of senkyunolide A isolated from C... | 12/07/2010 |
| 7825159 | Mixtures of aromatic esters for marking or tagging organic products, marker compositions comprising the same and manufacturing methods thereof The present invention is directed to a mixture of at least two different alkylated phenolphthalein ester compounds. Specifically, the present invention is directed to a mixture of at least two different compounds of formula I: | 11/02/2010 |
| 7723381 | Compounds for the treatment of inflammatory diseases Compounds of formula 1 and hetero derivatives thereof and the pharmacologically acceptable salts, enantiomers, racemates, hydrates, or solvates thereof, which are suitable for the treatment of respiratory or gastrointestina... | 05/25/2010 |
| 7700647 | Fluorinated bis (phthalic anhydride) and method for producing the same It is an object of the present invention to provide fluorinated bis(phthalic anhydride) which has less coloration and higher solubility in comparison with conventional compounds, and a method for producing the same. Further, it is also an object of the present inven... | 04/20/2010 |
| 7649015 | Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other... | 01/19/2010 |
| 7507763 | Resistance-repellent retroviral protease inhibitors Resistance-repellent and multidrug resistant retroviral protease inhibitors are provided. Pharmaceutical composition comprising such compounds, and methods of using such compounds to treat HIV infections in mammals, are also provided. ... | 03/24/2009 |
| 7498357 | Chalcone compounds The present invention provides a novel chalcone compound, its derivative or a salt thereof, each having a suppressive action of NO production or an inhibitory action of aldose reductase. In addition, the present invention provides a medicament, a food, a beverage or... | 03/03/2009 |
| 7470724 | Phosphonate compounds having immuno-modulatory activity The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for p... | 12/30/2008 |
| 7419967 | Sulfonamide inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. T... | 09/02/2008 |
| 7420001 | Biaryl sulfonamides and methods for using same The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors. ... | 09/02/2008 |
| 7393825 | Microdose therapy Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve administration of nitric oxide (NO), agents which are able to provid... | 07/01/2008 |
| 7378441 | Resistance-repellent retroviral protease inhibitors Resistance-repellent and multidrug resistant retroviral protease inhibitors are provided. Pharmaceutical composition comprising such compounds, and methods of using such compounds to treat HIV infections in mammals, are also provided. ... | 05/27/2008 |
| 7371774 | Benzofurans and benzothiophenes The invention relates to compounds of the general formula (I) below: in which R1, R2, R3, R4, R5, R6 and X are as defined in claim 1. These compounds can be used in the treatment of pathologies associated wi... | 05/13/2008 |
| 7351735 | Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders ... | 04/01/2008 |
| 7332522 | Liver function protecting or ameliorating agent A liver function protecting or improving agent which comprises a compound represented by the formula (I) {in the formula (I), R1, R2, R3, R4, R5, R6 | 02/19/2008 |
| 7309497 | Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. The invention relates in particular to an injectable pharmaceutical composition comprising (a) a pharmacologically active ingredient i... | 12/18/2007 |
| 7273886 | Benzofuran inhibitors of factor VIIa Compounds of Formula I are useful for inhibiting serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein and have improved pharmacokinetic properties. These compounds may be used in methods of preventing and/or treating clotting disorders... | 09/25/2007 |
| 7241756 | Combinations of dipeptidyl peptidase IV inhibitors and other antidiabetic agents for the treatment of diabetes mellitus A method for the treatment of diabetes mellitus, especially Type 2 diabetes and conditions associated with diabetes mellitus in a mammal such as a human, which method comprises administering an effective, non-toxic and pharmaceutically acceptable amount of a dipepti... | 07/10/2007 |
| 7223799 | Color-developing composition and cosmetic, fragrance products and miscellaneous goods for display with the use of the same The invention provides a color-developing composition without using a pigment or dye and capable of being colored sustainably and stably after mixing two liquid phases which are colorless before mixing. The composition consists of two discrete liquid phases, wherein... | 05/29/2007 |
| 7220749 | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use The invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compo... | 05/22/2007 |
| 7208467 | Lipid-altering compositions for the treatment of infertility SR-BI is present at relatively high levels on the membranes of hepatocytes and steroidogenic tissues, including the adrenal gland, testes, and ovaries, where it mediates the uptake and transport of cholesteryl ester from high density lipoproteins. It has been demons... | 04/24/2007 |
| 7189758 | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof A compound of Formula (I) wherein R1, R2, R3, R4, R5, and R6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutic... | 03/13/2007 |
| 7189761 | Nitric oxide donor composition and method for treatment of anal disorders A pharmaceutical composition contains a nitric oxide donor and advantageously an optional corticosteroid and/or topical anesthetic. The composition is useful in a method for treating anal disorders such as anal fissure, anal ulcer, hemorrhoidal disease, levator spas... | 03/13/2007 |
| 7179791 | Inhibiting GS-FDH to modulate NO bioactivity Patients needing NO donor therapy or inhibition of pathologically proliferating cells or increased NO bioactivity are treated with a therapeutically effective amount of an inhibitor of glutathione-dependent formaldehyde dehydrogenase. ... | 02/20/2007 |
| 7169768 | Method of decreasing atherosclerosis and its complications A method of decreasing atherosclerosis and its complications including but not limited to myocardial infarction, stroke and peripheral vascular disease wherein the method involves administering to a human or an animal an amount of an inhibitor of the release of LHRH... | 01/30/2007 |
| 7153871 | Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs PDE4 inhibition is achieved by novel compounds, e.g., aminoindazole and aminobenzofuran analogs. The compounds of the present invention are of Formulas I and II: wherein R1, R2, R3 | 12/26/2006 |
| 7148240 | Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same The invention relates to benzofuran or benzothiophene derivatives of general formula: These compounds are of use as medicinal products, in particular in the treatment of pathological syndromes of the cardiovascular... | 12/12/2006 |
| 7129270 | Nonsteroidal antiinflammatory agents Compounds of Formula 1 are useful in the treatment of inflammation. ... | 10/31/2006 |
| 7126012 | Substituted cyclic compounds The invention concerns compounds of formula (I): R-A-R′ wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R1, R2, R3, v and R4 are as defined in the description; Râ... | 10/24/2006 |
| 7115252 | Therapeutic compositions and methods of use thereof A method and composition for the restoration and maintenance of gingival and periodontal health are provided. The composition includes a potassium as an essential ingredient, which acts as an anti-bacterial agent. In some embodiments, the compositions include an osm... | 10/03/2006 |
| 7101912 | Carbidopa prodrugs and derivatives, and compositions and uses thereof Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and compositions of prodrugs of carbidopa and derivatives thereof are disclosed... | 09/05/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 7005428 | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors Novel methods for the medical treatment and/or inhibition of the development of hypercholesterolemia in susceptible warm-blooded animals including humans involving administration of selective estrogen receptor modulator particularly compounds having the general stru... | 02/28/2006 |
