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| Number | Title | Issue Date |
| 8173619 | Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer The compounds are phosphoramidate derivatives of nucleoside compounds such as cladribine, isocladribine, fludarabine and clofarabine useful in the treatment of cancer. ... | 05/08/2012 |
| 8173620 | BHQ-caged nucleotide probes photolysable by two-photon excitation The disclosure encompasses caged compounds such as caged nucleoside phosphoesters (caged nucleotides). In an embodiment, the caged nucleotides include compounds corresponding to those described by formula (I) that may be activated by two-photon excitation, and metho... | 05/08/2012 |
| 8153609 | Purine nucleotide derivatives This invention provides novel 8-carbyl substituted cAMPS and a novel procedures for the preparation of 8-Br-cAMP, a key starting material. ... | 04/10/2012 |
| 8097600 | Method of increasing tear production with purinergic receptor agonists A method and preparation for the stimulation of tear secretion in a subject in need of such treatment is disclosed. The method comprises administering to the ocular surfaces of the subject a purinergic receptor agonist such as uridine 5′-triphosphate (UTP), dinucl... | 01/17/2012 |
| 7994153 | Chloasma amelioration composition and dullness amelioration composition The present invention provides a composition that can effectively improve melasma and a composition that can effectively reduce skin dullness. The composition for improving melasma comprises a purine nucleic acid-related substance and a pharmaceutically or co... | 08/09/2011 |
| 7906491 | Compounds for modulating the activity of exchange proteins directly activated by cAMP (Epacs) The present invention relates to novel compounds for modulating the activity of exchange proteins directly activated by cAMP (Epacs). In particular, the present invention relates to cAMP analogues that specifically modulate the activity of Epacs. Examples of the com... | 03/15/2011 |
| 7879814 | Methods and therapeutic compositions in the treatment of advanced cancer Adenine nucleotides such as adenosine 5′-monophosphate (AMP), adenosine 5′-diphosphate (ADP) or adenosine 5′-triphosphate (ATP) and/or adenosine and inorganic phosphate are administered in the treatment of advanced cancer in an out-patient setting and without ... | 02/01/2011 |
| 7851456 | P2Y6 receptor agonists for treating lung diseases This invention is directed to a method of enhancing or facilitating the clearance of the lung mucus secretions in a subject. This invention is also directed to a method of facilitating the hydration of the lung mucus secretions in a subject. This invention is furthe... | 12/14/2010 |
| 7807653 | Nucleotide mimics and their prodrugs The present invention relates to nucleoside diphosphate mimics and nucleoside triphosphate mimics, which contain diphosphate or triphosphate moiety mimics and optionally sugar-modifications and/or base-modifications. The nucleotide mimics of the present invention, i... | 10/05/2010 |
| 7759322 | Method of treating dry eye disease with purinergic receptor agonists A method and preparation for the stimulation of tear secretion in a subject in need of such treatment is disclosed. The method comprises administering to the ocular surfaces of the subject a purinergic receptor agonist such as uridine 5′-triphosphate (UTP), dinucl... | 07/20/2010 |
| 7629329 | Method for increasing muscle mass and strength through administration of adenosine triphosphate The present invention is directed to compositions having an effective amount of Adenosine Triphosphate (“ATP”) sufficient to effect intracellular and extracellular concentrations of ATP in a mammal to improve anaerobic exercise capacity by increasing muscle size... | 12/08/2009 |
| 7592326 | Method for stimulating the immune, inflammatory or neuroprotective response Cycic di-GMP, or a cyclic dinucleotide analogue thereof that has the same effect as cyclic di-GMP, stimulates or enhances immune or inflammatory response in a patient or enhances the immune response to a vaccine by serving as an adjuvant. Cyclic di-GMP, or a cyclic ... | 09/22/2009 |
| 7557092 | Purinergic modulation of smell Disclosed are compositions and methods for modulating odor sensitivity, as well as screening methods for detecting compounds that modulate odor sensitivity. ... | 07/07/2009 |
| 7557093 | Composition for promoting collagen production The invention provides a composition for promoting collagen production, and more specifically, provides a composition capable of promoting collagen production in human dermis. Further, the invention provides a method for promoting collagen production. The invention ... | 07/07/2009 |
| 7521432 | Compositions and methods for identifying agents which regulate chromosomal stability, gene activation and aging Novel compositions and methods are provided for identifying agents which affect chromosomal stability and aging. ... | 04/21/2009 |
| 7468357 | Nucleosides with anti-hepatitis B virus activity A method for the treatment of a host, and in particular, a human, infected with hepatitis B virus (HBV) is provided that includes administering an effective amount of a β-L-nucleotide, optionally in combination therapy with other drugs for the treatment of HBV or h... | 12/23/2008 |
| 7439349 | Method for preparation of large volume batches of poly-ICLC with increased biological potency; therapeutic, clinical and veterinary uses thereof Method for producing large lots of final sterile Poly-ICLC suitable for clinical use with reduced toxicity at effective dose levels, and method for using Poly-ICLC to regulate genes, and method for using Poly-ICLC to treat certain human and veterinary infectious, ne... | 10/21/2008 |
| 7435724 | Degradation-resistant mononucleoside phosphate compounds The present invention relates to mononucleoside phosphate compounds that have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that has been modified by attaching a degradation-resistant substituent on ... | 10/14/2008 |
| 7429570 | Methods of optimizing drug therapeutic efficacy for treatment of immune-mediated gastrointestinal disorders The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. The method of the invention includes ... | 09/30/2008 |
| 7427606 | Method to reduce inflammatory response in transplanted tissue The present invention provides a therapeutic method for treating biological diseases that includes the administration of an effective amount of a suitable antibiotic agent, antifungal agent or antiviral agent in conjunction with an A2A adenosine receptor ... | 09/23/2008 |
| 7425547 | Nucleoside derivatives for treating hepatitis C virus infection Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus. Such compounds are represented by Formula IB as follows: and pharmaceutically... | 09/16/2008 |
| 7425546 | Methods of optimizing drug therapeutic efficacy for treatment of immune-mediated gastrointestinal disorders The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. The method of the invention includes ... | 09/16/2008 |
| 7419965 | Nucleotide lipid ester derivatives The subject of the present invention is specific lipidesters of halogenated nucleotides of the following formula wherein R1, R2, R3, X and Y are defined as described herein and salts thereof... | 09/02/2008 |
| 7407944 | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods for generating an immune response or for treating a patient in need of... | 08/05/2008 |
| 7399754 | N-quinoline or isoquinoline substituted purine derivatives Novel compound having the following formula: wherein W represents a hydrogen, an optionally substituted C1-6 alkyl, an optionally substituted C3-6 cycloalkyl, or an optionally substituted C1-6 | 07/15/2008 |
| 7387798 | Method and composition for resuscitation The key obstacle for current resuscitation is the acutely limited time window. The major reason for the limited time window is that the brain and spinal cord are extremely vulnerable to hypoxic-ischemic insult. A method and a lymph-like fluid composition for resusci... | 06/17/2008 |
| 7378400 | Method to reduce an inflammatory response from arthritis The present invention provides a therapeutic method for treating an inflammatory response caused by autoimmune stimulation, comprising the administration to a patient in need thereof of an antiinflammatory amount amount of an A2A adenosine receptor agonis... | 05/27/2008 |
| 7378401 | Use of Fosfluridine Tidoxil (FT) for the treatment of intraepithelial proliferative diseases The present invention is directed to the systemic administration of Fosfluridine Tidoxil, (5-fluorouridine)-5′-phosphoric acid (3-dodecylmercapto-2-decyloxy)propylester or a salt thereof, for the treatment of intraepithelial proliferative diseases such as actinic ... | 05/27/2008 |
| 7368438 | Non-nucleotide compositions and method for inhibiting platelet aggregation This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharm... | 05/06/2008 |
| 7368439 | Dinucleoside poly(borano)phosphate derivatives and uses thereof The present invention provides dinucleoside boranophosphate derivatives of the general formula I: wherein X and X′ each independently is an unsubstituted or substituted purine or pyrimidine residue; Y and Y′ each independ... | 05/06/2008 |
| 7354907 | Short immunomodulatory oligonucleotides The invention relates to modulation of the immune system. More particularly, the invention relates to modulating the immune system through the use of oligonucleotide-derived compounds. The invention provides immunostimulatory agents that are less expensive to make t... | 04/08/2008 |
| 7348315 | Methods of treating heart failure with modified ATP, ADP and AMP compounds Disclosed herein are methods of using an adenosine analog or derivative for treating heart failure, increasing cardiac muscle contractility, increasing cardiac diastolic relaxation, and increasing vasodilation. Exemplary adenosine analogs/derivatives include compoun... | 03/25/2008 |
| 7345028 | Energy-protective composition comprising adenosine phosphates Compositions comprising inorganic phosphate and the nucleotides adenosine diphosphate and adenosine monophosphate; and their use for neutralizing effects of excess incident energy on the human body, particularly effects of ionizing radiation from nuclear or radiolog... | 03/18/2008 |
| 7342003 | Synthesis of 2-aralkyloxyadenosines, 2-alkoxyadenosines, and their analogs Provided is a method for the synthesis of an aralkyloxyadenosine or an alkoxyadenosine. The method includes protecting the hydroxyl sugar groups with a protecting group to produce a protected halogenated adenosine. The protected halogenated adenosine is alkoxylated,... | 03/11/2008 |
| 7341990 | Methods and uses of leukotriene Bhydroxylases to treat diseases Methods and uses are described for treating or preventing diseases of humans or non-human animals by reducing the amount of active leukotriene B4 (LTB4) in those in need of such treatment using LTB4 hydroxylases. In certain embodimen... | 03/11/2008 |
| 7335648 | Non-nucleotide composition and method for inhibiting platelet aggregation This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a compounds usefu... | 02/26/2008 |
| 7332479 | Extracellular NAD and cADPR as potent anti-inflammatory agents A method of prophylaxis or treatment of inflammatory conditions, including, but not limited to, intestinal epithelial inflammation due to intestine-specific conditions (e.g., Crohn's disease or ulcerative colitis) or systemic causes of inflammation (e.g., endotoxemi... | 02/19/2008 |
| 7326694 | Methods of optimizing drug therapeutic efficacy for treatment of immune-mediated gastrointestinal disorders The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. The method of the invention includes ... | 02/05/2008 |
| 7323452 | Method for the accelerated in vivo removal of ethanol A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives... | 01/29/2008 |
| 7323453 | Methods of inhibiting orthopoxvirus replication with nucleoside compounds The present invention provides methods of inhibiting orthopoxvirus replication and/or treating orthopoxvirus infection with certain nucleoside compounds and derivatives thereof. These compounds are particularly useful as inhibitors of vaccinia virus and variola viru... | 01/29/2008 |
