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Magician Harry Houdini patented a "Diver's Suit" enabling the wearer to "quickly divest himself of the suit while being submerged and to safely escape and reach the surface of the water."
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| Number | Title | Issue Date |
| 8124653 | Methods and compositions for the treatment of attention deficit hyperactivity disorder and hyperphenylalanemia Disclosed is a composition that includes a tetrahydrobiopterin in a controlled-release pharmaceutical preparation. Also disclosed is a method of treating a patient with phenylketonuria that includes administering, to the patient, a composition that contains tetrahyd... | 02/28/2012 |
| 8110601 | Compound, αadrenergic receptor antagonistic agent, and composition A novel compound, a novel α1 adrenergic receptor antagonistic agent, and a novel composition are provided which are capable of exerting a therapeutic effect on treatment of hypertension as well as treatment of prostatic hypertrophy and the like. The comp... | 02/07/2012 |
| 8088821 | Fused cyclic compounds The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof. The compound or a salt thereof or a prodrug thereof has a GPR40 receptor fun... | 01/03/2012 |
| 8084492 | Benzofuran compound and pharmaceutical composition containing the same The present invention relates to a compound having a leukotriene (particularly leukotriene B4) inhibitory action, and useful for the prophylaxis or treatment of diseases such as allergy, asthma, inflammation, cancer and the like. ... | 12/27/2011 |
| 8084493 | Pharmaceutical composition of peptide drug and enzyme-inhibition compounds The invention relates to a method of co-administering a peptide or protein drug with an enzyme-resistant PGA-complexone compound orally so to mitigate enzyme attack in the gastrointestinal tract of an animal subject. ... | 12/27/2011 |
| 8080582 | Derivatives of 8-epiblechnic acid and their effects on down-regulation of endothelin (ETA) receptor mRNA The present application discloses derivatives of 8-epiblechnic acid and use thereof in treating a disease related to endothelin receptor A or endothelin-1 (ET-1) over-expression, such as hypertension, cancer, atherosclerosis, and myocardial infarction. ... | 12/20/2011 |
| 7977380 | Inhibitors of plasma kallikrein The present invention provides compounds that inhibit the activity of plasma kallikrein (PK) and methods of preventing and treating the formation of thrombin during or after a PK dependent disease or condition, for example, after fibrinolysis treatment. ... | 07/12/2011 |
| 7884129 | Composition comprising the alcohol compound isolated from the extract of cucurbitaceae family plant having anti-adipogenic and anti-obesity activity The present invention is related to an alcohol compound isolated from the extract of Cucurbitaceae family plant having anti-adipogenic and anti-obesity activity, and a composition comprising the same. The compound showed potent reducing activity of body weight, decr... | 02/08/2011 |
| 7872044 | Inhibitors of chymase The present invention is directed to a compound of Formula (I): or an enantiomer, diastereomer, polymorph or pharmaceutically acceptable salt thereof and methods for preparing said compounds and compositions, intermediates ... | 01/18/2011 |
| 7834054 | Hydroxamates as therapeutic agents The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase... | 11/16/2010 |
| 7825158 | Therapeutic agent for substance dependence The present invention provides a therapeutic agent for substance dependence, which prevents relapse/recurrence of compulsive substance-taking behavior based on craving for addictive substances such as stimulant substances, opioids, barbiturate type anesthetics, hall... | 11/02/2010 |
| 7723380 | Antiviral protease inhibitors The invention is related to compounds of Formula I: or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the adminis... | 05/25/2010 |
| 7714023 | Treatment or prophylaxis of migraine or headache disorders using citalopram, escitalopram or citalopram metabolites Methods for prophylaxis of or treating or preventing migraine or migraine headaches, or other headache disorders include administering to a subject in need of treatment a therapeutically effective amount of citalopram, escitalopram, or a racemic or optically pure ci... | 05/11/2010 |
| 7687540 | Substituted propane phosphinic acid esters The present invention relates to certain esters of substituted 3-aminopropane phosphinic acid derivatives of formula I: wherein R, R1 and R2 are as defined herein. The compounds of this invention are u... | 03/30/2010 |
| 7632861 | Substituted heterocyclic ethers and their use in CNS disorders The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS disorders. ... | 12/15/2009 |
| 7625944 | Inhibitors of plasma kallikrein The present invention provides compounds that inhibit the activity of plasma kallikrein (PK) and methods of preventing and treating the formation of thrombin during or after a PK dependent disease or condition, for example, after fibrinolysis treatment. ... | 12/01/2009 |
| 7622500 | Antiparasitic agents The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts thereof, compositions containing such compounds and the uses of such compounds as antiparasitic agents. ... | 11/24/2009 |
| 7589122 | Method for soybean aphid population suppression and monitoring using aphid- and host-plant-associated semiochemical compositions Soybean volatile compounds, soybean aphid-induced volatile compounds and soybean aphid sex pheromones are semiochemicals of the invention used to suppress soybean aphid population. Methyl salicylate is an embodiment of a soybean aphid-induced volatile compound usefu... | 09/15/2009 |
| 7569604 | Heterocyclic derivatives for modulation of calcium channels Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions. ... | 08/04/2009 |
| 7569605 | Methods of treating central nervous system disorders with a low dose combination of escitalopram and bupropion The present invention relates to a method of treating a central nervous system disorder, such as a mood disorder (e.g., major depressive disorder) or an anxiety disorder (e.g., general anxiety disorder, social anxiety disorder, post traumatic stress disorder, and pa... | 08/04/2009 |
| 7538138 | Amines as histamine-3 receptor ligands and their therapeutic applications Compounds of formula (I) or a pharmaceutically acceptable salts or prodrug thereof which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the treatment of disorders ameliorated ... | 05/26/2009 |
| 7524882 | PPAR alpha selective compounds for the treatment of dyslipidemia and other lipid disorders A class of benzodihydrofuran compounds having the structure of formula (I) below and pharmaceutically acceptable salts thereof are useful as therapeutic compounds, particularly in the treatment of hyperlipidemia, hypercholesterolemia, dyslipidemia, and other lipid d... | 04/28/2009 |
| 7517908 | Method for augmenting the effects of serotonin reuptake inhibitors A method of treating a subject for a serotonergic neurotransmission dysregulation disorder, comprises administering the subject a serotonin enhancer (e.g., a serotonin reuptake inhibitor) in an amount effective to treat the disorder; and concurrently administering t... | 04/14/2009 |
| 7488752 | Thrombin receptor antagonists Heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein z,1 represents an optional double bond, the dotted line is optionally a... | 02/10/2009 |
| 7439374 | Azabenzofuran substituted thioureas; inhibitors of viral replication The present invention provides compounds of Formula 1, wherein the variables Ar, A1, A2, A3, A4, R5, R6, R7, V, W, X, and Y are defined herein. | 10/21/2008 |
| 7420001 | Biaryl sulfonamides and methods for using same The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors. ... | 09/02/2008 |
| 7420069 | Crystalline composition containing escitalopram Crystalline particles of escitalopram oxalate with a particle size of at least 40 μm is disclosed. Method for the manufacture of said crystalline particles and pharmaceutical compositions comprising said crystalline particles are also disclosed. ... | 09/02/2008 |
| 7420068 | Crystalline composition containing escitalopram The present invention discloses crystalline particles of escitalopram oxalate which either have a broad particle size distribution or comprise at least 0.01% (w/w) of Z-4-(4-dimethylamino-1-(4-fluorophenyl)-but-1-enyl)-3-hydroxymethyl-benzonitrile, said particles be... | 09/02/2008 |
| 7420000 | Amino phosphonate and amino bis-phosphonate derivatives Aminophosphonate and amino bisphosphonate compounds and methods for their preparation are provided. Also provided are pharmaceutical and agricultural compositions containing the compounds. The compounds and compositions are useful in methods for treatment of various... | 09/02/2008 |
| 7420066 | Benzofuran derivatives useful for treating hyper-proliferative disorders The invention relates to novel heterocycles of formula (I), processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders. ... | 09/02/2008 |
| 7417158 | Cationic substituted benzofurans as antimicrobial agents A method of treating a Mycobacterium tuberculosis infection in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of treating microbial infections, including infections from pro... | 08/26/2008 |
| 7405311 | Antagonist of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential hypertension, which are critically associated with the decreased binding of m... | 07/29/2008 |
| 7396857 | Therapeutic combinations for the treatment or prevention of depression Therapeutic combinations useful in the treatment or prevention of depression or other mood disorders, to pharmaceutical compositions containing said combinations, and to their use in the treatment or prophylaxis of depression or other mood disorders are provided. Su... | 07/08/2008 |
| 7384956 | Anti-constipation composition An object of the present invention is to provide an anti-constipation composition containing a halogenated-bi-cyclic compound as an active ingredient in a ratio of bi-cyclic/mono-cyclic structure of at least 1:1. The halogenated-bi-cyclic compound is represented by ... | 06/10/2008 |
| 7368476 | Hydroxamates as therapeutic agents The present invention is directed to certain hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparin... | 05/06/2008 |
| 7368471 | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) This invention provides compounds of the formula: wherein: X is a chemical bond, —CH2— or —C(O)—; R1 is alkyl, cycloalkyl, —CH2-cycloalkyl, pyridinyl, —CH2-pyridinyl, ... | 05/06/2008 |
| 7368477 | Benzofuranyl alkanamine derivatives and uses thereof Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R1′, R2, R3, R4, n, and Ar are as defined, and described in clas... | 05/06/2008 |
| 7361684 | Screening of compounds for treatment of atherosclerosis and heart attack Transgenic animals that do not express functional SR-BI and ApoE develop severe atherosclerosis, by age four weeks in transgenic mice. Moreover, these animals exhibit progressive heart dysfunction by as early as age four weeks, and die by age nine weeks. This animal... | 04/22/2008 |
| 7361690 | Compositions and methods for the treatment of urinary incontinence A method for treating increased uninary urgency or urinary incontinence, comprising administering an effective amount of a compound corresponding to formula I It has been surprisingly discovered that the methods of the pres... | 04/22/2008 |
| 7358236 | Control of acute hypertension and cardiotoxicity in patients treated with vascular targeting agents The present invention provides a method of using anti-hypertensive agents (“AHAs”) to attenuate the transient increase in blood pressure observed in patients where Vascular Targeting Agents (“VTAs”) are administered to treat diseases associated with malignan... | 04/15/2008 |
