Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 8053468 | Glycerol levulinate ketals and their use The present disclosure relates to the preparation of ketal compounds from glycerol and levulinic acid and esters, and uses thereof. ... | 11/08/2011 |
| 7956087 | Cosmetic composition for skin and wrinkle improver The present invention is to provide skin cosmetics and anti-wrinkle agents which are excellent in reducing effect on wrinkle caused by photoaging. Skin cosmetics and anti-wrinkle agents which comprise a sugar alcohol derivative represented by the following fo... | 06/07/2011 |
| 7879906 | GABA analogs, compositions and methods for manufacturing thereof The invention provides compounds of Formula (I), pharmaceutical compositions and methods of synthesis thereof. ... | 02/01/2011 |
| 7816401 | Process for total synthesis of pladienolide B and pladienolide D A process for producing a compound represented by Formula (11): wherein P1, P7, P8, P9 and R1 are the same as defined herein, characterized by including reacting a comp... | 10/19/2010 |
| 7666903 | Reaction products of 2-propylheptanol with 1-halogen-2,3-epoxypropanes and 1-hydroxy-2,3-epoxypropane The invention relates to reaction products of 2-propylheptanol with 1-halo-2,3-epoxypropanes and 1-hydroxy-2,3-epoxypropane (glycidol), to methods for their production, and to their use as cosurfactants, cleaning surfactants or thickeners. ... | 02/23/2010 |
| 7629382 | Use of tellurium containing compounds as nerve protecting agents A novel neuroprotective agent is disclosed for the treatment and prevention of neurodegenerative disorders which is based on the administration of an effective amount of a tellurium compound which has a specific ability to induce the differentiation and interfere wi... | 12/08/2009 |
| 7342038 | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment or prevention of diseases characterized by abnormal cell proliferation The present invention provides substituted 3,3-diphenyl indole compounds, as well as analogues thereof, which are specific potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a ther... | 03/11/2008 |
| 7339078 | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to ... | 03/04/2008 |
| 7323493 | Solid pharmaceutical composition containing benzofuran derivatives The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and ... | 01/29/2008 |
| 7307043 | Aqueous neonicotinoid compositions for seed treatment An aqueous composition suitable for applying insecticides or acaricides to plant propagation materials comprising water, an insecticidally or acaricidally effective amount of at least one nitroimino- or nitroguanidino-compound in free form or in agrochemically usefu... | 12/11/2007 |
| 7271274 | Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease The invention relates to compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds, wherein the compounds are of the following Formulas: or a pharmaceutically acceptable ... | 09/18/2007 |
| 7271194 | Treatment of neurotic disorders Use of escitalopram (the S-(+)-enantiomer of citalopram) or a pharmaceutically acceptable salt thereof for the preparation of a medicament useful in the treatment of neurotic disorders is provided, including anxiety states, in particular generalised anxiety disorder... | 09/18/2007 |
| 7268239 | Process for the preparation of prostaglandins and analogues thereof Disclosed are processes for the synthesis and purification of prostaglandins and analogues thereof, especially analogues of PGF2α. ... | 09/11/2007 |
| 7264822 | Conjugated drug-polymer coated stent One aspect of the invention is a system for treating vascular conditions, including a catheter, a stent coupled to the catheter, and a polymeric coating on the stent comprising at least one conjugated drug. Each conjugated drug includes a control agent and a bioacti... | 09/04/2007 |
| 7196089 | EPreceptor antagonists Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O... | 03/27/2007 |
| 7160946 | Method to improve high temperature cohesive strength with adhesive having multi-phase system A method for improving the cohesive strength at elevated temperature of a die attach adhesive formulation of a liquid curable resin, initiator, and filler, comprises adding to the adhesive formulation an aromatic bismaleimide resin powder that does not dissolve in t... | 01/09/2007 |
| 7105552 | Heterocyclic analogs of diphenylethylene compounds Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II di... | 09/12/2006 |
| 7078400 | 20-HETE synthase inhibitor The present invention relates to an inhibitor for production of 20-hydroxyeicosatetraenoic acid, comprising, as an effective ingredient, specific hydroxyformamidine derivatives or pharmaceutically-acceptable salts thereof. The inhibitors according to the present inv... | 07/18/2006 |
| 7049460 | Selective inhibitors of the urokinase plasminogen activator The present invention relates to novel selective inhibitors of the urokinase plasminogene activator (uPA, EC 3.4.21.31) of the aryl guanidine type. ... | 05/23/2006 |
| 7045150 | Tellurium containing nutrient formulation and process for enhancing the cumulative weight gain or feed efficacy in poultry A novel nutrient formulation containing tellurium for use in poultry, and a method of feeding it which improves subsequent livability, cumulative feed efficacy or weight gain is disclosed. ... | 05/16/2006 |
| 7034015 | Aminobenzoephenones The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compounds, and to the use of said ... | 04/25/2006 |
| 7026315 | Fungicide mixtures which are based on derivatives of morpholine or piperidine and derivatives oxime ether Fungicidal mixtures, comprising as active components a) a morpholine or piperidine derivative I selected from the group of the compounds Ia, Ib, Ic and Id and b) compounds of the formula II | 04/11/2006 |
| 7001924 | Inhibitors of RNase P proteins as antibacterial compounds The present invention features compounds useful for inhibiting RNase P activity. These compounds can be used as therapeutics for treating or preventing a variety of bacterial infections. The compounds belong to several classes including mono- and bis-guanylhydrazone... | 02/21/2006 |
| 6926913 | Composition containing molecular iodine The invention provides a composition of matter comprising molecular iodine and tetraglycol. ... | 08/09/2005 |
| 6903086 | Alkoxycarbonylamino benzoic acid or alkoxycarbonylamino tetrazolyl phenyl derivatives as IP antagonists This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein G1 is selected from the group consisting of a, b1 and b2,... | 06/07/2005 |
| 6894074 | Synergistic insecticidal mixtures The invention relates to insecticidal mixtures comprising compounds of the formula (I) in which X′, Y′, Z′, n, G′, A′ and B′ are as defined above and agonists and/or antagonists of nicotinic acety... | 05/17/2005 |
| 6890955 | Aryloxypropanolamine derivatives, method of preparation and applications thereof The invention concerns aryloxypropanolamine derivatives having at least an anti-diabetic and anti-fat activity and their methods of preparation and applications, particularly as human and veterinary medicine and animal food additive. These derivatives comply with th... | 05/10/2005 |
| 6864254 | Inhibitor for 20-hete-yielding enzyme An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is useful especially as a remedy for kidney diseases, cerebrovascular dis... | 03/08/2005 |
| 6861539 | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to ... | 03/01/2005 |
| 6849626 | Aza-amino acid derivatives (factor Xa inhibitors 15) The invention relates to semicarbazides of the general formula I where R1, R2, R3, R4 and I have the meaning indicated in claim 1. The compounds of the formul... | 02/01/2005 |
| 6825231 | Substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics, and a medicament comprising them The application discloses substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics and a medicament comprising them Substituted norbornylamino derivatives having exo-configured nitrogen and an endo-fused... | 11/30/2004 |
| 6800658 | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell prolifera... | 10/05/2004 |
| 6790463 | Uses of targeted oxidative therapeutic formulation in arteriosclerosis The use of a pharmaceutical formulation in treating coronary arteriosclerosis and a two-component pharmaceutical formulation. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by a... | 09/14/2004 |
| 6777440 | HIV integrase inhibitors The present invention relates to the inhibition of HIV integrase, and to the treatment of AIDS or ARC by administering compounds of the following formula, or a tautomer of said compound, or a pharmaceutically acceptable salt, solvate or prodrug thereof: ... | 08/17/2004 |
| 6730783 | Process for preparing aminoguanidines and alkoxyguanidines as protease inhibitors Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: wherein X is O or NR9 and R1-R4, R6-R9, R11, R12, Ra | 05/04/2004 |
| 6677330 | Fluorides of 4-substituted piperidine derivatives The present invention provides a novel compound having an excellent acetylcholinesterase inhibitory effect. That is, it provides a 4-substituted piperidine compound fluoride represented by the following formula, a pharmaceutically acceptable salt thereof ... | 01/13/2004 |
| 6653318 | 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use The present invention relates to pyrimidine nucleoside compounds and their use to treat viral infections of Varicella Zoster virus and Epstein Barr Virus, as well as cancers which are complications of Epstein Barr virus.... | 11/25/2003 |
| 6653322 | Therapeutic combinations of RAR antagonists and RXR agonists and use thereof The present invention provides compositions and methods for treating an animal, preferably a human, suffering from or predisposed to a physical disorder by administering an effective amount of a composition comprising at least one RAR antagonist, preferab... | 11/25/2003 |
| 6649652 | Prodrugs for antimicrobial amidines A methods of treating an infection comprises administering a therapeutically effective amount of a compound described by the Formula (I) ##STR1##... | 11/18/2003 |
| 6638931 | Aminoguanidines and alkoxyguanidines as protease inhibitors Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: ##STR1## wherein X is O or NR9 and R1 -R4, R6 -R9, R11, R12, Ra, Rb, R | 10/28/2003 |
