Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 8188063 | Use of adenosine Amodulators to treat spinal cord injury The present invention is a method for treatment or prevention of injury to nerve cells. The method can use at least one A2A receptor modulator to prevent injury to or enhance the healing of the injured cells. ... | 05/29/2012 |
| 8183225 | Inhibition of bone resorption using medical implants containing adenosine receptor antagonists The invention provides methods and compositions for reducing or inhibiting bone resorption, osteoclast differentiation and stimulation and the loosening of medical prostheses by administering a compound or agent that modulates an adenosine receptor such as the adeno... | 05/22/2012 |
| 8183224 | Purine derivatives as adenosine Areceptor agonists and methods of use thereof The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or p... | 05/22/2012 |
| 8183226 | Myocardial perfusion imaging method The present disclosure provides 2-adenosine N-pyrazole compounds exemplified by the structure shown below that are potent and selective agonists for A2A adenosine receptor, compositions comprising these compounds, and methods for using these compounds in ... | 05/22/2012 |
| 8178509 | Method to treat sickle cell disease The present invention provides a therapeutic method for treating an inflammatory response caused by a sickle cell crisis, comprising administration of an effective amount of an A2A adenosine receptor agonist. Optionally, the method includes administration... | 05/15/2012 |
| 8173618 | Formulations for reducing neuronal degeneration Nutriceutical and pharmaceutical formulations for treating neurodegenerative disorders such as Alzheimer's disease are provided. Nutriceutical formulations include two or more of folate, vitamin E, and acetyl-L-carnitine (ALCAR). Pharmaceutical formulations include ... | 05/08/2012 |
| 8158604 | 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here. ... | 04/17/2012 |
| 8148348 | Method of stabilizing S-adenosyl-L-methionine and stabilized composition Provided are a process for producing a S-adenosyl-L-methionine-containing composition which is very excellent in a stability by adding at least ascorbic acids or salts thereof to a composition liquid containing S-adenosyl-L-methionine and then drying the above compo... | 04/03/2012 |
| 8133880 | Purine derivatives and methods of use thereof The invention relates to Purine Derivatives having the formula; The invention also relates to pharmaceutical compositions comprising an effective amount of the Purine Derivative; and methods for treating or preventing an isch... | 03/13/2012 |
| 8133879 | Myocardial perfusion imaging methods and compositions The present disclosure provides 2-adenosine N-pyrazole compounds of structural formula shown below that are potent and selective agonists for A2A adenosine receptor, compositions comprising these compounds, and methods for using these compounds in a varie... | 03/13/2012 |
| 8129357 | Method of making and using an adenosine analogue This document describes compounds, extracts, and pharmaceutical compositions relating to Gastrodia spp., and methods for the treatment subjects having metabolic disorders or medical conditions such as Huntington's disease, a trinucleotide repeat disease or ab... | 03/06/2012 |
| 8119614 | Substitution derivatives of N-benzyladenosine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds The invention concerns novel substitution derivatives of N6-benzyladenosine having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells. This invention also relates to the methods of preparation of these N | 02/21/2012 |
| 8106029 | Use of Aadenosine receptor agonists Myocardial imaging methods are provided that are accomplished by administering doses of a pharmaceutical composition comprising one or more adenosine A2A receptor agonists, in particular regadenoson, useful for, among other indications, myocardial imaging... | 01/31/2012 |
| 8076311 | Compositions and methods for modulating the immune system The present invention provides methods and compositions for the prophylaxis of blood cell disorders such as neutropenia, thrombocytopenia, lymphocytopenia, and anaemia. The invention provides methods wherein compositions comprising at least one cytokinin compound ar... | 12/13/2011 |
| 8071566 | Methods of coronary imaging The present invention provides methods of myocardial perfusion imaging and increasing coronary blood flow of a mammal that are accomplished by administering doses of a compound that is a selective partial A2A receptor agonist with a short duration of acti... | 12/06/2011 |
| 8071565 | Purine derivatives as a2a agonists Compounds of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, wherein W, R1, R2 and R3 have the meanings as indicated in the specification, are useful for treating conditions mediated by activation of the a... | 12/06/2011 |
| 8063024 | Use of S-adenosylmethionine, vitamin E, and vitamin C for the treatment of oxidative liver injury and insulin resistance The present invention provides antioxidant compositions comprising S-adenosylmethionine (SAMe), vitamin E and vitamin C and uses thereof for the treatment of liver injury and insulin resistance. ... | 11/22/2011 |
| 8058259 | Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as AR agonists The present invention provides substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters and pharmaceutical compositions containing the same that are selective agonists of A2A adenosi... | 11/15/2011 |
| 8030294 | Compounds for the treatment of psychiatric or substance abuse disorders The invention provides methods for treating or preventing psychiatric and substance abuse disorders, involving administration of a therapeutically-effective amount of a cytosine-containing or cytidine-containing compound, creatine-containing compound, adenosine-cont... | 10/04/2011 |
| 7989431 | 2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein. ... | 08/02/2011 |
| 7939509 | Partial and full agonists of Aadenosine receptors Disclosed are novel compounds a compound of Formula I that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular dyslipidemia, diabetes, decreased insulin ... | 05/10/2011 |
| 7888329 | Substituted aryl piperidinylalkynyladenosines as AR agonists A2A agonists of formula (I) is provided, wherein R1, R2, R4, R5, X, Y, Z, n, p, and q are as described herein. Also provided are compositions comprising and methods of ... | 02/15/2011 |
| 7888328 | Oral formulations of cladribine Provided are compositions of cladribine and cyclodextrin which are especially suited for the oral administration of cladribine. ... | 02/15/2011 |
| 7875595 | 2-polycyclic propynyl adenosine analogs having A2A agonist activity The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein. ... | 01/25/2011 |
| 7863253 | Purine Derivatives and methods of use thereof The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for treating or preventing an ischemic condition, reperfusion injury, a cellular proliferative disorder, a cardiovascular disease, a neurolog... | 01/04/2011 |
| 7825102 | Treatment of dry eye conditions The present invention provides a method for treating dry eye condition in an individual comprising administrating to said individual an amount of A3 adenosine receptor (A3AR) agonist, the amount being effective to ameliorate symptoms of dry eye... | 11/02/2010 |
| 7790698 | Use of adenosine receptor agonists in therapy Compounds of the class of adenosines, represented by structural formula I, wherein R is C1-4 alkoxy, and X is H or OH, are useful in a method of preventing, treating, or ameliorating various conditions or disorders, e.g., inflammation, which comprises adm... | 09/07/2010 |
| 7772206 | Methods and compositions for the treatment of autoimmune disorders using clofarabine This invention relates to methods of treating or preventing an autoimmune disorder comprising the administration of clofarabine or a pharmaceutically acceptable salt, hydrate, solvate, clathrate, prodrug or metabolite thereof to a patient in need of such treatment. ... | 08/10/2010 |
| 7759321 | Compounds for the treatment of pain Compounds of the class of adenosines, represented by structural formula I, wherein R is C1-4 alkoxy, and X is H or OH, excluding 2-methoxyadenosine, are useful as analgesics, particularly in a method of preventing, treating, or ameliorating pain which com... | 07/20/2010 |
| 7749981 | Drug-eluting stents coated with non-nucleotide P2Yreceptor antagonist compound The present invention provides a drug-eluting stent, wherein the stent is coated with one or more non-nucleotide P2Y12 receptor antagonist compounds or a pharmaceutically acceptable salt, solvate, or hydrate thereof. When the stent is placed in a narrowed... | 07/06/2010 |
| 7745420 | Methods for increasing in vivo efficacy of oligonucleotides and inhibiting inflammation in mammals The invention relates to the use of nucleotide substitutes for increasing the in vivo efficacy of nucleic acid molecules and also for inhibiting inflammation in mammals. More particularly, the present invention relates to the use of 2′6′diaminopurine (DAP) and a... | 06/29/2010 |
| 7741310 | Methods for stimulating nervous system regeneration and repair by regulating arginase I and polyamine synthesis This invention relates to the novel identification of arginase as an enzymatic activity which can reverse inhibition of neuronal regeneration in the central and peripheral nervous system. Assays to monitor the effects of various agents on arginase expression and thu... | 06/22/2010 |
| 7737127 | 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here. ... | 06/15/2010 |
| 7737126 | Purine derivative A compound of formula (I) and salts and solvates thereof are disclosed. Compounds of formula (I) are agonists of the adenosine A2A receptor and are believed to be of potential use in the treatment of inflammatory... | 06/15/2010 |
| 7732424 | Purine derivatives and methods of use thereof The present invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's core body temperature, protecting an animal's heart against myocardial damage during cardioplegia; or for tr... | 06/08/2010 |
| 7713946 | Partial and full agonists Aadenosine receptors Disclosed are novel compounds a compound of Formula I that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular dyslipidemia, diabetes, decreased insulin ... | 05/11/2010 |
| 7713947 | Cladribine regimen for treating multiple sclerosis The present invention is related to the use of Cladribine for the preparation of a pharmaceutical formulation for the treatment of multiple sclerosis, especially relapsing-remitting multiple sclerosis or early secondary progressive multiple sclerosis, wherein the pr... | 05/11/2010 |
| 7696181 | Partial and full agonists of Aadenosine receptors Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, myocardial infarction and hyperlipidemia. The structure of the compou... | 04/13/2010 |
| 7691825 | Adenosine Areceptor agonists The present invention provides compounds of the formula wherein R1, R2, R3 and n have meaning as described in the specification, methods for their preparation, and pharmaceutical composition... | 04/06/2010 |
| 7683037 | Myocardial perfusion imaging method The present invention relates to methods for myocardial imaging by administering at least one 2-adenosine N-pyrazole, 2-adenosine C-pyrazole or a combination thereof A2A adenosine receptor agonist to a human undergoing myocardial imaging. The invention al... | 03/23/2010 |
