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| Number | Title | Issue Date |
| 8188143 | Pharmaceutical composition useful as acetylcholinesterase inhibitors The present invention relates to pharmaceutical composition comprising the naturally occurring compounds selected from (±) Marmesin, Columbianetin, Dihydroxanthyletin and substituted coumarin derivatives of 7-allyloxy coumarin, 7-benzyloxy coumarin, 7-methoxy couma... | 05/29/2012 |
| 8163795 | Chroman derivatives, medicaments and use in therapy Novel chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described. ... | 04/24/2012 |
| 8067461 | 3-acyl coumarins, thiochromones and quinolones and therapeutic uses thereof Compounds of Formula I: wherein R1, R2, M, Q and n are as defined herein, are useful as antiproliferative agents including, for example, as anticancer agents. ... | 11/29/2011 |
| 7846966 | Chroman derivatives as estrogenic compounds The invention provides chroman compounds having formula 1 wherein R1 is (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl, and independently R1 has a cis-orientation in relation to the exocyclic phenyl gr... | 12/07/2010 |
| 7745487 | Method for enhancing physical performance or immune system recovery from intense physical excercise with quercetin-containing compositions This invention relates to a composition containing quercetin, vitamin B3, vitamin C, and folic acid. Also disclosed is a method of using the composition for enhancing physical or mental performance or treating various diseases or disorders. ... | 06/29/2010 |
| 7745486 | Quercetin-containing compositions This invention relates to a composition containing quercetin, vitamin B3, and vitamin C. Also disclosed is a method of using the composition for enhancing physical or mental performance or treating various diseases or disorders. ... | 06/29/2010 |
| 7696246 | Bicyclic androgen and progesterone receptor modulator compounds and methods The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agon... | 04/13/2010 |
| 7666902 | Haloalkyl ester derivatives of coumarin for the treatment of coagulation disorders The subject invention provides anticoagulant compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R1, R3, n and Ar are as defined herein. The compounds of the subject inventio... | 02/23/2010 |
| 7585893 | Anti-cancer composition comprising DMXAA or related compound The present invention relates to the use of compounds such as compounds of the xanthenone acetic acid class such as 5,6-dimethylxanthenone-4-acetic acid (DMXAA) for the treatment of cancer, wherein the compounds are administered gastrointestinally, preferably orally... | 09/08/2009 |
| 7531571 | Chroman derivatives as estrogenic compounds The invention provides chroman compounds having formula 1 wherein R1 is (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl, and independently R1 has a cis-orientation in relation to the exocyclic phenyl gr... | 05/12/2009 |
| 7491746 | Compounds, compositions and methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. ... | 02/17/2009 |
| 7439077 | Coumarin analog compounds for safer anticoagulant treatment The present invention relates to the albumin-guided development of coumarin analogs and the analogs developed thereby. The coumarin analogs of the present invention are identified and isolated by the fact that they have binding sites to albumin which are different t... | 10/21/2008 |
| 7429616 | Synthesis and complete stereochemical assignment of psymberin/irciniastatin for use as antitumor compounds The invention relates to the synthesis and complete stereochemical assignments of cytotoxic compounds such as compound 28-a and its stereoisomers: The invention further provides processes for making the compounds, their syn... | 09/30/2008 |
| 7399783 | Methods for the treatment of scar tissue A topical composition and method for the reduction of scar tissue and/or improving the appearance of scar tissue after it has formed. The topical composition includes one or more flavonoids formulated in a pharmaceutically acceptable topical carrier. The method incl... | 07/15/2008 |
| 7396856 | Benzopyran analogs and their use for the treatment of glaucoma Novel benzopyran analogs are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present... | 07/08/2008 |
| 7371874 | 6-Alkylamino-2-methyl-2′-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative as anti-inflammatory inhibitor The present invention relates to a noble 6-alkylamino-2-methyl-2′-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative, a method for preparing the same with high efficiency using a parallel synthetic method, one of combinatorial chemical synthetic t... | 05/13/2008 |
| 7368582 | Amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-yl compounds, a process and intermediates for their production, and pharmaceutical compositions containing them Compounds corresponding to formula I: in which R1, R2, R3, R4, R5 and R6 have the meanings given in the description; a process for the preparation of these c... | 05/06/2008 |
| 7361774 | Chalcone compound The present invention relates to a chalcone compound represented by the following general formula: wherein R1 and R2 are taken together with the carbon atom to which they are bound, respectively, to fo... | 04/22/2008 |
| 7332522 | Liver function protecting or ameliorating agent A liver function protecting or improving agent which comprises a compound represented by the formula (I) {in the formula (I), R1, R2, R3, R4, R5, R6 | 02/19/2008 |
| 7329687 | Flavanoid compounds as chemotherapeutic, chemopreventive, and antiangiogenic agents Compounds useful as chemotherapeutic, chemopreventive, and antiangiogenic agents are provided. The compounds are flavanoids, including flavanones, flavanols, and chalcones. The compounds have the structure of formula (I) | 02/12/2008 |
| 7323452 | Method for the accelerated in vivo removal of ethanol A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives... | 01/29/2008 |
| 7285671 | Materials and methods for treating coagulation disorders The subject invention provides anticoagulant compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R1, R3, n and Ar are as defined herein. The compounds of the subje... | 10/23/2007 |
| 7276491 | Anticoagulant and fibrinolytic therapy using p38 MAP kinase inhibitors Disclosed are methods for a treating a disease or condition relating to blood coagulation and fibrinolysis using p38 MAP kinase inhibitors. ... | 10/02/2007 |
| 7259188 | Methods and pharmaceutical compositions for treatment of anti-estrogen resistant breast cancer using RXR modulators Methods and compositions for the treatment of anti-estrogen resistant breast cancer using retinoid compounds which are modulators of Retinoid X Receptors. ... | 08/21/2007 |
| 7259185 | Stable warfarin sodium liquid formulation and method of making same A stable liquid composition comprising warfarin sodium, glycerin, an alcohol such as ethanol, and a pH buffer such as a phosphate buffer providing a pH above 7 is provided. The stability of the composition is characterized by the amount of warfarin sodium in the com... | 08/21/2007 |
| 7256158 | 2,4,5,-trisubstituted phenylketo-enols for use as pesticides and herbicides The invention relates to new phenyl-substituted cyclic ketoenols of the formula (I) in which Het represents one of the groups w... | 08/14/2007 |
| 7253208 | Materials and methods for treating coagulation disorders The subject invention provides anticoagulant compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R1, R3, n and Ar are as defined herein. The compounds of the subje... | 08/07/2007 |
| 7235674 | Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, and Z are defined herein. The present invention also relate... | 06/26/2007 |
| 7226945 | Estrogen receptor-β ligands A method for treating a disease associated with the estrogen receptor-β, comprising the step of administiering a therapeutically-effective amount of a compound that satifies the equation: KiαA/KiβA>25, optionally having general structure (I)... | 06/05/2007 |
| 7214706 | Chroman derivatives as estrogenic compounds The invention provides chroman compounds having Formula (1), wherein R1 is (1C–4C)alkyl, (2C–4C)alkenyl or (2C–4C)alkynyl, and independently R1 has a cis-orientation in relation to the exocyclic phenyl group at the 2-position of the skele... | 05/08/2007 |
| 7179838 | Coumarin analog compounds for safer anticoagulant treatment The present invention relates to the albumin-guided development of coumarin analogs and the analogs developed thereby. The coumarin analogs of the present invention are identified and isolated by the fact that they have binding sites to albumin which are different t... | 02/20/2007 |
| 7169819 | Pharmaceutical compositions of fenretinide having increased bioavailability and methods of using the same A pharmaceutical composition for parenteral delivery, comprising a retinide such as fenretinide in combination with a solvent capable of dispersing or solubilizing the retinide. The solvent comprises an alcohol, such as ethanol, in combination with an alkoxylated ca... | 01/30/2007 |
| 7150124 | Rabid animal control method A method is disclosed for luring attack-prone, rabies-infected mammals (e.g., carnivores, bats) into restraint and/or euthanasia but not luring normal, uninfected animals. ... | 12/19/2006 |
| 7150967 | Fluorescent tags for amino acid and nucleic acid analysis Methods and kits for labeling and detecting thiol containing species and nucleic acids using mercurimethyl-dihydropsoralen compounds and derivatives thereof which intercalate nucleic acids and are highly reactive with thiol containing species are provided. Fluoresce... | 12/19/2006 |
| 7148253 | 4-thio coumarins 4-Thio substituted coumarin derivatives, 4,5-dithio substituted coumarin derivatives, and coumarin dimers are provided, as well as processes for their preparation. The invention also provides a method and composition for the treatment of hepatitis C virus (HCV) by a... | 12/12/2006 |
| 7148252 | Use of benzopyranones for treating or preventing a primary brain cancer or a brain metastasis This invention relates to methods for using benzopyranones, or their pharmaceutically acceptable salts, for treating or preventing a primary brain cancer or a brain metastasis. The benzopyranones have the formula: | 12/12/2006 |
| 7105310 | Detection of biomolecules by sensitizer-linked substrates Methods and compositions for detecting and characterizing target biomolecules using sensitizer-linked substrate molecules are disclosed. High throughput screening assays and therapeutic applications of the inventions are also included ... | 09/12/2006 |
| 7101676 | Methods for identifying compounds which inhibit binding of nucleocapsid 7 protein to HIV-1 RNA The present invention relates to methods of identifying a molecule from a library of molecules that inhibits binding of human immunodeficiency virus nucleocapsid 7 polypeptide (NCp7) to an oligonucleotide which comprises admixing an NCp7 polypeptide with at one labe... | 09/05/2006 |
| 7097916 | Organic light emitting element and light emitting device using the element A chelate complex having as its central metal tungsten which is an inexpensive metal and which is a heavy atom is applied to an organic light emitting element, thereby obtaining an organic light emitting element capable of converting the triplet excitation energy in... | 08/29/2006 |
| 7098244 | Antibacterial agent Provided is an antibacterial agent exhibiting an excellent antibacterial activity effect and exerting a mild influence on the environment and humans. The antibacterial agent of the present invention comprises, as an effective component, a mixture of coumarin analogu... | 08/29/2006 |
