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| Number | Title | Issue Date |
| 8183283 | Dendrite elongation inhibitor for melanocyte and skin preparation for external use containing the same The present invention relates to a dendrite elongation inhibitor for melanocytes consisting of a compound represented by the following general formula (1): and/or a salt thereof, wherein R... | 05/22/2012 |
| 8153684 | Use of equol for treating androgen mediated diseases Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the... | 04/10/2012 |
| 8148424 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, h... | 04/03/2012 |
| 8143308 | Synthesis of oligo/poly(catechins) and methods of use A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, so... | 03/27/2012 |
| 8138223 | Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them Compounds of formula (I): wherein R1, R2 and R3, which may be the same or different, each represent a hydrogen atom or the group of formula (A): M... | 03/20/2012 |
| 8124652 | Use of parthenolide derivatives as antileukemic and cytotoxic agents The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R... | 02/28/2012 |
| 8110599 | AMPelopsin unsaturated sodium salt preparation and applications thereof The present application relates to a novel AMPelopsin unsaturated sodium salt compound (AMP-Na), a method for preparing the same and the applications thereof. The physicochemical properties of AMP-Na according to the present application are significantly altered com... | 02/07/2012 |
| 8097649 | Composition and method for stabilizing the same Disclosed is a novel composition comprising a novel bi-cyclic compound, which is expected to be pharmaceutically active, and a glyceride. The stability of the bi-cyclic compound can be improved significantly by dissolving the same in a glyceride. ... | 01/17/2012 |
| 8093289 | Oral composition comprising 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl]propionic acid or salt thereof An oral composition contains 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid or a salt thereof and polyvinylpyrrolidone is advantageous as an oral medication composition (1) which can be produced without r... | 01/10/2012 |
| 8080580 | Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives Compounds of Formula (I) are described herein and the uses thereof for the treatment of diseases, conditions and/or disorders mediated by sodium-glucose transporter inhibitors (in particular, SGLT2 inhibitors). ... | 12/20/2011 |
| 8058308 | Substituted 1,3-diphenylprop-2-en-1-one derivatives, preparation and uses thereof The invention concerns novel substituted 1,3-diphenylprop-2-en-1-one derivatives, pharmaceutical compositions comprising same, their therapeutic uses, in particular for treating cerebral ischemia. The invention also concerns a method for preparing said derivatives. | 11/15/2011 |
| 8048912 | Benzopyran derivatives having inhibitory activities against liver fibrosis and cirrhosis and their pharmaceutical uses The present invention relates to a novel benzopyran derivative having goodantagonistic activity on TGF-β receptor which can be effectively used as a prophylactic and therapeutic agent for liver disease as well as several fibroplasiadiseases such as hepatic fibrosis... | 11/01/2011 |
| 8048913 | Compositions and products containing S-equol, and methods for their making A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition can be used to make articles of commerce such as food supplements, p... | 11/01/2011 |
| 8044095 | Mixture of catechins or rather polyphenols extracted from chinese green tea or other vegetables for the prevention of prostate cancer and for the treatment of prostate hypertrophy (BPH) The formulation and modality of use of a pharmaceutical preparation having the properties described below is described. This preparation is a product comprising a mixture of catechins or polyphenols extracted from chinese green tea or other vegetables that has prove... | 10/25/2011 |
| 8044097 | Chroman derivatives The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I wherein the substituents are as defined in the specification. They are useful in the treatment of disorder... | 10/25/2011 |
| 8044096 | Method for treating addiction using quercetin-containing compositions This invention relates to a method of treating addiction using a composition containing quercetin. Preferably, it also contains vitamin B3, and vitamin C. ... | 10/25/2011 |
| 8039510 | Methods of making and using theaflavin, theaflavin-3-gallate, theaflavin-3′-gallate and theaflavin 3,3′-digallate and mixtures thereof The present invention discloses methods of making a mixture of theaflavin, theaflavin-3-gallate, theaflavin-3′-gallate and theaflavin 3,3′-digallate, pharmaceutical compositions of the above mixture of theaflavins, diet supplement compositions of the above mixtu... | 10/18/2011 |
| 8034838 | Composition and method for the treatment of neurological disorders The composition for treating neurological disorders such as Alzheimer's Disease is provided. The composition includes a modified flavonoid compound having enhanced binding affinity to metabolic modulating enzymes. The composition is effective to down-regulate beta- ... | 10/11/2011 |
| 8022101 | Method of treating a knee meniscus with a cross-linking reagent to increase resistance to tearing or rupturing A method of treatment of native, non-denatured tissue to increase resistance to tearing, fissuring, rupturing, and/or delamination, comprising the step of: contacting at least a portion of the tissue with an effective amount of a reagent that increases crosslinks in... | 09/20/2011 |
| 8017649 | Flavonoid compounds and uses thereof Novel flavonoid compounds having anti-oxidant activity are described. The compounds and compositions have been shown to exhibit anti-oxidant properties and are particularly useful in the treatment of ischemia and reperfusion injuries. The invention also describes a ... | 09/13/2011 |
| 8013012 | Spiroketals The present invention relates to spiroketal compounds that are useful in methods of treating or preventing protozoal infections, parasitic infections, bacterial infections, cell proliferative disorders and anti inflammatory disorders. The spiroketal compounds are al... | 09/06/2011 |
| 8008344 | Compounds for the inhibition of histone deacetylase The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhanc... | 08/30/2011 |
| 8003688 | Method of treating symptoms of common cold, allergic rhinitis and infections relating to the respiratory tract The present invention relates to methods of treating conditions and/or symptoms related to common cold of the upper and/or lower respiratory tract and/or eyes. In particular the invention relates to the methods of treating conditions and/or symptoms related to commo... | 08/23/2011 |
| 7999003 | Antioxidant compositions and methods thereto The present invention provides a performance assay that measures the total antioxidant activity of a composition using oxygen uptake in contrast to prior art methods that measure antioxidant capacity by indirectly measuring degradation of a fluorescent compound by f... | 08/16/2011 |
| 7994216 | Stage-specific reduction of LUTS in prostate disease Methods and compositions are presented in which catechin-containing compositions have statistically significant and strong therapeutic effect in the treatment of LUTS wherein such compositions are stage-specifically administered to a patient diagnosed with HG-PIN an... | 08/09/2011 |
| 7989492 | Epigallocatechin dimers or trimers having lipase inhibitory activity and/or antioxidant activity An object of the present invention is to provide a lipase activity inhibitor that shows high inhibitory activity against pancreatic lipase to suppress the absorption of meal-derived fat and/or which contributes to suppressing and preventing obesity, as well as a foo... | 08/02/2011 |
| 7985770 | Pharmaceutical composition comprising a bi-cyclic compound and method for stabilizing the bi-cyclic compound Disclosed is a method for stabilizing a pharmaceutically active bi-cyclic compound of formula (i): comprising the step of: admixing the same with a polyol and/or a fatty acid ester other than glyceride and a composition obt... | 07/26/2011 |
| 7977378 | Compositions and methods for enhancing weight-loss by cyclical administration of compounds Compositions and methods are provided for the treatment of obesity in a human in need of such treatment which comprises administration to the human of a therapeutically effective amount of a compound of a weight loss enhancing beta-3-adrenergic compound of Cycle I, ... | 07/12/2011 |
| 7973075 | Kainate receptor-selective epimeric analogs of dysiherbaine Disclosed are compounds, pharmaceutical compositions, methods of treatment, and methods for selectively antagonizing a GluR5 receptor, a GluR6 receptor, or both receptors. The pharmaceutical compositions include and the methods utilize compounds that are analogs and... | 07/05/2011 |
| 7968595 | Substituted 4-aryl-chromene as activator of caspases and inducer of apoptosis and as antivascular agent and the use thereof The present invention is directed to a substituted 4H-chromene represented by the Formula 1R, substantially free from the corresponding (S)-stereoisomer: The present invention also relates to the discovery that compound 1R,... | 06/28/2011 |
| 7960432 | Compositions and products containing S-equol, and methods for their making A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition can be used to make articles of commerce such as food supplements, p... | 06/14/2011 |
| 7951838 | Substituted spirocyclic chromanamine compounds as Beta-Secretase modulators and methods of use The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compound... | 05/31/2011 |
| 7947733 | Phosphorylated pyrone analogs and methods The invention relates to phosphorylated polyphenols, phosphorylated flavonoids, and phosphorylated pyrone analogs. Methods and compositions for the modulation of side effects of substances using such phosphorylated compounds are described. Methods and compositions a... | 05/24/2011 |
| 7943662 | Flavonoid complexes The invention relates to complexes of certain flavonoid derivatives, of the formula (I), where R1 and R2 are selected from H and OR11, where OR11 stands, independently of one another, for OH, straight-chain or branched C | 05/17/2011 |
| 7939559 | Lipase inhibitors The present invention provides lipase inhibitors containing flavan-3-ol monomers or acylates thereof derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors contai... | 05/10/2011 |
| 7919524 | Compounds, compositions and methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. ... | 04/05/2011 |
| 7915308 | Therapeutic methods and compositions involving isoflavones Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (1), in which Z is H, R1 is H, or RACO where RA is C1-10alkyl or an amino acid, R | 03/29/2011 |
| 7910621 | Small molecule antagonists of XIAP family proteins The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of XIAP family proteins. In particular, the present invention provides embelin and other XIAP inhibitors and methods of using these compounds as antagonists of... | 03/22/2011 |
| 7906554 | Combination chemotherapy compositions and methods This invention relates to combination therapies involving anticancer chemotherapeutic agents and isoflavones or analogues thereof. The invention further relates to compounds, methods and therapeutic uses involving, containing, comprising, including and/or for prepar... | 03/15/2011 |
| 7902253 | Isoflavone derivatives of tectorigenin, the preparation thereof and the antiviral medicine containing the same as an effective constituent An isoflavone derivative of tectorigenin compound as shown in formula (II), its preparation method and the antiviral medicine containing it as an effective constituent. The compound structure is shown as follows: Where:: R | 03/08/2011 |
